The miniature CRISPR-Cas12m effector binds DNA to block transcription

Molecular Cell - Tập 82 - Trang 4487-4502.e7 - 2022
Wen Y. Wu1, Prarthana Mohanraju1, Chunyu Liao2, Belén Adiego-Pérez1, Sjoerd C.A. Creutzburg1, Kira S. Makarova3, Karlijn Keessen1, Timon A. Lindeboom1, Tahseen S. Khan1, Stijn Prinsen1, Rob Joosten1, Winston X. Yan4, Anzhela Migur2, Charlie Laffeber5, David A. Scott4, Joyce H.G. Lebbink5,6, Eugene V. Koonin3, Chase L. Beisel2,7, John van der Oost1
1Laboratory of Microbiology, Wageningen University and Research, Stippeneng 4, 6708 WE Wageningen, The Netherlands
2Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Centre for Infection Research (HZI), 97080 Würzburg, Germany
3National Centre for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
4Arbor Biotechnologies, Cambridge, MA 02139, USA
5Department of Molecular Genetics, Oncode Institute, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3000 CA Rotterdam, the Netherlands
6Department of Radiation Oncology, Erasmus University Medical Center, 3000 CA Rotterdam, the Netherlands
7Medical Faculty, University of Würzburg, 97080 Würzburg, Germany

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Molecular Cell

Tập 82

4487-4502.e7

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