The hippocampal–prefrontal pathway: The weak link in psychiatric disorders?

Adhikari, 2010, Synchronized activity between the ventral hippocampus and the medial prefrontal cortex during anxiety, Neuron, 65, 257, 10.1016/j.neuron.2009.12.002

Adhikari, 2011, Single units in the medial prefrontal cortex with anxiety-related firing patterns are preferentially influenced by ventral hippocampal activity, Neuron, 71, 898, 10.1016/j.neuron.2011.07.027

Admon, 2009, Human vulnerability to stress depends on amygdala's predisposition and hippocampal plasticity, Proc. Natl. Acad. Sci. USA, 106, 14120, 10.1073/pnas.0903183106

Anderson, 2010, Theta oscillations mediate interaction between prefrontal cortex and medial temporal lobe in human memory, Cereb. Cortex, 20, 1604, 10.1093/cercor/bhp223

Andrews, 2009, The bright side of being blue: depression as an adaptation for analyzing complex problems, Psychol. Rev., 116, 620, 10.1037/a0016242

Artigas, 2010, The prefrontal cortex: a target for antipsychotic drugs, Acta Psychiatr. Scand., 121, 11, 10.1111/j.1600-0447.2009.01455.x

Baker, 2012, Is there a core neuropsychiatric phenotype in 22q11.2 deletion syndrome?, Curr. Opin. Neurol., 25, 131, 10.1097/WCO.0b013e328352dd58

Barbas, 1995, Topographically specific hippocampal projections target functionally distinct prefrontal areas in the rhesus monkey, Hippocampus, 5, 511, 10.1002/hipo.450050604

Barch, 2005, The cognitive neuroscience of schizophrenia, Annu. Rev. Clin. Psychol., 1, 321, 10.1146/annurev.clinpsy.1.102803.143959

Barker, 2011, When is the hippocampus involved in recognition memory?, J. Neurosci., 31, 10721, 10.1523/JNEUROSCI.6413-10.2011

Bast, 2011, The hippocampal learning-behavior translation and the functional significance of hippocampal dysfunction in schizophrenia, Curr. Opin. Neurobiol., 21, 492, 10.1016/j.conb.2011.01.003

Belujon, 2011, Hippocampus, amygdala, and stress: interacting systems that affect susceptibility to addiction, Ann. N. Y. Acad. Sci., 1216, 114, 10.1111/j.1749-6632.2010.05896.x

Benchenane, 2010, Coherent theta oscillations and reorganization of spike timing in the hippocampal–prefrontal network upon learning, Neuron, 66, 921, 10.1016/j.neuron.2010.05.013

Benetti, 2009, Functional integration between the posterior hippocampus and prefrontal cortex is impaired in both first episode schizophrenia and the at risk mental state, Brain, 132, 2426, 10.1093/brain/awp098

Bouton, 2006, Contextual and temporal modulation of extinction: behavioral and biological mechanisms, Biol. Psychiatry, 60, 352, 10.1016/j.biopsych.2005.12.015

Braga, 2005, Anxiety disorders in outpatients with schizophrenia: prevalence and impact on the subjective quality of life, J. Psychiatr. Res., 39, 409, 10.1016/j.jpsychires.2004.09.003

Brown, 2012, Potential therapeutic avenues to tackle social cognition problems in schizophrenia, Expert Rev. Neurotherapeutics, 12, 71, 10.1586/ern.11.183

Buchy, 2012, Diffusion tensor imaging tractography of the fornix and belief confidence in first-episode psychosis, Schizophr. Res., 137, 80, 10.1016/j.schres.2012.02.015

Buckner, 2008, The brain's default network: anatomy, function, and relevance to disease, Ann. N. Y. Acad. Sci., 1124, 1, 10.1196/annals.1440.011

Burette, 1997, Reversal of LTP in the hippocampal afferent fiber system to the prefrontal cortex in vivo with low-frequency patterns of stimulation that do not produce LTD, J. Neurophysiol., 78, 1155, 10.1152/jn.1997.78.2.1155

Burgos-Robles, 2009, Sustained conditioned responses in prelimbic prefrontal neurons are correlated with fear expression and extinction failure, J. Neurosci., 29, 8474, 10.1523/JNEUROSCI.0378-09.2009

Burton, 2009, Lesion of the ventral and intermediate hippocampus abolishes anticipatory activity in the medial prefrontal cortex of the rat, Behav. Brain Res., 199, 222, 10.1016/j.bbr.2008.11.045

Carr, 1996, Hippocampal afferents to the rat prefrontal cortex: synaptic targets and relation to dopamine terminals, J. Comp. Neurol., 369, 1, 10.1002/(SICI)1096-9861(19960520)369:1<1::AID-CNE1>3.0.CO;2-7

Caudal, 2010, Acute stress induces contrasting changes in AMPA receptor subunit phosphorylation within the prefrontal cortex, amygdala and hippocampus, PLoS One, 5, e15282, 10.1371/journal.pone.0015282

Cavada, 2000, The anatomical connections of the macaque monkey orbitofrontal cortex, Rev. Cereb. Cortex, 10, 220, 10.1093/cercor/10.3.220

Celada, 2008, The hallucinogen DOI reduces low-frequency oscillations in rat prefrontal cortex: reversal by antipsychotic drugs, Biol. Psychiatry, 64, 392, 10.1016/j.biopsych.2008.03.013

Cenquizca, 2007, Spatial organization of direct hippocampal field CA1 axonal projections to the rest of the cerebral cortex, Brain Res. Rev., 56, 1, 10.1016/j.brainresrev.2007.05.002

Cerqueira, 2007, The prefrontal cortex as a key target of the maladaptive response to stress, J. Neurosci., 27, 2781, 10.1523/JNEUROSCI.4372-06.2007

Conde, 1995, Afferent connections of the medial frontal cortex of the rat. II. Cortical and subcortical afferents, J. Comp. Neurol., 352, 567, 10.1002/cne.903520407

Corcoran, 2003, The stress cascade and schizophrenia: etiology and onset, Schizophr. Bull., 29, 671, 10.1093/oxfordjournals.schbul.a007038

Corcoran, 2007, Activity in prelimbic cortex is necessary for the expression of learned, but not innate, fears, J. Neurosci., 27, 840, 10.1523/JNEUROSCI.5327-06.2007

Corcoran, 2007, Recalling safety: cooperative functions of the ventromedial prefrontal cortex and the hippocampus in extinction, CNS Spectrums, 12, 200, 10.1017/S1092852900020915

Croxson, 2005, Quantitative investigation of connections of the prefrontal cortex in the human and macaque using probabilistic diffusion tractography, J. Neurosci., 25, 8854, 10.1523/JNEUROSCI.1311-05.2005

Curley, 2012, Cortical basket cell dysfunction in schizophrenia, J. Physiol., 590, 715, 10.1113/jphysiol.2011.224659

Degenetais, 2003, Synaptic influence of hippocampus on pyramidal cells of the rat prefrontal cortex: an in vivo intracellular recording study, Cereb. Cortex, 13, 782, 10.1093/cercor/13.7.782

Dickerson, 2012, Clozapine administration ameliorates disrupted long-range synchrony in a neurodevelopmental animal model of schizophrenia, Schizophr. Res., 135, 112, 10.1016/j.schres.2011.12.016

Dickie, 2011, Neural correlates of recovery from post-traumatic stress disorder: a longitudinal fMRI investigation of memory encoding, Neuropsychologia, 49, 1771, 10.1016/j.neuropsychologia.2011.02.055

Drevets, 1997, Subgenual prefrontal cortex abnormalities in mood disorders, Nature, 386, 824, 10.1038/386824a0

Dupin, 2006, Common efficacy of psychotropic drugs in restoring stress-induced impairment of prefrontal plasticity, Neurotox. Res., 10, 193, 10.1007/BF03033356

Elvevag, 2000, Cognitive impairment in schizophrenia is the core of the disorder, Crit. Rev. Neurobiol., 14, 1, 10.1615/CritRevNeurobiol.v14.i1.10

Engel, 1999, Temporal binding, binocular rivalry, and consciousness, Conscious. Cogn., 8, 128, 10.1006/ccog.1999.0389

Esslinger, 2009, Neural mechanisms of a genome-wide supported psychosis variant, Science, 324, 605, 10.1126/science.1167768

Falls, 1992, Extinction of fear-potentiated startle: blockade by infusion of an NMDA antagonist into the amygdala, J. Neurosci., 12, 854, 10.1523/JNEUROSCI.12-03-00854.1992

Fanselow, 2000, Contextual fear, gestalt memories, and the hippocampus, Behav. Brain Res., 110, 73, 10.1016/S0166-4328(99)00186-2

Fanselow, 2010, Are the dorsal and ventral hippocampus functionally distinct structures?, Neuron, 65, 7, 10.1016/j.neuron.2009.11.031

Fanselow, 2005, The neuroscience of mammalian associative learning, Annu. Rev. Psychol., 56, 207, 10.1146/annurev.psych.56.091103.070213

Floresco, 1997, Selective roles for hippocampal, prefrontal cortical, and ventral striatal circuits in radial-arm maze tasks with or without a delay, J. Neurosci., 17, 1880, 10.1523/JNEUROSCI.17-05-01880.1997

French, 2002, Hippocampal and prefrontal cortical inputs monosynaptically converge with individual projection neurons of the nucleus accumbens, J. Comp. Neurol., 446, 151, 10.1002/cne.10191

Frodl, 2010, Interaction of childhood stress with hippocampus and prefrontal cortex volume reduction in major depression, J. Psychiatr. Res., 44, 799, 10.1016/j.jpsychires.2010.01.006

Fujisawa, 2011, A 4Hz oscillation adaptively synchronizes prefrontal, VTA, and hippocampal activities, Neuron, 72, 153, 10.1016/j.neuron.2011.08.018

Gabbott, 2002, Morphological evidence that CA1 hippocampal afferents monosynaptically innervate PV-containing neurons and NADPH-diaphorase reactive cells in the medial prefrontal cortex (Areas 25/32) of the rat, Brain Res., 946, 314, 10.1016/S0006-8993(02)02487-3

Garcia, 2008, Hippocampal low-frequency stimulation and chronic mild stress similarly disrupt fear extinction memory in rats, Neurobiol. Learn. Mem., 89, 560, 10.1016/j.nlm.2007.10.005

Ghods-Sharifi, 2009, Fundamental contribution by the basolateral amygdala to different forms of decision making, J. Neurosci., 29, 5251, 10.1523/JNEUROSCI.0315-09.2009

Goghari, 2010, The functional neuroanatomy of symptom dimensions in schizophrenia: a qualitative and quantitative review of a persistent question, Neurosci. Biobehav. Rev., 34, 468, 10.1016/j.neubiorev.2009.09.004

Goldman-Rakic, 1995, Architecture of the prefrontal cortex and the central executive, Ann. N. Y. Acad. Sci., 769, 71, 10.1111/j.1749-6632.1995.tb38132.x

Goldman-Rakic, 1984, Dual pathways connecting the dorsolateral prefrontal cortex with the hippocampal formation and parahippocampal cortex in the rhesus monkey, Neuroscience, 12, 719, 10.1016/0306-4522(84)90166-0

Gordon, 2011, Oscillations and hippocampal–prefrontal synchrony, Curr. Opin. Neurobiol., 21, 486, 10.1016/j.conb.2011.02.012

Gorelova, 2002, Mechanisms of dopamine activation of fast-spiking interneurons that exert inhibition in rat prefrontal cortex, J. Neurophysiol., 88, 3150, 10.1152/jn.00335.2002

Goto, 2008, Dopamine modulation of hippocampal–prefrontal cortical interaction drives memory-guided behavior, Cereb. Cortex, 18, 1407, 10.1093/cercor/bhm172

Goto, 2008, Limbic and cortical information processing in the nucleus accumbens, Trends Neurosci., 31, 552, 10.1016/j.tins.2008.08.002

Gourley, 2008, Regionally specific regulation of ERK MAP kinase in a model of antidepressant-sensitive chronic depression, Biol. Psychiatry, 63, 353, 10.1016/j.biopsych.2007.07.016

Goveas, 2011, Neural correlates of the interactive relationship between memory deficits and depressive symptoms in nondemented elderly: resting fMRI study, Behav. Brain Res., 219, 205, 10.1016/j.bbr.2011.01.008

Grace, 2007, Regulation of firing of dopaminergic neurons and control of goal-directed behaviors, Trends Neurosci., 30, 220, 10.1016/j.tins.2007.03.003

Gruber, 2010, More is less: a disinhibited prefrontal cortex impairs cognitive flexibility, J. Neurosci., 30, 17102, 10.1523/JNEUROSCI.4623-10.2010

Gurden, 2000, Essential role of D1 but not D2 receptors in the NMDA receptor-dependent long-term potentiation at hippocampal–prefrontal cortex synapses in vivo, J. Neurosci., 20, RC106, 10.1523/JNEUROSCI.20-22-j0003.2000

Gurden, 1999, Integrity of the mesocortical dopaminergic system is necessary for complete expression of in vivo hippocampal–prefrontal cortex long-term potentiation, Neuroscience, 94, 1019, 10.1016/S0306-4522(99)00395-4

Hao, 2009, Schizophrenia patients and their healthy siblings share disruption of white matter integrity in the left prefrontal cortex and the hippocampus but not the anterior cingulate cortex, Schizophr. Res., 114, 128, 10.1016/j.schres.2009.07.001

Hartley, 2010, Changing fear: the neurocircuitry of emotion regulation, Neuropsychopharmacology, 35, 136, 10.1038/npp.2009.121

Hayes, 2010, Staying cool when things get hot: emotion regulation modulates neural mechanisms of memory encoding, Front. Hum. Neurosci., 4, 230, 10.3389/fnhum.2010.00230

Herry, 2008, Switching on and off fear by distinct neuronal circuits, Nature, 454, 600, 10.1038/nature07166

Herry, 2010, Neuronal circuits of fear extinction, Eur. J. Neurosci., 31, 599, 10.1111/j.1460-9568.2010.07101.x

Hobin, 2006, Ventral hippocampal muscimol disrupts context-specific fear memory retrieval after extinction in rats, Hippocampus, 16, 174, 10.1002/hipo.20144

Holt, 2009, Extinction memory is impaired in schizophrenia, Biol. Psychiatry, 65, 455, 10.1016/j.biopsych.2008.09.017

Hoover, 2007, Anatomical analysis of afferent projections to the medial prefrontal cortex in the rat, Brain Struct. Funct., 212, 149, 10.1007/s00429-007-0150-4

Hsieh, 2011, Neural oscillations associated with item and temporal order maintenance in working memory, J. Neurosci., 31, 10803, 10.1523/JNEUROSCI.0828-11.2011

Hughes, 2009, Novel consortium to address shortfall in innovative medicines for psychiatric disorders, Nat. Rev. Drug Discov., 8, 523, 10.1038/nrd2939

Hyman, 2012, Contextual encoding by ensembles of medial prefrontal cortex neurons, Proc. Natl. Acad. Sci. USA, 109, 5086, 10.1073/pnas.1114415109

Insel, 2010, Research domain criteria (RDoC): toward a new classification framework for research on mental disorders, Am. J. Psychiatry, 167, 748, 10.1176/appi.ajp.2010.09091379

Ishikawa, 2003, Convergence and interaction of hippocampal and amygdalar projections within the prefrontal cortex in the rat, J. Neurosci., 23, 9987, 10.1523/JNEUROSCI.23-31-09987.2003

Ishikawa, 2006, Ventral hippocampal neurons project axons simultaneously to the medial prefrontal cortex and amygdala in the rat, J. Neurophysiol., 96, 2134, 10.1152/jn.00069.2006

Izaki, 2000, Disturbance of rat lever-press learning by hippocampo-prefrontal disconnection, Brain Res., 860, 199, 10.1016/S0006-8993(00)02039-4

Izaki, 2003, Compatibility of bidirectional synaptic plasticity on hippocampo-prefrontal cortex pathway in rats, Neurosci. Lett., 345, 69, 10.1016/S0304-3940(03)00492-0

Janowsky, 1989, Source memory impairment in patients with frontal lobe lesions, Neuropsychologia, 27, 1043, 10.1016/0028-3932(89)90184-X

Jay, 1995, NMDA receptor-dependent long-term potentiation in the hippocampal afferent fibre system to the prefrontal cortex in the rat, Eur. J. Neurosci., 7, 247, 10.1111/j.1460-9568.1995.tb01060.x

Jay, 1992, Excitatory amino acid pathway from the hippocampus to the prefrontal cortex. Contribution of AMPA receptors in hippocampo-prefrontal cortex transmission, Eur. J. Neurosci., 4, 1285, 10.1111/j.1460-9568.1992.tb00154.x

Jay, 1991, Distribution of hippocampal CA1 and subicular efferents in the prefrontal cortex of the rat studied by means of anterograde transport of Phaseolus vulgaris-leucoagglutinin, J. Comp. Neurol., 313, 574, 10.1002/cne.903130404

Ji, 2007, Hippocampal involvement in contextual modulation of fear extinction, Hippocampus, 17, 749, 10.1002/hipo.20331

Johansen, 2011, Molecular mechanisms of fear learning and memory, Cell, 147, 509, 10.1016/j.cell.2011.10.009

Johansen, 2010, Optical activation of lateral amygdala pyramidal cells instructs associative fear learning, Proc. Natl. Acad. Sci. USA, 107, 12692, 10.1073/pnas.1002418107

Jones, 2005, Theta rhythms coordinate hippocampal–prefrontal interactions in a spatial memory task, PLoS Biol., 3, e402, 10.1371/journal.pbio.0030402

Jovanovic, 2010, How the neurocircuitry and genetics of fear inhibition may inform our understanding of PTSD, Am. J. Psychiatry, 167, 648, 10.1176/appi.ajp.2009.09071074

Judo, 2010, Early stress exposure impairs synaptic potentiation in the rat medial prefrontal cortex underlying contextual fear extinction, Neuroscience, 169, 1705, 10.1016/j.neuroscience.2010.06.035

Kalisch, 2006, Context-dependent human extinction memory is mediated by a ventromedial prefrontal and hippocampal network, J. Neurosci., 26, 9503, 10.1523/JNEUROSCI.2021-06.2006

Karayiorgou, 2010, 22q11.2 microdeletions: linking DNA structural variation to brain dysfunction and schizophrenia, Nat. Rev. Neurosci., 11, 402, 10.1038/nrn2841

Karl, 2006, A meta-analysis of structural brain abnormalities in PTSD, Neurosci. Biobehav. Rev., 30, 1004, 10.1016/j.neubiorev.2006.03.004

Kaufman, 2000, Comorbidity of mood and anxiety disorders, Depress. Anxiety, 12, 69, 10.1002/1520-6394(2000)12:1+<69::AID-DA9>3.0.CO;2-K

Kegeles, 2003, Response of cortical metabolic deficits to serotonergic challenge in familial mood disorders, Am. J. Psychiatry, 160, 76, 10.1176/appi.ajp.160.1.76

Kesner, 2011, An analysis of rat prefrontal cortex in mediating executive function, Neurobiol. Learn. Mem., 96, 417, 10.1016/j.nlm.2011.07.002

Kirkbride, 2012, Incidence of schizophrenia and other psychoses in England, 1950–2009: a systematic review and meta-analyses, PLoS One, 7, e31660, 10.1371/journal.pone.0031660

Kiss, 2011, Delta oscillation and short-term plasticity in the rat medial prefrontal cortex: modelling NMDA hypofunction of schizophrenia, Int. J. Neuropsychopharmacol., 14, 29, 10.1017/S1461145710000271

Knapska, 2009, Reciprocal patterns of c-Fos expression in the medial prefrontal cortex and amygdala after extinction and renewal of conditioned fear, Learn. Mem., 16, 486, 10.1101/lm.1463909

Kolling, 2012, Neural mechanisms of foraging, Science, 336, 95, 10.1126/science.1216930

Kubicki, 2005, DTI and MTR abnormalities in schizophrenia: analysis of white matter integrity, Neuroimage, 26, 1109, 10.1016/j.neuroimage.2005.03.026

Kucewicz, 2011, Dysfunctional prefrontal cortical network activity and interactions following cannabinoid receptor activation, J. Neurosci., 31, 15560, 10.1523/JNEUROSCI.2970-11.2011

Lakshminarasimhan, 2012, Stress leads to contrasting effects on the levels of brain derived neurotrophic factor in the hippocampus and amygdala, PLoS One, 7, e30481, 10.1371/journal.pone.0030481

Laroche, 1990, Long-term potentiation in the prefrontal cortex following stimulation of the hippocampal CA1/subicular region, Neurosci. Lett., 114, 184, 10.1016/0304-3940(90)90069-L

Lederbogen, 2011, City living and urban upbringing affect neural social stress processing in humans, Nature, 474, 498, 10.1038/nature10190

Lewis, 2012, Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia, Trends Neurosci., 35, 57, 10.1016/j.tins.2011.10.004

Li, 2008, Inhibitory control and emotional stress regulation: neuroimaging evidence for frontal-limbic dysfunction in psycho-stimulant addiction, Neurosci. Biobehav. Rev., 32, 581, 10.1016/j.neubiorev.2007.10.003

Liberzon, 2008, The functional neuroanatomy of PTSD: a critical review, Prog. Brain Res., 167, 151, 10.1016/S0079-6123(07)67011-3

Likhtik, 2008, Amygdala intercalated neurons are required for expression of fear extinction, Nature, 454, 642, 10.1038/nature07167

Lim, 2010, Locus coeruleus stimulation and noradrenergic modulation of hippocampo-prefrontal cortex long-term potentiation, Int. J. Neuropsychopharmacol., 13, 1219, 10.1017/S1461145709991131

Liston, 2009, Psychosocial stress reversibly disrupts prefrontal processing and attentional control, Proc. Natl. Acad. Sci. USA, 106, 912, 10.1073/pnas.0807041106

Lodge, 2011, Hippocampal dysregulation of dopamine system function and the pathophysiology of schizophrenia, Trends Pharmacol. Sci., 32, 507, 10.1016/j.tips.2011.05.001

Lopez, 1999, Neural circuits mediating stress, Biol. Psychiatry, 46, 1461, 10.1016/S0006-3223(99)00266-8

Mailliet, 2008, Protection of stress-induced impairment of hippocampal/prefrontal LTP through blockade of glucocorticoid receptors: implication of MEK signaling, Exp. Neurol., 211, 593, 10.1016/j.expneurol.2008.02.030

Mantella, 2007, Cognitive impairment in late-life generalized anxiety disorder, Am. J. Geriatr. Psychiatry, 15, 673, 10.1097/JGP.0b013e31803111f2

Maren, 2001, Neurobiology of Pavlovian fear conditioning, Annu. Rev. Neurosci., 24, 897, 10.1146/annurev.neuro.24.1.897

Mayberg, 1997, Limbic-cortical dysregulation: a proposed model of depression, J. Neuropsychiatry Clin. Neurosci., 9, 471, 10.1176/jnp.9.3.471

Mayberg, 1999, Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness, Am. J. Psychiatry, 156, 675, 10.1176/ajp.156.5.675

Mayberg, 2005, Deep brain stimulation for treatment-resistant depression, Neuron, 45, 651, 10.1016/j.neuron.2005.02.014

McEwen, 2007, Physiology and neurobiology of stress and adaptation: central role of the brain, Physiol. Rev., 87, 873, 10.1152/physrev.00041.2006

McNally, 1997, Memory and anxiety disorders, Philos. Trans. R. Soc. London B Biol. Sci., 352, 1755, 10.1098/rstb.1997.0158

Meyer-Lindenberg, 2005, Regionally specific disturbance of dorsolateral prefrontal–hippocampal functional connectivity in schizophrenia, Arch. Gen. Psychiatry, 62, 379, 10.1001/archpsyc.62.4.379

Milad, 2009, Neurobiological basis of failure to recall extinction memory in posttraumatic stress disorder, Biol. Psychiatry, 66, 1075, 10.1016/j.biopsych.2009.06.026

Milad, 2002, Neurons in medial prefrontal cortex signal memory for fear extinction, Nature, 420, 70, 10.1038/nature01138

Milad, 2012, Fear extinction as a model for translational neuroscience: ten years of progress, Annu. Rev. Psychol., 63, 129, 10.1146/annurev.psych.121208.131631

Milad, 2007, Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concert, Biol. Psychiatry, 62, 446, 10.1016/j.biopsych.2006.10.011

Mobbs, 2009, From threat to fear: the neural organization of defensive fear systems in humans, J. Neurosci., 29, 12236, 10.1523/JNEUROSCI.2378-09.2009

Moore, 2007, Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review, Lancet, 370, 319, 10.1016/S0140-6736(07)61162-3

Muller, 2006, The functional neuroanatomy of working memory: contributions of human brain lesion studies, Neuroscience, 139, 51, 10.1016/j.neuroscience.2005.09.018

Noakes, 2012, Olympics: run for your life, Nature, 487, 295, 10.1038/487295a

O'Donnell, 1995, Synaptic interactions among excitatory afferents to nucleus accumbens neurons: hippocampal gating of prefrontal cortical input, J. Neurosci., 15, 3622, 10.1523/JNEUROSCI.15-05-03622.1995

O'Mara, 2009, Roles for the subiculum in spatial information processing, memory, motivation and the temporal control of behaviour, Prog. Neuropsychopharmacol. Biol. Psychiatry, 33, 782, 10.1016/j.pnpbp.2009.03.040

Ohashi, 2003, The serotonergic modulation of synaptic plasticity in the rat hippocampo-medial prefrontal cortex pathway, Neurosci. Lett., 342, 179, 10.1016/S0304-3940(03)00293-3

Ongur, 2000, The organization of networks within the orbital and medial prefrontal cortex of rats, monkeys and humans, Cereb. Cortex, 10, 206, 10.1093/cercor/10.3.206

Orsini, 2011, Hippocampal and prefrontal projections to the Basal amygdala mediate contextual regulation of fear after extinction, J. Neurosci., 31, 17269, 10.1523/JNEUROSCI.4095-11.2011

Parent, 2010, Identification of the hippocampal input to medial prefrontal cortex in vitro, Cereb. Cortex, 20, 393, 10.1093/cercor/bhp108

Parker, 2002, Initial demonstration of in vivo tracing of axonal projections in the macaque brain and comparison with the human brain using diffusion tensor imaging and fast marching tractography, Neuroimage, 15, 797, 10.1006/nimg.2001.0994

Peen, 2010, The current status of urban–rural differences in psychiatric disorders, Acta Psychiatr. Scand., 121, 84, 10.1111/j.1600-0447.2009.01438.x

Pezawas, 2005, 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression, Nat. Neurosci., 8, 828, 10.1038/nn1463

Pittenger, 2008, Stress, depression, and neuroplasticity: a convergence of mechanisms, Neuropsychopharmacology, 33, 88, 10.1038/sj.npp.1301574

Porter, 2003, Neurocognitive impairment in drug-free patients with major depressive disorder, Br. J. Psychiatry, 182, 214, 10.1192/bjp.182.3.214

Qi, 2009, Antidepressants reverse the attenuation of the neurotrophic MEK/MAPK cascade in frontal cortex by elevated platform stress; reversal of effects on LTP is associated with GluA1 phosphorylation, Neuropharmacology, 56, 37, 10.1016/j.neuropharm.2008.06.068

Qiu, 2009, Hippocampal-cortical structural connectivity disruptions in schizophrenia: an integrated perspective from hippocampal shape, cortical thickness, and integrity of white matter bundles, Neuroimage, 52, 1181, 10.1016/j.neuroimage.2010.05.046

Rasetti, 2011, Altered cortical network dynamics: a potential intermediate phenotype for schizophrenia and association with ZNF804A, Arch. Gen. Psychiatry, 68, 1207, 10.1001/archgenpsychiatry.2011.103

Ressler, 2007, Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic, Nat. Neurosci., 10, 1116, 10.1038/nn1944

Richter-Levin, 2010, Stress and amygdala suppression of metaplasticity in the medial prefrontal cortex, Cereb. Cortex, 20, 2433, 10.1093/cercor/bhp311

Robbe, 2006, Cannabinoids reveal importance of spike timing coordination in hippocampal function, Nat. Neurosci., 9, 1526, 10.1038/nn1801

Rocher, 2004, Acute stress-induced changes in hippocampal/prefrontal circuits in rats: effects of antidepressants, Cereb. Cortex, 14, 224, 10.1093/cercor/bhg122

Romcy-Pereira, 2004, Distinct modulatory effects of sleep on the maintenance of hippocampal and medial prefrontal cortex LTP, Eur. J. Neurosci., 20, 3453, 10.1111/j.1460-9568.2004.03808.x

Sanderson, 2008, The role of the GluR-A (GluR1) AMPA receptor subunit in learning and memory, Prog. Brain Res., 169, 159, 10.1016/S0079-6123(07)00009-X

Santana, 2011, Activation of thalamocortical networks by the N-methyl-d-aspartate receptor antagonist phencyclidine: reversal by clozapine, Biol. Psychiatry, 69, 918, 10.1016/j.biopsych.2010.10.030

Schiller, 2008, From fear to safety and back: reversal of fear in the human brain, J. Neurosci., 28, 11517, 10.1523/JNEUROSCI.2265-08.2008

Schmiedt, 2005, Event-related theta oscillations during working memory tasks in patients with schizophrenia and healthy controls, Brain Res. Cogn. Brain Res., 25, 936, 10.1016/j.cogbrainres.2005.09.015

Seamans, 2008, Comparing the prefrontal cortex of rats and primates: insights from electrophysiology, Neurotox. Res., 14, 249, 10.1007/BF03033814

Seamans, 2004, The principal features and mechanisms of dopamine modulation in the prefrontal cortex, Prog. Neurobiol., 74, 1, 10.1016/j.pneurobio.2004.05.006

Sebban, 1999, Contrasting EEG profiles elicited by antipsychotic agents in the prefrontal cortex of the conscious rat: antagonism of the effects of clozapine by modafinil, Br. J. Pharmacol., 128, 1055, 10.1038/sj.bjp.0702893

Seminowicz, 2004, Limbic-frontal circuitry in major depression: a path modeling metanalysis, Neuroimage, 22, 409, 10.1016/j.neuroimage.2004.01.015

Shamy, 2011, Alterations of white matter tracts following neurotoxic hippocampal lesions in macaque monkeys: a diffusion tensor imaging study, Hippocampus, 20, 906, 10.1002/hipo.20737

Sheline, 2009, The default mode network and self-referential processes in depression, Proc. Natl. Acad. Sci. USA, 106, 1942, 10.1073/pnas.0812686106

Sheline, 1996, Hippocampal atrophy in recurrent major depression, Proc. Natl. Acad. Sci. USA, 93, 3908, 10.1073/pnas.93.9.3908

Shimamura, 1990, Memory for the temporal order of events in patients with frontal lobe lesions and amnesic patients, Neuropsychologia, 28, 803, 10.1016/0028-3932(90)90004-8

Siapas, 2005, Prefrontal phase locking to hippocampal theta oscillations, Neuron, 46, 141, 10.1016/j.neuron.2005.02.028

Sigurdsson, 2010, Impaired hippocampal–prefrontal synchrony in a genetic mouse model of schizophrenia, Nature, 464, 763, 10.1038/nature08855

Singer, 1999, Neuronal synchrony: a versatile code for the definition of relations?, Neuron, 24, 111

Sotres-Bayon, 2010, Prefrontal control of fear: more than just extinction, Curr. Opin. Neurobiol., 20, 231, 10.1016/j.conb.2010.02.005

Sotres-Bayon, 2012, Gating of fear in prelimbic cortex by hippocampal and amygdala inputs, Neuron, 76, 804, 10.1016/j.neuron.2012.09.028

Spedding, 2005, A pathophysiological paradigm for the therapy of psychiatric disease, Nat. Rev. Drug Discov., 4, 467, 10.1038/nrd1753

Sripada, 2012, Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorder, J. Psychiatry Neurosci., 37, 110069, 10.1503/jpn.110069

St Onge, 2012, Separate prefrontal–subcortical circuits mediate different components of risk-based decision making, J. Neurosci., 32, 2886, 10.1523/JNEUROSCI.5625-11.2012

Stopper, 2011, Contributions of the nucleus accumbens and its subregions to different aspects of risk-based decision making, Cogn. Affect. Behav. Neurosci., 11, 97, 10.3758/s13415-010-0015-9

Swanson, 1981, A direct projection from Ammon's horn to prefrontal cortex in the rat, Brain Res., 217, 150, 10.1016/0006-8993(81)90192-X

Takashima, 2006, Declarative memory consolidation in humans: a prospective functional magnetic resonance imaging study, Proc. Natl. Acad. Sci. USA, 103, 756, 10.1073/pnas.0507774103

Takita, 1999, Induction of stable long-term depression in vivo in the hippocampal–prefrontal cortex pathway, Eur. J. Neurosci., 11, 4145, 10.1046/j.1460-9568.1999.00870.x

Tierney, 2004, Influence of the hippocampus on interneurons of the rat prefrontal cortex, Eur. J. Neurosci., 20, 514, 10.1111/j.1460-9568.2004.03501.x

Uhlhaas, 2010, Abnormal neural oscillations and synchrony in schizophrenia, Nat. Rev. Neurosci., 11, 100, 10.1038/nrn2774

Uylings, 2003, Do rats have a prefrontal cortex?, Behav. Brain Res., 146, 3, 10.1016/j.bbr.2003.09.028

Verwer, 1997, Collateral projections from the rat hippocampal formation to the lateral and medial prefrontal cortex, Hippocampus, 7, 397, 10.1002/(SICI)1098-1063(1997)7:4<397::AID-HIPO5>3.0.CO;2-G

Vidal-Gonzalez, 2006, Microstimulation reveals opposing influences of prelimbic and infralimbic cortex on the expression of conditioned fear, Learn. Mem., 13, 728, 10.1101/lm.306106

Vyas, 2002, Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons, J. Neurosci., 22, 6810, 10.1523/JNEUROSCI.22-15-06810.2002

Wallis, 2011, Cross-species studies of orbitofrontal cortex and value-based decision-making, Nat. Neurosci, 15, 13, 10.1038/nn.2956

Wang, 2009, Activation of M2 muscarinic receptors leads to sustained suppression of hippocampal transmission in the medial prefrontal cortex, J. Physiol., 587, 5139, 10.1113/jphysiol.2009.174821

Weinberger, 1992, Evidence of dysfunction of a prefrontal-limbic network in schizophrenia: a magnetic resonance imaging and regional cerebral blood flow study of discordant monozygotic twins, Am. J. Psychiatry, 149, 890, 10.1176/ajp.149.7.890

Wolf, 2009, Temporally anticorrelated brain networks during working memory performance reveal aberrant prefrontal and hippocampal connectivity in patients with schizophrenia, Prog. Neuropsychopharmacol. Biol. Psychiatry, 33, 1464, 10.1016/j.pnpbp.2009.07.032

Yehuda, 2007, Response variation following trauma: a translational neuroscience approach to understanding PTSD, Neuron, 56, 19, 10.1016/j.neuron.2007.09.006

Yuen, 2009, Acute stress enhances glutamatergic transmission in prefrontal cortex and facilitates working memory, Proc. Natl. Acad. Sci. USA, 106, 14075, 10.1073/pnas.0906791106

Zhong, 2006, Distinctive morphology of hippocampal CA1 terminations in orbital and medial frontal cortex in macaque monkeys, Exp. Brain Res., 169, 549, 10.1007/s00221-005-0187-7

Zhou, 2008, Altered resting-state functional connectivity and anatomical connectivity of hippocampus in schizophrenia, Schizophr. Res., 100, 120, 10.1016/j.schres.2007.11.039