The myocardium and sex steroid hormone influences

Vaccarino, 2011, Ischaemic heart disease in women: are there sex differences in pathophysiology and risk factors? Position paper from the working group on coronary pathophysiology and microcirculation of the European Society of Cardiology, Cardiovasc Res, 90, 9, 10.1093/cvr/cvq394 Go, 2014, Executive summary: heart disease and stroke statistics—2014 update: a report from the American Heart Association, Circulation, 129, 399, 10.1161/01.cir.0000442015.53336.12 Manson, 2013, Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women's Health Initiative randomized trials, JAMA, 310, 1353, 10.1001/jama.2013.278040 Lacey, 2014, The WHI ten year's later: an epidemiologist's view, J Steroid Biochem Mol Biol, 142, 12, 10.1016/j.jsbmb.2013.08.006 Rossouw, 2002, Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial, JAMA, 288, 321, 10.1001/jama.288.3.321 Oskui, 2013, Testosterone and the cardiovascular system: a comprehensive review of the clinical literature, J Am Heart Assoc, 2, e000272, 10.1161/JAHA.113.000272 Pope, 2014, Adverse health consequences of performance-enhancing drugs: an Endocrine Society scientific statement, Endocr Rev, 35, 341, 10.1210/er.2013-1058 Menazza, 2016, The expanding complexity of estrogen receptor signaling in the cardiovascular system, Circ Res, 118, 994, 10.1161/CIRCRESAHA.115.305376 Lizotte, 2009, Expression, distribution and regulation of sex steroid hormone receptors in mouse heart, Cell Physiol Biochem, 23, 75, 10.1159/000204096 Steagall, 2017, Estrogen receptor alpha activation enhances its cell surface localization and improves myocardial redox status in ovariectomized rats, Life Sci, 182, 41, 10.1016/j.lfs.2017.06.005 Jankowski, 2001, Estrogen receptors activate atrial natriuretic peptide in the rat heart, Proc Natl Acad Sci U S A, 98, 11765, 10.1073/pnas.201394198 Nordmeyer, 2004, Upregulation of myocardial estrogen receptors in human aortic stenosis, Circulation, 110, 3270, 10.1161/01.CIR.0000147610.41984.E8 Pedernera, 2017, Androgen receptor is expressed in mouse cardiomyocytes at prenatal and early postnatal developmental stages, BMC Physiology, 17, 7, 10.1186/s12899-017-0033-8 Pugach, 2016, Estrogen receptor profiling and activity in cardiac myocytes, Mol Cell Endocrinol, 431, 62, 10.1016/j.mce.2016.05.004 Bell, 2013, Sex and sex hormones in cardiac stress—mechanistic insights, J Steroid Biochem Mol Biol, 137, 124, 10.1016/j.jsbmb.2013.05.015 James, 2007, Recent advances in understanding sex differences in cardiac repolarization, Prog Biophys Mol Biol, 94, 265, 10.1016/j.pbiomolbio.2005.05.010 Abehsira, 2016, Complex influence of gonadotropins and sex steroid hormones on QT interval duration, J Clin Endocrinol Metab, 101, 2776, 10.1210/jc.2016-1877 Tse, 2001, Effect of gender on atrial electrophysiologic changes induced by rapid atrial pacing and elevation of atrial pressure, J Cardiovasc Electrophysiol, 12, 986, 10.1046/j.1540-8167.2001.00986.x Kurokawa, 2008, Acute effects of oestrogen on the guinea pig and human IKr channels and drug-induced prolongation of cardiac repolarization, J Physiol, 586, 2961, 10.1113/jphysiol.2007.150367 Zhang, 1998, Effects of sex hormones on action potential and contraction of guinea pig papillary muscle, Zhongguo Yao Li Xue Bao, 19, 248 Saba, 2002, Effects of estrogen on cardiac electrophysiology in female mice, J Cardiovasc Electrophysiol, 13, 276, 10.1046/j.1540-8167.2002.00276.x Moller, 1999, Beta-estradiol acutely potentiates the depression of cardiac excitability by lidocaine and bupivacaine, J Cardiovasc Pharmacol, 34, 718, 10.1097/00005344-199911000-00014 Jiang, 1992, Effect of 17 beta-oestradiol on contraction, Ca2+ current and intracellular free Ca2+ in guinea-pig isolated cardiac myocytes, Br J Pharmacol, 106, 739, 10.1111/j.1476-5381.1992.tb14403.x Ayaz, 2015, Testosterone modulates cardiac contraction and calcium homeostasis: cellular and molecular mechanisms, Biol Sex Differ, 6, 9, 10.1186/s13293-015-0027-9 Liu, 2003, In vivo androgen treatment shortens the QT interval and increases the densities of inward and delayed rectifier potassium currents in orchiectomized male rabbits, Cardiovasc Res, 57, 28, 10.1016/S0008-6363(02)00673-9 Curl, 2001, Effects of gender on intracellular [Ca2+] in rat cardiac myocytes, Pflugers Arch, 441, 709, 10.1007/s004240000473 Papp, 2017, Genomic upregulation of cardiac Cav1.2alpha and NCX1 by estrogen in women, Biol Sex Differ, 8, 26, 10.1186/s13293-017-0148-4 Fares, 2012, Ovariectomy enhances SR Ca(2)(+) release and increases Ca(2)(+) spark amplitudes in isolated ventricular myocytes, J Mol Cell Cardiol, 52, 32, 10.1016/j.yjmcc.2011.09.002 Parks, 2017, The impact of ovariectomy on cardiac excitation–contraction coupling is mediated through cAMP/PKA-dependent mechanisms, J Mol Cell Cardiol, 111, 51, 10.1016/j.yjmcc.2017.07.118 Bell, 2015, Cardiac CaMKIIdelta splice variants exhibit target signaling specificity and confer sex-selective arrhythmogenic actions in the ischemic-reperfused heart, Int J Cardiol, 181, 288, 10.1016/j.ijcard.2014.11.159 Curl, 2012, ‘Gain’-ful insight into the cardiomyocyte Ca(2)(+) seX factor, J Mol Cell Cardiol, 52, 7, 10.1016/j.yjmcc.2011.10.006 Feridooni, 2017, Acute exposure to progesterone attenuates cardiac contraction by modifying myofilament calcium sensitivity in the female mouse heart, Am J Physiol Heart Circ Physiol, 312, H46, 10.1152/ajpheart.00073.2016 Clapp, 1997, Cardiovascular function before, during, and after the first and subsequent pregnancies, Am J Cardiol, 80, 1469, 10.1016/S0002-9149(97)00738-8 Heidemann, 2003, Changes in maternal physiology during pregnancy, BJA CEPD Rev, 3, 65, 10.1093/bjacepd/mkg065 Vaccarino, 2013, Presentation, management, and outcomes of ischaemic heart disease in women, Nat Rev Cardiol, 10, 508, 10.1038/nrcardio.2013.93 Roger, 2012, Heart disease and stroke statistics—2012 update: a report from the American Heart Association, Circulation, 125, e2 Leening, 2014, Sex differences in lifetime risk and first manifestation of cardiovascular disease: prospective population based cohort study, BMJ, 349, g5992, 10.1136/bmj.g5992 Garcia, 2016, Cardiovascular disease in women: clinical perspectives, Circ Res, 118, 1273, 10.1161/CIRCRESAHA.116.307547 Bell, 2008, The intrinsic resistance of female hearts to an ischemic insult is abrogated in primary cardiac hypertrophy, Am J Physiol Heart Circ Physiol, 294, H1514, 10.1152/ajpheart.01283.2007 Shao, 2016, Characterization of the sex-dependent myocardial S-nitrosothiol proteome, Am J Physiol Heart Circ Physiol, 310, H505, 10.1152/ajpheart.00681.2015 Zhai, 2000, Effect of estrogen on global myocardial ischemia–reperfusion injury in female rats, Am J Physiol Heart Circ Physiol, 279, H2766, 10.1152/ajpheart.2000.279.6.H2766 Menazza, 2017, Non-nuclear estrogen receptor alpha activation in endothelium reduces cardiac ischemia–reperfusion injury in mice, J Mol Cell Cardiol, 107, 41, 10.1016/j.yjmcc.2017.04.004 Kabir, 2015, G protein-coupled estrogen receptor 1 mediates acute estrogen-induced cardioprotection via MEK/ERK/GSK-3beta pathway after ischemia/reperfusion, PLOS ONE, 10, e0135988, 10.1371/journal.pone.0135988 Deschamps, 2009, Activation of a novel estrogen receptor, GPER, is cardioprotective in male and female rats, Am J Physiol Heart Circ Physiol, 297, H1806, 10.1152/ajpheart.00283.2009 Lin, 2009, Estrogen receptor-beta activation results in S-nitrosylation of proteins involved in cardioprotection, Circulation, 120, 245, 10.1161/CIRCULATIONAHA.109.868729 Pongkan, 2015, Chronic testosterone replacement exerts cardioprotection against cardiac ischemia–reperfusion injury by attenuating mitochondrial dysfunction in testosterone-deprived rats, PLOS ONE, 10, e0122503, 10.1371/journal.pone.0122503 Boon, 2010, The multiple roles of estrogens and the enzyme aromatase, Prog Brain Res, 181, 209, 10.1016/S0079-6123(08)81012-6 Bell, 2011, Aromatase deficiency confers paradoxical postischemic cardioprotection, Endocrinology, 152, 4937, 10.1210/en.2011-1212 Li, 2001, Altered structure and function of reproductive organs in transgenic male mice overexpressing human aromatase, Endocrinology, 142, 2435, 10.1210/endo.142.6.8211 Bell, 2014, Aromatase transgenic upregulation modulates basal cardiac performance and the response to ischemic stress in male mice, Am J Physiol Heart Circ Physiol, 306, H1265, 10.1152/ajpheart.00012.2014 Fu, 2017, Cardioprotection by low-dose of estrogen and testosterone at the physiological ratio on ovariectomized rats during ischemia/reperfusion injury, J Cardiovasc Pharmacol, 70, 87, 10.1097/FJC.0000000000000497 Scantlebury, 2011, Why are women more likely than men to develop heart failure with preserved ejection fraction?, Curr Opin Cardiol, 26, 562, 10.1097/HCO.0b013e32834b7faf Douglas, 1998, Hypertrophic remodeling: gender differences in the early response to left ventricular pressure overload, J Am Coll Cardiol, 32, 1118, 10.1016/S0735-1097(98)00347-7 Fliegner, 2010, Female sex and estrogen receptor-β attenuate cardiac remodeling and apoptosis in pressure overload, Am J Physiol Regul Integr Comp Physiol, 298, R1597, 10.1152/ajpregu.00825.2009 Pirompol, 2016, Supra-physiological dose of testosterone induces pathological cardiac hypertrophy, J Endocrinol, 229, 13, 10.1530/JOE-15-0506 Gaasch, 2011, Left ventricular structural remodeling in health and disease: with special emphasis on volume, mass, and geometry, J Am Coll Cardiol, 58, 1733, 10.1016/j.jacc.2011.07.022 Donaldson, 2009, Estrogen attenuates left ventricular and cardiomyocyte hypertrophy by an estrogen receptor-dependent pathway that increases calcineurin degradation, Circ Res, 104, 265, 10.1161/CIRCRESAHA.108.190397 Babiker, 2006, Estrogen receptor beta protects the murine heart against left ventricular hypertrophy, Arterioscler Thromb Vasc Biol, 26, 1524, 10.1161/01.ATV.0000223344.11128.23 Harrington, 2017, A systems biology approach to investigating sex differences in cardiac hypertrophy, J Am Heart Assoc, 6 Zwadlo, 2015, Antiandrogenic therapy with finasteride attenuates cardiac hypertrophy and left ventricular dysfunction, Circulation, 131, 1071, 10.1161/CIRCULATIONAHA.114.012066 Tripathi, 2017, Enhanced heart failure, mortality and renin activation in female mice with experimental dilated cardiomyopathy, PLOS ONE, 12, e0189315, 10.1371/journal.pone.0189315 Haines, 2012, Estrogens mediate cardiac hypertrophy in a stimulus-dependent manner, Endocrinology, 153, 4480, 10.1210/en.2012-1353 Iorga, 2016, Rescue of pressure overload-induced heart failure by estrogen therapy, J Am Heart Assoc, 5, 10.1161/JAHA.115.002482 Kannel, 1998, Sudden coronary death in women, Am Heart J, 136, 205, 10.1053/hj.1998.v136.90226 O’Neal, 2017, Sex hormones and the risk of atrial fibrillation: the Multi-Ethnic Study of Atherosclerosis (MESA), Endocrine, 58, 91, 10.1007/s12020-017-1385-3 Lujan, 2007, Sex influences the susceptibility to reperfusion-induced sustained ventricular tachycardia and β-adrenergic receptor blockade in conscious rats, Am J Physiol Heart Circ Physiol, 293, H2799, 10.1152/ajpheart.00596.2007 Chen, 2010, 17beta-estradiol decreases vulnerability to ventricular arrhythmias by preserving connexin43 protein in infarcted rats, Eur J Pharmacol, 629, 73, 10.1016/j.ejphar.2009.11.050 Bienvenu, 2017, Chronic in vivo nitric oxide deficiency impairs cardiac functional recovery after ischemia in female (but not male) mice, J Mol Cell Cardiol, 112, 8, 10.1016/j.yjmcc.2017.08.012 Grohe, 1998, Expression of oestrogen receptor alpha and beta in rat heart: role of local oestrogen synthesis, J Endocrinol, 156, R1, 10.1677/joe.0.156R001 Bernasochi, 2017, Pericardial adipose and aromatase: a new translational target for aging, obesity and arrhythmogenesis?, J Mol Cell Cardiol, 111, 96, 10.1016/j.yjmcc.2017.08.006 Nelson, 1992, Differential contributions of ovarian and extraovarian factors to age-related reductions in plasma estradiol and progesterone during the estrous cycle of C57BL/6J mice, Endocrinology, 130, 805 Jazbutyte, 2012, Aromatase inhibition attenuates desflurane-induced preconditioning against acute myocardial infarction in male mouse heart in vivo, PLoS ONE, 7, e42032, 10.1371/journal.pone.0042032 Stanic, 2014, Characterization of aromatase expression in the adult male and female mouse brain. I. Coexistence with oestrogen receptors alpha and beta, and androgen receptors, PLOS ONE, 9, e90451, 10.1371/journal.pone.0090451