The lymph nodes draining the small intestine and colon are anatomically separate and immunologically distinct

Mucosal Immunology - Tập 9 Số 2 - Trang 468-478 - 2016
Stephanie Houston1, Vuk Cerovic1, Carolyn A. Thomson1, James M. Brewer1, A M Mowat1, Simon Milling1
1Centre for Immunobiology, Institute for Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK

Tóm tắt

Từ khóa


Tài liệu tham khảo

Mowat, 2014, Regional specialization within the intestinal immune system, Nat. Rev. Immunol., 14, 667, 10.1038/nri3738

Belkaid, 2014, Role of the microbiota in immunity and inflammation, Cell, 157, 121, 10.1016/j.cell.2014.03.011

Hooper, 2010, Immune adaptations that maintain homeostasis with the intestinal microbiota, Nat. Rev. Immunol., 10, 159, 10.1038/nri2710

Pabst, 2012, Oral tolerance to food protein, Mucosal Immunol., 5, 232, 10.1038/mi.2012.4

Svensson, 2008, Retinoic acid receptor signaling levels and antigen dose regulate gut homing receptor expression on CD8+ T cells, Mucosal Immunol., 1, 38, 10.1038/mi.2007.4

Kim, 2013, GPR15-mediated homing controls immune homeostasis in the large intestine mucosa, Science, 340, 1456, 10.1126/science.1237013

Jaensson, 2008, Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans, J. Exp. Med., 205, 2139, 10.1084/jem.20080414

Annacker, 2005, Essential role for CD103 in the T cell-mediated regulation of experimental colitis, J. Exp. Med., 202, 1051, 10.1084/jem.20040662

Balic, 2009, Dynamics of CD11c(+) dendritic cell subsets in lymph nodes draining the site of intestinal nematode infection, Immunol. Lett., 127, 68, 10.1016/j.imlet.2009.09.001

Bowcutt, 2014, Heterogeneity across the murine small and large intestine, World J. Gastroenterol., 20, 15216, 10.3748/wjg.v20.i41.15216

Carter, 1974, The route of enteric infection in normal mice, J. Exp. Med., 139, 1189, 10.1084/jem.139.5.1189

Tilney, 1971, Patterns of lymphatic drainage in the adult laboratory rat, J. Anat., 109, 14

Van den Broeck, 2006, Anatomy and nomenclature of murine lymph nodes: Descriptive study and nomenclatory standardization in BALB/cAnNCrl mice, J. Immunol. Methods, 312, 12, 10.1016/j.jim.2006.01.022

Laffont, 2010, Intestinal inflammation abrogates the tolerogenic properties of MLN CD103+ dendritic cells, Eur. J. Immunol., 40, 1877, 10.1002/eji.200939957

Cerovic, 2015, Lymph-borne CD8alpha dendritic cells are uniquely able to cross-prime CD8 T cells with antigen acquired from intestinal epithelial cells, Mucosal Immunol., 8, 38, 10.1038/mi.2014.40

Tomura, 2008, Monitoring cellular movement in vivo with photoconvertible fluorescence protein “Kaede” transgenic mice, Proc. Natl Acad. Sci. USA, 105, 10871, 10.1073/pnas.0802278105

Schmidt, 2013, CXCR4 promotes B cell egress from Peyer's patches, J. Exp. Med., 210, 1099, 10.1084/jem.20122574

Cerovic, 2013, Intestinal CD103(-) dendritic cells migrate in lymph and prime effector T cells, Mucosal Immunol., 6, 104, 10.1038/mi.2012.53

Scott, 2014, Signal regulatory protein alpha (SIRPalpha) regulates the homeostasis of CD103(+) CD11b(+) DCs in the intestinal lamina propria, Eur. J. Immunol., 44, 3658, 10.1002/eji.201444859

Jung, 2000, Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion, Mol. Cell. Biol., 20, 4106, 10.1128/MCB.20.11.4106-4114.2000

Vezys, 2000, Expression of intestine-specific antigen reveals novel pathways of CD8 T cell tolerance induction, Immunity, 12, 505, 10.1016/S1074-7613(00)80202-2

Denning, 2011, Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory T cell responses are dependent on the T cell/APC ratio, source of mouse strain, and regional localization, J. Immunol., 187, 733, 10.4049/jimmunol.1002701

Bruder, 2004, Neuropilin-1: a surface marker of regulatory T cells, Eur. J. Immunol., 34, 623, 10.1002/eji.200324799

Schiering, 2014, The alarmin IL-33 promotes regulatory T-cell function in the intestine, Nature, 513, 564, 10.1038/nature13577

Sun, 2007, Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid, J. Exp. Med., 204, 1775, 10.1084/jem.20070602

Coombes, 2007, A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism, J. Exp. Med., 204, 1757, 10.1084/jem.20070590

Johansson-Lindbom, 2005, Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing, J. Exp. Med., 202, 1063, 10.1084/jem.20051100

Scott, 2015, CCR2+CD103+ intestinal dendritic cells develop from DC-committed precursors and induce interleukin-17 production by T cells, Mucosal Immunol., 8, 327, 10.1038/mi.2014.70

Rivollier, 2012, Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon, J. Exp. Med., 209, 139, 10.1084/jem.20101387

Persson, 2013, IRF4 transcription-factor-dependent CD103(+)CD11b(+) dendritic cells drive mucosal T helper 17 cell differentiation, Immunity, 38, 958, 10.1016/j.immuni.2013.03.009

Kamath, 2002, Developmental kinetics and lifespan of dendritic cells in mouse lymphoid organs, Blood, 100, 1734, 10.1182/blood.V100.5.1734.h81702001734_1734_1741

Diehl, 2013, Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells, Nature, 494, 116, 10.1038/nature11809

Chirdo, 2005, Immunomodulatory dendritic cells in intestinal lamina propria, Eur. J. Immunol., 35, 1831, 10.1002/eji.200425882

Yang, 2008, Molecular antagonism and plasticity of regulatory and inflammatory T cell programs, Immunity, 29, 44, 10.1016/j.immuni.2008.05.007

Nguyen, 2015, Role and species-specific expression of colon T cell homing receptor GPR15 in colitis, Nat. Immunol., 16, 207, 10.1038/ni.3079