The influence of social rank on the susceptibility of rats toMycoplasma arthritidis
Tóm tắt
Social ranks (A, O, rest) of adult male inbred rats housed in groups of four per cage were determined by repeated observations of their ejaculatory patterns under competitive conditions. Once ranked, they were intravenously infected. Fifteen clinical, hematological, and serological characters were continously observed during 110 days. Body weight reduction, arthritis score, and specific IgG antibody titers were chosen as guideline characteristics and compared between different genotypes and social rank classes. Genotypic differences account for 60–80% of the individual differences and social rank differences account for 0–40% of the individual differences within isogenic animals. Social rank affects the individual genotypes in an opposite way. Rank A males are less susceptible in genotype DA but showed increased susceptibility in genotypes AS. In genotype LEW, influence of social rank on susceptibility to Mycoplasma arthritidiscould not be verified. Specific IgG antibody titers are lower in ranks showing a higher degree of susceptibility.
Tài liệu tham khảo
Ader, R., Cohen, N., and Bovbjerg, D. (1982). Conditioned suppression of humoral immunity in the rat.J. Comp. Physiol. Psychol. 96: 517–521.
Amkraut, A. A., Solomon, G. F., and Kraemer, A. C. (1971). Stress, early experience and adjuvant induced arthritis in the rat.Psychosom. Med. 33: 203–214.
Ammar, A. M., Heitmann, J., and Kirchhoff, H. (1980). Untersuchungen von Stutenseren auf Antikörper gegen Acheloplasmen mit dem Enzyme Linked Immunosorbent Assay (ELISA).Zentralbl. Bakteriol. Abt. 1 Orig. A 247: 517–525.
Besedovsky, H. O., del Rey, A. E., and Sorkin, E. (1985). Immune-neuroendocrine interactions.J. Immunol. 135: 750–754.
Binder, A. K. U., Gärtner, K., Hedrich, H. J., Hermanns, W., Kirchhoff, H. B., and Wonigeit, K. (1988). Strain differences in the sensitivity of rats to Mycoplasma arthritidis ISR1 infection are under multiple gene control (in preparation).
Deicher, H., and Schulz, L. C. (1981).Arthritis. Models and Mechanisms, Springer Verlag, Berlin, Heidelberg, New York.
Dewsbury, D. A. (1967). A quantitative description of the behaviour of rats during copulation.Behaviour 29: 154–178.
Documenta Geigy (1968).Wissenschaftliche Tabellen, J. R. Geigy A. G., Pharma, Basel.
Feldman, D., and Gagnon, J. (1986). Stat View 512+, Brain Power, Calabasas.
Gärtner, K., Döhler, K., and Rechenberg, I. (1981). Internal selection and hormonal balance in rat population. In Stark, E., Makara, G. B., and Endröczi, Z. A. E. (eds.),Adv. Physiol. Sci. Vol. 13. Endocrinology, Neuroendocrinology, Neuropeptides—I, Akadémiai Kiadó, Budapest, pp. 263–267.
Gärtner, K., Amelang, D., Bredereck, W., and Tessmer, Ch. (1986). Promiskuitive Kopulation bei Laboratoriumsratten.Fertilität 2: 224–230.
GV-SOLAS (1977). Liste von Erregern zur Spezifizierung bei SPF-Versuchstieren. (Veröffentlichungen der Gesellschaft für Versuchstierkunde), No. 2, Zürich.
Henry, J. P. (1982). The relation of social to biological processes in disease.Soc. Sci. Med. 16: 369–380.
Hermanns, W., Schulz, L. C., Kirchhoff, H., and Heitmann, J. (1983). Studies of polyarthritis caused by Mycoplasma arthritis in rats. III. Histopathological findings.Zentralbl. Bakteriol. Abt. 1. Orig. A. 254: 423–434.
Holst, D. v., Fuchs, E., and Stöhr, W. (1983). Physiological changes in male Tupaia belangeri under different types of social stress.Karger Biobehav. Med. Ser. 2: 382–390.
Kirchhoff, H., Heitmann, J., Ammar, A., Hermanns, W., and Schulz, L.-C. (1983). Studies of polyarthritis caused by Mycoplasma arthritidis in rats. I. Detection of the persisting Mycoplasma antigen by the enzyme immune assay (EIA) and conventional culture technique.Zentralbl. Bakteriol. Abt. 1. Orig. A 254: 129–138.
Klosterhalfen, W. (1987).Experimenteller Stress und Adjuvans-Arthritis. Ein Beitrag zur Psychoimmunologie, Athenäum, Frankfurt.
Mensing, K. A. (1987).Verlauf und Schwere einer experimentellen Infektion mit Mycoplasma arthritidis bei der Ratte und Einfluβ von Psychotypen, Hannover, Tierärztl. Hochsch. Diss.
Militzer, K., and Reinhard, H.-J. (1982). Rank positions in rats and their relations to tissue parameters.Physiol. Psychol. 10(2): 251–260.
Rogers, M. P., Trentham, D. E., McCune, W. J., Ginsberg, B. I., Rennke, H. G., Reich, P., and David, J. R. (1980). Effect of psychological stress on the introduction of arthritis in rats.Arthr. Rheum. 23(12): 1337–1342.
Rogers, M. P., Trentham, D. E., Dynesius-Trentham, R., Daffner, K., and Reich, P. (1983). Exacerbation of collagen arthritis by noise stress.J. Rheumatol. 10: 651–654.
Sachs, L. (1984).Angewandte Statistik, Springer Verlag, Berlin, Heidelberg, New York, Tokyo.
Sachser, N. (1987). Short-term responses of plasma norepinephrine, epinephrine, glucocorticoid and testosterone titers to social and non-social stressors in male guinea pigs of different social status.Physiol. Behav. 39: 11–20.
Schütze, E., and Laber, G. (1985). Mycoplasma-Infektionen bei Labortieren. In Gylstorff, I. (Hrsg.),Infektionen durch Mycoplasmatales, Enke Verlag, Stuttgart.
Sofia, R. D. (1980). The effect of overcrowding stress on the development of adjuvant induced polyarthritis in the rat.J. Pharm. Pharmacol. 38: 874–875.
Velleuer, R. (1986).Entwicklung eines Modelles zur Untersuchung genetischer und psychosozialer Einflüsse auf den Verlauf einer experimentellen Infektion mit Mycoplasma arthritidis bei der Ratte. Hannover, Tierärztl. Hochsch. Diss.
Weber, E. (1972).Grundriβ der biologischen Statistik, Gustav Fischer Verlag, Stuttgart.