The impact of early pregnancy metabolic disorders on pregnancy outcome and the specific mechanism
Tóm tắt
Từ khóa
Tài liệu tham khảo
Bender AR, et al. ESHRE guideline: recurrent pregnancy loss. Hum Reprod Open. 2018. https://doi.org/10.1093/hropen/hoy004.
Blencowe H, et al. Born too soon: the global epidemiology of 15 million preterm births. Reprod Health. 2013. https://doi.org/10.1186/1742-4755-10-S1-S2.
Quenby S, et al. Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss. Lancet. 2021;397(10285):1658–67.
Christiansen OB, et al. Multifactorial etiology of recurrent miscarriage and its scientific and clinical implications. Gynecol Obstet Invest. 2008;66(4):257–67.
Toth B, et al. Recurrent miscarriage: current concepts in diagnosis and treatment. J Reprod Immunol. 2010;85(1):25–32.
Bashiri A, et al. Recurrent pregnancy loss–evaluation and treatment. Harefuah. 2011;150(11):852–6.
Liang L, et al. Metabolic dynamics and prediction of gestational age and time to delivery in pregnant women. Cell. 2020;181(7):1680-1692.e15.
Li X, et al. Metabolomic profiling of plasma samples from women with recurrent spontaneous abortion. Med Sci Monit. 2018;24:4038–45.
Herrera E, et al. Enhanced utilization of glycerol for glyceride synthesis in isolated adipocytes from early pregnant rats. J Physiol Biochem. 2010;66(3):245–53.
Villar J, et al. Effect of fat and fat-free mass deposition during pregnancy on birth weight. Am J Obstet Gynecol. 1992;167(5):1344–52.
Herrera E. Metabolic adaptations in pregnancy and their implications for the availability of substrates to the fetus. Eur J Clin Nutr. 2000;54(Suppl 1):S47-51.
Herrera E. Lipid metabolism in pregnancy and its consequences in the fetus and newborn. Endocrine. 2002;19(1):43–55.
Teixeira P, et al. Central growth hormone action regulates metabolism during pregnancy. Am J Physiol Endocrinol Metab. 2019;317(5):E925–40.
Zeng Z, Liu F, Li S. Metabolic adaptations in pregnancy: a review. Ann Nutr Metab. 2017;70(1):59–65.
Burton GJ, Scioscia M, Rademacher TW. Endometrial secretions: creating a stimulatory microenvironment within the human early placenta and implications for the aetiopathogenesis of preeclampsia. J Reprod Immunol. 2011;89(2):118–25.
Banerjee RR, et al. Gestational diabetes mellitus from inactivation of prolactin receptor and MafB in islet beta-cells. Diabetes. 2016;65(8):2331–41.
Huang C, Snider F, Cross JC. Prolactin receptor is required for normal glucose homeostasis and modulation of beta-cell mass during pregnancy. Endocrinology. 2009;150(4):1618–26.
Sorenson RL, Brelje TC. Adaptation of islets of Langerhans to pregnancy: beta-cell growth, enhanced insulin secretion and the role of lactogenic hormones. Horm Metab Res. 1997;29(6):301–7.
Ernst S, et al. Mechanisms in the adaptation of maternal beta-cells during pregnancy. Diabetes Manag (Lond). 2011;1(2):239–48.
Grattan DR, Kokay IC. Prolactin: a pleiotropic neuroendocrine hormone. J Neuroendocrinol. 2008;20(6):752–63.
Bell AW, Bauman DE. Adaptations of glucose metabolism during pregnancy and lactation. J Mammary Gland Biol Neoplasia. 1997;2(3):265–78.
Mueckler M, Thorens B. The SLC2 (GLUT) family of membrane transporters. Mol Aspects Med. 2013;34(2–3):121–38.
Stanirowski PJ, et al. Expression of placental glucose transporter proteins in pregnancies complicated by fetal growth disorders. Adv Protein Chem Struct Biol. 2021;123:95–131.
Stanirowski PJ, et al. Placental expression of glucose transporter proteins in pregnancies complicated by gestational and pregestational diabetes mellitus. Can J Diabetes. 2018;42(2):209–17.
Jansson T, Wennergren M, Illsley NP. Glucose transporter protein expression in human placenta throughout gestation and in intrauterine growth retardation. J Clin Endocrinol Metab. 1993;77(6):1554–62.
Brown K, et al. Glucose transporter 3 (GLUT3) protein expression in human placenta across gestation. Placenta. 2011;32(12):1041–9.
Janzen C, et al. Placental glucose transporter 3 (GLUT3) is up-regulated in human pregnancies complicated by late-onset intrauterine growth restriction. Placenta. 2013;34(11):1072–8.
Wang Q, Liu C, Zhang Z. Transthyretin and normal human pregnancy: mini review. Crit Rev Eukaryot Gene Expr. 2016;26(3):273–7.
Murphy SP, Abrams BF. Changes in energy intakes during pregnancy and lactation in a national sample of US women. Am J Public Health. 1993;83(8):1161–3.
Palacin M, et al. Circulating metabolite utilization by periuterine adipose tissue in situ in the pregnant rat. Metabolism. 1991;40(5):534–9.
Duttaroy AK, Basak S. Maternal fatty acid metabolism in pregnancy and its consequences in the feto-placental development. Front Physiol. 2021;12: 787848.
Catov JM, et al. Maternal leptin across pregnancy in women with small-for-gestational-age infants. Am J Obstet Gynecol. 2007;196(6):558.e1-8.
Martineau MG, et al. The metabolic profile of intrahepatic cholestasis of pregnancy is associated with impaired glucose tolerance, dyslipidemia, and increased fetal growth. Diabetes Care. 2015;38(2):243–8.
Li Z, Zhang H. Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression. Cell Mol Life Sci. 2016;73(2):377–92.
Economides DL, et al. Plasma amino acids in appropriate- and small-for-gestational-age fetuses. Am J Obstet Gynecol. 1989;161(5):1219–27.
Cetin I, et al. Maternal concentrations and fetal-maternal concentration differences of plasma amino acids in normal and intrauterine growth-restricted pregnancies. Am J Obstet Gynecol. 1996;174(5):1575–83.
Desforges M, et al. The SNAT4 isoform of the system A amino acid transporter is functional in human placental microvillous plasma membrane. J Physiol. 2009;587(1):61–72.
Audette MC, et al. Antenatal dexamethasone treatment in midgestation reduces system A-mediated transport in the late-gestation murine placenta. Endocrinology. 2011;152(9):3561–70.
Regnault TR, de Vrijer B, Battaglia FC. Transport and metabolism of amino acids in placenta. Endocrine. 2002;19(1):23–41.
Agarwal A, et al. Redox considerations in female reproductive function and assisted reproduction: from molecular mechanisms to health implications. Antioxid Redox Signal. 2008;10(8):1375–403.
Chapple SJ, Siow RC, Mann GE. Crosstalk between Nrf2 and the proteasome: therapeutic potential of Nrf2 inducers in vascular disease and aging. Int J Biochem Cell Biol. 2012;44(8):1315–20.
Chigusa Y, et al. Decreased lectin-like oxidized LDL receptor 1 (LOX-1) and low Nrf2 activation in placenta are involved in preeclampsia. J Clin Endocrinol Metab. 2012;97(10):E1862–70.
Cullinan SB, et al. Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol Cell Biol. 2003;23(20):7198–209.
Hirsila M, et al. Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor. J Biol Chem. 2003;278(33):30772–80.
Li HS, et al. HIF-1alpha protects against oxidative stress by directly targeting mitochondria. Redox Biol. 2019;25: 101109.
Clambey ET, et al. Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa. Proc Natl Acad Sci U S A. 2012;109(41):E2784–93.
Edugbe AE, et al. Beta-cell dysfunction and abnormal glucose metabolism among non-diabetic women with recurrent miscarriages. Arch Gynecol Obstet. 2020;301(2):559–64.
Milwidsky A, Palti Z, Gutman A. Glycogen metabolism of the human endometrium. J Clin Endocrinol Metab. 1980;51(4):765–70.
Burton GJ, et al. Uterine glands provide histiotrophic nutrition for the human fetus during the first trimester of pregnancy. J Clin Endocrinol Metab. 2002;87(6):2954–9.
Salker MS, et al. Loss of endometrial sodium glucose cotransporter SGLT1 is detrimental to embryo survival and fetal growth in pregnancy. Sci Rep. 2017;7(1):12612.
Gonzalez FJ, Xie C, Jiang C. The role of hypoxia-inducible factors in metabolic diseases. Nat Rev Endocrinol. 2018;15(1):21–32.
Ma LN, et al. Lactic acid: a novel signaling molecule in early pregnancy? Front Immunol. 2020;11:279.
Gardner DK. Lactate production by the mammalian blastocyst: manipulating the microenvironment for uterine implantation and invasion? BioEssays. 2015;37(4):364–71.
Gao L, et al. Trophoblast-derived lactic acid orchestrates decidual macrophage differentiation via SRC/LDHA signaling in early pregnancy. Int J Biol Sci. 2022;18(2):599–616.
Catrina SB, Zheng X. Hypoxia and hypoxia-inducible factors in diabetes and its complications. Diabetologia. 2021;64(4):709–16.
Wang XH, et al. Low chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk. Nat Commun. 2021;12(1):3428.
Kaczmarek E, et al. Identification and characterization of CD39/vascular ATP diphosphohydrolase. J Biol Chem. 1996;271(51):33116–22.
Zimmermann H. 5’-Nucleotidase: molecular structure and functional aspects. Biochem J. 1992;285(Pt 2):345–65.
Eltzschig HK, Sitkovsky MV, Robson SC. Purinergic signaling during inflammation. N Engl J Med. 2013;368(13):1260.
Zhu J, et al. CD39/CD73 dysregulation of adenosine metabolism increases decidual natural killer cell cytotoxicity: implications in unexplained recurrent spontaneous abortion. Front Immunol. 2022;13: 813218.
Emilio H, Henar OS. Maternal lipid metabolism during normal pregnancy and its implications to fetal development. Clinical Lipidology. 2014;15(1):24–31.
Risto K. Lipid abnormalities in pre-eclampsia:implications for vascular health. Clinical Lipidology. 2011;6(1):71–8.
Spracklen CN, et al. Maternal hyperlipidemia and the risk of preeclampsia: a meta-analysis. Am J Epidemiol. 2014;180(4):346–58.
Towfighi A, Ovbiagele B. Partial peroxisome proliferator-activated receptor agonist angiotensin receptor blockers. Potential multipronged strategy in stroke prevention. Cerebrovasc Dis. 2008;26(2):106–12.
Giaginis C, Spanopoulou E, Theocharis S. PPAR-gamma signaling pathway in placental development and function: a potential therapeutic target in the treatment of gestational diseases. Expert Opin Ther Targets. 2008;12(8):1049–63.
Pham J, et al. The role of Sirtuin1-PPARgamma axis in placental development and function. J Mol Endocrinol. 2018;60(4):R201–12.
Schaiff WT, et al. Ligand-activated peroxisome proliferator activated receptor gamma alters placental morphology and placental fatty acid uptake in mice. Endocrinology. 2007;148(8):3625–34.
Yessoufou A, et al. Peroxisome proliferator-activated receptor alpha deficiency increases the risk of maternal abortion and neonatal mortality in murine pregnancy with or without diabetes mellitus: Modulation of T cell differentiation. Endocrinology. 2006;147(9):4410–8.
Barak Y, et al. Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer. Proc Natl Acad Sci USA. 2002;99(1):303–8.
Barak Y, et al. PPAR gamma is required for placental, cardiac, and adipose tissue development. Mol Cell. 1999;4(4):585–95.
Wieser F, et al. PPAR action in human placental development and pregnancy and its complications. PPAR Res. 2008;2008: 527048.
Al-Gubory KH, Fowler PA, Garrel C. The roles of cellular reactive oxygen species, oxidative stress and antioxidants in pregnancy outcomes. Int J Biochem Cell Biol. 2010;42(10):1634–50.
Schisterman EF, et al. Influence of endogenous reproductive hormones on F2-isoprostane levels in premenopausal women: the BioCycle Study. Am J Epidemiol. 2010;172(4):430–9.
Patterson E, et al. Health implications of high dietary omega-6 polyunsaturated Fatty acids. J Nutr Metab. 2012;2012: 539426.
Kim K, et al. Associations between preconception plasma fatty acids and pregnancy outcomes. Epidemiology. 2019;30(Suppl 2):S37–46.
Liu Y, et al. Triglyceride induced metabolic inflammation: potential connection of insulin resistance and recurrent pregnancy loss. Front Endocrinol. 2021;12: 621845.
Li M, et al. The arachidonic acid metabolism mechanism based on UPLC-MS/MS metabolomics in recurrent spontaneous abortion rats. Front Endocrinol. 2021;12: 652807.
Zhao ZA, et al. Arachidonic acid regulation of the cytosolic phospholipase A 2alpha/cyclooxygenase-2 pathway in mouse endometrial stromal cells. Fertil Steril. 2012;97(5):1199–205.
Wang H, Dey SK. Roadmap to embryo implantation: clues from mouse models. Nat Rev Genet. 2006;7(3):185–99.
Srinivasan G, et al. Leptin receptor stimulation in late pregnant mouse uterine tissue inhibits spontaneous contractions by increasing NO and cGMP. Cytokine. 2021;137: 155341.
Tabe Y, Lorenzi PL, Konopleva M. Amino acid metabolism in hematologic malignancies and the era of targeted therapy. Blood. 2019;134(13):1014–23.
Hong L, et al. Multi-omics reveals a relationship between endometrial amino acid metabolism and autophagy in women with recurrent miscarriagedagger. Biol Reprod. 2021;105(2):393–402.
Ye J, et al. The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation. EMBO J. 2010;29(12):2082–96.
Oh SY, et al. Autophagy-related proteins, LC3 and Beclin-1, in placentas from pregnancies complicated by preeclampsia. Reprod Sci. 2008;15(9):912–20.
Bolnick JM, et al. Sildenafil prevents apoptosis of human first-trimester trophoblast cells exposed to oxidative stress: possible role for nitric oxide activation of 3’,5’-cyclic guanosine monophosphate signaling. Reprod Sci. 2015;22(6):718–24.
Tsatsaris V, et al. Calcitonin gene-related peptide (CGRP) and CGRP receptor expression at the human implantation site. J Clin Endocrinol Metab. 2002;87(9):4383–90.
Rochette L, et al. Nitric oxide synthase inhibition and oxidative stress in cardiovascular diseases: possible therapeutic targets? Pharmacol Ther. 2013;140(3):239–57.
Matsuguma K, et al. Molecular mechanism for elevation of asymmetric dimethylarginine and its role for hypertension in chronic kidney disease. J Am Soc Nephrol. 2006;17(8):2176–83.
Hao F, et al. Decreased nitric oxide content mediated by asymmetrical dimethylarginine and protein l-arginine methyltransferase 3 in macrophages induces trophoblast apoptosis: a potential cause of recurrent miscarriage. Hum Reprod. 2021;36(12):3049–61.
Ota K, et al. Effects of MTHFR C677T polymorphism on vitamin D, homocysteine and natural killer cell cytotoxicity in women with recurrent pregnancy losses. Hum Reprod. 2020;35(6):1276–87.
Poddar R, et al. Homocysteine induces expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human aortic endothelial cells: implications for vascular disease. Circulation. 2001;103(22):2717–23.
Dudman NP, et al. Homocysteine enhances neutrophil-endothelial interactions in both cultured human cells and rats In vivo. Circ Res. 1999;84(4):409–16.
Nelen WL, et al. Genetic risk factor for unexplained recurrent early pregnancy loss. Lancet. 1997;350(9081):861.
Schalinske KL, Smazal AL. Homocysteine imbalance: a pathological metabolic marker. Adv Nutr. 2012;3(6):755–62.
Nandi AA, et al. Maternal vitamin D deficiency influences long-chain polyunsaturated fatty acids and pregnancy outcome in association with alterations in one-carbon metabolism. Nutr Res. 2021;86:37–49.
Zhang Y, et al. Hyperandrogenism and insulin resistance-induced fetal loss: evidence for placental mitochondrial abnormalities and elevated reactive oxygen species production in pregnant rats that mimic the clinical features of polycystic ovary syndrome. J Physiol. 2019;597(15):3927–50.
Agarwal A, Allamaneni SS. Role of free radicals in female reproductive diseases and assisted reproduction. Reprod Biomed Online. 2004;9(3):338–47.
Lu J, et al. A novel and compact review on the role of oxidative stress in female reproduction. Reprod Biol Endocrinol. 2018;16(1):80.
Poston L, et al. Role of oxidative stress and antioxidant supplementation in pregnancy disorders. Am J Clin Nutr. 2011;94(6 Suppl):1980S-1985S.
Xu Q, et al. Effect of Fas/FasL signaling pathway activation in trophoblasts on recurrent spontaneous abortion. J Obstet Gynaecol Res. 2021;47(6):1978–86.
Simsek M, et al. Blood plasma levels of lipoperoxides, glutathione peroxidase, beta carotene, vitamin A and E in women with habitual abortion. Cell Biochem Funct. 1998;16(4):227–31.
Hussain T, et al. The Role of Oxidative Stress and Antioxidant Balance in Pregnancy. Mediators Inflamm. 2021;2021:9962860.
Nair RR, Khanna A, Singh K. Association of GSTT1 and GSTM1 polymorphisms with early pregnancy loss in an Indian population and a meta-analysis. Reprod Biomed Online. 2013;26(4):313–22.
Polimanti R, et al. Glutathione S-transferase genes and the risk of recurrent miscarriage in Italian women. Fertil Steril. 2012;98(2):396–400.
Hu L, et al. SO2 derivatives induce dysfunction in human trophoblasts via inhibiting ROS/IL-6/STAT3 pathway. Ecotoxicol Environ Saf. 2021;210: 111872.
Rumbold A, Crowther CA. Vitamin C supplementation in pregnancy. Cochrane Database Syst Rev. 2005. https://doi.org/10.1002/14651858.CD004069.pub2.
Tarin JJ, et al. Oral administration of pharmacological doses of vitamins C and E reduces reproductive fitness and impairs the ovarian and uterine functions of female mice. Theriogenology. 2002;57(5):1539–50.
Cederberg J, Siman CM, Eriksson UJ. Combined treatment with vitamin E and vitamin C decreases oxidative stress and improves fetal outcome in experimental diabetic pregnancy. Pediatr Res. 2001;49(6):755–62.
Chen Y, et al. Astaxanthin alleviates gestational diabetes mellitus in mice through suppression of oxidative stress. Naunyn Schmiedebergs Arch Pharmacol. 2020;393(12):2517–27.
Di Tucci C, et al. Alpha lipoic acid in obstetrics and gynecology. Gynecol Endocrinol. 2018;34(9):729–33.
Monastra G, et al. Immunomodulatory activities of alpha lipoic acid with a special focus on its efficacy in preventing miscarriage. Expert Opin Drug Deliv. 2016;13(12):1695–708.
Smith S, Pfeifer SM, Collins JA. Diagnosis and management of female infertility. JAMA. 2003;290(13):1767–70.
Tulppala M, et al. A prospective study of 63 couples with a history of recurrent spontaneous abortion: contributing factors and outcome of subsequent pregnancies. Hum Reprod. 1993;8(5):764–70.
Tempfer C, et al. Endothelial nitric oxide synthase gene polymorphism in women with idiopathic recurrent miscarriage. Hum Reprod. 2001;16(8):1644–7.
Morales SA, et al. FAK activation and the role of epithelial membrane protein 2 (EMP2) in collagen gel contraction. Invest Ophthalmol Vis Sci. 2009;50(1):462–9.
Fu M, et al. Epithelial membrane protein-2 promotes endometrial tumor formation through activation of FAK and Src. PLoS ONE. 2011;6(5): e19945.
Williams CJ, et al. Epithelial membrane protein 2 (EMP2) deficiency alters placental angiogenesis, mimicking features of human placental insufficiency. J Pathol. 2017;242(2):246–59.
Bahia W, et al. Contribution of ADIPOQ variants to the genetic susceptibility of recurrent pregnancy loss. Reprod Sci. 2021;28(1):263–70.
Dendana M, et al. Association of adiponectin gene variants with idiopathic recurrent miscarriage according to obesity status: a case-control study. J Transl Med. 2018;16(1):76.
Mor G, Cardenas I. The immune system in pregnancy: a unique complexity. Am J Reprod Immunol. 2010;63(6):425–33.
Cho HY, et al. Association of complement factor D and H polymorphisms with recurrent pregnancy loss. Int J Mol Sci. 2019. https://doi.org/10.3390/ijms21010017.
Zhao J, et al. Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility. PLoS Genet. 2011;7(5): e1002079.
Brai M, et al. Combined homozygous factor H and heterozygous C2 deficiency in an Italian family. J Clin Immunol. 1988;8(1):50–6.
Xu YY, et al. Hypoxic effects on the mitochondrial content and functions of the placenta in fetal growth restriction. Placenta. 2021;114:100–7.
Anton L, et al. HIF-1alpha stabilization increases miR-210 eliciting first trimester extravillous trophoblast mitochondrial dysfunction. Front Physiol. 2019;10:699.
Fang M, et al. Hypoxia-inducible microRNA-218 inhibits trophoblast invasion by targeting LASP1: Implications for preeclampsia development. Int J Biochem Cell Biol. 2017;87:95–103.