The long-term outcome and justification for early treatment

Abruzzo, 1982, Rheumatoid arthritis and mortality, Arthritis and Rheumatism, 25, 1020, 10.1002/art.1780250819 Amor, 1981, Follow up study of patients with Rheumatoid Arthritis over a period of more than 10 years (1966–1978): analysis of disease progression and treatment in 100 cases, Annales de Médecine Interne, 132, 168 Axon, 1990, A novel index for measuring patients' satisfaction, British Journal of Rheumatology, 29, 80 Ayesh, 1987, Sodium aurothiomalate toxicity and sulphoxidation capacity in rheumatoid arthritis patients, British Journal of Rheumatology, 26, 197, 10.1093/rheumatology/26.3.197 Beltran, 1987, Rheumatoid arthritis: MRI imaging manifestations, Radiology, 165, 153, 10.1148/radiology.165.1.3628762 Bensen, 1990, Remodelling the pyramid: The therapeutic target of rheumatoid arthritis, Journal of Rheumatology, 17, 987 Boers, 1991, Longacting drug combinations in rheumatoid arthritis: A formal overview, Journal of Rheumatology, 18, 316 Brook, 1977, Radiographic changes in early rheumatoid disease, Annals of the Rheumatic Diseases, 36, 71, 10.1136/ard.36.1.71 Calin, 1989, Destructive arthritis, rheumatoid factor, and HLA-DR4: susceptibility versus severity, a case controlled study, Arthritis and Rheumatism, 32, 1221, 10.1002/anr.1780321006 Donnelly, 1992, Comparison of a patient satisfaction index with the arthritis impact measurement scales (AIMS), British Journal of Rheumatology Duthie, 1957, Course and prognosis in rheumatoid arthritis, Annals of the Rheumatic Diseases, 16, 411, 10.1136/ard.16.4.411 Duthie, 1964, Course and prognosis in rheumatoid arthritis: a further report, Annals of the Rheumatic Diseases, 23, 193, 10.1136/ard.23.3.193 Emery, 1984, d-Penicillamine induced toxicity in rheumatoid arthritis: the role of sulphoxidation status and HLA-DR3, Journal of Rheumatology, 11, 244 Emery, 1989, Poor sulphoxidation: A genetically determined factor associated with persistent disease in rheumatoid arthritis, British Journal of Rheumatology, 28, 49 Fagenbaum, 1979, Prognosis in RA: A longitudinal study of newly diagnosed younger adult patients, American Journal of Medicine, 66, 377, 10.1016/0002-9343(79)91055-6 Felson, 1990, The comparative efficacy and toxicity of second line drugs in rheumatoid arthritis. Results of two meta-analyses, Arthritis and Rheumatism, 33, 1449, 10.1002/art.1780331001 Fries, 1990, Re-evaluating the therapeutic approach to rheumatoid arthritis: the ‘saw-tooth strategy’, Journal of Rheumatology, 17, 12 Fries, 1980, Measurement of patient outcome in rheumatoid arthritis, Arthritis and Rheumatism, 23, 146, 10.1002/art.1780230202 Geirsson, 1987, Clinical and serological features of severe vasculitis in rheumatoid arthritis: prognostic implications, Annals of the Rheumatic Diseases, 46, 727, 10.1136/ard.46.10.727 Gibson, 1987, Combined d-penicillamine and chloroquine treatment in rheumatoid arthritis. A comparative study, British Journal of Rheumatology, 26, 279, 10.1093/rheumatology/26.4.279 Hamdy, 1987, Low dose methotrexate compared with azathioprine in the treatment of rheumatoid arthritis. A twenty four week controlled clinical trial, Arthritis and Rheumatism, 30, 361, 10.1002/art.1780300401 Healey, 1991, Evaluating combination drug therapy in rhematoid arthritis, Journal of Rheumatology, 18, 641 Hill, 1990, The Arthritis Impact Measurement Scales: An anglicized version to assess the outcome of British patients with rheumatoid arthritis, British Journal of Rheumatology, 29, 193, 10.1093/rheumatology/29.3.193 Huskisson, 1974, Proceedings: Penicillamine or gold for rheumatoid arthritis: Multicentre trial using ‘blind’ observers. The first six months, Annals of the Rheumatic Diseases, 33, 399, 10.1136/ard.33.4.399-a Jacoby, 1975, Onset, early stages and prognosis of rheumatoid arthritis: A clinical study of 100 patients with 11 year follow-up, British Medical Journal, ii, 96 Kaarela, 1985, Prognostic factors and diagnostic criteria in early rheumatoid arthritis, Scandinavian Journal of Rheumatology, 1, 10.3109/03009748509104317 Kushner, 1959, Does aggressive therapy of rheumatoid arthritis affect outcome?, Journal of Rheumatology, 16, 1 Lukkainen, 1983, The prediction of radiological deterioration during the early stage of rheumatoid arthritis, Clinical and Experimental Rheumatology, 1, 295 McCarthy, 1990, Suppress rheumatoid inflammation early and leave the pyramid to the Egyptians, Journal of Rheumatology, 17, 1115 Pinals, 1981, Preliminary criteria for clinical remission in rheumatoid arthritis, Arthritis and Rheumatism, 24, 1308, 10.1002/art.1780241012 Pinals, 1986, Sulphasalazine in rheumatoid arthritis: A double-blind placebo controlled trial, Arthritis and Rheumatism, 81, 1427, 10.1002/art.1780291202 Pincus, 1988, Rheumatoid arthritis: Disappointing long term outcomes despite successful clinical trials, Journal of Clinical Epidemiology, 41, 1037, 10.1016/0895-4356(88)90072-8 Pincus, 1986, Taking mortality in rheumatoid arthritis seriously: Predictive markers, socioeconomic status and co-morbidity, Journal of Rheumatology, 13, 841 Pincus, 1984, Severe functional declines, worse disability, and increased mortality in seventy-five rheumatoid arthritis patients studied over nine years, Arthritis and Rheumatism, 27, 864, 10.1002/art.1780270805 Pincus, 1987, Questionnaire, walking time and button test measures of functional capacity as predictive markers for mortality in rheumatoid arthritis, Journal of Rheumatology, 14, 240 Ragan, 1962, The clinical features of rheumatoid arthritis, Journal of the American Medical Association, 181, 663, 10.1001/jama.1962.03050340001001 Rasker, 1984, The natural history of rheumatoid arthritis. A fifteen year follow up study, Clinical Rheumatology, 3, 11, 10.1007/BF02715690 Rasker, 1987, The natural history of rheumatoid arthritis over 20 years. Clinical symptoms, radiological signs, treatment, mortality and prognostic significance ofearly features, Clinical Rheumatology, 6, 5, 10.1007/BF02203379 Research Subcommittee of the Empire Rheumatism Council, 1960, Gold therapy in rheumatoid arthritis: A report of multicentre controlled trial, Annals of the Rheumatic Diseases, 19, 95, 10.1136/ard.19.2.95 Scott, 1987, Long term outcome of treating rheumatoid arthritis. Results after twenty years, Lancet, i, 1108, 10.1016/S0140-6736(87)91672-2 Scott, 1989, Combination therapy with gold and hydroxychloroquine in rheumatoid arthritis: a randomized, placebo-controlled study, British Journal of Rheumatology, 28, 128, 10.1093/rheumatology/28.2.128 Sherrer, 1986, The development of disability in rheumatoid arthritis, Arthritis and Rheumatism, 29, 494, 10.1002/art.1780290406 Sherrer, 1987, Disability in rheumatoid arthritis: Comparison of prognostic factors across three populations, Journal of Rheumatology, 14, 705 Short, 1957 Spector, 1988, What happens to patients with rheumatoid arthritis. The long term outcome of treatment, Clinical Rheumatology, 7, 315, 10.1007/BF02239187 Spector, 1988, Are slow-acting anti-rheumatic drugs being given earlier in rheumatoid arthritis?, British Journal of Rheumatology, 27, 498, 10.1093/rheumatology/27.6.498 Stastny, 1988, HLA-DR4 and other genetic markers in rheumatoid arthritis, British Journal of Rheumatology, 27, 132, 10.1093/rheumatology/XXVII.suppl_2.132 Steinbroker, 1949, Therapeutic criteria in rheumatoid arthritis, Journal of the American Medical Association, 140, 650 Swinden, 1991, Health Assessment Questionnaire and the Nottingham Health Profile in chronic inflammatory arthritis, British Journal of Rheumatology, 30, 105 Van der Heijde, 1988, Influence of prognostic factors on the final outcome in rheumatoid arthritis: a review of the literature, 17, 284 Van der Heijde, 1990, Judging disease activity in clinical practice in rheumatoid arthritis: First step in the development of a disease activity score, Annals of the Rheumatic Diseases, 49, 916, 10.1136/ard.49.11.916 Willske, 1989, Remodelling the pyramid—a concept whose time has come, Journal of Rheumatology, 16, 565 Wolfe, 1990, Termination of slow acting anti-rheumatic therapy in rheumatoid arthritis. A fourteen year prospective evaluation of 1017 consecutive starts, Journal of Rheumatology, 17, 994 Woolf, 1991, Predictors of the long term outcome of early synovitis. A five year follow up study, Journal of Rheumatology, 30, 251, 10.1093/rheumatology/30.4.251 Wordsworth, 1989, HLA-DR4 subtype frequencies in rheumatoid arthritis indicate that DR B1 is the major susceptibility locus within the HLA class II region, Proceedings of the National Academy of Sciences of the USA, 86, 10049, 10.1073/pnas.86.24.10049 Young, 1984, Association of HLA-DR4/DW4 and DR2/DW2 with radiological changes in a prospective study of patients with rheumatoid arthritis, Arthritis and Rheumatism, 27, 20, 10.1002/art.1780270104 Young, 1991, Early rheumatoid arthritis study report of first 506 patients, Arthritis and Rheumatism, 34, S548