The impact of palliative radiotherapy on health-related quality of life in patients with head and neck cancer – Results of a multicenter prospective cohort study

Longo, 2020, Head and neck cancer, New Engl J Med, 382, 60, 10.1056/NEJMra1715715 Grewal, 2019, Palliative radiation therapy for head and neck cancers, Int J Radiat Oncol Biol Phys, 105, 254, 10.1016/j.ijrobp.2019.05.024 Christ, 2022, Validation and extension of the METSSS score in a metastatic cancer patient cohort after palliative radiotherapy within the last phase of life, CtRO, 34, 107 Howdon, 2022, Replacing performance status with a simple patient-reported outcome in palliative radiotherapy prognostic modelling, CtRO, 37, 137 Shahid Iqbal, 2018, Palliative radiotherapy for locally advanced non-metastatic head and neck cancer: a systematic review, Radiother Oncol, 126, 558, 10.1016/j.radonc.2017.12.011 LeBlanc, 2017, Patient-reported outcomes in cancer care - hearing the patient voice at greater volume, Nat Rev Clin Oncol, 14, 763, 10.1038/nrclinonc.2017.153 Wilson, 2015, Outcomes and endpoints in trials of cancer treatment: the past, present, and future, Lancet Oncol, 16, e32, 10.1016/S1470-2045(14)70375-4 Howell, 2021, Analysis of patient-reported outcome utilization within national clinical trials network cooperative group radiation oncology trials over the past 2 decades, Int J Radiat Oncol Biol Phys, 109, 1151, 10.1016/j.ijrobp.2020.12.007 Fabian, 2021, Patient-reported outcomes assessing the impact of palliative radiotherapy on quality of life and symptom burden in head and neck cancer patients: a systematic review, Front Oncol, 11, 10.3389/fonc.2021.683042 von Elm, 2007, The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies, PLoS Med, 4, e296, 10.1371/journal.pmed.0040296 Calvert, 2013, Reporting of patient-reported outcomes in randomized trials: the CONSORT PRO extension, JAMA, 309, 814, 10.1001/jama.2013.879 Snyder, 2019, Making a picture worth a thousand numbers: recommendations for graphically displaying patient-reported outcomes data, Qual Life Res, 28, 345, 10.1007/s11136-018-2020-3 Aaronson, 1993, The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology, J Natl Cancer Inst, 85, 365, 10.1093/jnci/85.5.365 Singer, 2019, International validation of the revised European Organisation for Research and Treatment of Cancer Head and Neck Cancer Module, the EORTC QLQ-HN43: phase IV, Head Neck, 41, 1725, 10.1002/hed.25609 Taylor, 2023, Serious long-term effects of Head and Neck Cancer from the survivors’ point of view, Healthcare, 11, 906, 10.3390/healthcare11060906 Fayers, 2001 Osoba, 1998, Interpreting the significance of changes in health-related quality-of-life scores, J Clin Oncol, 16, 139, 10.1200/JCO.1998.16.1.139 King, 2011, A point of minimal important difference (MID): a critique of terminology and methods, Expert Rev Pharmacoecon Outcomes Res, 11, 171, 10.1586/erp.11.9 Al-Mamgani, 2020, Randomized controlled trial to identify the optimal radiotherapy scheme for palliative treatment of incurable head and neck squamous cell carcinoma, Radiother Oncol, 149, 181, 10.1016/j.radonc.2020.05.020 Fortin, 2016, Palliative radiation therapy for advanced head and neck carcinomas: A phase 2 study, Int J Radiat Oncol Biol Phys, 95, 647, 10.1016/j.ijrobp.2016.01.039 Corry, 2005, The ’QUAD SHOT’–a phase II study of palliative radiotherapy for incurable head and neck cancer, Radiother Oncol, 77, 137, 10.1016/j.radonc.2005.10.008 Porceddu, 2007, Hypofractionated radiotherapy for the palliation of advanced head and neck cancer in patients unsuitable for curative treatment–“Hypo Trial”, Radiother Oncol, 85, 456, 10.1016/j.radonc.2007.10.020 Ferro, 2021, Advanced head and neck cancer in older adults: results of a short course accelerated radiotherapy trial, J Geriatr Oncol, 12, 441, 10.1016/j.jgo.2020.10.006 Karsten, 2018, Web-based patient-reported outcomes using the international consortium for health outcome measurement dataset in a major german university hospital: observational study, JMIR Cancer, 4, e11373, 10.2196/11373 Niska, 2017, Electronic patient-reported outcomes and toxicities during radiotherapy for head-and-neck cancer, Qual Life Res, 26, 1721, 10.1007/s11136-017-1528-2 Sprave, 2020, App-Controlled treatment monitoring and support for head and neck cancer patients (APCOT): protocol for a prospective randomized controlled trial, JMIR Res Protoc, 9, e21693, 10.2196/21693 Fabian, 2022, Use and reporting of patient-reported outcomes in trials of palliative radiotherapy: a systematic review, JAMA Netw Open, 5, e2231930, 10.1001/jamanetworkopen.2022.31930 Bossi, 2019, The point of pain in head and neck cancer, Crit Rev Oncol Hematol, 138, 51, 10.1016/j.critrevonc.2019.04.001 Finnegan, 2016, Cyclical hypofractionated radiotherapy technique for palliative treatment of locally advanced head and neck cancer: Institutional experience and review of palliative regimens, J Community Supportive Oncol, 14, 29, 10.12788/jcso.0201 Toya, 2020, Hypofractionated palliative volumetric modulated arc radiotherapy with the Radiation Oncology Study Group 8502 “QUAD shot” regimen for incurable head and neck cancer, Radiat Oncol, 15, 10.1186/s13014-020-01548-w Al-mamgani, 2009, Hypofractionated radiotherapy denoted as the “Christie scheme”: an effective means of palliating patients with head and neck cancers not suitable for curative treatment, Acta Oncol, 48, 562, 10.1080/02841860902740899 Desideri, 2021, Palliative radiotherapy in older adults with head and neck squamous cell carcinoma: a systematic review, Oral Oncol, 119, 105355, 10.1016/j.oraloncology.2021.105355 Fiteni, 2014, Endpoints in cancer clinical trials, J Visc Surg, 151, 17, 10.1016/j.jviscsurg.2013.10.001 Fabian, 2022, Clinical endpoints in trials of palliative radiotherapy: a systematic meta-research analysis, Radiother Oncol, 174, 123, 10.1016/j.radonc.2022.07.013