The imidazole antimycotics econazole and miconazole reduce agonist-evoked protein-tyrosine phosphorylation and evoke membrane depolarisation in human platelets: cautions for their use in studying Ca2+ signalling pathways

Alonso, 1991, Agonist-induced Ca2+ influx into human platelets is secondary to the emptying of intracellular Ca2+ stores, Biochem. J., 280, 1783, 10.1042/bj2800783 Sargeant, 1992, Calcium influx evoked by Ca2+ store depletion in human platelets is more susceptible to cytochrome P-450 inhibitors than receptor-mediated calcium entry, Cell Calcium, 13, 553, 10.1016/0143-4160(92)90035-Q Putney, 1986, A model for receptor-regulated Ca2+ entry, Cell Calcium, 7, 1, 10.1016/0143-4160(86)90026-6 Putney, 1990, Capacitative Ca2+ entry revisited, Cell Calcium, 11, 611, 10.1016/0143-4160(90)90016-N Takemura, 1989, Activation of calcium entry by the tumour promoter thapsigargin in parotid acinar cells, J. Biol. Chem., 264, 12266, 10.1016/S0021-9258(18)63852-9 Montero, 1992, Control of plasma-membrane Ca2+ entry by the intracellular Ca2+ stores: kinetic evidence for a short-lived mediator, Biochem. J., 288, 519, 10.1042/bj2880519 Randriamampita, 1993, Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx, Nature, 364, 809, 10.1038/364809a0 Alvarez, 1992, Cytochrome P-450 may regulate plasma membrane Ca2+ permeability according to the filling state of the intracellular Ca2+ stores, FASEB J., 6, 786, 10.1096/fasebj.6.2.1537469 Mason, 1993, Inhibition of Ca2+ transport pathways in thymic lymphocytes by econazole, miconazole and SKF 96365, Am. J. Physiol., 264, C654, 10.1152/ajpcell.1993.264.3.C654 Vostal, 1991, Cytosolic and stored calcium antagonistically control tyrosine phosphorylation of specific platelet proteins, J. Biol. Chem., 266, 16911, 10.1016/S0021-9258(18)55389-8 Sargeant, 1992, The tyrosine kinase inhibitors methyl 2,5-dihydroxycinnamate and genistein reduce thrombin-evoked tyrosine phosphorylation and Ca2+ entry and human platelets, FEBS Lett., 315, 242, 10.1016/0014-5793(93)81172-V Sargeant, 1993, ADP- and thapsigargin-evoked Ca2+ entry and protein-tyrosine phosphorylation are inhibited by the tyrosine kinase inhibitors genistein and methyl-2,5-dihydroxycinnamate in fura-2-loaded human platelets, J. Biol. Chem., 268, 18151, 10.1016/S0021-9258(17)46823-2 Sargeant, 1994, Calcium store depletion in dimethyl BAPTA-loaded human platelets increases protein tyrosine phosphorylation in the absence of a rise in cytosolic calcium, Exp. Physiol., 79, 269, 10.1113/expphysiol.1994.sp003762 MacIntyre, 1982, The role of platelet membrane potential in the initiation of platelet aggregation, Thromb. Haemostasis, 47, 22, 10.1055/s-0038-1657117 Mahaut-Smith, 1990, Voltage-gated potassium channels and the control of membrane potential in human platelets, J. Physiol., 428, 723, 10.1113/jphysiol.1990.sp018237 Pipili, 1985, Platelet membrane potential: simultaneous measurement of diS-C3(5) fluorescence and optical density, Thromb. Haemostasis, 54, 645, 10.1055/s-0038-1660089 Sage, 1992, Thromboxane receptor stimulation inhibits adenylate cyclase and reduces cyclic AMP-mediated inhibition of ADP-evoked responses in fura-2-loaded human platelets, FEBS Lett., 298, 199, 10.1016/0014-5793(92)80056-M Sage, 1990, Agonist-evoked changes in cytosolic pH and calcium concentration in human platelets: studies in physiological bicarbonate, J. Physiol., 420, 31, 10.1113/jphysiol.1990.sp017900 Laemmli, 1970, Cleavage of structural proteins during the assembly of the head of bacteriophage T4, Nature, 227, 680, 10.1038/227680a0 Alvarez, 1992, High affinity inhibition of Ca2+-dependent K+ channels by cytochrome P-450 inhibitors, J. Biol. Chem., 267, 11793, 10.1016/S0021-9258(19)49767-6 Mahaut-Smith, 1994, Ca2+-activated K+ channels in human platelets, J. Physiol., 476, 59 Vostal, 1993, Econazole inhibits thapsigargin-induced platelet calcium influx by mechanisms other than cytochrome P-450 inhibition, Biochem. J., 295, 525, 10.1042/bj2950525