The lncRNA MIR4435-2HG is upregulated in hepatocellular carcinoma and promotes cancer cell proliferation by upregulating miRNA-487a

Qingcong Kong1, Caiqian Liang1, Y. Jin2, Yuhang Pan2, Dayue Tong3, Jing Zhou2
1Department of Emergency Medicine, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou City, Guangdong Province, 510630, People's Republic of China
2Department of Pathology, Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital, Sun Yat-Sen University, No. 600 Tianhe Road, Guangzhou City, Guangdong Province, 510630, People's Republic of China
3Department of Forensic Medicine, ZhongShan Medical School, Sun Yat-Sen University, Guangzhou City, Guangdong Province, 510080, People's Republic of China

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Tài liệu tham khảo

White DL, Kanwal F, Jiao L. Epidemiology of hepatocellular carcinoma. Hepatocellular Carcinoma. Cham: Springer; 2016. p. 3–24.

Altekruse SF, Henley SJ, Cucinelli JE, McGlynn KA. Changing hepatocellular carcinoma incidence and liver cancer mortality rates in the United States. Am J Gastroenterol. 2014;109(4):542–53.

Papatheodoridis GV, Chan HL, Hansen BE, Janssen HL, Lampertico P. Risk of hepatocellular carcinoma in chronic hepatitis B: assessment and modification with current antiviral therapy. J Hepatol. 2015;62(4):956–67.

Chang KC, Tseng PL, Wu YY, Hung HC, Huang CM, Lu SN, et al. A polymorphism in interferon L3 is an independent risk factor for development of hepatocellular carcinoma after treatment of hepatitis C virus infection. Clin Gastroenterol Hepatol. 2015;13(5):1017–24.

Dufour JF, Johnson P. Liver cancer: from molecular pathogenesis to new therapies: summary of the EASL single topic conference. J Hepatol. 2010;52(2):296–304.

Mattick JS, Makunin IV. Non-coding RNA. Hum Mol Genet 2006;15 Spec No 1:R17–R29.

Esteller M. Non-coding RNAs in human disease. Nat Rev Genet. 2011;12(12):861–74.

Gutschner T, Diederichs S. The hallmarks of cancer: a long non-coding RNA point of view. RNA Biol. 2012;9(6):703–19.

Farazi TA, Hoell JI, Morozov P. MicroRNAs in human cancer. MicroRNA Cancer regulation. Dordrecht: Springer; 2013. p. 1–20.

Qian H, Chen L, Huang J, Wang X, Ma S, Cui F, et al. The lncRNA MIR4435-2HG promotes lung cancer progression by activating beta-catenin signalling. J Mol Med (Berl). 2018. https://doi.org/10.1007/s00109-018-1654-5 .

Chang RM, Xiao S, Lei X, Yang H, Fang F, Yang LY. miRNA-487a promotes proliferation and metastasis in hepatocellular Carcinoma. Clin Cancer Res. 2017;23(10):2593–604.

Zhu J, Liu S, Ye F, Shen Y, Tie Y, Zhu J, et al. The long noncoding RNA expression profile of hepatocellular carcinoma identified by microarray analysis. PLoS One. 2014;9(7):e101707.

Murakami Y, Tanahashi T, Okada R, Toyoda H, Kumada T, Enomoto M, et al. Comparison of hepatocellular carcinoma miRNA expression profiling as evaluated by next generation sequencing and microarray. PLoS One. 2014;9(9):e106314.

Hayes CN, Chayama K. MicroRNAs as biomarkers for liver disease and hepatocellular Carcinoma. Int J Mol Sci. 2016;17(3):280.

Yang X, Xie X, Xiao YF, Xie R, Hu CJ, Tang B, et al. The emergence of long non-coding RNAs in the tumorigenesis of hepatocellular carcinoma. Cancer Lett. 2015;360(2):119–24.

Jalali S, Bhartiya D, Lalwani MK, Sivasubbu S, Scaria V. Systematic transcriptome wide analysis of lncRNA-miRNA interactions. PLoS One. 2013;8(2):e53823.

Ge Y, Yan X, Jin Y, Yang X, Yu X, Zhou L, et al. MiRNA-192 [corrected] and miRNA-204 directly suppress lncRNA HOTTIP and interrupt GLS1-mediated Glutaminolysis in hepatocellular Carcinoma. PLoS Genet. 2015;11(12):e1005726.