The molecular basis of growthhormone action

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Dinerstein, 1995, The proline-rich region of the GH receptor is essential for JAK2 phosphorylation, activation of cell proliferation, and gene transcription, Mol Endocrinol, 9, 1701, 10.1210/me.9.12.1701

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Hackett, 1997, Mapping of a cytoplasmic domain of the human growth hormone receptor that regulates rates of inactivation of Jak2 and Stat proteins, J Biol Chem, 272, 11128, 10.1074/jbc.272.17.11128

Wang, 1995, Intracellular tyrosine residues of the human growth hormone receptor are not required for the signaling of proliferation or Jak-STAT activation, J Biol Chem, 270, 7021, 10.1074/jbc.270.13.7021

Lobie, 1995, Requirement of tyrosine residues 333 and 338 of the growth hormone (GH) receptor for GH-stimulated function, J Biol Chem, 270, 21745, 10.1074/jbc.270.37.21745

VanderKuur, 1995, Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2, J Biol Chem, 270, 7587, 10.1074/jbc.270.13.7587

Gronowski, 1994, Rapid changes in nuclear protein tyrosine phosphorylation after growth hormone treatment in vivo: identification of phosphorylated MAP kinase andSTAT91, J Biol Chem, 269, 7874, 10.1016/S0021-9258(17)37132-6

Gronowski, 1995, In vivo growth hormone treatment rapidly stimulates the tyrosine phosphorylation and activation of Stat3, Mol Endocrinol, 9, 171, 10.1210/me.9.2.171

Waxman, 1995, Intermittent plasma growth hormone triggers tyrosine phosphorylation and nuclear translocation of a liver-expressed, Stat 5-related DNA bindingprotein, J Biol Chem, 270, 13262, 10.1074/jbc.270.22.13262

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Winston, 1995, JAK2, Ras, and Raf are required for activation of extracellular signal-regulated kinase/mitogen-activated protein kinase by growth hormone, J Biol Chem, 270, 30837, 10.1074/jbc.270.52.30837

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David, 1995, Requirement for MAP kinase (ERK2) activity in interferon α- and interferon β-stimulated gene expression through STAT proteins, Science, 269, 1721, 10.1126/science.7569900

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Meyer, 1994, Growth hormone induces a DNA binding factor related to the interferon-stimulated 91-kD transcription factor, J Biol Chem, 269, 4701, 10.1016/S0021-9258(17)37599-3

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Hackett, 1995, Mapping of the cytoplasmic domain of the human growth hormone receptor required for activation of Jak2 and Stat proteins, J Biol Chem, 270, 21326, 10.1074/jbc.270.36.21326

Sotiropoulos, 1996, Differential activation of Stat3 and Stat5 by distinct regions of the growth hormone receptor, Mol Endocrinol, 10, 998, 10.1210/me.10.8.998

Yi, 1996, Growth hormone receptor cytoplasmic domain differentially promotes tyrosine phosphorylation of signal transducers and activators of transcription 5b and 3 by activated JAK2 kinase, Mol Endocrinol, 10, 1425, 10.1210/me.10.11.1425

Ram, 1996, Growth hormone activation of Stat 1, Stat 3, and Stat 5 in rat liver, J Biol Chem, 271, 5929, 10.1074/jbc.271.10.5929

Gebert, 1997, Regulation of signal transducer and activator of transcription (STAT) 5b activation by the temporal pattern of growth hormone stimulation, Mol Endocrinol, 11, 400, 10.1210/me.11.4.400

Ashcom, 1992, Growth hormone synergizes with serum growth factors in inducing c-fos transcription in 3T3-F442A cells, Endocrinology, 131, 1915, 10.1210/en.131.4.1915

Meyer, 1993, The serum response element can mediate induction of c-fos by growth hormone, Proc Natl Acad Sci USA, 90, 6721, 10.1073/pnas.90.14.6721

Gronowski, 1996, Acute nuclear actions of growth hormone (GH): Cycloheximide inhibits inducible activator protein-1 activity, but does not block GH-regulated signaltransducer and activator of transcription activation or gene expression, Endocrinology, 137, 55, 10.1210/en.137.1.55

Yoon, 1990, An inducible nuclear factor binds to a growth hormone-regulated gene, J Biol Chem, 265, 19947, 10.1016/S0021-9258(17)45466-4

Bergad, 1995, Growth hormone induction of hepatic serine protease inhibitor 2.1 transcription is mediated by a Stat5-related factor binding synergistically to two γ-activated sites, J Biol Chem, 270, 24903, 10.1074/jbc.270.42.24903

Le Cam, 1994, Cis-acting elements controlling transcription from rat serine protease inhibitor 2.1 gene promoter, J Biol Chem, 269, 21532, 10.1016/S0021-9258(17)31837-9

Legraverend, 1996, A novel growth hormone response element unrelated to STAT (signal transducer and activator of transcription)-binding sites is a bifunctional enhancer, Mol Endocrinol, 10, 1507, 10.1210/me.10.12.1507

Wood, 1995, Mediation of growth hormone-dependent transcriptional activation by mammary gland factor/Stat 5, J Biol Chem, 270, 9448, 10.1074/jbc.270.16.9448

Subramanian, 1995, A STAT factor mediates the sexually dimorphic regulation of hepatic cytochrome P450 3A10/lithocholic acid beta hydroxylase gene expression by growth hormone, Mol Cell Biol, 15, 4672, 10.1128/MCB.15.9.4672

Galsgaard, 1996, Identification of a growth hormone-responsive STAT5-binding element in the rat insulin 1 gene, Mol Endocrinol, 10, 652, 10.1210/me.10.6.652

Boisclair, 1996, Organization and chromosomal localization of the gene encoding the mouse acid labile subunit of the insulin-like growth factor binding complex, Proc Natl Acad Sci USA, 93, 10028, 10.1073/pnas.93.19.10028

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Gronowski, 1995, Rapid changes in gene expression after in vivo growth hormone treatment, Endocrinology, 136, 4741, 10.1210/en.136.11.4741

Hu, 1996, Growth hormone modulates insulin regulation of hepatic insulin-like growth factor binding protein-1 transcription, Endocrinology, 137, 3702, 10.1210/en.137.9.3702

Tollet, 1995, Growth hormone signaling leading to CYP2C12 gene expression in rat hepatocytes involves phospholipase A2, J Biol Chem, 270, 12569, 10.1074/jbc.270.21.12569

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Tollet, 1995, CCAAT/enhancer binding protein-α-dependent transactivation of CYP2C12 in rat hepatocytes, Mol Endocrinol, 9, 1771, 10.1210/me.9.12.1771

Waxman, 1996, Interaction of a novel sex-dependent, growth hormone-regulated liver nuclear factor with CYP2C12 promoter, J Biol Chem, 271, 29978, 10.1074/jbc.271.47.29978

Samadani, 1996, The transcriptional activator hepatocyte nuclear factor 6 regulates liver gene expression, Mol Cell Biol, 16, 6273, 10.1128/MCB.16.11.6273

Bichell, 1992, Growth hormone rapidly activates insulin-like growth factor I gene transcription in vivo, Mol Endocrinol, 6, 1899, 10.1210/me.6.11.1899

Thomas, 1994, Rapid activation of rat insulin-like growth factor-I gene transcription by growth hormone reveals no alterations in DNA-protein interactions withinthe major promoter, Endocrinology, 135, 1584, 10.1210/en.135.4.1584

Thomas, 1995, Growth hormone rapidly activates rat serine protease inhibitor 2.1 gene transcription and induces a DNA-binding activity distinct from those of Stat1, -3, and -4, Mol Cell Biol, 15, 12, 10.1128/MCB.15.1.12

Le Stunff, 1995, Rapid activation of rat insulin-like growth factor-I gene transcription by growth hormone reveals no changes in deoxyribonucleic acid-proteininteractions within the second promoter, Endocrinology, 136, 2230, 10.1210/en.136.5.2230

Barcellini-Couget, 1993, The regulation by growth hormone of lipoprotein lipase gene expression is mediated by c-fos protooncogene, Endocrinology, 132, 53, 10.1210/en.132.1.53

Clarkson, 1995, Early responses to trans-activating factors to growth hormone in preadipocytes: Differential regulation of CCAAT enhancer-binding protein-β(C/EBPβ) and C/EBPδ, Mol Endocrinol, 9, 108, 10.1210/me.9.1.108

Lobie, 1994, Nuclear translocation and anchorage of the growth hormone receptor, J Biol Chem, 269, 31735, 10.1016/S0021-9258(18)31758-7

Frank, 1994, Treatment of IM-9 cells with human growth hormone (GH) promotes rapid disulfide linkage of the GH receptor, Endocrinology, 135, 148, 10.1210/en.135.1.148

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Strous, 1997, Growth hormone-induced signal transduction depends on an intact ubiquitin system, J Biol Chem, 272, 40, 10.1074/jbc.272.1.40

King, 1996, Distinct cytoplasmic domains of the growth hormone receptor are required for glucocorticoid- and phorbol ester-induced decreases in growth hormone (GH) binding, J Biol Chem, 271, 18088, 10.1074/jbc.271.30.18088

King, 1995, Dexamethasone-induced antagonism of growth hormone (GH) action by down-regulation of GH binding in 3T3-F442A fibroblasts, Endocrinology, 136, 4796, 10.1210/en.136.11.4796

Souza, 1994, Growth hormone stimulates tyrosine phosphorylation of insulin receptor substrate-1, J Biol Chem, 269, 30085, 10.1016/S0021-9258(18)43776-3

Argetsinger, 1995, Growth hormone, interferon-γ, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1, J Biol Chem, 270, 14685, 10.1074/jbc.270.24.14685

RidderstrÅle, 1995, Growth hormone stimulates the tyrosine phosphorylation of the insulin receptor substrate-1 and its association with phosphatidylinositol 3-kinasein primary adipocytes, J Biol Chem, 270, 3471, 10.1074/jbc.270.8.3471

Pelicci, 1992, A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction, Cell, 70, 93, 10.1016/0092-8674(92)90536-L

Sekine, 1996, Postreceptor signalling of growth hormone and prolactin and their effects in the differentiated insulin-secreting cell line, INS-1, Endocrinology, 137, 1841, 10.1210/en.137.5.1841