The human homolog of fission yeast Rad17 is implicated in tumor growth

Cancer Letters - Tập 266 - Trang 194-202 - 2008
Giovanni L. Beretta1, Laura Gatti1, Michelandrea De Cesare1, Elisabetta Corna1, Stella Tinelli1, Nives Carenini1, Franco Zunino1, Paola Perego1
1Department of Experimental Oncology and Laboratories, Fondazione IRCCS Istituto Nazionale Tumori, via Venezian 1, 20133 Milan, Italy

Tài liệu tham khảo

Hartwell, 1989, Checkpoints: controls that ensure the order of cell cycle events, Science, 246, 629, 10.1126/science.2683079 Hartwell, 1994, Cell cycle control and cancer, Science, 266, 1821, 10.1126/science.7997877 Elledge, 1996, Cell cycle checkpoints: preventing an identity crisis, Science, 274, 1664, 10.1126/science.274.5293.1664 Hartwell, 1992, Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells, Cell, 71, 543, 10.1016/0092-8674(92)90586-2 Nojima, 1997, Cell cycle checkpoints, chromosome stability and the progression of cancer, Hum. Cell., 10, 221 Carr, 1995, The cellular responses to DNA damage, Trends Cell Biol., 5, 32, 10.1016/S0962-8924(00)88934-5 Savitsky, 1995, A single ataxia telangiectasia gene with a product similar to PI-3 kinase, Science, 268, 1749, 10.1126/science.7792600 Bentley, 1996, The Schizosaccharomyces pombe rad3 checkpoint gene, EMBO J., 15, 6641, 10.1002/j.1460-2075.1996.tb01054.x Cimprich, 1996, cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein, Proc. Natl. Acad. Sci. USA, 93, 2850, 10.1073/pnas.93.7.2850 Lieberman, 1996, A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene, Proc. Natl. Acad. Sci. USA, 93, 13890, 10.1073/pnas.93.24.13890 Parker, 1998, Identification of a human homologue of the Schizosaccharomyces pombe rad17+ checkpoint gene, J. Biol. Chem., 273, 18340, 10.1074/jbc.273.29.18340 Griffiths, 1995, Fission yeast rad17: a homologue of budding yeast RAD24 that shares regions of sequence similarity with DNA polymerase accessory proteins, EMBO J., 14, 5812, 10.1002/j.1460-2075.1995.tb00269.x Parrilla-Castellar, 2004, Dial 9-1-1 for DNA damage: the Rad9-Hus1-Rad1 (9-1-1) clamp complex, DNA Repair (Amst), 3, 1009, 10.1016/j.dnarep.2004.03.032 Niida, 2006, DNA damage checkpoints in mammals, Mutagenesis, 21, 3, 10.1093/mutage/gei063 Green, 2000, A novel Rad24 checkpoint protein complex closely related to replication factor C, Curr. Biol., 10, 39, 10.1016/S0960-9822(99)00263-8 Kai, 2001, Fission yeast rad17 associates with chromatin in response to aberrant genomic structures, Mol. Cell. Biol., 21, 3289, 10.1128/MCB.21.10.3289-3301.2001 Sancar, 2004, Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints, Annu. Rev. Biochem., 73, 39, 10.1146/annurev.biochem.73.011303.073723 Gewurz, 2006, DNA-damage control: Claspin destruction turns off the checkpoint, Curr. Biol., 16, 932, 10.1016/j.cub.2006.09.046 Cortez, 2001, ATR and ATRIP: partners in checkpoint signaling, Science, 294, 1713, 10.1126/science.1065521 Majka, 2006, Replication protein A directs loading of the DNA damage checkpoint clamp to 5′-DNA junctions, J. Biol. Chem., 281, 27855, 10.1074/jbc.M605176200 Yang, 2006, Recruitment of ATR–ATRIP, Rad17, and 9-1-1 complexes to DNA damage, Methods Enzymol., 409, 118, 10.1016/S0076-6879(05)09007-5 Zou, 2003, Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes, Science, 300, 1542, 10.1126/science.1083430 Zou, 2002, Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin, Genes Dev., 16, 198, 10.1101/gad.950302 Wang, 2006, Rad17 phosphorylation is required for Claspin recruitment and Chk1 activation in response to replication stress, Mol. Cell., 23, 331, 10.1016/j.molcel.2006.06.022 Chini, 2003, Human Claspin is required for replication checkpoint control, J. Biol. Chem., 278, 30057, 10.1074/jbc.M301136200 Chini, 2006, Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function, J. Biol. Chem., 281, 33276, 10.1074/jbc.M604373200 Yong, 2007, Mice lacking protein phosphatase 5 are defective in ataxia telangiectasia mutated (ATM)-mediated cell cycle arrest, J. Biol. Chem., 182, 14690, 10.1074/jbc.C700019200 Salvati, 2007, Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect, J. Clin. Invest., 117, 3236, 10.1172/JCI32461 Song, 2007, A conserved physical and functional interaction between the cell cycle checkpoint clamp loader and DNA ligase I of eukaryotes, J. Biol. Chem., 282, 22721, 10.1074/jbc.M703774200 Maundrell, 1993, Thiamine-repressible expression vectors pREP and pRIP for fission yeast, Gene, 123, 127, 10.1016/0378-1119(93)90551-D Gatti, 2004, Global gene expression of fission yeast in response to cisplatin, Cell Mol. Life Sci., 61, 2253, 10.1007/s00018-004-4218-5 Moreno, 1991, Molecular genetic analysis of fission yeast Schizosaccharomyces pombe, Methods Enzymol., 194, 795, 10.1016/0076-6879(91)94059-L Rowley, 1992, Checkpoint controls in Schizosaccharomyces pombe: rad1, EMBO J., 11, 1335, 10.1002/j.1460-2075.1992.tb05178.x Laemmli, 1970, Cleavage of structural proteins during the assembly of the head of bacteriophage T4, Nature, 227, 680, 10.1038/227680a0 Gatti, 2002, Apoptosis and growth arrest induced by platinum compounds in U2-OS cells reflect a specific DNA damage recognition associated with a different p53-mediated response, Cell Death Diff., 9, 1352, 10.1038/sj.cdd.4401109 Parker, 1998, A human homologue of the Schizosaccharomyces pombe rad1+ checkpoint gene encodes an exonuclease, J. Biol. Chem., 273, 18332, 10.1074/jbc.273.29.18332 Fasano, 1984, Analysis of the transforming potential of the human H-ras gene by random mutagenesis, Proc. Natl. Acad. Sci. USA, 81, 4008, 10.1073/pnas.81.13.4008 Lindsey-Boltz, 2001, Purification and characterization of human DNA damage checkpoint Rad complexes, Proc. Natl. Acad. Sci. USA, 98, 11236, 10.1073/pnas.201373498 Ellison, 2003, Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5′ recessed DNA, PLoS Biol., 1, 231, 10.1371/journal.pbio.0000033 Mazur, 2001, Excision of 3′ termini by the Trex1 and TREX2 3′–>5′ exonucleases. Characterization of the recombinant proteins, J. Biol. Chem., 276, 17022, 10.1074/jbc.M100623200 LinksEl-Shemerly, 2008, ATR-dependent pathways control hEXO1 stability in response to stalled forks, Nucleic Acids Res., 36, 511, 10.1093/nar/gkm1052 Yang, 2007, Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease, Cell, 131, 873, 10.1016/j.cell.2007.10.017 Bao, 1999, HRad17, a human homologue of the Schizosaccharomyces pombe checkpoint gene rad17, is overexpressed in colon carcinoma, Cancer Res., 59, 2023 Miura, 1992, Chromosome alterations in human small cell lung cancer: frequent involvement of 5q, Cancer Res., 52, 1322 Shibagaki, 1994, Allelotype analysis of esophageal squamous cell carcinoma, Cancer Res., 54, 2996 Budzowska, 2004, Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination, EMBO J., 23, 3548, 10.1038/sj.emboj.7600353 von Deimling, 1999, Human and mouse RAD17 genes: identification, localization, genomic structure and histological expression pattern in normal testis and seminoma, Hum. Genet., 105, 17, 10.1007/s004390051058 Hopkins, 2003, Expression of mammalian paralogues of HRAD9 and Mrad9 checkpoint control genes in normal and cancerous testicular tissue, Cancer Res., 63, 5291 Wang, 2001, Human Rad17 is phosphorylated upon DNA damage and also overexpressed in primary non-small cell lung cancer tissues, Cancer Res., 61, 7417 Sasaki, 2001, Overexpression of Hrad17 gene in non-small cell lung cancers correlated with lymph node metastasis, Lung Cancer, 34, 47, 10.1016/S0169-5002(01)00223-9 Kataoka, 2001, Overexpression of HRad17 mRNA in human breast cancer: correlation with lymph node metastasis, Clin. Cancer Res., 9, 2815 Bai, 2001, Tumor suppression and potentiation by manipulation of pp32 expression, Oncogene, 20, 2153, 10.1038/sj.onc.1204294