The novel tellurium immunomodulator AS101 inhibits interleukin-10 production and p38 MAPK expression in atopic dermatitis

Miles, 2003, Production of lymphocyte-derived cytokines by whole umbilical cord blood cultures stimulated with mitogens and allergens, Cytokines, 21, 74, 10.1016/S1043-4666(02)00502-1 Seneviratne, 2006, Severe atopic dermatitis is associated with a reduced frequency of IL-10 producing allergen-specific CD4+ T cells, Clin Exp Dermatol, 31, 689, 10.1111/j.1365-2230.2006.02172.x Gardner, 2004, Induction of T “regulatory” cells by standardized house dust mite immunotherapy: an increase in CD4+ CD25+ interleukin-10+ T cells expressing peripheral tissue trafficking markers, Clin Exp Allergy, 34, 1209, 10.1111/j.1365-2222.2004.02009.x Akdis, 2004, Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells, J Exp Med, 199, 1567, 10.1084/jem.20032058 Sakamoto, 2004, Improvement of dermatitis by iontophoretically delivered antisense oligonucleotides for interleukin-10 in NC̃Nga mice, Gene Therapy, 11, 317, 10.1038/sj.gt.3302171 Kalechman, 2004, Inhibition of interleukin-10 by the immunomodulator AS101 reduces mesangial cell proliferation in experimental mesangioproliferative glomerulonephritis: association with dephosphorylation of STAT3, J Biol Chem, 4, 24724, 10.1074/jbc.M312006200 Sredni, 1996, Predominance of TH1 response in tumor-bearing mice and cancer patients treated with AS101, J Natl Cancer Inst, 88, 1276, 10.1093/jnci/88.18.1276 Hanifin, 1980, Diagnostic features of atopic dermatitis, Acta Dermatol Venereol, 92, 44, 10.2340/00015555924447 Veiopoulou, 2004, Thyphronitis G. IL-2 and IL-10 production by human CD4+ T cells is differentially regulated by p38: mode of stimulation-dependent regulation of IL-2, Neuroimmunomodulation, 11, 199, 10.1159/000078437 Lester, 1995, Down regulation effects of IL-4 and IL-10 on the IFNγ response in Atopic dermatitis, J Immunol, 154, 6174, 10.4049/jimmunol.154.11.6174