The mechanism of the formation and secretion of chylomicrons

DeNigris, 1998, Lingual and gastric lipases: species differences in the origin of prepancreatic digestive lipases and in the localization of gastric lipase, Biochim Biophys Acta, 959, 38, 10.1016/0005-2760(88)90147-6 Hamosh, 1996, Digestion in the newborn, Clin Perinatol, 23, 191, 10.1016/S0095-5108(18)30238-0 Verger, 1980, Enzyme kinetics of lipolysis, Methods Enzymol, 64, 340, 10.1016/S0076-6879(80)64016-6 Mattson, 1956, The specificity of pancreatic lipase on the primary hydroxyl groups of glycerides, J Biol Chem, 219, 735, 10.1016/S0021-9258(18)65733-3 Mattson, 1964, The digestion and absorption of triglycerides, J Biol Chem, 239, 2772, 10.1016/S0021-9258(18)93813-5 Mattson, 1968, Hydrolysis of primary and secondary esters of glycerol by pancreatic juice, J Lipid Res, 9, 79, 10.1016/S0022-2275(20)43146-3 Borgstrom, 1964, Influence of bile salt, pH, and time on the action of pancreatic lipase; physiological implications, J Lipid Res, 5, 522, 10.1016/S0022-2275(20)40179-8 Hofmann, 1963, Hydrolysis of long-chain monoglycerides in micellar solution by pancreatic lipase, Biochim Biophys Acta, 70, 317, 10.1016/0006-3002(63)90755-8 Hofmann, 1962, Physico-chemical state of lipids in intestinal content during their digestion and absorption, Fed Proc, 21, 43 Hofmann, 1964, The intraluminal phase of fat digestion in man: the lipid content of the micellar and oil phases of intestinal content obtained during fat digestion and absorption, J Clin Invest, 43, 247, 10.1172/JCI104909 Dietschy, 1971, Unstirred water layers and absorption across the intestinal mucosa, Gastroenterology, 61, 932, 10.1016/S0016-5085(19)33408-0 Wilson, 1971, Unstirred water layers in intestine: rate determinant of fatty acid from micellar solutions, Science, 174, 1031, 10.1126/science.174.4013.1031 Westergaard, 1976, The mechanism whereby bile acid micelles increase the rate of fatty acid and cholesterol uptake into the intestinal mucosal cell, J Clin Invest, 58, 97, 10.1172/JCI108465 Carey, 1983, Lipid digestion and absorption, Ann Rev Physiol, 45, 651, 10.1146/annurev.ph.45.030183.003251 Woollett, 2006, Micellar solubilization of cholesterol is essential for absorption in humans, Gut, 55, 197, 10.1136/gut.2005.069906 Chow, 1979, A dual, concentration-dependent absorption mechanism of linoleic acid by rat jejunum in vitro, J Lipid Res, 20, 349, 10.1016/S0022-2275(20)40617-0 Hsieh, 2009, Glucagon-like peptide-2 increases intestinal lipid absorption and chylomicron production via CD36, Gastroenterology, 137, 997, 10.1053/j.gastro.2009.05.051 Newberry, 2009, Intestinal lipid absorption, GLP-2, and CD36: still more mysteries to moving fat, Gastroenterology, 137, 775, 10.1053/j.gastro.2009.07.034 Storch, 2000, The fatty acid transport function of fatty acid-binding proteins, Biochim Biophys Acta, 1486, 28, 10.1016/S1388-1981(00)00046-9 Vassileva, 2000, The intestinal fatty acid binding protein is not essential for dietary fat absorption in mice, FASEB, 14, 2040, 10.1096/fj.99-0959com Newberry, 2006, Protection against Western diet-induced obesity and hepatic steatosis in liver fatty acid-binding protein knockout mice, Hepatology, 44, 1191, 10.1002/hep.21369 Johnston, 1976, Triglyceride biosynthesis in the intestinal mucosa, 85 Kuksis, 1986, Biochemical characterization and purification of intestinal acylglycerol acyltransferases, 233 Yen, 2008, Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis, J Lipid Res, 49, 2283, 10.1194/jlr.R800018-JLR200 Shi, 2009, Beyond triglyceride synthesis: the dynamic functional roles of MGAT and DGAT enzymes in energy metabolism, Am J Physiol Endocrinol Metab, 297, E10, 10.1152/ajpendo.90949.2008 Buhman, 2002, DGAT1 is not essential for intestinal triacylglycerol absorption or chylomicron synthesis, J Biol Chem, 277, 25474, 10.1074/jbc.M202013200 Yen, 2005, The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters, J Lipid Res, 46, 1502, 10.1194/jlr.M500036-JLR200 Cao, 2007, Catalytic properties of MGAT3, a putative triacylgycerol synthase, J Lipid Res, 48, 583, 10.1194/jlr.M600331-JLR200 Yen, 2009, Deficiency of the intestinal enzyme acyl CoA:monoacylclyderol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding, Nat Med, 15, 442, 10.1038/nm.1937 Wu, 1975, Transmucosal triglyceride transport rates in proximal and distal rat intestine in vivo, J Lipid Res, 16, 251, 10.1016/S0022-2275(20)36711-0 Wu, 1980, Composition of lymph chylomicrons from proximal or distal rat small intestine, Am J Clin Nutr, 33, 582, 10.1093/ajcn/33.3.582 Gallo, 1977, Role of pancreatic cholesterol esterase in the uptake and esterification of cholesterol by isolated intestinal cells, Proc Soc Exp Biol Med, 156, 277, 10.3181/00379727-156-39921 Borja, 1964, Role of bile and pancreatic juice in cholesterol absorption and esterification, Am J Physiol, 206, 223, 10.1152/ajplegacy.1964.206.1.223 Norum, 1983, Influence of diets on acyl-CoA: cholesterol acyltransferase in villous and crypt cells from rat small intestinal mucosa and in the liver, Biochim Biophys Acta, 751, 153, 10.1016/0005-2760(83)90169-8 Norum, 1977, Coenzyme-A-dependent esterification of cholesterol in intestinal mucosa from guinea-pig, Scand J Gastroenterol, 12, 281, 10.3109/00365527709180929 Field, 1982, Regulation of rabbit intestinal acid acyl coenzyme A-cholesterol acyltransferase in vivo and in vitro, Gastroenterology, 83, 873, 10.1016/S0016-5085(82)80019-X Ockner, 1974, Fatty acid binding protein in small intestine. Identification, isolation and evidence for its role in cellular fatty acid transport, J Clin Invest, 54, 326, 10.1172/JCI107768 Zilversmit, 1965, The composition and structure of lymph chylomicrons in dog, rat, and man, J Clin Invest, 44, 1610, 10.1172/JCI105267 Lindgren, 1972, The isolation and quantitative analysis of serum lipoproteins, 181 Ockner, 1969, Very low density lipoproteins in intestinal lymph: role in triglyceride and cholesterol transport during fat absorption, J Clin Invest, 48, 2367, 10.1172/JCI106203 Mahley, 1971, Lipoproteins associated with Golgi apparatus isolated from epithelial cells of rat small intestine, Lab Invest, 25, 435 Vahouny, 1981, Differential transport of cholesterol and oleic acid in lymph lipoproteins: sex differences in puromycin sensitivity, J Lipid Res, 21, 415, 10.1016/S0022-2275(20)39791-1 Tso, 1981, Acute inhibition of intestinal lipid transport by Pluronic L-81 in the rat, Am J Physiol, 241, G487 Tso, 1980, Effect of hydrophobic surfactant (Pluronic L-81) on lymphatic lipid transport in the rat, Am J Physiol, 239, G348 Tso, 1984, Evidence for separate pathways of chylomicron and very low-density lipoprotein assembly and transport by rat small intestine, Am J Physiol, 247, G599 Nutting, 1989, Further studies on the mechanism of inhibition of intestinal chylomicron transport by Pluronic L-81, Biochim Biophys Acta, 22, 357, 10.1016/0005-2760(89)90084-2 Edge, 1985, Apolipoprotein B synthesis is humans: liver synthesizes only apolipoprotein B-100, Metabolism, 34, 726, 10.1016/0026-0495(85)90022-8 Glickman, 1991, Apolipoprotein synthesis in normal and abetalipoproteinemic intestinal mucosa, Gastroenterology, 101, 749, 10.1016/0016-5085(91)90535-S Chen, 1987, Apolipoprotein B-48 is the product of a messenger RNA with an organ-specific in-frame stop codon, Science, 238, 363, 10.1126/science.3659919 Powell, 1987, A novel form of tissue-specific RNA processing produces apolipoprotein-B48 in intestine, Cell, 50, 831, 10.1016/0092-8674(87)90510-1 Kane, 1980, Heterogeneity of apolipoprotein B: isolation of a new species from human chylomicrons, Proc Natl Acad Sci USA, 77, 2465, 10.1073/pnas.77.5.2465 Cardin, 1982, Sulfhydryl chemistry and solubility properties of human plasma apolipoprotein B, Biochemistry, 21, 4503, 10.1021/bi00261a048 Martins, 1994, Lipid and apolipoprotein B-48 transport in mesenteric lymph and the effect of hyperphagia on the clearance of chylomicron-like emulsions in insulin-deficient rats, Diabetologia, 37, 238, 10.1007/BF00398049 Lo, 2008, Why does the gut choose apolipoprotein B48 but not B100 for CM formation?, Am J Physiol Gastrointest Liver Physiol, 294, G344, 10.1152/ajpgi.00123.2007 Levy, 1966, The lipoproteins and lipid transport in abetalipoproteinemia, J Clin Invest, 45, 531, 10.1172/JCI105367 Ohashi, 2000, Novel mutations in the microsomal triglyceride transfer protein gene causing abetalipoproteinemia, J Lipid Res, 41, 1199, 10.1016/S0022-2275(20)33426-X Wang, 2000, Microsomal triglyceride transfer protein (MTP) gene mutations in Candian subjects with abetalipoproteinemia, Hum Mutat, 15, 294, 10.1002/(SICI)1098-1004(200003)15:3<294::AID-HUMU14>3.0.CO;2-E Berriot-Varoqueaux, 2000, The role of the microsomal triglyceride transfer protein in abetalipoproteinemia, Annu Rev Nutr, 20, 663, 10.1146/annurev.nutr.20.1.663 Hussain, 2000, A proposed model for the assembly of chylomicrons, Atherosclerosis, 148, 1, 10.1016/S0021-9150(99)00397-4 Anderson, 1961, Unusual causes of steatorrhoea in infancy and childhood, Med J Aust, 11, 617, 10.5694/j.1326-5377.1961.tb69860.x Bouma, 1986, Hypobetalipoproteinemia with accumulation of an apoprotein B-like protein in intestinal cells. Immunoenzymatic and biochemical characterization of seven cases of Anderson's disease, J Clin Invest, 78, 398, 10.1172/JCI112590 Roy, 1987, Malabsorption, hypocholesterolemia and fat filled enterocytes with increased intestinal apo B. Chylomicron retention disease, Gastroenterology, 92, 390, 10.1016/0016-5085(87)90133-8 Dannoura, 2000, Anderson's disease: exclusion of apolipoprotein and intracellular lipid transport genes, Arteriosclerosis, Thrombosis, and Vascular Biology, 19, 2494, 10.1161/01.ATV.19.10.2494