The hepatitis B virus transactivator HBx causes elevation of diacylglycerol and activation of protein kinase C

Research in Virology - Tập 144 - Trang 311-321 - 1993
B. Luber1, U. Lauer1, L. Weiss1, M. Höhne2, P.H. Hofschneider1, A.S. Kekulé1
1Max-Planck-Institut für Biochemie, 8033 Martinsried, Germany
2Institut für Medizinische Virologie, 6300 Giessen (Germany)

Tài liệu tham khảo

Aaronson, 1968, Basis for the acquisition of malignant potential by mouse cells cutivated in vitro, Science, 162, 1024, 10.1126/science.162.3857.1024 Angel, 1991, The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation, Biochim. Biophys. Acta (Amst), 1072, 129 Baniahmad, 1990, Modular structure of a chicken lysozyme silencer: involvement of an unusual thyroid hormone receptor binding site, Cell, 61, 505, 10.1016/0092-8674(90)90532-J Beasley, 1981, Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22707 men in Taiwan, Lancet, 1129, 10.1016/S0140-6736(81)90585-7 Billah, 1990, Review article: The regulation and cellular functions of phosphatidylcholine hydrolysis, Biochem. J., 269, 281, 10.1042/bj2690281 Chang, 1954, Continuous subcultivation of epithelial-like cells from normal human tissues, Proc. Soc. Exp. Biol., 87, 440, 10.3181/00379727-87-21406 Dejean, 1986, Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma, Nature (Lond.), 322, 70, 10.1038/322070a0 Gorman, 1982, Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells, Mol. Cell. Biol., 2, 1044, 10.1128/MCB.2.9.1044 Graham, 1973, A new technique for the assay of infectivity of human adenovirus 5 DNA, Virology, 52, 456, 10.1016/0042-6822(73)90341-3 Haliotis, 1990, Expression of ras oncogene leads to downregulation of protein kinase C, Int. J. Cancer, 45, 1177, 10.1002/ijc.2910450631 Hannun, 1986, Shingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets, J. Biol. Chem., 261, 12604, 10.1016/S0021-9258(18)67133-9 Hidaka, 1984, Isoquinoline sulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase, C. Biochemistry, 23, 5036, 10.1021/bi00316a032 Höhne, 1990, Malignant transformation of immortalized transgenic hepatocytes after transfection with hepatitis B virus DNA, EMBO J., 9, 1137, 10.1002/j.1460-2075.1990.tb08220.x Hoffmann, 1989, Proliferation of fetal rat hepatocytes in response to growth factors and hormones in primary culture, J. Cell. Physiol., 139, 654, 10.1002/jcp.1041390328 Kekulé, 1993, Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway, Nature (Lond.), 361, 742, 10.1038/361742a0 Kim, 1991, HBx gene of hepatitis B virus induces liver cancer in transgenic mice, Nature (Lond.), 351, 317, 10.1038/351317a0 Lee, 1990, Hepatitis B virus transactivator X protein is not tumorigenic in transgenic mice, J. Virol., 64, 5939, 10.1128/JVI.64.12.5939-5947.1990 Loomis, 1988, Sangivamycin, a nucleoside analogue, is a potent inhibitor of protein kinase C, J. Biol. Chem., 263, 1682, 10.1016/S0021-9258(19)77930-7 Maguire, 1991, HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions, Science, 252, 842, 10.1126/science.1827531 Maly, 1989, Ha-ras activates the Na+/H+ antiporter by a protein kinase C-independent mechanism, J. Biol. Chem., 264, 11839, 10.1016/S0021-9258(18)80142-9 Megidish, 1989, A mutant protein kinase C that can transform fibroblasts, Nature (Lond.), 342, 807, 10.1038/342807a0 Nishizuka, 1984, The role of protein kinase C in cell surface signal transduction and tumour promotion, Nature (Lond.), 308, 693, 10.1038/308693a0 Piccoletti, 1990, Activity and distribution of protein kinase C in liver during the acute-phase response, Biochem. Biophys. Res. Commun., 167, 345, 10.1016/0006-291X(90)91771-J Preiss, 1986, Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells, J. Biol. Chem., 261, 8597, 10.1016/S0021-9258(19)84420-4 Rossner, 1992, Review: Hepatitis B virus X-gene product: A promiscuous transcriptional activator, J. Med. Virol., 36, 101, 10.1002/jmv.1890360207 Schütte, 1989, Deregulated expression of human c-jun transforms primary rat embryo cells in cooperation with an activated c-Ha-ras gene and transforms Rat-1a cells as a single gene, 86, 2257 Seifer, 1991, In vitro tumorigenicity of hepatitis B virus DNA and HBx protein, J. Hepatology, 13, S61, 10.1016/0168-8278(91)90026-8 Seto, 1990, Transactivation by the hepatitis B virus X protein depends on AP-2 and other transcription factors, Nature (Lond.), 344, 72, 10.1038/344072a0 Shirakata, 1989, The X gene of hepatitis B virus induced growth stimulation and tumorigenic transformation of mouse NIH3T3 cells, Jap. J. Cancer Res., 80, 617, 10.1111/j.1349-7006.1989.tb01686.x Spandau, 1988, Trans-activation of viral enhancers by the hepatitis B virus X protein, J. Virol., 62, 427, 10.1128/JVI.62.2.427-434.1988 Twu, 1987, Transcriptional trans-activating function of hepatitis B virus, J. Virol., 61, 3448, 10.1128/JVI.61.11.3448-3453.1987 Unger, 1990, The X protein of the hepatitis V virus acts as a transcription factor when targeted to its responsive element, EMBO J., 9, 1889, 10.1002/j.1460-2075.1990.tb08315.x Van Veldhoven, 1988, Effect of harvesting methods, growth conditions and growth phase on diacylglycerol levels in cultured human adherent cells, Biochem. Biophys. Acta (Amst.), 959, 185, 10.1016/0005-2760(88)90030-6 Wang, 1990, Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma, Nature (Lond.), 343, 555, 10.1038/343555a0 Wolfman, 1987, Elevated levels of diacylglycerol and decreased phorol ester sensitivity in ras-transformed fibroblasts, Nature (Lond.), 325, 359, 10.1038/325359a0 Wollersheim, 1988, A transactivating function encoded in the hepatitis B virus X gene is conserved in the integrated state, Oncogene, 3, 545 Wu, 1990, The hepatitis B virus-encoded transcriptional Trans-activator hbx appears to be a novel protein serine/threonine kinase, Cell, 63, 687, 10.1016/0092-8674(90)90135-2 Young, 1987, Downregulation of protein kinase C is due to an increased rate of degradation, Biochem. J., 244, 775, 10.1042/bj2440775 Zahm, 1988, The HBV X-ORF encodes a transactivator: a potential factor in viral hepatocarcinogenesis, Oncogene, 3, 169