The lactose tolerance test and intestinal lactase activity

Springer Science and Business Media LLC - Tập 152 - Trang 196-198 - 1983
J. F. Flelding1,2, Shella Baynes1,2, P. J. Fottrell1,2
1Department of Medicine and Gastroenterology, The Charitable Infirmary, Dublin 1
2The Department of Biochemistry, University College, Galway

Tóm tắt

THERE is a correlation between the maximum blood glucose rise following the oral investion of lactose and jejunal lactase activity. Many patients with a low maximum blood glucose rise have normal lactase activity and so the test may only be employed as a screening test. Following the ingestion of 50 G lactose a maximum blood glucose rise of at least 1.5 mmol/l is required before one may assume normal lactase activity. A normal maximum blood glucose rise in the presence of low lactase activity is rare and is not associated with lactose intolerance.

Tài liệu tham khảo

Arvantikes, C., Gram-hum, C., Folscroft, J. and Klotz, A. P. 1977. Lactose deficiency—a comparative study of diagnostic methods. Amer. J. Clin. Nutr. 30, 1597–602. Fielding, J. F. 1978., Clinical and radiological manifestations of the irritable bowel syndroem. Irish J Colls. Phys. Surgs. 8, 11–5. Fielding, J. F. 1980. The half-hour lastose ‘tolerance’ test in adults. J. Irish Med. Assoc. 73, 21–2. Fielding, J. F. 1981. The value of a second oral lactose tolerance test in detecting hypolactasia. Iris J. Med. Sci. 150, 210–2. Fielding, J. F., Harrington, M. G. and Fottrel, P. F. 1981. The incidence of primary hypolactasia amongst native. Irish. J. Med. Sci. 150, 276–7. Johnson, J. D., Simoons, F. J., Hurwitz, R., Grange, A., Sinatra, F. R., Sunshine, P., Robertson, W. V., Bennett, P. H. and Kretchner, N. 1978. Lactose malabsorption among adult Indians of the Great Basin and American Southwest. Amer. J. Clin. Nutr. 31, 381–7. McMichael, H. B., Webb, J and Dawson, A. M. 1965. Lactase deficiency in adults. A case of “functional” diarrhoea. Lancet i, 717–20. Newcomer, A. D., McGill, D. B., Thomas, P. J. and Hofmann, A. F. 1980. Prospective comparison of indirect methods for detecting lactase deficiency. New Eng. J. Medfl 293, 1231–6.