The human cytochrome P4507B1: catalytic activity studies

Zhang, 1995, 7α-Hydroxylation of 27-hydroxy-cholesterol in rat brain microsomes, C.R. Acad. Sci. III, 318, 345 Wu, 1999, Structure and functions of human oxysterol 7 alpha-hydroxylase cDNAs and gene CYP7B1, J. Lipid Res., 40, 2195, 10.1016/S0022-2275(20)32094-0 Lafaye, 1999, The 7 alpha-hydroxysteroids produced in human tonsils enhance the immune response to tetanus toroid and Bordetella pertussis antigens, Bba. Gen. Subjects, 1472, 222, 10.1016/S0304-4165(99)00124-5 Weill-Engerer, 2003, In vitro metabolism of dehydroepiandrosterone (DHEA) to 7alpha-hydroxy-DHEA and delta5-androstene-3beta,17beta-diol in specific regions of the aging brain from Alzheimer's and non-demented patients, Brain Res., 969, 117, 10.1016/S0006-8993(03)02288-1 Schwarz, 2001, Alternate pathways of bile acid synthesis in the cholesterol 7 alpha-hydroxylase knockout mouse are not upregulated by either cholesterol or cholestyramine feeding, J. Lipid Res., 42, 1594, 10.1016/S0022-2275(20)32213-6 Weihua, 2002, An endocrine pathway in the prostate, ERbeta, AR, 5alpha-androstane-3beta,17beta-diol, and CYP7B1, regulates prostate growth, Proc. Natl. Acad. Sci. U.S.A, 99, 13589, 10.1073/pnas.162477299 Morfin, 2002, Involvement of steroids and cytochromes P(450) species in the triggering of immune defenses, J. Steroid Biochem. Mol. Biol., 80, 273, 10.1016/S0960-0760(02)00025-0 Jellinck, 2001, Metabolism of dehydroepiandrosterone by rat hippocampal cells in culture: possible role of aromatization and 7-hydroxylation in neuroprotection, J. Steroid Biochem. Mol. Biol., 78, 313, 10.1016/S0960-0760(01)00106-6 Dudas, 2004, Protection against inflammatory neurodegeneration and glial cell death by 7beta-hydroxy epiandrosterone, a novel neurosteroid, Neurobiol. Dis., 15, 262, 10.1016/j.nbd.2003.11.001 Setchell, 1998, Identification of a new inborn error in bile acid synthesis: mutation of the oxysterol 7 alpha-hydroxylase gene causes severe neonatal liver disease, J. Clin. Invest., 102, 1690, 10.1172/JCI2962 Trincal, 2002, DHEA metabolism in the brain: production and effects of the 7alpha-hydroxylated derivative, 117 Chalbot, 2002, Use of bioconversion for the preparation of [4-14C]-labeled 7alpha- and 7beta-hydroxylated derivatives of dehydroepiandrosterone and epiandrosterone, Steroids, 67, 1121, 10.1016/S0039-128X(02)00072-7 Rose, 1997, Cyp7b, a novel brain cytochrome p450, catalyzes the synthesis of neurosteroids 7 alpha-hydroxy dehydroepiandrosterone and 7 alpha-hydroxy pregnenolone, Proc. Natl. Acad. Sci. U.S.A., 94, 4925, 10.1073/pnas.94.10.4925 Doostzadeh, 1997, Dehydroepiandrosterone 7 alpha- and 7 beta-hydroxylation in mouse brain microsomes. effects of cytochrome p450 inhibitors and structure-specific inhibition by steroid hormones, J. Neuroendocrinol., 9, 923, 10.1046/j.1365-2826.1997.00661.x Urban, 1993, Xenobiotic metabolism in humanized yeast: engineered yeast cells producing human NADPH-cytochrome P-450 reductase, cytochrome b5, epoxide hydrolase and P-450s, Biochem. Soc. Trans., 21, 1028, 10.1042/bst0211028 Gietz, 1992, Improved method for high efficiency transformation of intact yeast cells, Nucleic Acids Res., 20, 1425, 10.1093/nar/20.6.1425 Pompon, 1996, Yeast expression of animal and plant P450s in optimized redox environments, Methods Enzymol., 272, 51, 10.1016/S0076-6879(96)72008-6 Omura, 1964, The carbon monoxide binding pigment of liver microsomes. I. Evidence for its hemoprotein nature, J. Biol. Chem., 239, 2370, 10.1016/S0021-9258(20)82244-3 Doostzadeh, 1996, Studies of the enzyme complex responsible for pregnenolone and dehydroepiandrosterone 7a-hydroxylation in mouse tissues, Steroids, 61, 613, 10.1016/S0039-128X(96)00122-5 Renaud, 1990, Expression of human liver cytochrome P450 IIIA4 in yeast. A functional model for the hepatic enzyme, Eur. J. Biochem., 194, 889, 10.1111/j.1432-1033.1990.tb19483.x Morfin, 2001, Neurosteroid 7-hydroxylation products in the brain, Int. Rev. Neurobiol., 46, 79, 10.1016/S0074-7742(01)46059-4 Cotillon, 1997, The inducible and cytochrome p450-containing dehydroepiandrosterone 7 alpha-hydroxylating enzyme system of Fusarium moniliforme, J. Steroid Biochem. Mol. Biol., 62, 467, 10.1016/S0960-0760(97)00060-5 Hampl, 2001, 7-Hydroxydehydroepiandrosterone epimers in the life span, J. Steroid Biochem. Mol. Biol., 78, 367, 10.1016/S0960-0760(01)00108-X Lathe, 2002, Steroid and sterol 7-hydroxylation: ancient pathways, Steroids, 67, 967, 10.1016/S0039-128X(02)00044-2 Robinzon, 2003, Glucocorticoids inhibit interconversion of 7-hydroxy and 7-oxo metabolites of dehydroepiandrosterone: a role for 11beta-hydroxysteroid dehydrogenases?, Arch. Biochem. Biophys., 412, 251, 10.1016/S0003-9861(03)00056-0 Strömstedt, 1993, Role of brain cytochrome P450 in regulation of the level of anesthetic steroids in the brain, Mol. Pharmacol., 44, 1077 Jakobsson, 2004, A functional C–G polymorphism in the CYP7B1 promoter region and its different distribution in Orientals and Caucasians, Pharmacogenomics. J., 4, 245, 10.1038/sj.tpj.6500236 Pringle, 2003, 7-Hydroxylated epiandrosterone (7-OH-EPIA) reduces ischemia-induced neuronal damage both in vivo and in vitro, Eur. J. Neurosci., 18, 117, 10.1046/j.1460-9568.2003.02734.x Sticht, 1995, Structure of amyloid A4-(1–40)-peptide of Alzheimer's disease, Eur. J. Biochem., 233, 293, 10.1111/j.1432-1033.1995.293_1.x Liu, 2004, Residues 17–20 and 30–35 of beta-amyloid play critical roles in aggregation, J. Neurosci. Res., 75, 162, 10.1002/jnr.10859 Yau, 2003, Dehydroepiandrosterone 7-hydroxylase cyp7b: predominant expression in primate hippocampus and reduced expression in Alzheimer's disease, Neuroscience, 121, 307, 10.1016/S0306-4522(03)00438-X