The molecular understanding of osteoclast differentiation

Alliston, 2002, Interfering with bone remodelling, Nature, 416, 686, 10.1038/416686a

Anderson, 1997, A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function, Nature, 390, 175, 10.1038/36593

Ansel, 2006, Regulation of Th2 differentiation and Il4 locus accessibility, Annu. Rev. Immunol., 24, 607, 10.1146/annurev.immunol.23.021704.115821

Anusaksathien, 2001, Tissue-specific and ubiquitous promoters direct the expression of alternatively spliced transcripts from the calcitonin receptor gene, J. Biol. Chem., 276, 22663, 10.1074/jbc.M007104200

Aoki, 1999, The tyrosine phosphatase SHP-1 is a negative regulator of osteoclastogenesis and osteoclast resorbing activity: increased resorption and osteopenia in mev/mev mutant mice, Bone, 25, 261, 10.1016/S8756-3282(99)00174-X

Arai, 1999, Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor kappaB (RANK) receptors, J. Exp. Med., 190, 1741, 10.1084/jem.190.12.1741

Armstrong, 2002, A RANK/TRAF6-dependent signal transduction pathway is essential for osteoclast cytoskeletal organization and resorptive function, J. Biol. Chem., 277, 44347, 10.1074/jbc.M202009200

Asagiri, 2005, Autoamplification of NFATc1 expression determines its essential role in bone homeostasis, J. Exp. Med., 202, 1261, 10.1084/jem.20051150

Baron, 2004, Arming the osteoclast, Nat. Med., 10, 458, 10.1038/nm0504-458

Bouwmeester, 2004, A physical and functional map of the human TNF-α/NF-KB signal transduction pathway, Nat. Cell Biol., 6, 97, 10.1038/ncb1086

Boyle, 2003, Osteoclast differentiation and activation, Nature, 423, 337, 10.1038/nature01658

Cavey, 2005, Loss of ubiquitin-binding associated with Paget's disease of bone p62 (SQSTM1) mutations, J. Bone Miner. Res., 20, 619, 10.1359/JBMR.041205

Cella, 2003, Impaired differentiation of osteoclasts in TREM-2-deficient individuals, J. Exp. Med., 198, 645, 10.1084/jem.20022220

Chang, 2001, Mammalian MAP kinase signalling cascades, Nature, 410, 37, 10.1038/35065000

Chen, 1998, Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA, Nature, 392, 42, 10.1038/32100

Clausen, 1999, Conditional gene targeting in macrophages and granulocytes using LysMcre mice, Transgenic Res., 8, 265, 10.1023/A:1008942828960

Crabtree, 2002, NFAT signaling: choreographing the social lives of cells, Cell, 109, S67, 10.1016/S0092-8674(02)00699-2

Crotti, 2006, NFATc1 regulation of the human β3 integrin promoter in osteoclast differentiation, Gene, 372, 92, 10.1016/j.gene.2005.12.012

Dabovic, 2005, Osteopetrosis-like phenotype in latent TGF-β binding protein 3 deficient mice, Bone, 37, 25, 10.1016/j.bone.2005.02.021

Dai, 2002, Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects, Blood, 99, 111, 10.1182/blood.V99.1.111

Darnay, 1998, Characterization of the intracellular domain of receptor activator of NF-KB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-KB and c-Jun N-terminal kinase, J. Biol. Chem., 273, 20551, 10.1074/jbc.273.32.20551

Darnay, 1999, Activation of NF-KB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-κB-inducing kinase. Identification of a novel TRAF6 interaction motif, J. Biol. Chem., 274, 7724, 10.1074/jbc.274.12.7724

David, 2002, JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanisms, J. Cell Sci., 115, 4317, 10.1242/jcs.00082

de la Pompa, 1998, Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum, Nature, 392, 182, 10.1038/32419

de la Serna, 2006, Chromatin remodelling in mammalian differentiation: lessons from ATP-dependent remodellers, Nat. Rev., Genet., 7, 461, 10.1038/nrg1882

Deng, 2000, Activation of the IKB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain, Cell, 103, 351, 10.1016/S0092-8674(00)00126-4

Dougall, 1999, RANK is essential for osteoclast and lymph node development, Genes Dev., 13, 2412, 10.1101/gad.13.18.2412

Duran, 2004, The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis, Dev. Cell, 6, 303, 10.1016/S1534-5807(03)00403-9

Eferl, 2004, The Fos-related antigen Fra-1 is an activator of bone matrix formation, EMBO J., 23, 2789, 10.1038/sj.emboj.7600282

Eferl, 2003, AP-1: a double-edged sword in tumorigenesis, Nat. Rev., Cancer, 3, 859, 10.1038/nrc1209

Faccio, 2003, c-Fms and the αvβ3 integrin collaborate during osteoclast differentiation, J. Clin. Invest., 111, 749, 10.1172/JCI200316924

Felix, 1996, Recent developments in the understanding of the pathophysiology of osteopetrosis, Eur. J. Endocrinol., 134, 143, 10.1530/eje.0.1340143

Ferron, 2005, Targeted expression of Cre recombinase in macrophages and osteoclasts in transgenic mice, Genesis, 41, 138, 10.1002/gene.20108

Franzoso, 1997, Requirement for NF-KB in osteoclast and B-cell development, Genes Dev., 11, 3482, 10.1101/gad.11.24.3482

Frattini, 2000, Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis, Nat. Genet., 25, 343, 10.1038/77131

Fukuda, 2005, Regulation of osteoclast apoptosis and motility by small GTPase binding protein Rac1, J. Bone Miner. Res., 20, 2245, 10.1359/JBMR.050816

Fuller, 2000, A role for TGFβ1 in osteoclast differentiation and survival, J. Cell Sci., 113, 2445, 10.1242/jcs.113.13.2445

Galibert, 1998, The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-KB, a member of the TNFR superfamily, J. Biol. Chem., 273, 34120, 10.1074/jbc.273.51.34120

Ghosh, 2002, Missing pieces in the NF-KB puzzle, Cell, 109, S81, 10.1016/S0092-8674(02)00703-1

Gohda, 2005, RANK-mediated amplification of TRAF6 signaling leads to NFATc1 induction during osteoclastogenesis, EMBO J., 24, 790, 10.1038/sj.emboj.7600564

Gowen, 1999, Cathepsin K knockout mice develop osteopetrosis due to a deficit in matrix degradation but not demineralization, J. Bone Miner. Res., 14, 1654, 10.1359/jbmr.1999.14.10.1654

Grigoriadis, 1994, c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling, Science, 266, 443, 10.1126/science.7939685

Hayden, 2004, Signaling to NF-κB, Genes Dev., 18, 2195, 10.1101/gad.1228704

Hodgkinson, 1993, Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix–loop–helix-zipper protein, Cell, 74, 395, 10.1016/0092-8674(93)90429-T

Hogan, 2003, Transcriptional regulation by calcium, calcineurin, and NFAT, Genes Dev., 17, 2205, 10.1101/gad.1102703

Horne, 2005, The role(s) of Src kinase and Cbl proteins in the regulation of osteoclast differentiation and function, Immunol. Rev., 208, 106, 10.1111/j.0105-2896.2005.00335.x

Hotokezaka, 2002, U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells, J. Biol. Chem., 277, 47366, 10.1074/jbc.M208284200

Hsu, 1999, Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand, Proc. Natl. Acad. Sci. U. S. A., 96, 3540, 10.1073/pnas.96.7.3540

Ikeda, 2004, Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation, J. Clin. Invest., 114, 475, 10.1172/JCI200419657

Inoue, 2000, Tumor necrosis factor receptor-associated factor (TRAF) family: adapter proteins that mediate cytokine signaling, Exp. Cell Res., 254, 14, 10.1006/excr.1999.4733

Iotsova, 1997, Osteopetrosis in mice lacking NF-κB1 and NF-κB2, Nat. Med., 3, 1285, 10.1038/nm1197-1285

Ishida, 2002, Large scale gene expression analysis of osteoclastogenesis in vitro and elucidation of NFAT2 as a key regulator, J. Biol. Chem., 277, 41147, 10.1074/jbc.M205063200

Jimi, 2004, Selective inhibition of NF-κ B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo, Nat. Med., 10, 617, 10.1038/nm1054

Johnson, 1992, Pleiotropic effects of a null mutation in the c-fos proto-oncogene, Cell, 71, 577, 10.1016/0092-8674(92)90592-Z

Kadono, 2005, Strength of TRAF6 signalling determines osteoclastogenesis, EMBO Rep., 6, 171, 10.1038/sj.embor.7400345

Kaifu, 2003, Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice, J. Clin. Invest., 111, 323, 10.1172/JCI16923

Kanazawa, 2003, TRAF5 functions in both RANKL- and TNFα-induced osteoclastogenesis, J. Bone Miner. Res., 18, 443, 10.1359/jbmr.2003.18.3.443

Kanazawa, 2005, TRAF2 is essential for TNF-α-induced osteoclastogenesis, J. Bone Miner. Res., 20, 840, 10.1359/JBMR.041225

Kaneda, 2000, Endogenous production of TGF-β is essential for osteoclastogenesis induced by a combination of receptor activator of NF-KB ligand and macrophage-colony-stimulating factor, J. Immunol., 165, 4254, 10.4049/jimmunol.165.8.4254

Karsenty, 2002, Reaching a genetic and molecular understanding of skeletal development, Dev. Cell, 2, 389, 10.1016/S1534-5807(02)00157-0

Kenner, 2004, Mice lacking JunB are osteopenic due to cell-autonomous osteoblast and osteoclast defects, J. Cell Biol., 164, 613, 10.1083/jcb.200308155

Kim, 2005, Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis, J. Biol. Chem., 280, 35209, 10.1074/jbc.M505815200

Kim, 2005, Osteoclast differentiation independent of the TRANCE–RANK–TRAF6 axis, J. Exp. Med., 202, 589, 10.1084/jem.20050978

Kim, 2002, A novel member of the leukocyte receptor complex regulates osteoclast differentiation, J. Exp. Med., 195, 201, 10.1084/jem.20011681

Kim, 2005, Contribution of nuclear factor of activated T cells c1 to the transcriptional control of immunoreceptor osteoclast-associated receptor but not triggering receptor expressed by myeloid cells-2 during osteoclastogenesis, J. Biol. Chem., 280, 32905, 10.1074/jbc.M505820200

Kiviranta, 2005, Impaired bone resorption in cathepsin K-deficient mice is partially compensated for by enhanced osteoclastogenesis and increased expression of other proteases via an increased RANKL/OPG ratio, Bone, 36, 159, 10.1016/j.bone.2004.09.020

Kobayashi, 2001, Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis, EMBO J., 20, 1271, 10.1093/emboj/20.6.1271

Kobayashi, 2003, TRAF6 is a critical factor for dendritic cell maturation and development, Immunity, 19, 353, 10.1016/S1074-7613(03)00230-9

Koga, 2004, Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis, Nature, 428, 758, 10.1038/nature02444

Kong, 1999, OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis, Nature, 397, 315, 10.1038/16852

Kornak, 2001, Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man, Cell, 104, 205, 10.1016/S0092-8674(01)00206-9

Krings, 1997, Neandertal DNA sequences and the origin of modern humans, Cell, 90, 19, 10.1016/S0092-8674(00)80310-4

Kuhn, 1995, Inducible gene targeting in mice, Science, 269, 1427, 10.1126/science.7660125

Kukita, 2004, RANKL-induced DC-STAMP is essential for osteoclastogenesis, J. Exp. Med., 200, 941, 10.1084/jem.20040518

Lacey, 1998, Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation, Cell, 93, 165, 10.1016/S0092-8674(00)81569-X

Lagasse, 1997, Enforced expression of Bcl-2 in monocytes rescues macrophages and partially reverses osteopetrosis in op/op mice, Cell, 89, 1021, 10.1016/S0092-8674(00)80290-1

Laurin, 2002, Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of bone, Am. J. Hum. Genet., 70, 1582, 10.1086/340731

Lewis, 1988, N-ethyl-N-nitrosourea-induced null mutation at the mouse Car-2 locus: an animal model for human carbonic anhydrase II deficiency syndrome, Proc. Natl. Acad. Sci. U. S. A., 85, 1962, 10.1073/pnas.85.6.1962

Li, 2006, Mice lacking cathepsin K maintain bone remodeling but develop bone fragility despite high bone mass, J. Bone Miner. Res., 21, 865, 10.1359/jbmr.060313

Li, 2004, Over-expression of activated NFATc1 plus RANKL rescues the osteoclastogenesis defect of NF-KB p50/p52 double knockout splenocytes, J. Bone Miner. Res., 19, S2

Li, 2000, RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism, Proc. Natl. Acad. Sci. U. S. A., 97, 1566, 10.1073/pnas.97.4.1566

Li, 1999, Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification, Nat. Genet., 23, 447, 10.1038/70563

Lomaga, 1999, TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling, Genes Dev., 13, 1015, 10.1101/gad.13.8.1015

Lowe, 1993, Osteopetrosis in Src-deficient mice is due to an autonomous defect of osteoclasts, Proc. Natl. Acad. Sci. U. S. A., 90, 4485, 10.1073/pnas.90.10.4485

Matsumoto, 2004, Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1, J. Biol. Chem., 279, 45969, 10.1074/jbc.M408795200

Matsumoto, 2000, Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-κB ligand (RANKL), J. Biol. Chem., 275, 31155, 10.1074/jbc.M001229200

Matsuo, 2004, Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos, J. Biol. Chem., 279, 26475, 10.1074/jbc.M313973200

Matsuo, 2000, Fosl1 is a transcriptional target of c-Fos during osteoclast differentiation, Nat. Genet., 24, 184, 10.1038/72855

McClung, 2006, Denosumab in postmenopausal women with low bone mineral density, N. Engl. J. Med., 354, 821, 10.1056/NEJMoa044459

McGill, 2002, Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability, Cell, 109, 707, 10.1016/S0092-8674(02)00762-6

McHugh, 2000, Mice lacking β3 integrins are osteosclerotic because of dysfunctional osteoclasts, J. Clin. Invest., 105, 433, 10.1172/JCI8905

McKercher, 1996, Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities, EMBO J., 15, 5647, 10.1002/j.1460-2075.1996.tb00949.x

Merck, 2004, OSCAR is an FcRγ-associated receptor that is expressed by myeloid cells and is involved in antigen presentation and activation of human dendritic cells, Blood, 104, 1386, 10.1182/blood-2004-03-0850

Miyazaki, 2000, Reciprocal role of ERK and NF-κB pathways in survival and activation of osteoclasts, J Cell Biol, 148, 333, 10.1083/jcb.148.2.333

Mizukami, 2002, Receptor activator of NF-κB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6, Mol. Cell. Biol., 22, 992, 10.1128/MCB.22.4.992-1000.2002

Mocsai, 2004, The immunomodulatory adapter proteins DAP12 and Fc receptor γ-chain (FcRγ) regulate development of functional osteoclasts through the Syk tyrosine kinase, Proc. Natl. Acad. Sci. U. S. A., 101, 6158, 10.1073/pnas.0401602101

Naito, 1999, Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice, Genes Cells, 4, 353, 10.1046/j.1365-2443.1999.00265.x

Nakamura, 1997, Phosphatidylinositol-3 kinase is involved in ruffled border formation in osteoclasts, J. Cell Physiol., 172, 230, 10.1002/(SICI)1097-4652(199708)172:2<230::AID-JCP10>3.0.CO;2-D

Nakamura, 2004, Genetic evidence of androgen receptor function in osteoclasts: generation and characterization of osteoclast-specific androgen receptor knockout mice, J. Bone Miner. Res., 19, S3

Novack, 2003, The IKB function of NF-KB2 p100 controls stimulated osteoclastogenesis, J. Exp. Med., 198, 771, 10.1084/jem.20030116

Paloneva, 2000, Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts, Nat. Genet., 25, 357, 10.1038/77153

Paloneva, 2003, DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features, J. Exp. Med., 198, 669, 10.1084/jem.20030027

Paloneva, 2002, Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype, Am. J. Hum. Genet., 71, 656, 10.1086/342259

Peng, 2001, NFATc1 and NFATc2 together control both T and B cell activation and differentiation, Immunity, 14, 13, 10.1016/S1074-7613(01)00085-1

Quinn, 2001, Transforming growth factor β affects osteoclast differentiation via direct and indirect actions, J. Bone Miner. Res., 16, 1787, 10.1359/jbmr.2001.16.10.1787

Ranger, 1998, The transcription factor NF-ATc is essential for cardiac valve formation, Nature, 392, 186, 10.1038/32426

Reth, 1989, Antigen receptor tail clue, Nature, 338, 383, 10.1038/338383b0

Robertson, 2002, DNA methylation and chromatin—Unraveling the tangled web, Oncogene, 21, 5361, 10.1038/sj.onc.1205609

Ross, 2005, αvβ3 and macrophage colony-stimulating factor: partners in osteoclast biology, Immunol. Rev., 208, 88, 10.1111/j.0105-2896.2005.00331.x

Ruocco, 2005, IKB kinase (IKK)β, but not IKKα, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss, J. Exp. Med., 201, 1677, 10.1084/jem.20042081

Saftig, 1998, Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice, Proc. Natl. Acad. Sci. U. S. A., 95, 13453, 10.1073/pnas.95.23.13453

Sato, 2006, Osteoclasts, rheumatoid arthritis, and osteoimmunology, Curr. Opin. Rheumatol., 18, 419, 10.1097/01.bor.0000231912.24740.a5

Shui, 2002, The immunosuppressant rapamycin, alone or with transforming growth factor-β, enhances osteoclast differentiation of RAW264.7 monocyte–macrophage cells in the presence of RANK-ligand, Calcif. Tissue Int., 71, 437, 10.1007/s00223-001-1138-3

Sly, 1983, Carbonic anhydrase II deficiency identified as the primary defect in the autosomal recessive syndrome of osteopetrosis with renal tubular acidosis and cerebral calcification, Proc. Natl. Acad. Sci. U. S. A., 80, 2752, 10.1073/pnas.80.9.2752

Soriano, 1991, Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice, Cell, 64, 693, 10.1016/0092-8674(91)90499-O

Suda, 1992, Modulation of osteoclast differentiation, Endocr. Rev., 13, 66

Sugatani, 2005, Akt1/Akt2 and mammalian target of rapamycin/Bim play critical roles in osteoclast differentiation and survival, respectively, whereas Akt is dispensable for cell survival in isolated osteoclast precursors, J. Biol. Chem., 280, 3583, 10.1074/jbc.M410480200

Takahashi, 1988, Osteoblastic cells are involved in osteoclast formation, Endocrinology, 123, 2600, 10.1210/endo-123-5-2600

Takatsuna, 2005, Inhibition of RANKL-induced osteoclastogenesis by (−)-DHMEQ, a novel NF-KB inhibitor, through downregulation of NFATc1, J. Bone Miner. Res., 20, 653, 10.1359/JBMR.041213

Takayanagi, 2005, Inflammatory bone destruction and osteoimmunology, J. Periodontal. Res., 40, 287, 10.1111/j.1600-0765.2005.00814.x

Takayanagi, 2005, Mechanistic insight into osteoclast differentiation in osteoimmunology, J. Mol. Med., 83, 170, 10.1007/s00109-004-0612-6

Takayanagi, 2002, Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling for terminal differentiation of osteoclasts, Dev. Cell, 3, 889, 10.1016/S1534-5807(02)00369-6

Takayanagi, 2000, T cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ, Nature, 408, 600, 10.1038/35046102

Takeshita, 2002, SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts, Nat. Med., 8, 943, 10.1038/nm752

Teitelbaum, 2003, Genetic regulation of osteoclast development and function, Nat. Rev., Genet., 4, 638, 10.1038/nrg1122

Theill, 2002, RANK-L and RANK: T cells, bone loss, and mammalian evolution, Annu. Rev. Immunol., 20, 795, 10.1146/annurev.immunol.20.100301.064753

Tolar, 2004, Osteopetrosis, N. Engl. J. Med., 351, 2839, 10.1056/NEJMra040952

Tondravi, 1997, Osteopetrosis in mice lacking haematopoietic transcription factor PU.1, Nature, 386, 81, 10.1038/386081a0

Umeda, 1999, Deficiency of SHP-1 protein-tyrosine phosphatase activity results in heightened osteoclast function and decreased bone density, Am. J. Pathol., 155, 223, 10.1016/S0002-9440(10)65116-4

Vanhaesebroeck, 2000, The PI3K–PDK1 connection: more than just a road to PKB, Biochem. J., 346, 561, 10.1042/bj3460561

Wada, 2005, The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis, Nat. Med., 11, 394, 10.1038/nm1203

Wagner, 2005, Fos/AP-1 proteins in bone and the immune system, Immunol. Rev., 208, 126, 10.1111/j.0105-2896.2005.00332.x

Walker, 1975, Bone resorption restored in osteopetrotic mice by transplants of normal bone marrow and spleen cells, Science, 190, 784, 10.1126/science.1105786

Wang, 1992, Bone and haematopoietic defects in mice lacking c-fos, Nature, 360, 741, 10.1038/360741a0

Weilbaecher, 2001, Linkage of M-CSF signaling to Mitf, TFE3, and the osteoclast defect in Mitfmi/mi mice, Mol. Cell, 8, 749, 10.1016/S1097-2765(01)00360-4

Wiktor-Jedrzejczak, 1990, Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse, Proc. Natl. Acad. Sci. U. S. A., 87, 4828, 10.1073/pnas.87.12.4828

Wong, 1999, TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src, Mol. Cell, 4, 1041, 10.1016/S1097-2765(00)80232-4

Wong, 1998, The TRAF family of signal transducers mediates NF-kB activation by the TRANCE receptor, J Biol Chem, 273, 28355, 10.1074/jbc.273.43.28355

Wong, 1997, TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells, J. Biol. Chem., 272, 25190, 10.1074/jbc.272.40.25190

Yagi, 2005, DC-STAMP is essential for cell–cell fusion in osteoclasts and foreign body giant cells, J. Exp. Med., 202, 345, 10.1084/jem.20050645

Yasuda, 1998, Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL, Proc. Natl. Acad. Sci. U. S. A., 95, 3597, 10.1073/pnas.95.7.3597

Ye, 2002, Distinct molecular mechanism for initiating TRAF6 signalling, Nature, 418, 443, 10.1038/nature00888

Yoshida, 1990, The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene, Nature, 345, 442, 10.1038/345442a0

Zhang, 1994, The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor, Mol. Cell. Biol., 14, 373