The history, genotoxicity, and carcinogenicity of carbon-based fuels and their emissions: Part 5. Summary, comparisons, and conclusions

Mutation Research/Reviews in Mutation Research - Tập 763 - Trang 103-147 - 2015
Larry D. Claxton1
1LDC Scientific Services, 6012 Brass Lantern Court, Raleigh, NC 27606, United States

Tài liệu tham khảo

Claxton, 2014, The history, genotoxicity and carcinogenicity of carbon-based fuels and their emissions: Part 1. Principles and background, Mutat. Res. Rev. Mutat. Res. Claxton, 2014, The history, genotoxicity and carcinogenicity of carbon-based fuels and their emissions: Part 2. Solid fuels, Mutat. Res. Rev. Mutat. Res. Claxton, 2014, The history, genotoxicity and carcinogenicity of carbon-based fuels and their emissions: Part 3. diesel and gasoline, Mutat. Res. Rev. Mutat. Res. Claxton, 2014, The history, genotoxicity and carcinogenicity of carbon-based fuels and their emissions: Part 4. alternative fuels, Mutat. Res. Rev. Mutat. Res. Hall, 2003, Hydrocarbons and the evolution of human culture, Nature, 426, 318, 10.1038/nature02130 Boffetta, 2006, Human cancer from environmental pollutants: the epidemiological evidence, Mutat. Res./Genet. Toxicol. Environ. Mutagen., 608, 157, 10.1016/j.mrgentox.2006.02.015 Claxton, 2014, The history, genotoxicity, and carcinogenicity of carbon-based fuels and their emissions: Part 5. Summary, comparisons, and conclusions, Mutat. Res. Rev. Mutat. Res. Dole, 1949, The history of oxygen, Science, 109, 77, 10.1126/science.109.2822.77 Gammon, 1985, History of carbon dioxide in the atmosphere, 25 Fields, 2004, GLOBAL, Environ. Health Perspect., 112, A556 The National Hydrogen Association (NHA), USDOE (United States Department of Energy), 2005 Dalton, 2005, The Leeuwenhoek lecture 2000: the natural and unnatural history of methane-oxidizing bacteria, Philos. Trans. R. Soc. B: Biol. Sci., 360, 1207, 10.1098/rstb.2005.1657 Marsh, 1982, Proportional mortality patterns among chemical plant workers exposed to formaldehyde, Br. J. Ind. Med., 39, 313 Zhang, 2009, Formaldehyde exposure and leukemia: a new meta-analysis and potential mechanisms, Mutat. Res. Rev. Mutat. Res., 681, 150, 10.1016/j.mrrev.2008.07.002 Rubin, 2001, The history of ozone: the Schönbein period. 1839–1868, Bull. Histol. Chem., 26, 40 Haagen-Smit, 1952, Chemistry and physiology of Los Angeles smog, J. Ind. Eng. Chem., 44, 1342, 10.1021/ie50510a045 Mader, 1952, Composition of organic portion of atmospheric aerosols in the Los Angeles area, J. Ind. Eng. Chem., 44, 1352, 10.1021/ie50510a047 Graedel, 1978 Graedel, 1986 Goldstein, 2007, Known and unexplored organic constituents in the earth's atmosphere, Environ. Sci. Technol., 41, 1514, 10.1021/es072476p Fishbein, 1976, Environmental metallic carcinogens: an overview of exposure levels, J. Toxicol. Environ. Health, 2, 77, 10.1080/15287397609529419 Fishbein, 1984, Overview of analysis of carcinogenic and/or mutagenic metals in biological and environmental samples. I. Arsenic, beryllium, cadmium, chromium and selenium, Int. J. Environ. Anal. Chem., 17, 113, 10.1080/03067318408079924 Belpomme, 2007, The multitude and diversity of environmental carcinogens, Environ. Res., 105, 414, 10.1016/j.envres.2007.07.002 IARC (International Agency for Research on Cancer), 1980, vol. 23 IARC (International Agency for Research on Cancer), 1980 IARC (International Agency for Research on Cancer), 1979, vol. 20 IARC (International Agency for Research on Cancer), 1979, vol. 9 IARC (International Agency For Research On Cancer), 2012, vols. 1–100 IARC (International Agency for Research on Cancer), 2012, 526 Gao, 1996, Risk factors for lung cancer among nonsmokers with emphasis on lifestyle factors, Lung Cancer, 1, S39, 10.1016/S0169-5002(96)90209-3 Gao, 1987, Lung cancer among Chinese women, Int. J. Cancer, 40, 604, 10.1002/ijc.2910400505 Medina, 1996, Primary lung cancer in Mexico city: a report of 1019 cases, Lung Cancer, 2–3, 185, 10.1016/0169-5002(96)00545-4 Gupta, 1998, Primary bronchogenic carcinoma: clinical profile of 279 cases from mid-west Rajasthan, India, J. Chest Dis. Allied Sci., 40, 109 Smith, 1993, Indoor air pollution in developing countries Bruce, 2000, Indoor air pollution in developing countries: a major environmental and public health challenge, Bull. World Health Organ., 78., 1078 Bruce, 2002 Bond, 2007, Historical emissions of black and organic carbon aerosol from energy-related combustion, 1850–2000, Global Biogeochem. Cycles, 21, 10.1029/2006GB002840 Harrison, 1996, Source apportionment of atmospheric polycyclic aromatic hydrocarbons collected from an urban location in Birmingham, UK, Environ. Sci. Technol., 30, 825, 10.1021/es950252d Claxton, 1979, The mutagenicity of diesel exhaust exposed to smog chamber conditions as shown by Salmonella typhimurium, 309 Claxton, 1985, The effect of atmospheric transformation upon the bacterial mutagenicity of airborne organics: the EPA experience, 205 Arey, 2000, Urban air – causes and consequences of urban air pollution, 52 Wingo, 1999, Annual report to the nation on the status of cancer, 1973–1996, with a special section on lung cancer and tobacco smoking, J. Natl. Cancer Inst., 91, 675, 10.1093/jnci/91.8.675 Jemal, 2008, Annual report to the nation on the status of cancer, 1975–2005, featuring trends in lung cancer, tobacco use, and tobacco control, J. Natl. Cancer Inst., 100, 1672, 10.1093/jnci/djn389 Jemal, 2010, Cancer statistics, CA. Cancer J. Clin., 60, 277, 10.3322/caac.20073 Alberg, 2005, Epidemiology of lung cancer: looking to the future, J. Clin. Oncol., 23, 3175, 10.1200/JCO.2005.10.462 Alberg, 2007, Epidemiology of lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition), Chest, 132, S29, 10.1378/chest.07-1347 Wen Cheng, 2003, Environmental exposure and lung cancer among nonsmokers: an example of Taiwanese female lung cancer, J. Environ. Sci. Health C, 21, 1, 10.1081/GNC-120021371 Cornfield, 2009, Smoking and lung cancer: recent evidence and a discussion of some questions, Int. J. Epidemiol., 38, 1175, 10.1093/ije/dyp289 Samet, 2009, Lung cancer in never smokers: clinical epidemiology and environmental risk factors, Clin. Cancer Res., 15, 5626, 10.1158/1078-0432.CCR-09-0376 Toh, 2009, The changing epidemiology of lung cancer, Methods Mol. Biol., 472, 397, 10.1007/978-1-60327-492-0_19 Alberg, 2003, Epidemiology of lung cancer, Chest, 123, 21S, 10.1378/chest.123.1_suppl.21S Li, 2002, Economic status, smoking, occupational exposure to rubber, and lung cancer: a case-cohort study, J. Environ. Sci. Health C, 20, 21, 10.1081/GNC-120003926 Subramanian, 2007, Lung cancer in never smokers: a review, J. Clin. Oncol., 25, 561, 10.1200/JCO.2006.06.8015 Jemal, 2011, Global cancer statistics, CA. Cancer J. Clin., 61, 69, 10.3322/caac.20107 WHO (World Health Organization of the United Nations), 2012, 180 Siegel, 2012, CA. Cancer J. Clin., 62, 10, 10.3322/caac.20138 Briggs, 2003, Environmental pollution and the global burden of disease, Br. Med. Bull., 68, 1, 10.1093/bmb/ldg019 Boffetta, 1997, Cancer risk from occupational and environmental exposure to polycyclic aromatic hydrocarbons, Cancer Cause Control, 8, 444, 10.1023/A:1018465507029 Cohen, 2005, The global burden of disease due to outdoor air pollution, J. Toxicol. Environ. Health A, 68, 1301, 10.1080/15287390590936166 WHO (World Health Organization), 2002 Cohen, 2000, Outdoor air pollution and lung cancer, Environ. Health Perspect., 108, 743 Cohen, 2003, Air pollution and lung cancer: what more do we need to know?, Thorax, 58, 1010, 10.1136/thorax.58.12.1010 Cohen, 1995, Lung cancer and air pollution, Environ. Health Perspect., 103, 219 Cohen, 1997, Ambient air pollution as a risk factor for lung cancer, Salud Publica Mex., 39, 346, 10.1590/S0036-36341997000400012 Haber, 2007, Cancer: drivers and passengers, Nature, 446, 145, 10.1038/446145a Claxton, 1977, Chemical mutagenesis: an emerging issue for public health, Am. J. Public Health, 67, 1037, 10.2105/AJPH.67.11.1037 McKusick, 1998 Amberger, 2009, McKusick's online mendelian inheritance in man (OMIM), Nucleic Acids Res., 37, D793, 10.1093/nar/gkn665 Krewski, 2009, Evaluating the effects of ambient air pollution on life expectancy, N. Engl. J. Med., 360, 413, 10.1056/NEJMe0809178 Pope, 2009, Fine-particulate air pollution and life expectancy in the United States, N. Engl. J. Med., 360, 376, 10.1056/NEJMsa0805646 Brunekreef, 1997, Air pollution and life expectancy: is there a relation?, Occup. Environ. Med., 54, 781, 10.1136/oem.54.11.781 Nevalainen, 1998, The effect of particulate air pollution on life expectancy, Sci. Total Environ., 217, 137, 10.1016/S0048-9697(98)00172-7 Coyle, 2003, Impact of particulate air pollution on quality-adjusted life expectancy in Canada, J. Toxicol. Environ. Health A, 66, 1847, 10.1080/15287390306447 Krewski, 2000 Krewski, 2003, Overview of the reanalysis of the Harvard Six Cities Study and American Cancer Society study of particulate air pollution and mortality, J. Toxicol. Environ. Health A, 66, 1507, 10.1080/15287390306424 Pope, 2002, Lung cancer. cardiopulmonary mortality, and long-term exposure to fine particulate air pollution, J. Am. Med. Assoc., 287, 1132, 10.1001/jama.287.9.1132 Krewski, 2009 NRC (National Research Council), 2002 Weir, 2003, Annual report to the nation on the status of cancer, 1975–2000, featuring the uses of surveillance data for cancer prevention and control, J. Natl. Cancer Inst., 95, 1276, 10.1093/jnci/djg040 Harper, 2005, Methods for Measuring Cancer Disparities: Using Data Relevant to Healthy People 2010 Cancer-Related Objectives DHHS (U.S. Department of Health and Human Services), 2000 Davis, 2000, Healthy people 2010: objectives for the United States: impressive, but unwieldy, Br. Med. J., 320, 818, 10.1136/bmj.320.7238.818 Byers, 1999, for the ACS Reduction in Cancer Incidence and Mortality Committee, The American Cancer Society Challenge Goals: How far can cancer rates decline in the U.S. by the year 2015?, Cancer, 86, 715, 10.1002/(SICI)1097-0142(19990815)86:4<715::AID-CNCR22>3.0.CO;2-O Edwards, 2013, Annual report to the nation on the status of cancer, 1975–2010, featuring prevalence of comorbidity and impact on survival among persons with lung, colorectal, breast, or prostate cancer, Cancer Rosen, 1993 U.S. Surgeon General, 1989 Luoto, 1983, Reducing the health consequences of smoking—a progress report, Public Health Rep., 98, 34 Messer, 2008, Smoking cessation rates in the United States: a comparison of young adult and older smokers, Am. J. Public Health, 98, 317, 10.2105/AJPH.2007.112060 Monteiro, 2007, Population-based evidence of a strong decline in the prevalence of smokers in Brazil (1989–2003), Bull. World Health Organ., 85, 527, 10.2471/BLT.06.039073 Inoue, 2013, Genetically engineered mouse models for human lung cancer Fairley, 2010, Racial/ethnic disparities and geographic differences in lung cancer incidence-38 states and the District of Columbia, 1998–2006, vol. 59, 1433 Saracci, 1994, Interactions of tobacco smoking with other causes of lung cancer, Lung Biol. Health Dis., 74, 465 Berry, 1972, Combined effect of asbestos exposure and smoking on mortality from lung cancer in factory workers, Lancet, 300, 476, 10.1016/S0140-6736(72)91867-3 Hoffmann, 1997, The changing cigarette, Prev. Med., 26, 427, 10.1006/pmed.1997.0183 Raaschou-Nielsen, 2013, Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE), Lancet Oncol., 14, 813, 10.1016/S1470-2045(13)70279-1 Jemal, 2010, Global patterns of cancer incidence and mortality rates and trends, Cancer Epidemiol. Biomarkers Prev., 19, 1893, 10.1158/1055-9965.EPI-10-0437 Yang, 2013, Air pollution and lung health: an epilogue, Respirology, 18, 3, 10.1111/j.1440-1843.2012.02229.x Ko, 2012, Air pollution and chronic obstructive pulmonary disease, Respirology, 17, 395, 10.1111/j.1440-1843.2011.02112.x Lim, 2012, Biomass fuels and lung cancer, Respirology, 17, 20, 10.1111/j.1440-1843.2011.02088.x Benbrahim-Tallaa, 2012, Carcinogenicity of diesel-engine and gasoline-engine exhausts and some nitroarenes, Lancet Oncol., 13, 663, 10.1016/S1470-2045(12)70280-2 Samet, 1994 Churg, 1994, Lung cancer cell type and occupational exposure, 413 Charloux, 1997, The increasing incidence of lung adenocarcinoma: reality or artefact? A review of the epidemiology of lung adenocarcinoma, Int. J. Epidemiol., 26, 14, 10.1093/ije/26.1.14 Thun, 1997, Cigarette smoking and changes in the histopathology of lung cancer, J. Natl. Cancer Inst., 89, 1580, 10.1093/jnci/89.21.1580 George, 2007, Surveillance for the detection of early lung cancer in patients with bronchial dysplasia, Thorax, 62, 43, 10.1136/thx.2005.052191 Öberg, 2011, Worldwide burden of disease from exposure to second-hand smoke: a retrospective analysis of data from 192 countries, Lancet, 377, 139, 10.1016/S0140-6736(10)61388-8 Besaratinia, 2008, Second-hand smoke and human lung cancer, Lancet Oncol., 9, 657, 10.1016/S1470-2045(08)70172-4 Couraud, 2012, Lung cancer in never smokers – a review, Eur. J. Cancer (Oxford), 48, 1299, 10.1016/j.ejca.2012.03.007 Brownson, 1997, Family history of cancer and risk of lung cancer in lifetime non-smokers and long-term ex-smokers, Int. J. Epidemiol., 26, 256, 10.1093/ije/26.2.256 Forastiere, 1993, Indirect estimates of lung cancer death rates in Italy not attributable to active smoking, Epidemiology, 4, 502, 10.1097/00001648-199311000-00005 Lee, 2011, Lung cancer in never smokers: change of a mindset in the molecular era, Lung Cancer, 72, 9, 10.1016/j.lungcan.2010.12.013 Thun, 2008, Lung cancer occurrence in never-smokers: an analysis of 13 cohorts and 22 cancer registry studies, PLoS Med., 5, e185, 10.1371/journal.pmed.0050185 Schneiderman, 1989, Lung cancer that is not attributable to smoking, JAMA, 261, 2635, 10.1001/jama.1989.03420180059019 Davis, 1993, Trends in nonsmoking lung cancer, Epidemiology, 4, 489, 10.1097/00001648-199311000-00002 Axelson, 1990, Lung cancer not attributable to smoking, Ann. N.Y. Acad. Sci., 609, 165, 10.1111/j.1749-6632.1990.tb32065.x Enstrom, 1979, Rising lung cancer mortality among nonsmokers, J. Natl. Cancer Inst., 62, 755 Swaen, 1991, Mortality of coke plant workers in The Netherlands, Br. J. Ind. Med., 48, 130 Graedel, 1987, Atmospheric compounds: merging the chemical and bioassay data, 257 Kagawa, 2002, Health effects of diesel exhaust emissions – a mixture of air pollutants of worldwide concern, Toxicology, 181–182, 349, 10.1016/S0300-483X(02)00461-4 Parent, 2007, Exposure to diesel and gasoline engine emissions and the risk of lung cancer, Am. J. Epidemiol., 165, 53, 10.1093/aje/kwj343 Sapkota, 2008, Indoor air pollution from solid fuels and risk of hypopharyngeal/laryngeal and lung cancers: a multicentric case–control study from India, Int. J. Epidemiol., 37, 321, 10.1093/ije/dym261 Mumford, 1987, Lung cancer and indoor air pollution in Xuan Wei, China, Science, 235, 217, 10.1126/science.3798109 Loomis, 2013, The carcinogenicity of outdoor air pollution, Lancet Oncol., 10.1016/S1470-2045(13)70487-X Hemminki, 1994, Cancer risk of air pollution: epidemiological evidence, Environ. Health Perspect., 102, 187 Vineis, 2004, Outdoor air pollution and lung cancer: recent epidemiologic evidence, Int. J. Cancer, 111, 647, 10.1002/ijc.20292 Kafadar, 1996, Urbanicity-related trends in lung cancer mortality in US counties: white females and white males, 1970–1987, Int. J. Epidemiol., 25, 918, 10.1093/ije/25.5.918 Blot, 1976, Geographic patterns of lung cancer: industrial correlations, Am. J. Epidemiol., 103, 539, 10.1093/oxfordjournals.aje.a112258 Pless-Mulloli, 1998, Lung cancer, proximity to industry, and poverty in northeast England, Environ. Health Perspect., 106, 189, 10.1289/ehp.98106189 Gottlieb, 1982, Lung cancer mortality and residential proximity to industry, Environ. Health Perspect., 45, 157, 10.1289/ehp.8245157 Filleul, 2005, Twenty five year mortality and air pollution: results from the French PAARC survey, Occup. Environ. Med., 62, 453, 10.1136/oem.2004.014746 Gazdar, 2007, Lung cancer, smoke exposure, and sex, J. Clin. Oncol., 25, 469, 10.1200/JCO.2006.09.4623 Wakelee, 2007, Lung cancer incidence in never smokers, J. Clin. Oncol., 25, 472, 10.1200/JCO.2006.07.2983 Henschke, 2006, Women's susceptibility to tobacco carcinogens and survival after diagnosis of lung cancer, JAMA, 296, 180, 10.1001/jama.296.2.180 Chen, 2007, Time trend and geographic patterns of lung adenocarcinoma in the United States, 1973–2002, Cancer Epidemiol. Biomarkers Prev., 16, 2724, 10.1158/1055-9965.EPI-07-0455 Brody, 2007, Environmental pollutants, diet, physical activity, body size, and breast cancer: where do we stand in research to identify opportunities for prevention?, Cancer, 109, 2627, 10.1002/cncr.22656 Brody, 2007, Environmental pollutants and breast cancer: epidemiologic studies, Cancer, 109, 2667, 10.1002/cncr.22655 Gilman, 1995, Childhood cancers: space-time distribution in Britain, J. Epidemiol. Community Health, 49, 158, 10.1136/jech.49.2.158 Fajersztajn, 2013, Air pollution: a potentially modifiable risk factor for lung cancer, Nat. Rev. Cancer, 13, 674, 10.1038/nrc3572 Alexandrov, 2013, Signatures of mutational processes in human cancer, Nature, 500, 415, 10.1038/nature12477 Heinrich, 1982, Objectives and experimental conditions of a VW/Audi diesel engine exhaust inhalation study, 429 Taubes, 1995, Epidemiology faces its limits, Science, 269, 164, 10.1126/science.7618077 Epler, 1978, Energy-related pollutants in the environment: use of short-term tests for mutagenicity in the isolation and identification of biohazards, Environ. Health Perspect., 27, 11, 10.1289/ehp.782711 Agurell, 1992, Salmonella mutagenicity of three complex mixtures assayed with the microsuspension technique. A WHO/IPCS/CSCM study, Mutat. Res., 276, 87, 10.1016/0165-1110(92)90057-G Claxton, 2010, The Salmonella mutagenicity assay: the stethoscope of genetic toxicology for the 21st century, Environ. Health Perspect., 118, 1515, 10.1289/ehp.1002336 Fernández, 2005, Ecological risk assessment of contaminated soils through direct toxicity assessment, Ecotoxicol. Environ. Saf., 62, 174, 10.1016/j.ecoenv.2004.11.013 White, 2002, The genotoxicity of priority polycyclic aromatic hydrocarbons in complex mixtures, Mutat. Res./Genet. Toxicol. Environ. Mutagen., 515, 85, 10.1016/S1383-5718(02)00017-7 MacGregor, 1994, Monitoring environmental genotoxicants, 171 Reisman, 1998, Bioremediation risk assessment: merging human health and ecological methods, Bioremediation, 3, 3 Claxton, 1982, Review of fractionation and bioassay characterization techniques for the evaluation of organics associated with ambient air particles, 19 Claxton, 1997, The development, validation, and analysis of Salmonella mutagenicity test methods for environmental situations, 591 Claxton, 2002, Challenges and approaches for identifying carcinogens in contaminated media: production in the atmosphere of mutagenic products from simple hydrocarbons, 79 White, 2004, Mutagens in contaminated soil: a review, Mutat. Res./Rev. Mutat. Res., 567, 227, 10.1016/j.mrrev.2004.09.003 Pitts, 1979, Chemical and microbiological studies of mutagenic pollutants in real and simulated atmospheres, 354 Chriswell, 1979, Mutagenic analysis of drinking water, 478 Lewtas, 1988, Genotoxicity of complex mixtures: strategies for the identification and comparative assessment of airborne mutagens and carcinogens from combustion sources, Fundam. Appl. Toxicol., 10, 571, 10.1016/0272-0590(88)90184-4 Claxton, 1983, The integration of bioassay and physio-chemical information for complex mixtures, 153 Schuetzle, 1986, Bioassay-directed chemical analysis in environmental research, Anal. Chem., 58, 1060A Nemery, 2001, The Meuse Valley fog of 1930: an air pollution disaster, Lancet (London, England), 357, 704, 10.1016/S0140-6736(00)04135-0 Hamill, 2008, Unveiling a museum, a Pennsylvania town remembers the smog that killed 20 Jacobsen, 2002 Walbridge, 1976, Energy consumption, pollutant production, and dollar costs of diesel suburban commuter trains, Transportation, 5, 285, 10.1007/BF00148380 Hidy, 2002, Multiscale impact of fuel consumption on air quality, Energy Fuels, 16, 270, 10.1021/ef0101659 Finlayson-Pitts, 1997, Tropospheric air pollution: ozone, airborne toxics, polycyclic aromatic hydrocarbons, and particles, Science, 276, 1045, 10.1126/science.276.5315.1045 Ji, 2012, Electric vehicles in China: emissions and health impacts, Environ. Sci. Technol., 46, 2018, 10.1021/es202347q Holzman, 2012, When it comes to electric vehicle emissions, location matters, Environ. Health Perspect., 120, a230, 10.1289/ehp.120-a230a Bailey, 2004, 76 Schmidt, 2002, Polar fuel constituents: compound identification and equilibrium partitioning between nonaqueous phase liquids and water, Environ. Sci. Technol., 36, 4074, 10.1021/es010307d Hoffman, 1985, Stormwater runoff from highways, Water Air Soil Pollut., 25, 349, 10.1007/BF00283788 Skinner, 1989 USEPA (Environmental Protection Agency), 1989, 2 National Park Service, U.S. Department of the Interior, 2009 Bragg, 1994, Effectiveness of bioremediation for the Exxon Valdez oil spill, Nature, 368, 413, 10.1038/368413a0 Pritchard, 1991, EPA's Alaska oil spill bioremediation project. Part 5, Environ. Sci. Technol., 25, 372, 10.1021/es00015a002 Pritchard, 1992, Oil spill bioremediation: experiences, lessons and results from the Exxon Valdez oil spill in Alaska, Biodegradation, 3, 315, 10.1007/BF00129091 Seymour, 1992, Fates and effects of oil spills, Annu. Rev. Energy Environ., 17, 261, 10.1146/annurev.eg.17.110192.001401 Claxton, 1991, Oil spill clean-up, Nature, 353, 24, 10.1038/353024d0 Claxton, 1991, Effect of bioremediation on the mutagenicity of oil spilled in Prince William Sound, Alaska, Chemosphere, 23, 643, 10.1016/0045-6535(91)90286-M Chen, 2004, The mutagenic hazards of aquatic sediments: a review, Mutat. Res./Rev. Mutat. Res., 567, 151, 10.1016/j.mrrev.2004.08.005 Etkin, 2006, Risk assessment of oil spills to US inland waterways NAS (National Academies of Science), 2007, 1 da Silva, 2009, Using the Salmonella assay to delineate the dispersion routes of mutagenic compounds from coal wastes in contaminated soil, Mutat. Res., 673, 116, 10.1016/j.mrgentox.2008.12.005 da Costa, 2012, Runoff of genotoxic compounds in river basin sediment under the influence of contaminated soils, Ecotoxicol. Environ. Saf., 75, 63, 10.1016/j.ecoenv.2011.08.007 Purohit, 2000, Mutagenicity of nitroaromatic compounds, Chem. Res. Toxicol., 13, 673, 10.1021/tx000002x Tokiwa, 1993, Genetic toxicity and carcinogenicity of mono- and dinitrofluoranthenes, Mutat. Res., 297, 181, 10.1016/0165-1110(93)90002-5 USDHHS (US Department of Health and Human Services), 1998, 250 El-Bayoumy, 1992, Environmental carcinogens that may be involved in human breast cancer etiology, Chem. Res. Toxicol., 5, 585, 10.1021/tx00029a001 Malling, 1974, Mutagenic activation or dimethylnitrosamine and diethylnitrosamine in the host-mediated assay and the microsomal system, Mutat. Res./Fundam. Mol. Mech. Mutagen., 26, 465, 10.1016/S0027-5107(74)80047-3 Malling, 1974, Metabolic activation of dimethylnitrosamine and diethylnitrosamine to mutagens, Mutat. Res./Fundam. Mol. Mech. Mutagen., 25, 179, 10.1016/0027-5107(74)90018-9 Ames, 1973, Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection, Proc. Natl. Acad. Sci. U.S.A., 70, 2281, 10.1073/pnas.70.8.2281 Ames, 1975, Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test, Mutat. Res., 31, 347, 10.1016/0165-1161(75)90046-1 Maron, 1983, Revised methods for the Salmonella mutagenicity assay, Mutat. Res., 88, 343, 10.1016/0165-1218(81)90025-2 Hodgson, 2004, 545 Judson, 2014, Knowledge-Based Approaches for Predicting the Sites and Products of Metabolism, 293 Gurbani, 2013, Polycyclic aromatic hydrocarbons and their quinones modulate the metabolic profile and induce DNA damage in human alveolar and bronchiolar cells, Int. J. Hyg. Environ. Health, 216, 553, 10.1016/j.ijheh.2013.04.001 Assem, 2011, The mutagenicity and carcinogenicity of inorganic manganese compounds: a synthesis of the evidence, J. Toxicol. Environ. Health B, 14, 537, 10.1080/10937404.2011.615111 Taxak, 2014, Drug metabolism, Resonance, 19, 259, 10.1007/s12045-014-0031-0 Carmichael, 2011, Using mode of action information to improve regulatory decision-making: an ECETOC/ILSI RF/HESI workshop overview, Crit. Rev. Toxicol., 4, 175, 10.3109/10408444.2010.541225 White, 2009, State-of-the-science workshop report: issues and approaches in low-dose–response extrapolation for environmental health risk assessment, Environ. Health Perspect., 117, 283, 10.1289/ehp.11502 Boutwell, 1964, Some biological aspects of skin carcinogenesis, Prog. Exp. Tumor Res., 4, 207, 10.1159/000385978 Weisburger, 1983, The distinct health risk analyses required for genotoxic carcinogens and promoting agents, Environ. Health Perspect., 50, 233, 10.1289/ehp.8350233 Hattis, 2009, A preliminary operational classification system for nonmutagenic modes of action for carcinogenesis, Crit. Rev. Toxicol., 39, 97, 10.1080/10408440802307467 Hanahan, 2000, The hallmarks of cancer, Cell, 100, 57, 10.1016/S0092-8674(00)81683-9 Silins, 2011, Combined toxic exposures and human health: biomarkers of exposure and effect, Int. J. Environ. Res. Public Health, 8, 629, 10.3390/ijerph8030629 Jäger, 1978, Detection and characterization of nitro derivatives of some polyclic aromatic hydrocarbons by fluorescence quenching after thin-layer chromatography: application to air pollution analysis, J. Chromatogr. A, 152, 575, 10.1016/S0021-9673(00)85103-1 Pitts, 1978, Atmospheric reactions of polycyclic aromatic hydrocarbons: facile formation of mutagenic nitro derivatives, Science, 202, 515, 10.1126/science.705341 Claxton, 1981, The mutagenicity of diesel-exhaust particle extracts collected under smog-chamber conditions using the Salmonella typhimurium test system, Mutat. Res./Genet. Toxicol., 88, 255, 10.1016/0165-1218(81)90037-9 Atkinson, 2000, Atmospheric chemistry of VOCs and NOx, Atmos. Environ., 34, 2063, 10.1016/S1352-2310(99)00460-4 Kleindienst, 1985, The mutagenic activity of the products of propylene photooxidation, Environ. Sci. Technol., 19, 620, 10.1021/es00137a007 IARC (International Agency for Research on Cancer), 2006 Kleindienst, 1985, Peroxyacetyl nitrate: measurement of its mutagenic activity using the Salmonella/mammalian microsome reversion assay, Mutat. Res., 157, 123, 10.1016/0165-1218(85)90106-5 DeMarini, 2000, Mutagenicity in lung of big Blue((R)) mice and induction of tandem-base substitutions in Salmonella by the air pollutant peroxyacetyl nitrate (PAN): predicted formation of intrastrand cross-links, Mutat. Res., 457, 41, 10.1016/S0027-5107(00)00121-4 Pitts, 1983, Formation and fate of gaseous and particulate mutagens and carcinogens in real and simulated atmospheres, Environ. Health Perspect., 47, 115, 10.1289/ehp.8347115 Nielsen, 1983, The fate of airborne polycyclic organic matter, Environ. Health Perspect., 47, 103, 10.1289/ehp.8347103 Bell, 1984, Mutagenic changes of dilute wood smoke and peat smoke under simulated atmospheric conditions: an out-door chamber study, 155 Kamens, 1984, Mutagenic transformations of dilute wood smoke systems in the presence of O3 and NO2, 663 Kamens, 1985, Mutagenic transformations of dilute wood smoke systems in the presence of ozone and nitrogen dioxide. Analysis of selected high-pressure liquid chromatography fractions from wood smoke particle extracts, Environ. Sci. Technol., 19, 63, 10.1021/es00131a006 Shepson, 1985, Mutagenic activity of the photooxidation products of C6H5NH2/C2H4/NOx mixtures, J. Environ. Sci. Health A (USA), 20, 503 Kleindienst, 1986, The mutagenic activity of irradiated C2H4/NOx mixtures in the presence of diethylhydroxylamine, Atmos. Environ. (1967), 20, 971, 10.1016/0004-6981(86)90281-7 Kleindienst, 1987, The atmospheric transformation and mutagenicity of volatile wood smoke emissions, 311 Kleindienst, 1986, Wood smoke: measurement of the mutagenic activities of its gas and particulate-phase photooxidation products, Environ. Sci. Technol., 20, 493, 10.1021/es00147a009 Shepson, 1986, Acetaldehyde: the mutagenic activity of its photooxidation products, Environ. Sci. Technol., 20, 1008, 10.1021/es00152a007 Kleindienst, 1990, Comparison of mutagenic activities of several peroxyacyl nitrates, Environ. Mol. Mutagen., 16, 70, 10.1002/em.2850160204 Kleindienst, 1991, The atmospheric transformation of combustion source emissions and the formation of mutagenic products, 1 Kleindienst, 1992, The photo-oxidation of automobile emissions: measurements of the transformation products and their mutagenic activity, Atmos. Environ. A Gen. Top., 26A, 3039, 10.1016/0960-1686(92)90294-U Kleindienst, 1992, Generation of mutagenic transformation products during the irradiation of simulated urban atmospheres, Environ. Sci. Technol., 26, 320, 10.1021/es00026a012 Claxton, 1990, Assessment of the mutagenicity of volatile organic air pollutants before and after atmospheric transformation, 103 IARC (International Agency for Research on Cancer), 1999 Klaric, 2013, Genotoxic effect of two bleaching agents on oral mucosa, Cancer Genomics Proteomics, 10, 209 Etkin, 2001, Analysis of oil spill trends in the United States and worldwide, 1291 Wang, 2003, 286 Bach, 2005, Enhancing the intrinsic bioremediation of PAH-contaminated anoxic estuarine sediments with biostimulating agents, J. Microbiol., 43, 319 Gale, 1980 Brack, 2003, Effect-directed analysis: a promising tool for the identification of organic toxicants in complex mixtures?, Anal. Bioanal. Chem., 377, 397, 10.1007/s00216-003-2139-z Brooks, 1998, Bioassay-directed fractionation and chemical identification of mutagens in bioremediated soils, Environ. Health Perspect., 106, 1435, 10.1289/ehp.98106s61435 Carere, 2002, In vitro toxicology methods: impact on regulation from technical and scientific advancements, Toxicol. Lett., 127, 153, 10.1016/S0378-4274(01)00495-7 Chrisp, 1979 Dron, 2002, Optimization of headspace solid-phase microextraction by means of an experimental design for the determination of methyl tert-butyl ether in water by gas chromatography-flame ionization detection, J. Chromatogr. A, 963, 259, 10.1016/S0021-9673(02)00359-X Rahimi, 2012, Monitoring of the physical and chemical properties of a gasoline engine oil during its usage, J. Anal. Methods Chem., 8 Siak, 1981, Diesel particulate extracts in bacterial test systems, Environ. Int., 5S, 243, 10.1016/0160-4120(81)90066-0 Chan, 1981, Diesel-particulate collection for biological testing. Comparison of electrostatic precipitation and filtration, Environ. Sci. Technol., 15, 89, 10.1021/es00083a009 Hughes, 1980, Ambient air pollutants: collection, chemical characterization and mutagenicity testing, Mutat. Res./Rev. Genet. Toxicol., 76, 51, 10.1016/0165-1110(80)90003-2 Schuetzle, 1983, Sampling of vehicle emissions for chemical analysis and biological testing, Environ. Health Perspect., Vol. 47, 65, 10.1289/ehp.834765 Claxton, 1992, Overview, conclusions, and recommendations of the IPCS collaborative study on complex mixtures, Mutat. Res./Rev. Genet. Toxicol., 276, 61, 10.1016/0165-1110(92)90055-E Hughes, 1997, Development of a standard reference material for diesel mutagenicity in the Salmonella plate incorporation assay, Mutat. Res./Genet. Toxicol. Environ. Mutagen., 391, 243, 10.1016/S1383-5718(97)00075-2 Poster, 1999, Certification of a diesel particulate related standard reference material (SRM 1975) for PAHs, Polycyclic Aromat. Compd., 14, 23, 10.1080/10406639908019108 Bernstein, 1982, An empirical approach to the statistical analysis of mutagenicity data from the Salmonella test, Mutat. Res., 97, 267, 10.1016/0165-1161(82)90026-7 Stead, 1981, Modeling the Ames test, Mutat. Res., 85, 13, 10.1016/0165-1161(81)90282-X Krewski, 1993, Modeling the Ames Salmonella/microsome assay, Biometrics, 49, 499, 10.2307/2532562 Claxton, 1995, GeneTox manager for bacterial mutagenicity assays: a personal computer and minicomputer system, Mutat. Res., 342, 87, 10.1016/0165-1218(95)90093-4 Arey, 2004, A tale of two diesels, Environ. Health Perspect., 112, 812, 10.1289/ehp.7031 Seagrave, 2008, Mechanisms and implications of air pollution particle associations with chemokines, Toxicol. Appl. Pharmacol., 232, 469, 10.1016/j.taap.2008.08.001 Shi, 2009, Diesel exhaust particulate material expression of in vitro genotoxic activities when dispersed into a phospholipid component of lung surfactant, J. Phys., 012021 DeMarini, 2004, Bioassay-directed fractionation and Salmonella mutagenicity of automobile and forklift diesel exhaust particles, Environ. Health Perspect., 112, 814, 10.1289/ehp.6578 Iba, 2013, Genotoxic bioactivation of constituents of a diesel exhaust particle extract by the human lung, Environ. Mol. Mutagen., 54, 158, 10.1002/em.21759 Courter, 2007, Diesel exhaust influences carcinogenic PAH-induced genotoxicity and gene expression in human breast epithelial cells in culture, Mutat. Res./Fundam. Mol. Mech. Mutagen., 625, 72, 10.1016/j.mrfmmm.2007.05.005 Bamford, 2003, Determination and comparison of nitrated-polycyclic aromatic hydrocarbons measured in air and diesel particulate reference materials, Chemosphere, 50, 575, 10.1016/S0045-6535(02)00667-7 Poster, 2003, Development and analysis of three diesel particulate-related standard reference materials for the determination of chemical, physical, and biological characteristics, Polycyclic Aromat. Compd., 23, 141, 10.1080/10406630308056 Wise, 2001, Recent developments in NIST Standard Reference Materials for polycyclic aromatic hydrocarbons in environmental matrices, Polycyclic Aromat. Compd., 19, 297, 10.1080/10406630008034741 Hughes, 1987, Vaporization technique to measure mutagenic activity of volatile organic chemicals in the Ames/Salmonella assay, Environ. Mutagen., 9, 421, 10.1002/em.2860090408 Nature Editorial, 2008, A bigger picture: beneath cancer's daunting complexity lies a simplicity that gives grounds for hope, Nature, 455, 138, 10.1038/455138a Shiraishi, 2012, A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population, Nat. Genet., 44, 900, 10.1038/ng.2353 Lan, 2012, Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia, Nat. Genet., 44, 1330, 10.1038/ng.2456 Hsiung, 2010, The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia, PLoS Genet., 6, e1001051, 10.1371/journal.pgen.1001051 Hayden, 2008, Cancer complexity slows quest for cure, Nature, 455, 148, 10.1038/455148a Clavel, 2007, Progress in the epidemiological understanding of gene-environment interactions in major diseases: cancer, CR Biol., 330, 306, 10.1016/j.crvi.2007.02.012 Anon., 2013 Bernard, 2013, TI – The p53 isoform, Δ133p53α, stimulates angiogenesis and tumour progression, Oncogene, 32, 2150, 10.1038/onc.2012.242 Hede, 2008, Superhighway or blind alley? The cancer genome atlas releases first results, J. Natl. Cancer Inst., 100, 1566, 10.1093/jnci/djn424 Kaiser, 2008, Cancer genetics: a detailed genetic portrait of the deadliest human cancers, Science, 321, 1280a, 10.1126/science.321.5894.1280a Caprino, 1998, Potential health effects of gasoline and its constituents: a review of current literature (1990–1997) on toxicological data, Environ. Health Perspect., 106, 115, 10.1289/ehp.98106115 Goldstein, 2004, Implications of the precautionary principle: is it a threat to science?, Int. J. Occup. Med. Environ. Health, 17, 153 Abt, 2010, Science and decisions: advancing risk assessment, Risk Anal., 30, 1028, 10.1111/j.1539-6924.2010.01426.x Ackerman, 2002, Prospering with precaution: employment, economics, and the precautionary principle, Tufts Univ., 18, 2004 Cranor, 2005, Scientific inferences in the laboratory and the law, Am. J. Public Health, 95, S121, 10.2105/AJPH.2004.044735 Cranor, 2004, Some legal implications of the precautionary principle: improving information-generation and legal protections, Int. J. Occup. Med. Environ. Health, 17, 17 Cranor, 2004, Toward understanding aspects of the precautionary principle, J. Med. Philos., 29, 259, 10.1080/03605310490500491 Tickner, 1999 Epstein, 1990, Losing the war against cancer: who's to blame and what to do about it, Int. J. Health Serv., 20, 53, 10.2190/W318-FRD5-KVX8-9QJJ Westly, 2013, One million deaths: what researchers are learning from an unprecedented survey of mortality in India, Nature, 504, 22, 10.1038/504022a Grosse, 2011, Carcinogenicity of chemicals in industrial and consumer products, food contaminants and flavourings, and water chlorination byproducts, Lancet Oncol., 12, 328, 10.1016/S1470-2045(11)70088-2 Danaei, 2005, Causes of cancer in the world: comparative risk assessment of nine behavioural and environmental risk factors, Lancet, 366, 1784, 10.1016/S0140-6736(05)67725-2 World Health Organization, 1990 Editor, 2013, Realities of risk: we should focus on dangers that we can control, and particularly on those of our own creation, Nature, 493, 134, 10.1038/493134a IARC (International Agency For Research On Cancer), 1989, Diesel and Gasoline Engine Exhausts and Some Nitroarenes: Summary of Data Reported and Evaluation Kielhorn, 2003, 424 Tokiwa, 1987, The nature of the mutagenicity and carcinogenicity of nitrated, aromatic compounds in the environment, Environ. Health Perspect., 73, 191, 10.1289/ehp.8773191 Dane, 2010, Investigation of nitro-organic compounds in diesel engine exhaust: Final Report February 2007–April 2008 (Subcontract Report NREL/SR-540-45597 June 2010), 56 Bostrom, 2002, Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air, Environ. Health Perspect., 110, 451 Kannan, 2005, Spatial and temporal distribution of polycyclic aromatic hydrocarbons in sediments from Michigan inland lakes, Environ. Sci. Technol., 39, 4700, 10.1021/es050064f Hypocrites, Air, water and places, (quote from) The Internet Classics Archive, Boston, MA, 400 B.C.E, Translated by Francis Adams, Available from: http://classics.mit.edu/Hippocrates/airwatpl.html. Kennedy, 1962 Robson, 2007, 659 Holmberg, 1983, Consensus report: mutagenicity and carcinogenicity of car exhausts and coal combustion emissions, Environ. Health Perspect., 47, 1, 10.2307/3429495 Barfknecht, 1984, Methodology for evaluating the genotoxicity of hazardous environmental samples, Hazard. Waste, 1, 93, 10.1089/hzw.1984.1.93 Zeiger, 2010, Historical perspective on the development of the genetic toxicity test battery in the United States, Environ. Mol. Mutagen., 51, 781, 10.1002/em.20602 Cimino, 2006, Comparative overview of current international strategies and guidelines for genetic toxicology testing for regulatory purposes, Environ. Mol. Mutagen., 47, 362, 10.1002/em.20216 Zeiger, 1987, Carcinogenicity of mutagens: predictive capability of the Salmonella mutagenesis assay for rodent carcinogenicity, Cancer Res., 47, 1287 Wilkenson, 1987, ES&T Series. Cancer risk assessment. 1. Being more realistic about chemical carcinogenesis, Environ. Sci. Technol., 21, 843, 10.1021/es00163a606 Carere, 1990, Strategies and governmental regulations, Teratog. Carcinog. Mutagen., 10, 199, 10.1002/tcm.1770100214 Rosenkranz, 2002, Relationship of sister chromatid exchanges, genotoxicity and carcinogenicity: an SAR-based analysis, Internet Electron. J. Mol. Des., 1, 227 NRC (National Research Council), 1983 NRC (National Research Council), 1994 Risk World, 2013 SRA-E (Society for Risk Analysis – Europe), 2013 SRA (Society for Risk Analysis), 2013 North Dakota State Government, 2013 ISACA (Information Systems Audit and Control Association), 2013 Albert, 1983, Comparative potency method for cancer risk assessment: application to diesel particulate emissions, Risk Anal., 3, 101, 10.1111/j.1539-6924.1983.tb00110.x Nielsen, 1996, Traffic contribution of polycyclic aromatic hydrocarbons in the center of a large city, Atmos. Environ., 30, 3481, 10.1016/1352-2310(96)00096-9 Lim, 1999, The contribution of traffic to atmospheric concentrations of polycyclic aromatic hydrocarbons, Environ. Sci. Technol., 33, 3538, 10.1021/es990392d Zheng, 2000, Concentrations of persistent organic pollutants in surface sediments of the mudflat and mangroves at Mai Po Marshes Nature Reserve, Hong Kong, Mar. Pollut. Bull., 40, 1210, 10.1016/S0025-326X(00)00190-9 Nielsen, 1996, City air pollution of polycyclic aromatic hydrocarbons and other mutagens: occurrence, sources and health effects, Sci. Total Environ., 189, 41, 10.1016/0048-9697(96)05189-3 Benner, 1995, Distinguishing the contributions of residential wood combustion and mobile source emissions using relative concentrations of dimethylphenanthrene isomers, Environ. Sci. Technol., 29, 2382, 10.1021/es00009a034 Duval, 1981, 62 Shaughnessy, 2011, Inhibition of fried meat-induced colorectal DNA damage and altered systemic genotoxicity in humans by crucifera, chlorophyllin, and yogurt, PLoS ONE, 6, e18707, 10.1371/journal.pone.0018707 Li, 2003, Application of EPA CMB8. 2 Model for source apportionment of sediment PAHs in Lake Calumet, Chicago, Environ. Sci. Technol., 37, 2958, 10.1021/es026309v Li, 1982, Coal-combustion fly ash extract as direct-acting mutagen in Salmonella and promutagen in Chinese hamster ovary cells, Environ. Mutagen., 4, 407 Bamford, 1999, Diffusive exchange of polycyclic aromatic hydrocarbons across the air–water interface of the Patapsco River, an urbanized subestuary of the Chesapeake Bay, Environ. Sci. Technol., 33, 2138, 10.1021/es981324e Bamford, 2002, Seasonal and annual air–water exchange of polychlorinated biphenyls across Baltimore Harbor and the northern Chesapeake Bay, Environ. Sci. Technol., 36, 4245, 10.1021/es0206893 Sabin, 2010, Exchange of polycyclic aromatic hydrocarbons among the atmosphere, water, and sediment in coastal embayments of southern California, USA, Environ. Toxicol. Chem., 29, 265, 10.1002/etc.54 Larsen, 2003, Source apportionment of polycyclic aromatic hydrocarbons in the urban atmosphere: a comparison of three methods, Environ. Sci. Technol., 37, 1873, 10.1021/es0206184 Simcik, 1999, Source apportionment and source/sink relationships of PAHs in the coastal atmosphere of Chicago and Lake Michigan, Atmos. Environ., 33, 5071, 10.1016/S1352-2310(99)00233-2 Jones, 2008, Core signaling pathways in human pancreatic cancers revealed by global genomic analyses, Sci. Signal., 321, 1801 Parsons, 2008, An integrated genomic analysis of human glioblastoma multiforme, Science, 321, 1807, 10.1126/science.1164382 Hertzberg, 2002, Evaluating quantitative formulas for dose–response assessment of chemical mixtures, Environ. Health Perspect., 110, 965, 10.1289/ehp.02110s6965 Hesterberg, 2006, A critical assessment of studies on the carcinogenic potential of diesel exhaust, Crit. Rev. Toxicol., 36, 727, 10.1080/10408440600908821 Krewski, 2005, Interpreting epidemiological studies of acute and long-term exposure to particulate matter for policy development, J. Toxicol. Environ. Health A, 68, 1049, 10.1080/15287390590935879 Craig, 2007, Strategies for clean air and health, J. Toxicol. Environ. Health A, 70, 183, 10.1080/15287390600882986 Craig, 2008, International perspectives on air quality: risk management principles for policy development – conference statement, J. Toxicol. Environ. Health A, 71, 4, 10.1080/15287390701557321 Craig, 2008, Air pollution and public health: a guidance document for risk managers, J. Toxicol. Environ. Health A, 71, 588, 10.1080/15287390801997732 Craig, 2008, Colloquium statement: strategic policy directions for air quality management, J. Toxicol. Environ. Health A, 71, 539, 10.1080/15287390801997377 Irigaray, 2007, Lifestyle-related factors and environmental agents causing cancer: an overview, Biomed. Pharmacother., 61, 640, 10.1016/j.biopha.2007.10.006 Silverman, 2012, The diesel exhaust in miners study: a nested case–control study of lung cancer and diesel exhaust, J. Natl. Cancer Inst., 10.1093/jnci/djs034 Firket, 1931, The cause of the symptoms found in the Meuse Valley during the fog of December, 1930, Bull. Acad. R. Med. Belg., 11, 683 Schrenk, 1949 Martin, 1964, Mortality and morbidity statistics and air pollution, Proc. R. Soc. Med., 57, 969 Bell, 2001, Reassessment of the lethal London fog of 1952: novel indicators of acute and chronic consequences of acute exposure to air pollution, Environ. Health Perspect., 109, 389 1954, United Kingdom Ministry of Health, Mortality and morbidity during the London fog of December 1952 Logan, 1956, Mortality from fog in London, January, 1956, Br. Med. J., 1, 722, 10.1136/bmj.1.4969.722 Greenbaum, 2003, A historical perspective on the regulation of particles, J. Toxicol. Environ. Health A, 66, 1493, 10.1080/15287390306436 E. US-DHEW (U.S. Department of Health, and Welfare), 1969 Brown, 1976 European Commission, 1997 USEPA (U.S. Environmental Protection Agency), 1986 Dockery, 1993, An association between air pollution and mortality in six U.S. cities, N. Engl. J. Med., 329, 1753, 10.1056/NEJM199312093292401 Pope, 1995, Particulate air pollution as a predictor of mortality in a prospective study of US adults, Am. J. Respir. Crit. Care Med., 151, 669, 10.1164/ajrccm/151.3_Pt_1.669 1995 USEPA (Environmental Protection Agency), 1997, National ambient air quality standards for particulate matter: final rule, Fed. Reg., 62, 38652 European Parliament and Council, 2003, 55 CCME (Canadian Council of Ministers of the Environment), 1994, 27 CCME (Canadian Council of Ministers of the Environment), 1990, 30 Labelle, 1998, The effects of smog on the health of Canadians, in, 21 WHO (World Health Organization of the United Nations), 1999 USEPA (Environmental Protection Agency), 2001 Brunekreef, 2008, A note on the 2008 EU standards for particulate matter, Atmos. Environ., 42, 6425, 10.1016/j.atmosenv.2008.04.036 Austin, 1985, Mutagenicity of the fractionated organic emissions from diesel, cigarette smoke condensate, coke oven and roofing tar in the Ames assay, Environ. Mutagen., 7, 471, 10.1002/em.2860070407 Lewtas, 1981, Mutagenic and carcinogenic potency of extracts of diesel and related environmental emissions: study design, sample generation, collection, and preparation, Environ. Int., 5, 383, 10.1016/0160-4120(81)90087-8 Claxton, 1981, Mutagenic and carcinogenic potency of diesel and related environmental emissions: Salmonella bioassay, Environ. Int., 5, 389, 10.1016/0160-4120(81)90088-X Kohan, 1983, Mutagenicity of diesel exhaust particle extract, 1-nitropyrene, and 2,7-dinitrofluorenone in Salmonella typhimurium under various metabolic activation conditions, Mutat. Res., 124, 191, 10.1016/0165-1218(83)90190-8 DeMarini, 1987, Use of limited protocols to evaluate the genotoxicity of hazardous wastes in mammalian cell assays: comparison to Salmonella, J. Toxicol. Environ. Health, 22, 225, 10.1080/15287398709531065 Zeiger, 1985, Strategies to reduce the cost of mutagenicity screening with the Salmonella assay, Environ. Mutagen., 7, 901, 10.1002/em.2860070611 Lighty, 2000, Combustion aerosols: factors governing their size and composition and implications to human health, J. Air Waste Manage. Assoc., 50, 1565, 10.1080/10473289.2000.10464197 Kelly, 2003, Characterization of exhaust particles from military vehicles fueled with diesel, gasoline, and JP-8, J. Air Waste Manage. Assoc., 53, 273, 10.1080/10473289.2003.10466151 Krahl, 2009, Comparison of exhaust emissions and their mutagenicity from the combustion of biodiesel, vegetable oil, gas-to-liquid and petrodiesel fuels, Fuel, 88, 1064, 10.1016/j.fuel.2008.11.015 IARC (International Agency for Research on Cancer), 1988, Volume 43: Man-made Mineral Fibres and Radon IARC (International Agency for Research on Cancer), 2010, Volume 95: Household Use of Solid Fuels and High-temperature Frying IARC (International Agency for Research on Cancer), 2010, Volume 93: Carbon Black, Titanium Dioxide, and Talc IARC (International Agency for Research on Cancer), 2010, Volume 92: Some Non-heterocyclic Polycyclic Aromatic Hydrocarbons and Some Related Exposures Vallyathan, 1988, Generation of free radicals from freshly fractured silica dust: potential role in acute silica-induced lung injury, Am. J. Respir. Crit. Care Med., 138, 1213 IARC (International Agency for Research on Cancer), 1997, Volume 68: Silica, Some Silicates, Coal Dust and Para-Aramid Fibrils Vallyathan, 1995, Freshly fractured quartz inhalation leads to enhanced lung injury and inflammation. Potential role of free radicals, Am. J. Respir. Crit. Care Med., 152, 1003, 10.1164/ajrccm.152.3.7663775 Davis, 1986, Pathogenesis of silisosis: current concepts and hypothesis, Lung, 164, 139, 10.1007/BF02713638 Mentnech, 1984, Effects of coal dust and diesel exhaust on immune competence in rats, J. Toxicol. Environ. Health A Curr. Issues, 13, 31, 10.1080/15287398409530479 Rabovsky, 1984, Chronic inhalation of diesel exhaust and coal dust: effect of age and exposure on selected enzyme activities associated with microsomal cytochrome p-450 in rat lung and liver, J. Toxicol. Environ. Health A Curr. Issues, 14, 655, 10.1080/15287398409530615 Castranova, 1985, The response of rat alveolar macrophages to chronic inhalation of coal dust and/or diesel exhaust, Environ. Res., 36, 405, 10.1016/0013-9351(85)90034-9 Hahon, 1988, Interferon induction inhibition and mutagenic activity of nitrosated coal dust extract, Environ. Res., 45, 213, 10.1016/S0013-9351(88)80048-3 IARC (International Agency for Research on Cancer), 1996, Volume 65: Printing Processes and Printing Inks, Carbon Black and Some Nitro Compounds IARC (International Agency for Research on Cancer), 1995, Volume 62: Wood Dust and Formaldehyde, 286 IARC (International Agency for Research on Cancer), 2012, 4 IARC (International Agency for Research on Cancer), 1998 Boogaard, 1994, Exposure to polycyclic aromatic hydrocarbons in petrochemical industries by measurement of urinary 1-hydroxypyrene, Occup. Environ. Med., 51, 250, 10.1136/oem.51.4.250 Andersen, 2009, Toxicity testing in the 21st century: bringing the vision to life, Toxicol. Sci., 107, 324, 10.1093/toxsci/kfn255 Andersen, 2010, The vision of toxicity testing in the 21st century: moving from discussion to action, Toxicol. Sci., 117, 17, 10.1093/toxsci/kfq188 Boekelheide, 2010, Toxicity testing in the 21st century: using the new toxicity testing paradigm to create a taxonomy of adverse effects, Toxicol. Sci., 114, 20, 10.1093/toxsci/kfp307 Dix, 2007, The Toxcast Program for prioritizing toxicity testing of environmental chemicals, Toxicol. Sci., 95, 5, 10.1093/toxsci/kfl103 Greenberg, 2009, Toxicity testing in the 21st century, Risk Anal., 29, 471, 10.1111/j.1539-6924.2009.01222.x Kavlock, 2009, Toxicity testing in the 21st century: implications for human health risk assessment, Risk Anal., 29, 485, 10.1111/j.1539-6924.2008.01168.x Krewski, 2009, Toxicity testing in the 21st century: implications for human health risk assessment, Risk Anal., 29, 474, 10.1111/j.1539-6924.2008.01150.x NRC (National Research Council), 2007 Rusyn, 2010, Computational toxicology: realizing the promise of the toxicity testing in the 21st century, Environ. Health Perspect., 118, 1047, 10.1289/ehp.1001925 Goodman, 2007, Genetic toxicity assessment: employing the best science for human safety evaluation, Toxicol. Sci., 96, 1, 10.1093/toxsci/kfl201 Pfuhler, 2007, Genetic toxicity assessment: employing the best science for human safety evaluation, Part IV: Recommendation of a workking group of the Gesellschaft fuer Umwelt-Mutationsforschung (GUM) for a simple and straightforward approach to genotoxicity testing, Toxicol. Sci., 97, 237, 10.1093/toxsci/kfm019 Witte, 2007, Genetic toxicity assessment: employing the best science for human safety evaluation. Part III: The comet assay as an alternative to in vitro clastogenicity tests for early drug candidate selection, Toxicol. Sci., 97, 21, 10.1093/toxsci/kfl192 Lorge, 2007, Genetic toxicity assessment: employing the best science for human safety evaluation. Part II: Performances of the in vitro micronucleus test compared to the mouse lymphoma assay and the in vitro chromosome aberration assay, Toxicol. Sci., 96, 214, 10.1093/toxsci/kfl193 Ku, 2007, Genetic toxicity assessment: employing the best science for human safety evaluation. Part VII: Why not start with a single test: a transformational alternative to genotoxicity hazard and risk assessment, Toxicol. Sci., 99, 20, 10.1093/toxsci/kfm147 Lorge, 2007, Genetic toxicity assessment: employing the best science for human safety evaluation. Part IV: A strategy in genotoxicity testing in drug development: some examples, Toxicol. Sci., 98, 39, 10.1093/toxsci/kfm056 Elespuru, 2009, Current and future application of genetic toxicity assays: the role and value of in vitro mammalian assays, Toxicol. Sci., 109, 172, 10.1093/toxsci/kfp067 Eastmond, 2009, Mutagenicity testing for chemical risk assessment: update of the WHO/IPCS Harmonized Scheme, Mutagenesis, 24, 341, 10.1093/mutage/gep014 Merlot, 2010, Computational toxicology – a tool for early safety evaluation, Drug Discov. Today, 15, 16, 10.1016/j.drudis.2009.09.010 Pfuhler, 2009, Reduction of use of animals in regulatory genotoxicity testing: identification and implementation opportunities – report from an ECVAM workshop, Mutat. Res. Gen. Tox. Environ., 680, 31, 10.1016/j.mrgentox.2009.09.002 Fromowitz, 2012, Bone marrow genotoxicity of 2,5-dimethylfuran, a green biofuel candidate, Environ. Mol. Mutagen., 53, 488, 10.1002/em.21707 Hartung, 2012, Food for thought – systems toxicology, ALTEX, 29, 119, 10.14573/altex.2012.2.119 Elespuru, 2009, Current and future application of genetic toxicity assays: the role and value of in vitro mammalian assays, Toxicol. Sci., 109, 172, 10.1093/toxsci/kfp067 Desai, 2004, Indoor smoke from solid fuels: assessing the environmental burden of disease at national and local levels, 82 USEPA, 2006 USEPA (Environmental Protection Agency), 2005 Aakko, 2003, Particle emissions at moderate and cold temperatures using different fuels CARB (California Air Resources Board), 2000 Burke, 2004 Romm, 2006, The car and fuel of the future, Energy Policy, 34, 2609, 10.1016/j.enpol.2005.06.025 2002, Solid Waste Disposal Act [As Amended Through P.L. 107-377, December 31, 2002], Title II—Solid Waste Disposal, 163 USEPA (Environmental Protection Agency), 2012 USEPA (Environmental Protection Agency), 2000, 2 Stensvaag, 1994, The not so fine print of environmental law, Loyola of Los Angeles Law Review, 27, 13 Kalyoncu, 2001, 12 Eyre, 2004, Preventing cancer, cardiovascular disease, and diabetes: a common agenda for the American Cancer Society, the American Diabetes Association, and the American Heart Association, Stroke, 35, 1999, 10.1161/01.STR.0000133321.00456.00 Zeise, 2013, Addressing human variability in next-generation human health risk assessments of environmental chemicals, Environ. Health Perspect., 121, 23, 10.1289/ehp.1205687 Kheirbek, 2013, PM2.5 and ozone health impacts and disparities in New York City: sensitivity to spatial and temporal resolution, Air Qual. Atmos. Health, 1 White, 2013, Workshop report: evaluation of epidemiological data consistency for application in regulatory risk assessment, Open Epidemiol. J., 6, 1, 10.2174/1874297101306010001 Barton, 2005, Assessing susceptibility from early-life exposure to carcinogens, Environ. Health Perspect., 113, 1125, 10.1289/ehp.7667 Freeman, 2004, Toxicogenomics data: the road to acceptance, Environ. Health Perspect., 112, A678, 10.1289/ehp.112-a678 Geller, 2005, Aging and the environment: a research framework, Environ. Health Perspect., 113, 1257, 10.1289/ehp.7569 Bare, 2006, Risk assessment and life-cycle impact assessment (LCIA) for human health cancerous and noncancerous emissions: integrated and complementary with consistency within the USEPA, Human Ecol. Risk Assess., 12, 493, 10.1080/10807030600561683 Faustman, 2000, Mechanisms underlying Children's susceptibility to environmental toxicants, Environ. Health Perspect., 108, 13 Carroquino, 1998, The US EPA conference on preventable causes of cancer in children: a research agenda, Environ. Health Perspect., 106, 867 Zeise, 2013, Addressing human variability innext-generation human health risk assessments of environmental chemicals, Environ. Health Perspect., 121, 23, 10.1289/ehp.1205687 Kramer, 2013, 148 Sacks, 2011, Particulate matter-induced health effects: who is susceptible?, Environ. Health Perspect., 119, 446, 10.1289/ehp.1002255 Goldstein, 2005, Advances in risk assessment and communication, Annu. Rev. Public Health, 26, 141, 10.1146/annurev.publhealth.26.021304.144410 Cherrie, 2009, Reducing occupational exposure to chemical carcinogens, Occup. Med. (Lond), 59, 96, 10.1093/occmed/kqn172 2004, European Parliament and the Council of the European Union, Corrigendum to Directive 2004/37/EC of the European Parliament and of the Council of 29 April 2004 on the protection of workers from the risks related to exposure to carcinogens or mutagens at work, Off. J. Eur. Union, 12 2008, Contract Bids, 25 2006, British Government, Disease Reduction Programme: Cancer Project – The nature and extent of use of, and occupational exposure to chemical carcinogens in current UK workplaces Hecht, 2014, Working toward a sustainable future, Sustain. Sci. Pract. Policy, 10, 1 Noorjahjan, 2014, Physicochemical characteristics, identification of fungi and biodegradation of industrial effluent, J. Environ. Earth Sci., 4, 32 Zurbrügg, 2014, How assessment methods can support solid waste management in developing countries – a critical review, Sustainability, 6, 545, 10.3390/su6020545 Tornero, 2014, Contamination by hazardous substances in the Gulf of Naples and nearby coastal areas: a review of sources, environmental levels and potential impacts in the MSFD perspective, Sci. Total Environ., 466, 820, 10.1016/j.scitotenv.2013.06.106 Wall, 2014 Needhidasan, 2014, Electronic waste – an emerging threat to the environment of urban India, J. Environ. Health Sci. Eng., 12, 36, 10.1186/2052-336X-12-36 Lemly, 2012, Wildlife and the coal waste policy debate: proposed rules for coal waste disposal ignore lessons from 45 years of wildlife poisoning, Environ. Sci. Technol., 46, 8595, 10.1021/es301467q Richardson, 2014, Economic impacts on West Virginia from projected future coal production and implications for policymakers, Environ. Res. Lett., 9, 024006, 10.1088/1748-9326/9/2/024006 Korb, 2012, Holding our breath: waiting for the Federal Government to recognize coal ash as a hazardous waste, John Marshall Law Rev., 45, 1177 Cooper, 2014, Toxic solid waste leaching from telephone poles? Navigating ambiguous definitions in RCRA, Boston Coll. Environ. Aff. Law Rev., 41, 14 Ghiani, 2014, Operations research in solid waste management: a survey of strategic and tactical issues, Comput. Oper. Res., 44, 22, 10.1016/j.cor.2013.10.006 Lamb, 2014, Waste management and public health, 146 Cherian, 2014, Toxicological considerations in the use of consumer products, Def. Sci. J., 37, 143, 10.14429/dsj.37.5899 Debnath, 2014, Evaluation of quality and impact of untreated waste water for irrigation, Am. J. Res. Commun., 2, 1 Vasseur, 2014, Ecogenotoxicology in earthworms: a review, Curr. Zool., 255, 10.1093/czoolo/60.2.255 Song, 2014, Multivariate assessment of polycyclic aromatic hydrocarbons in surface sediments of the Beijiang, a tributary of the Pearl River in Southern China, Environ. Monit. Assess., 186, 907, 10.1007/s10661-013-3423-9 Sudha, 2014, Microbial degradation of azo dyes: a review, Int. J. Curr. Microbiol. App. Sci, 3, 670 Masood, 2014, 39 Sardsella, 2005, Community-based energy: a return is long overdue, 5 EIA (U.S. Energy Information Administration), 2013 Blix, 1992, Electricity and the environment: the basis for choices – many countries face a dilemma, but options exist (Drawn from his opening statement at the Senior Expert Symposium on Electricity and the Environment, held in Helsinki from 13 to 17 May 1991), Energy Dig., 21, 39 Harper, 2013, Using inequality measures to incorporate environmental justice into regulatory analyses, Int. J. Environ. Res. Public Health, 10, 4039, 10.3390/ijerph10094039 Clinton, 1994 Braveman, 2003, Defining equity in health, J. Epidemiol. Community Health, 57, 254, 10.1136/jech.57.4.254 Allison, 1978, Measures of inequality, Am. Sociol. Rev., 43, 865, 10.2307/2094626 Cox, 2012, Why income inequality indexes do not apply to health risks, Risk Anal., 32, 192, 10.1111/j.1539-6924.2011.01756.x Fann, 2012, Why income inequality indexes do not apply to health risks response, Risk Anal., 32, 197, 10.1111/j.1539-6924.2011.01758.x Legrand, 1987, Inequalities in health – some international comparisons, Eur. Econ. Rev., 31, 182, 10.1016/0014-2921(87)90030-4 Fann, 2011, Maximizing health benefits and minimizing inequality: incorporating local-scale data in the design and evaluation of air quality policies, Risk Anal., 31, 908, 10.1111/j.1539-6924.2011.01629.x O’Neill, 2003, Health, wealth, and air pollution: advancing theory and methods, Environ. Health Perspect., 111, 1861, 10.1289/ehp.6334 Harper, 2008, An overview of methods for monitoring social disparities in cancer with an example using trends in lung cancer incidence by area-socioeconomic position and race-ethnicity, 1992–2004, Am. J. Epidemiol., 167, 889, 10.1093/aje/kwn016 Legatum Institute, 2008, 105 World Bank, 2013 World Bank: Sustainable Energy for All Initiative, 2013 World Bank: Sustainable Energy for All Initiative, 2013 Claxton, 1998, Genotoxicity of industrial wastes and effluents, Mutat. Res./Rev. Mutat. Res., 410, 237, 10.1016/S1383-5742(98)00008-8 Claxton, 1980, Comparative mutagenic activity of organics from combustion sources, 453 Claxton, 2004, The genotoxicity of ambient outdoor air, a review: Salmonella mutagenicity, Mutat. Res./Rev. Mutat. Res., 567, 347, 10.1016/j.mrrev.2004.08.002 Claxton, 2007, A review of the mutagenicity and rodent carcinogenicity of ambient air, Mutat. Res./Rev. Mutat. Res., 636, 36, 10.1016/j.mrrev.2007.01.001 DeMarini, 2004, Genotoxicity of tobacco smoke and tobacco smoke condensate: a review, Mutat. Res./Rev. Mutat. Res., 567, 447, 10.1016/j.mrrev.2004.02.001 Krishnan, 1997, Health risk assessment of drinking water contaminants in canada: the applicability of mixture risk assessment methods, Regul. Toxicol. Pharm., 26, 179, 10.1006/rtph.1997.1151 Richardson, 2005, Water analysis: emerging contaminants and current issues, Anal. Chem., 77, 3807, 10.1021/ac058022x Richardson, 2007, Occurrence, genotoxicity, and carcinogenicity of regulated and emerging disinfection by-products in drinking water: a review and roadmap for research, Mutat. Res./Rev. Mutat. Res., 636, 178, 10.1016/j.mrrev.2007.09.001 Lewtas, 2007, Air pollution combustion emissions: characterization of causative agents and mechanisms associated with cancer, reproductive, and cardiovascular effects, Mutat. Res./Rev. Mutat. Res., 636, 95, 10.1016/j.mrrev.2007.08.003 Vories, 2000, Proceedings of the use and disposal of coal combustion by-products at coal mines: a technical interactive forum, April 10–13, 2000, 290 Pucher, 2010, Walking and cycling to health: a comparative analysis of city, state, and international data, Am. J. Public Health, 100, 1986, 10.2105/AJPH.2009.189324 Pucher, 2003, Promoting safe walking and cycling to improve public health: lessons from the Netherlands and Germany, Am. J. Public Health, 93, 1509, 10.2105/AJPH.93.9.1509 NAS (National Academy of Sciences), National Research Council and Institute of Medicine, U.S. Health in International Perspective: Shorter Lives, Poorer Health, 2013 Anderson, 2009, Informing public health policy with the best available evidence, 436 Braveman, 2011, When do we know enough to recommend action on the social determinants of health?, Am. J. Prev. Med., 40, S58, 10.1016/j.amepre.2010.09.026 McQueen, 2009, The evaluation of health promotion practice: 21st century debates on evidence and effectiveness, 157 Rychetnik, 2002, Criteria for evaluating evidence on public health interventions, J. Epidemiol. Community Health, 56, 119, 10.1136/jech.56.2.119 Victora, 2004, Evidence-based public health: moving beyond randomized trials, Am. J. Public Health, 94, 400, 10.2105/AJPH.94.3.400 Baldasano, 2003, Air quality data from large cities, Sci. Total Environ., 307, 141, 10.1016/S0048-9697(02)00537-5 OECD (The Organisation for Economic Co-operation and Development), 2012 Parker, 2011, The international collaboration on air pollution and pregnancy outcomes: initial results, Environ. Health Perspect., 119, 1023, 10.1289/ehp.1002725 Santodonato, 1978, 165 Pepelko, 1979, 627 Harris, 1981 Ryan, 1981, The effects of fuel properties and composition on diesel engine exhaust emissions--a review, 4 Krewski, 1992, Carcinogenic mixtures, Risk Anal., 12, 105, 10.1111/j.1539-6924.1992.tb01313.x NIEHS (National Institute of Environmental Health Sciences), Carcinogens Review Group (RG1), 1998, FINAL – Report on carcinogens background document for diesel exhaust particulates, December 2–3, 1998 HEI (Health Effects Institute), 2002, 227 Faoro, 1981, Trends in benzo(a)Pyrene, 1966–77, J. Air Pollut. Control Assoc., 31, 62, 10.1080/00022470.1981.10465188 USEPA (Environmental Protection Agency), 1974, 45 Claxton, 1982, The utility of bacterial mutagenesis testing in the characterization of mobile source emissions: a review, 69 1992, Mutat. Res., 276 McClellan, 1982, Inhalation toxicology of diesel exhaust particles, 99 Gopinath, 2007, Radiation effects, nuclear energy and comparative risks, Curr. Sci., 93, 1230 Martin, 2012, Superfuel: thorium Jones, 2013, Richard Martin: superfuel (thorium, the green energy source for the future) – book review, Chromatographia, 76, 103, 10.1007/s10337-012-2356-8 BP Press Release, 2013 Hochman, 2014, Innovations & improvement – improvement happens: impacting health at its roots – an interview with Rishi Manchanda, J. Gen. Intern. Med., 10.1007/s11606-014-2902-1