The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29

Abdulla, 2007, Characterization and functional analysis of the promoter for the human equilibrative nucleoside transporter gene, hENT1, Nucleosides Nucleotides Nucleic Acids., 26, 99, 10.1080/15257770601052331

Badagnani, 2005, Functional analysis of genetic variants in the human concentrative nucleoside transporter 3 (CNT3, SLC28A3), Pharmacogenomics J., 5, 157, 10.1038/sj.tpj.6500303

Baldwin, 2004, The equilibrative nucleoside transporter family, SLC29, Pflugers. Arch-Eur. J. Physiol., 447, 735, 10.1007/s00424-003-1103-2

Baldwin, 2005, Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes, J. Biol. Chem., 280, 15880, 10.1074/jbc.M414337200

Barnes, 2006, Distribution and functional characterization of equilibrative nucleoside transporter-4, a novel cardiac adenosine transporter activated at acidic pH, Circ. Res., 99, 510, 10.1161/01.RES.0000238359.18495.42

Bergman, 2004, Antiproliferative activity and mechanism of action of fatty acid derivatives of arabinofuranosylcytosine in leukemia and solid tumor cell lines, Biochem. Pharmacol., 67, 503, 10.1016/j.bcp.2003.09.028

Bergman, 2011, Antiproliferative activity, mechanism of action and oral antitumor activity of CP-4126, a fatty acid derivative of gemcitabine, in in vitro and in vivo tumor models, Invest New Drugs, 29, 456, 10.1007/s10637-009-9377-7

Cano-Soldado, 2011, Functional analysis of the human concentrative nucleoside transporter-1 variant hCNT1S546P provides insight into the sodium-binding pocket, Am. J. Physiol. Cell Physiol., 302, C257, 10.1152/ajpcell.00198.2011

Chen, 2007, The type 1 equilibrative nucleoside transporter regulates anxiety-like behavior in mice, Genes Brain Behav., 6, 776, 10.1111/j.1601-183X.2007.00311.x

Chen, 2010, Altered glutamatergic neurotransmission in the striatum regulates ethanol sensitivity and intake in mice lacking ENT1, Behav. Brain Res., 208, 636, 10.1016/j.bbr.2010.01.011

Choi, 2004, The type 1 equilibrative nucleoside transporter regulates ethanol intoxication and preference, Nat. Neurosci., 7, 855, 10.1038/nn1288

Clarke, 2002, The role of membrane transporters in cellular resistance to anticancer nucleoside drugs, Cancer Treat. Res., 112, 27, 10.1007/978-1-4615-1173-1_2

Dahlin, 2007, Expression and immunolocalization of the plasma membrane monoamine transporter in the brain, Neuroscience, 146, 1193, 10.1016/j.neuroscience.2007.01.072

Damaraju, 2007, Localization of broadly selective equilibrative and concentrative nucleoside transporters, hENT1 and hCNT3, in human kidney, Am. J. Physiol. Renal Physiol., 293, F200, 10.1152/ajprenal.00007.2007

Damaraju, 2009, Human nucleoside transporters: biomarkers for response to nucleoside drugs, Nucleosides Nucleotides Nucleic Acids, 28, 450, 10.1080/15257770903044499

Damaraju, 2011, Influence of sugar ring conformation on the transportability of nucleosides by human nucleoside transporters, Chembiochem., 12, 2774, 10.1002/cbic.201100567

Damaraju, 2011, Interaction of fused-pyrimidine nucleoside analogs with human concentrative nucleoside transporters: High-affinity inhibitors of human concentrative nucleoside transporter 1, Biochem. Pharmacol., 81, 82, 10.1016/j.bcp.2010.09.009

Eltzschig, 2005, HIF-1-dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia, J. Exp. Med., 202, 1493, 10.1084/jem.20050177

Elwi, 2006, Renal nucleoside transporters: physiological and clinical implications, Biochem. Cell Biol., 84, 844, 10.1139/o06-198

Elwi, 2009, Human concentrative nucleoside transporter 3 is a determinant of fludarabine transportability and cytotoxicity in human renal proximal tubule cell cultures, Cancer Chemother. Pharmacol., 63, 289, 10.1007/s00280-008-0739-1

Elwi, 2009, Transepithelial fluxes of adenosine and 2’-deoxyadenosine across human renal proximal tubule cells: roles of nucleoside transporters hENT1, hENT2, and hCNT3, Am. J. Physiol. Renal Physiol., 296, F1439, 10.1152/ajprenal.90411.2008

Endres, 2009, The role of nucleoside transporters in the erythrocyte disposition and oral absorption of ribavirin in the wild-type and equilibrative nucleoside transporter 1-/- mice, J. Pharmacol. Exp. Ther., 331, 287, 10.1124/jpet.109.153130

Errasti-Murugarren, 2009, A splice variant of the SLC28A3 gene encodes a novel human concentrative nucleoside transporter-3 (hCNT3) protein localized in the endoplasmic reticulum, FASEB J., 23, 172, 10.1096/fj.08-113902

Errasti-Murugarren, 2010, The human concentrative nucleoside transporter-3 C602R variant shows impaired sorting to lipid rafts and altered specificity for nucleoside-derived drugs, Mol. Pharmacol., 78, 157, 10.1124/mol.110.063552

Escudero, 2008, Human equilibrative nucleoside transporters 1 and 2 may be differentially modulated by A2B adenosine receptors in placenta microvascular endothelial cells from pre-eclampsia, Placenta, 29, 816, 10.1016/j.placenta.2008.06.014

Farrell, 2009, Human equilibrative nucleoside transporter 1 levels predict response to gemcitabine in patients with pancreatic cancer, Gastroenterology, 136, 187, 10.1053/j.gastro.2008.09.067

Fukao, 2011, Effect of genetic polymorphisms of SLC28A1, ABCG2, and ABCC4 on bioavailability of mizoribine in healthy Japanese males, Drug Metab. Pharmacokinet., 26, 538, 10.2133/dmpk.DMPK-11-NT-040

Gati, 1989, Enantiomeric selectivity of adenosine transport systems in mouse erythrocytes and L1210 cells, Biochem. J., 263, 957, 10.1042/bj2630957

Gloeckner-Hofmann, 2006, Expression of the high-affinity fluoropyrimidine-preferring nucleoside transporter hCNT1 correlates with decreased disease-free survival in breast cancer, Oncology, 70, 238, 10.1159/000094541

Govindarajan, 2007, In situ hybridization and immunolocalization of concentrative and equilibrative nucleoside transporters in the human intestine, liver, kidneys, and placenta, Am. J. Physiol. Regul. Integr. Comp. Physiol., 293, R1809, 10.1152/ajpregu.00293.2007

Govindarajan, 2008, Expression and hepatobiliary transport characteristics of the concentrative and equilibrative nucleoside transporters in sandwich-cultured human hepatocytes, Am. J. Physiol. Gastrointest. Liver Physiol., 295, G570, 10.1152/ajpgi.00542.2007

Govindarajan, 2009, Facilitated mitochondrial import of antiviral and anticancer nucleoside drugs by human equilibrative nucleoside transporter-3, Am. J. Physiol. Gastrointest. Liver Physiol., 296, G910, 10.1152/ajpgi.90672.2008

Graham, 2011, Nucleoside transporter gene expression in wild-type and mENT1 knockout mice, Biochem. Cell Biol., 89, 236, 10.1139/O10-152

Gray, 2004, Functional and genetic diversity in the concentrative nucleoside transporter, CNT1, in human populations, Mol. Pharmacol., 65, 512, 10.1124/mol.65.3.512

Gumina, 2001, L-Nucleosides as chemotherapeutic agents, FEMS Microbiol. Lett., 202, 9

Gupte, 2009, CoMFA and CoMSIA 3D-QSAR studies on S-6-(4-nitrobenzyl)mercaptopurine riboside (NBMPR) analogs as inhibitors of human equilibrative nucleoside transporter 1 (hENT1), Bioorg. Med. Chem. Lett., 19, 314, 10.1016/j.bmcl.2008.11.092

Hamilton, 2001, Subcellular distribution and membrane topology of the mammalian concentrative Na+-nucleoside cotransporter rCNT1, J. Biol. Chem., 276, 27981, 10.1074/jbc.M100518200

Hsu, 2011, Equilibrative nucleoside transporter 3 deficiency perturbs lysosome function and macrophage homeostasis, Science, 335, 89, 10.1126/science.1213682

Johnson, 2012, Crystal structure of a concentrative nucleoside transporter from Vibrio cholerae at 2.4Å, Nature, 483, 489, 10.1038/nature10882

Kang, 2010, Human equilibrative nucleoside transporter-3 (hENT3) spectrum disorder mutations impair nucleoside transport, protein localization, and stability, J. Biol. Chem., 285, 28343, 10.1074/jbc.M110.109199

King, 2006, Nucleoside transporters: from scavengers to novel therapeutic agents, Trends Pharmacol. Sci., 27, 416, 10.1016/j.tips.2006.06.004

Kost, 2011, Behavioral effects of elevated expression of human equilibrative nucleoside transporter 1 in mice, Behav. Brain Res., 224, 44, 10.1016/j.bbr.2011.05.023

Lai, 2004, Mitochondrial expression of the human equilibrative nucleoside transporter 1 (hENT1) results in enhanced mitochondrial toxicity of antiviral drugs, J. Biol. Chem., 279, 4490, 10.1074/jbc.M307938200

Leisewitz, 2011, Regulation of ENT1 expression and ENT1-dependent nucleoside transport by c-Jun N-terminal kinase, Biochem. Biophys. Res. Commun., 404, 370, 10.1016/j.bbrc.2010.11.125

Li, 2007, Identification and functional analysis of variants in the human concentrative nucleoside transporter 2, hCNT2 (SLC28A2) in Chinese, Malays and Indians, Pharmacogenet. Genomics, 17, 783, 10.1097/FPC.0b013e3281c10e41

Li, 2008, Adenosine transporter ENT4 is a direct target of EWS/WT1 translocation product and is highly expressed in desmoplastic small round cell tumor, PLoS ONE, 3, e2353, 10.1371/journal.pone.0002353

Loewen, 1999, Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na+-nucleoside cotransporters hCNT1 and hCNT2, J. Biol. Chem., 274, 24475, 10.1074/jbc.274.35.24475

Mangravite, 2003, Nucleoside transporters in the disposition and targeting of nucleoside analogs in the kidney, Eur. J. Pharmacol., 479, 269, 10.1016/j.ejphar.2003.08.076

Mani, 1998, Demonstration of equilibrative nucleoside transporters (hENT1 and hENT2) in nuclear envelopes of cultured human choriocarcinoma (BeWo) cells by functional reconstitution in proteoliposomes, J. Biol. Chem., 273, 30818, 10.1074/jbc.273.46.30818

Maréchal, 2009, Human equilibrative nucleoside transporter 1 and human concentrative nucleoside transporter 3 predict survival after adjuvant gemcitabine therapy in resected pancreatic adenocarcinoma, Clin. Cancer Res., 15, 2913, 10.1158/1078-0432.CCR-08-2080

McIntosh, 2012, Adenosine receptor-mediated cardioprotection: are all 4 subtypes required or redundant?, J. Cardiovasc. Pharmacol. Ther., 17, 21, 10.1177/1074248410396877

Nam, 2011, Type 1 equilibrative nucleoside transporter regulates ethanol drinking through accumbal N-methyl-d-aspartate receptor signaling, Biol. Psychiatry., 69, 1043, 10.1016/j.biopsych.2011.02.013

Nivillac, 2009, Disrupted plasma membrane localization and loss of function reveal regions of human equilibrative nucleoside transporter 1 involved in structural integrity and activity, Biochim. Biophys. Acta, 1788, 10.1016/j.bbamem.2009.08.003

Okazaki, 2010, Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity, Clin. Cancer Res., 16, 320, 10.1158/1078-0432.CCR-09-1555

Osato, 2003, Functional characterization in yeast of genetic variants in the human equilibrative nucleoside transporter, ENT1, Pharmacogenetics, 13, 297, 10.1097/00008571-200305000-00010

Owen, 2005, Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2, Pharmacogenet. Genomics, 15, 83, 10.1097/01213011-200502000-00004

Owen, 2006, Functional characterization and haplotype analysis of polymorphisms in the human equilibrative nucleoside transporter, ENT2, Drug Metab. Dispos., 34, 12, 10.1124/dmd.105.006270

Paproski, 2008, The role of human nucleoside transporters in uptake of 3′-deoxy-3′-fluorothymidine, Mol. Pharmacol., 74, 1372, 10.1124/mol.108.048900

Paproski, 2010, Biodistribution and uptake of 3′-deoxy-3′-fluorothymidine in equilibrative nucleoside transporter 1 (ENT1) knockout mice and in an ENT1 knockdown tumor model, J. Nuclear Med., 51, 1447, 10.2967/jnumed.110.076356

Parkinson, 2011, Molecular biology of nucleoside transporters and their distributions and functions in the brain, Curr. Top. Med. Chem., 11, 948, 10.2174/156802611795347582

Pastor-Anglada, 2008, SLC28 genes and concentrative nucleoside transporter (CNT) proteins, Xenobiotica, 38, 972, 10.1080/00498250802069096

Peng, 2008, Up-regulation of MRP4 and down-regulation of influx transporters in human leukemic cells with acquired resistance to 6-mercaptopurine, Leuk. Res., 32, 799, 10.1016/j.leukres.2007.09.015

Radestock, 2011, The alternating-access mechanism of mfs transporters arises from inverted-topology repeats, J. Mol. Biol., 407, 698, 10.1016/j.jmb.2011.02.008

Rahn, 1997, Modulation of the metabolism of beta-L-(-)-2’,3’-dideoxy-3’-thiacytidine by thymidine, fludarabine, and nitrobenzylthioinosine, Antimicrob. Agents Chemother., 41, 918, 10.1128/AAC.41.5.918

Reyes, 2011, The equilibrative nucleoside transporter (ENT1) can be phosphorylated at multiple sites by PKC and PKA, Mol. Membr. Biol., 28, 412, 10.3109/09687688.2011.604861

Ritzel, 1997, Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1), Am. J. Physiol., 272, C707, 10.1152/ajpcell.1997.272.2.C707

Ritzel, 1998, Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine, Mol. Membr. Biol., 15, 203, 10.3109/09687689709044322

Ritzel, 2001, Molecular identification and characterization of novel human and mouse concentrative Na+-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib), J. Biol. Chem., 276, 2914, 10.1074/jbc.M007746200

Robins, 2010, Improved synthesis of SAENTA [5′-S-(2-aminoethyl)-6-N-(4-nitrobenzyl)-5′-thioadenosine], analoges, and fluorescent probe conjugates: analysis of cell-surface hENT1 levels for prediction of the antitumor efficacy of gemcitabine, J. Med. Chem., 53, 6040, 10.1021/jm100432w

Rose, 2010, Equilibrative nucleoside transporter 1 plays an essential role in cardioprotection, Am. J. Physiol. Heart Circ. Physiol., 298, H771, 10.1152/ajpheart.00711.2009

Sandvold, 2010, The activity of the lipophilic nucleoside derivatives elacytarabine and CP-4126 in a panel of tumor cell lines resistant to nucleoside analogues, Nucleosides Nucleotides Nucleic Acids, 29, 386, 10.1080/15257771003729625

Slugoski, 2008, A conformationally mobile cysteine residue (Cys-561) modulates Na+ and H+ activation of human CNT3, J. Biol. Chem., 283, 24922, 10.1074/jbc.M801793200

Smith, 2004, Electrophysiological characterization of a recombinant human Na+-coupled nucleoside transporter (hCNT1) produced in Xenopus oocytes, J. Physiol. (London), 558, 807, 10.1113/jphysiol.2004.068189

Smith, 2005, The broadly selective human Na+/nucleoside cotransporter (hCNT3) exhibits novel cation-coupled nucleoside transport characteristics, J. Biol. Chem., 280, 25436, 10.1074/jbc.M409454200

Smith, 2007, Cation coupling properties of human concentrative nucleoside transporters hCNT1, hCNT2 and hCNT3, Mol. Membr. Biol., 24, 53, 10.1080/09687860600942534

Spratlin, 2004, The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma, Clin. Cancer Res., 10, 6956, 10.1158/1078-0432.CCR-04-0224

Szkotak, 2003, Coupling of CFTR-mediated anion secretion to nucleoside transporters and adenosine homeostasis in Calu-3 cells, J. Membr. Biol., 192, 169, 10.1007/s00232-002-1073-x

Tanaka, 2010, Gemcitabine metabolic and transporter gene polymorphisms are associated with drug toxicity and efficacy in patients with locally advanced pancreatic cancer, Cancer, 116, 5325, 10.1002/cncr.25282

Vickers, 2004, Uridine recognition motifs of human equilibrative nucleoside transporters 1 and 2 produced in Saccharomyces cerevisiae, Nucleosides, Nucleotides & Nucleic Acids, 23, 361, 10.1081/NCN-120028333

Visscher, 2011, Canadian Pharmacogenomics Network for Drug Safety Consortium, Pharmacogenomic prediction of anthracycline-induced cardiotoxicity in children, J. Clin. Oncol. (Oct, 11

Wang, 1997, Molecular determinants of substrate selectivity in Na+-dependent nucleoside transporters, J. Biol. Chem., 272, 28845, 10.1074/jbc.272.46.28845

Wang, 2010, Biochem. Pharmacol., 79, 307, 10.1016/j.bcp.2009.08.028

Wright, 2000, Enhancement of retention and cytotoxicity of 2-chlorodeoxyadenosine in cultured human leukemic lymphoblasts by nitrobenzylthioinosine, an inhibitor of equilibrative nucleoside transport, Leukemia, 14, 52, 10.1038/sj.leu.2401633

Yao, 2002, An ancient prevertebrate Na+-nucleoside cotransporter (hfCNT) from the Pacific hagfish (Eptatretus stouti), Am. J. Physiol. Cell Physiol., 283, C155, 10.1152/ajpcell.00587.2001

Yao, 2011, Nucleobase transport by human equilibrative nucleoside transporter 1 (hENT1), J. Biol. Chem., 286, 32552, 10.1074/jbc.M111.236117

Young, 2000, Molecular mechanisms of nucleoside and nucleoside drug transport, 329

Young, 2003, Equilibrative nucleoside transport proteins, 321

Young, 2008, Human equilibrative nucleoside transporter (ENT) family of nucleoside and nucleobase transporter proteins, Xenobiotica, 38, 995, 10.1080/00498250801927427

Zhang, 2005, Uridine binding and transportability determinants of human concentrative nucleoside transporters, Mol. Pharmacol., 68, 830, 10.1124/mol.105.012187

Zhang, 2007, The role of nucleoside transporters in cancer chemotherapy with nucleoside drugs, Cancer Metastasis Rev., 26, 85, 10.1007/s10555-007-9044-4

Zhou, 2010, Adenosine transport by plasma membrane monoamine transporter: reinvestigation and comparison with organic cations, Drug Metab. Disposition, 38, 1798, 10.1124/dmd.110.032987

Zhu, 2008, Constrained NBMPR analogue synthesis, pharmacophore mapping and 3D-QSAR modeling of equilibrative nucleoside transporter 1 (ENT1) inhibitory activity, Bioorg. Med. Chem., 16, 3848, 10.1016/j.bmc.2008.01.044