The hydroxyanilide fenhexamid, a new sterol biosynthesis inhibitor fungicide efficient against the plant pathogenic fungus <i>Botryotinia fuckeliana</i> (<i>Botrytis cinerea</i>)

Pest Management Science - Tập 57 Số 11 - Trang 1060-1067 - 2001
Danièle Debieu1, Jocelyne J. Bach, M Hugon, Christian Malosse, Pierre Leroux
1INRA, Unité de Phytopharmacie et Médiateurs Chimiques, 78026 Versailles, France. [email protected]

Tóm tắt

AbstractFenhexamid, a recently developed botryticide, is shown here to inhibit sterol biosynthesis. When the fungus Botryotinia fuckeliana was grown in the presence of fenhexamid, the ergosterol content was reduced, and three 3‐keto compounds, 4α‐methylfecosterone, fecosterone and episterone, accumulated, suggesting an inhibition of the 3‐keto reductase involved in C‐4 demethylation. Thus, fenhexamid belongs to a new, promising class of sterol biosynthesis inhibitors not previously used in agriculture or in medicine.© 2001 Society of Chemical Industry

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Tài liệu tham khảo

Bulit J, 1988, Compendium of grape diseases, 13

10.1016/S0261-2194(99)00074-5

10.1016/S0261-2194(99)00095-2

10.1002/(SICI)1096-9063(199606)47:2<191::AID-PS415>3.0.CO;2-I

Rosslenbroich H J, 1998, Proc Brighton Crop Prot Conf‐Pests and Diseases, 327

Hänßler G, 1999, Effect of fenhexamid on the development of Botrytis cinerea, Pflanzenschutz‐Nachrichten Bayer, 52, 158

SutyA PontzenRandStenzelK KBR 2738: Mode d'action et sensibilité de B cinerea ANPP‐Cinquième conférence internationale sur les maladies des plantes Tours 3–5 décembre 1997 I:561–568(1997).

10.1007/PL00012925

10.1016/0031-9422(92)80265-G

Köller W, 1992, Target Sites of Fungicide Action, 119

10.1006/pest.2000.2485

10.1073/pnas.96.22.12655

10.1006/abbi.1994.1308

10.1002/(SICI)1096-9063(1998100)54:2<157::AID-PS799>3.0.CO;2-Y

10.1016/0031-9422(90)85250-J

10.1016/B978-0-12-024923-7.50007-8

10.1002/ps.2780150206

Swindell A C, 1968, Investigation of the component reactions of oxidative sterol demethylation. Formation and metabolism of 3‐ketosteroid intermediates, J Biol Chem, 243, 5546, 10.1016/S0021-9258(18)91903-4

10.1016/S0006-291X(05)80178-0

10.3109/10409238309102790

10.1146/annurev.mi.49.100195.000523

10.1016/0014-5793(82)80289-5

10.1006/abbi.1993.1100

Rottem S, 1971, Sterol requirements of T‐strain mycoplasmas, J Bacteriol, 105, 323, 10.1128/jb.105.1.323-330.1971

10.1016/0006-291X(92)91529-Y

10.1073/pnas.93.1.186

10.1002/ps.2780220107

10.1016/0031-9422(90)85178-I

10.1002/ps.2780360103

10.1002/ps.2780390102

10.1016/S0031-9422(00)94980-X

Marichal P, 1999, Accumulation of 3‐ketosteroids induced by itraconazole in azole‐resistant clinical Candida albicans isolates, Antimicrob Agents Chemother, 43, 2663, 10.1128/AAC.43.11.2663