The non-synonymous coding IKr-channel variant KCNH2-K897T is associated with atrial fibrillation: results from a systematic candidate gene-based analysis of KCNH2 (HERG)

European Heart Journal - Tập 29 Số 7 - Trang 907-914 - 2008
Moritz F. Sinner1,2, Arne Pfeufer2,3, Mahmut Akyol2,3, Britt-Maria Beckmann1, Martin Hinterseer1, A. Wacker4, Siegfried Perz5, Wiebke Sauter6, Thomas Illig6, Michael Näbauer1, Claus Schmitt7, Hans Wichmann6, Albert Schömig8,9, Gerhard Steinbeck1, Thomas Meitinger2,3, Stefan Kääb1
1Department of Medicine I, Ludwig-Maximilians-University Munich, Klinikum Großhadern, Marchioninistr. 15, Munich D-81377, Germany
2Institute of Human Genetics, GSF National Research Centre of Environment and Health, Ingolstädter Landstr. 1, Neuherberg D-85764, Germany
3Institute of Human Genetics, Technical University Munich, Klinikum rechts der Isar, Trogerstr. 32, Munich D-81675, Germany
4Department of Pediatric Cardiology, University of Tübingen, Children’s Hospital, Hoppe-Seyler-Str. 1, Tübingen 72076, Germany
5Institute of Medical Informatics, GSF National Research Centre of Environment and Health, IngolstädterLandstr. 1, Neuherberg 85764, Germany
6Institute of Epidemiology, GSF National Research Centre of Environment and Health, IngolstädterLandstr. 1, Neuherberg 85764, Germany
7Hospital of Karlsruhe, Moltkestr. 90, Karlsruhe 76133, Germany
8Department of Cardiovascular Diseases, The German Heart Centre, Lazarettstr. 36, Munich 80636, Germany
9Medical Department I, Technical University Munich, Klinikum rechts der Isar, Ismaninger Str. 22, Munich 81675, Germany

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