The impact of childhood obesity on morbidity and mortality in adulthood: a systematic review

Obesity Reviews - Tập 13 Số 11 - Trang 985-1000 - 2012
Min Hae Park1, Catherine Falconer2, Russell Viner3, Sanjay Kinra4
1Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK
2Bristol Dental School
3General and Adolescent Paediatrics Unit, UCL Institute of Child Health, London, UK
4Bristol Medical School (PHS)

Tóm tắt

Summary

The objective of this study was to evaluate the evidence on whether childhood obesity is a risk factor for adult disease, independent of adult body mass index (BMI). Ovid MEDLINE (1948–May 2011), EMBASE (1980–2011 week 18) and the Cochrane Library (1990–2011) were searched for published studies of BMI from directly measured weight and height in childhood (2–19 years) and disease outcomes in adulthood. Data were synthesized in a narrative fashion. Thirty‐nine studies (n 181–1.1 million) were included in the review. There was evidence for associations between childhood BMI and type 2 diabetes, hypertension and coronary heart disease. Few studies examined associations independent of adult BMI; these showed that effect sizes were attenuated after adjustment for adult BMI in standard regression analyses. Although there is a consistent body of evidence for associations between childhood BMI and cardiovascular outcomes, there is a lack of evidence for effects independent of adult BMI. Studies have attempted to examine independent effects using standard adjustment for adult BMI, which is subject to over‐adjustment and problems with interpretation. Studies that use more robust designs and analytical techniques are needed to establish whether childhood obesity is an independent risk factor for adult disease.

Từ khóa


Tài liệu tham khảo

10.1016/S0140-6736(07)61778-4

10.1016/S0140-6736(09)60318-4

10.1080/17477160600586747

10.1111/j.1467-789X.2008.00475.x

10.1038/ijo.2010.222

Butland B, 2007, Tackling Obesities: Future Choices – Project Report

10.1136/bmj.320.7244.1240

10.2307/2529310

10.1016/0895-4356(91)90152-Y

10.1093/oxfordjournals.aje.a114936

10.1056/NEJM199211053271904

10.1093/ije/dyn231

Al Mamun A, 2009, Childhood overweight status predicts diabetes at age 21 years: a follow‐up study, Obesity (Silver Spring), 17, 1255, 10.1038/oby.2008.660

10.1183/09031936.00080906

10.1016/j.amjhyper.2007.01.020

10.1056/NEJMoa1006992

10.1001/archpediatrics.2009.228

10.1007/s00125-006-0408-z

10.2337/diacare.26.9.2512

10.1093/ije/31.6.1235

10.1007/s00125-002-1012-5

10.1161/CIRCULATIONAHA.110.940809

10.2337/dc08-0898

10.1038/oby.2005.21

10.1097/HJH.0b013e3280f3c01a

10.1093/ajcn/67.6.1111

10.1016/0895-4356(89)90147-9

10.1136/bmj.318.7181.427

10.1038/sj.ijo.0803480

10.1093/aje/kwn096

10.1161/01.STR.0000254471.72186.03

10.1093/ajcn/83.4.767

10.1136/thx.54.5.396

10.1002/ijc.20423

10.1093/aje/kwh345

10.1111/j.1525-1438.2006.00698.x

10.1093/jnci/djg010

10.1093/aje/kwf219

10.1136/bmj.b496

10.1093/oxfordjournals.aje.a116486

10.1111/j.1467-789X.2010.00741.x

10.1186/bcr998

Weiderpass E, 2004, A prospective study of body size in different periods of life and risk of premenopausal breast cancer, Cancer Epidemiol Biomarkers Prev, 13, 1121, 10.1158/1055-9965.1121.13.7

10.1158/1055-9965.EPI-07-2524

10.1097/EDE.0b013e3181a819a1

10.1016/S0140-6736(02)09834-3

10.1093/aje/kwi002

10.1093/aje/kwj003

10.1136/bmj.319.7204.245

10.1038/sj.ijo.0801232

10.2105/AJPH.2004.060418

10.1093/aje/kwp047

10.1371/journal.pgen.1001307

10.1136/bmj.38453.422049.E0

10.1056/NEJMoa1010112

10.1136/bmj.38586.411273.E0

10.1093/ajcn/77.3.726

10.1038/sj.ijo.0802316

10.1080/03014460902980295

10.2337/dc08-0911

10.7326/0003-4819-133-3-200008010-00008

10.1371/journal.pone.0014126

10.1056/NEJMoa072515

10.1097/00004872-200210000-00013

10.1093/aje/kwh097

10.1136/bmj.322.7292.949

10.1136/heart.90.1.20

10.1161/01.CIR.0000161798.45728.4D

Thông tin
Thông tin xuất bản

Obesity Reviews

Tập 13 Số 11

985-1000

Thông tin tác giả