The mechanism of the acute hypoglycemic action of phenformin (DBI)

Altschuld, 1968, Inhibition of hepatic gluconeogenesis in guinea pig by phenformin, Ann NY Acad Sci, 148, 612, 10.1111/j.1749-6632.1968.tb27735.x Meyer, 1967, Specific inhibition of glucogenesis by biguanides, Nature, 213, 203, 10.1038/213203a0 Haeckel, 1972, Inhibition of gluconeogenesis from lactate by phenethylbiguanide in the perfused guinea pig liver, Diabetologia, 8, 117, 10.1007/BF01235636 Madison, 1960, Effect of phenformin on peripheral glucose utilization in human diabetic and non-diabetic subjects, Diabetes, 9, 202, 10.2337/diab.9.3.202 Tranquada, 1960, Some effects of phenethylbiguanide on human hepatic metabolism as measured by hepatic vein catheterization, Diabetes, 9, 207, 10.2337/diab.9.3.207 Dietze, 1978, Effect of phenformin on hepatic balances of glucogenic substrates in man, Diabetologia, 14, 234, 10.1007/BF01219423 Searle, 1966, Body glucose kinetics in non-diabetic subjects after phenethylbiguanide, Diabetes, 15, 173, 10.2337/diab.15.3.173 Kriesberg, 1968, Glucose metabolism in normal and obese subjects; Effects of phenformin, Diabetes, 17, 481, 10.2337/diab.17.8.481 Searle, 1969, Effect of phenformin in non-diabetic humans: Estimation of glucose turnover rate and Cori cycle activity, Metabolism, 18, 148, 10.1016/0026-0495(69)90109-7 Kreisberg, 1968, Kinetics of glucose utilization in obesity; The effect of phenformin, Ann NY Acad Sci, 148, 743, 10.1111/j.1749-6632.1968.tb27746.x Reichard, 1963, Quantitative estimation of the Cori Cycle in the human, J Biol Chem, 238, 495, 10.1016/S0021-9258(18)81288-1 Searle, 1974, Evaluation of ethanol hypoglycemia in man; Turnover studies with C-6 14C glucose, Metabolism, 23, 102, 10.1016/0026-0495(74)90069-9 Searle, 1974, Kinetics of lactate turnover and oxidation in man, vol 1, 473 Medes, 1946, Fatty acid metabolism. IV. Ketone bodies as intermediates of acetate oxidation in animal tissues, J Biol Chem, 162, 1, 10.1016/S0021-9258(17)41450-5 Dunn, 1957, Effects of insulin on blood glucose entry and removal rates, J Biol Chem, 225, 225, 10.1016/S0021-9258(18)64924-5 Steele, 1968, Plasma glucose and free fatty acid metabolism in normal and long fasted dogs, Am J Physiol, 214, 313, 10.1152/ajplegacy.1968.214.2.313 Searle, 1975, Lacticacidosis associated with phenformin therapy: Evidence that inhibited lactate oxidation is the causative factor, Diabetes, 24, 741, 10.2337/diabetes.24.8.741 Freminet, 1974, Effect of elevated lactemia on the rates of lactate turnover and oxidation in rats, Pflugers Arch, 346, 75, 10.1007/BF00592652 Krebs, 1966, The fate of isotopic carbon in kidney cortex synthesizing glucose from lactate, Biochem J, 101, 242, 10.1042/bj1010242 Searle, 1968, Glucose kinetics before and after phenformin in the human subject, Ann NY Acad Sci, 148, 734, 10.1111/j.1749-6632.1968.tb27745.x Lyngsoe, 1972, Influence of phenformin on fat and lactate metabolism and insulin production in starved normal subject, Metabolism, 21, 179, 10.1016/0026-0495(72)90039-X Bohannon, 1977, Plasma glucagon suppression by phenformin in man, Diabetologia, 13, 503, 10.1007/BF01234504 Kreisberg, 1971, Glucose lactate interrelationships; Effect of ethanol, J Clin Invest, 50, 175, 10.1172/JCI106471