The inhibitory effect of large doses of methimazole on iodine induced lymphocytic thyroiditis and serum anti-thyroglobulin antibody titers in BB/Wor rats

Pinchera A., Liberti P., Martino E., Fenzi G.F., Grasso L., Rovis L., Baschieri L., Doria G. Effects of anti-thyroid drug therapy on the long acting thyroid stimulator and the antithyroglobulin antibodies. J. Clin. Endocrinol. Metab. 29: 231, 1969.

Teng C.S., Yeung R.T.T. Changes in thyroid-stimulating antibody activity in Graves’ disease treated with anti-thyroid drug and its relationship to relapse: A prospective study. J. Clin. Endocrinol. Metab. 50: 144, 1980.

Fenzi G.F., Hashizume K., Roudeboush C.P., DeGroot L.J. Changes in thyroid stimulating immunoglobulins during antithyroid drug therapy. J. Clin. Endocrinol. Metab. 48: 572, 1980.

McGregor A.M., Petersen M.M., McLachlan S.M., Rooke P., Smith B.R., Hall R. Carbimazole and the autoimmune response in Graves’ disease. N. Engl.J. Med. 303: 302, 1980.

Karlsson F.A., Dahlberg P.A. Thyroid stimulating antibodies (TSAb) in patients with Graves’ disease undergoing antithyroid drug treatment. Indicators of activity of disease. Clin. Endocrinol. (Oxf.) 14: 579, 1981.

McGregor A.M., Ibbertson H.K., Smith B.R., Hall R. Carbimazole and autoantibody synthesis in Hashimoto’s thyroiditis. Br. Med. J. 288: 518, 1984.

Wilson R., McKillop J.H., Chopra M., Thompson J.A. The effect of antithyroid drugs on B and T cell activity in vitro. Clin. Endocrinol. (Oxf.) 28: 389, 1988.

Weetman A.P., McGregor A.M., Hall R. Evidence for an effect of antithyroid drugs on the natural history of Graves’ disease. Clin. Endocrinol. (Oxf.) 21: 163, 1984.

Codaccioni J.L., Orgiazzi J., Blanc P., Pugeat M., Roulier R., Carayon P. Lasting remissions in patients treated for Graves’ hyperthyroidism with propranolol alone: A pattern of spontaneous evolution of the disease. J. Clin. Endocrinol. Metab. 67: 656, 1988.

Totterman T.M., Karlsson F.A., Bengtsson M., Mendel-Hartvig I. Induction of circulating activated suppressor-like T cells by methimazole therapy for Graves’ disease. N. Engl. J. Med. 316: 15, 1987.

Ludgate M.E., McGregor A.M., Weetman A.P., Ratonachaiyavong S., Lazarus J.H., Hall R., Middleton G.W. Analysis of T cell subsets in Graves’ disease: alterations associated with carbimazole. Br. Med. J. 288: 526, 1984.

Volpe R., Karlsson A., Jansson R., Dahlberg P.A. Evidence that antithyroid drugs induce remissions in Graves’ disease by modulating thyroid cellular activity. Clin. Endocrinol. (Oxf.) 25: 453, 1986.

McGregor A.M., Rees-Smith B., Hall R., Petersen M.M., Miller M., Dewitz P.J. Prediction of relapse in hyperthyroid Graves’ disease. Lancet 1: 1101, 1980.

Volpe R. Autoimmune thyroid disease. In: Volpe R. (Ed.), Autoimmunity and endocrine disease. Marcel Dekker, New York, 1985, p. 109.

Davies T.F., Weiss I., Gruber M.A. Influence of methimazole on murine thyroiditis. J. Clin. Invest. 73: 367, 1984.

Rennie D.P., McGregor A.M., Keast D., Weetman A.P., Foord S.M., Dieguez C., Williams E.D., Hall R. The influence of methimazole on thyroglobin-induced autoimmune thyroiditis in the rat. Endocrinology 112: 326, 1983.

Allen E.M., Rajatanavin R., Nogimori T., Cushing G., Ingbar S.H., Braverman L. The effect of methimazole on the development of spontaneous lymphocytic thyroiditis in the diabetesprone BB/Wor rat. Am. J. Med. Sci. 292: 167, 1986.

Romaldini J.H., Bromberg N., Werner M.C. Comparison of effects of high and low dose regimens of antithyroid drugs in the management of Graves’ hyperthyroidism. J. Clin. Endocrinol. Metab. 57: 563, 1983.

Allen E.M., Appel M.C., Braverman L.E. The effect of iodide ingestion on the development of spontaneous lymphocytic thyroiditis in the diabetesprone BB/W rat. Endocrinology 118: 1972, 1986.

Solomon B.L., Euaul J.E., Burman K.D., Wartofsky L. Remission rates with antithyroid drug therapy: Continuing influence of iodine intake. Ann. Intern. Med. 107: 510, 1987.

Azizi F. Environmental iodine intake affects the response to methimazole in patients with diffuse toxic goiter. J. Clin. Endocrinol. Metab. 61: 374, 1987.

Czarnocka B., Ruf J., Ferrand M., Carayon P., Lis-sitzky S. Purification of the human thyroid peroxidase and its identification as the microsomal antigen involved in autoimmune thyroid diseases. FEBS. Lett. 190: 147, 1985.

Engler H., Taurog A., Luthy C., Dorris M.L. Reversible and irreversible inhibition of thyroid peroxidase-catalyzed iodination by thioureylene drugs. Endocrinology 112: 190, 1983.

Shiroozu A., Taurog H., Engler H., Dorris M.L. Mechanism of action of thyroureylene antithyroid drugs in the rat: Possible inactivation of thyroid peroxidase by propylthiouracil. Endocrinology 113: 362, 1983.

Sundick R.S., Herdegen D.M., Brown T.R., Bagchi N. The incorporation of dietary iodine into thyroglobulin increases its immunogenicity. Endocrinology 120: 2078, 1987.

Champion B.R., Rayner D.C., Byfield P.G.H., Page K.R., Yo Chan C.T., Roitt I.M. Critical role of iodination for T cell recognition of thyroglobulin in experimental murine autoimmunity. J.Immunol. 139: 3665, 1987.

Nunez J., Pommier J. Formation of thyroid hormones. Vitam. Horm. 39: 175, 1982.

Weetman A.P., Gunn C., Hall R., McGregor A.M. The accumulation of [35S] methimazole by monocytes and macrophages. Acta Endocrinol. (Kbh.) 107: 366, 1984.

Weetman A.P., Holt E., Campbell A.K., Hall R., McGregor A.M. Methimazole and generation of oxygen radicals by monocytes: Potential role in immunosuppression. Br. Med. J. 208: 518, 1984.

Taylor J.J., Wilson R.L., Kendall-Taylor P. Evidence for direct interactions between methimazole and free radicals. FEBS. Lett. 176: 337, 1984.

Reinhardt W., Paul T.L., Allen E.M., Alex S., Yang Y.N., Appel M.C., Braverman L.E. Effect of L-thyroxine administration on the incidence of iodine induced and spontaneous lymphocytic thyroiditis in the BB/Wor rat. Endocrinology 122: 1179, 1988.

Woda B.A., Like A.A., Padden C., McFadden M. Deficiency of phenotypic cytotoxic-suppressor T lymphocytes in the BB/W rat. J. Immunol. 136: 856, 1986.