The medicinal chemist's toolbox for late stage functionalization of drug-like molecules

Chemical Society Reviews - Tập 45 Số 3 - Trang 546-576
Tim Cernak1,2,3, Kevin D. Dykstra2,4,5, Sriram Tyagarajan2,4,5, Petr Váchal2,4,5, Shane W. Krska2,4,5
1Boston
2Discovery Chemistry - Automation & Capabilities Enhancement
3Merck Research Laboratories, Discovery Chemistry - Automation & Capabilities Enhancement, 33 Avenue Louis Pasteur, BMB2-116B, Boston, Massachusetts, USA
4Merck Research Laboratories, Discovery Chemistry - Automation & Capabilities Enhancement, Rahway, New Jersey, USA
5Rahway

Tóm tắt

The advent of modern C–H functionalization chemistries has enabled medicinal chemists to consider a synthetic strategy, late stage functionalization (LSF), which utilizes the C–H bonds of drug leads as points of diversification for generating new analogs.

Từ khóa


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