The heart is lost without the hypothalamus

Handbook of Clinical Neurology - Tập 182 - Trang 355-367 - 2021
Susan Pyner1
1Department of Biosciences, Durham University, Durham, United Kingdom

Tài liệu tham khảo

Affleck, 2012, The projection and synaptic organisation of NTS afferent connections with presympathetic neurons GABA and nNOS neurons in the paraventricular nucleus of the hypothalamus, Neuroscience, 219, 48, 10.1016/j.neuroscience.2012.05.070 Alderton, 2001, Nitric oxide synthases: structure, function and inhibition, Biochem J, 357, 593, 10.1042/bj3570593 Alkaitis, 2012, Recoupling the cardiac nitric oxide synthases: tetrahydrobiopterin synthesis and recycling, Curr Heart Fail Rep, 9, 200, 10.1007/s11897-012-0097-5 Bains, 1994, Angiotensin II neurotransmitter actions in paraventricular nucleus are potentiated by a nitric oxide synthase inhibitor, Regul Pept, 50, 53, 10.1016/0167-0115(94)90191-0 Bains, 1992, Angiotensin II actions in paraventricular nucleus: functional evidence for neurotransmitter role in efferents originating in subfornical organ, Brain Res, 599, 223, 10.1016/0006-8993(92)90395-P Bardgett, 2015, SD95 coupling of NMDA receptor activation and nitric oxide activity in the hypothalamic PVN, FASEB J, 29, 987.7, 10.1096/fasebj.29.1_supplement.652.5 Bender, 2000, Ubiquitination of neuronal nitric oxide synthase in vitro and in vivo, J Biol Chem, 275, 17407, 10.1074/jbc.M000155200 Biancardi, 2010, Altered balance of γ-aminobutyric acidergic and glutamatergic afferent inputs in rostral ventrolateral medulla-projecting neurons in the paraventricular nucleus of the hypothalamus of renovascular hypertensive rats, J Comp Neurol, 518, 567, 10.1002/cne.22256 Biancardi, 2014, Circulating angiotensin II gains access to the hypothalamus and brain stem during hypertension via breakdown of the blood-brain barrier, Hypertension, 63, 572, 10.1161/HYPERTENSIONAHA.113.01743 Bredt, 1996, Targeting nitric oxide to its target, Proc Soc Exp Biol Med, 211, 41, 10.3181/00379727-211-43950F Bredt, 1992, Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites, J Biol Chem, 267, 10976, 10.1016/S0021-9258(19)49862-1 Brenman, 1996, Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha-1 syntrophin mediated by PDZ domains, Cell, 84, 757, 10.1016/S0092-8674(00)81053-3 Brenman, 1996, Cloning and characterisation of postsynaptic density 93, a nitric oxide synthase interacting protein, J Neurosci, 16, 7407, 10.1523/JNEUROSCI.16-23-07407.1996 Brune, 1991, Phosphorylation of nitric oxide synthase by protein kinase a, Biochem Biophys Res Commun, 181, 921, 10.1016/0006-291X(91)91279-L Campos, 2006, Neurotransmission alterations in central cardiovascular control in experimental hypertension, Curr Hypertens Rev, 2, 193, 10.2174/157340206778132590 Cardinale, 2012, Angiotensin II induced hypertension is modulated by nuclear factor -κB in the paraventricular nucleus, Hypertension, 59, 113, 10.1161/HYPERTENSIONAHA.111.182154 Chaudhury, 2008, PIN/LC8 is associated with cytosolic but not membrane bound nNOS in the nitrergic varicosities of mice gut: implications for nitrergic neurotransmission, Am J Physiol, 295, G442 Chen, 2006, Regulation of synaptic input to hypothalamic presympathetic neurons by GABAB receptors, Neuroscience, 142, 595, 10.1016/j.neuroscience.2006.06.039 Chen, 2007, Signalling mechanisms of angiotensin II-induced attenuation of GABAergic input to hypothalamic presympathetic neurons, J Neurophysiol, 97, 3279, 10.1152/jn.01329.2006 Chen, 2000, AMPK signalling in contracting human skeletal muscle: acetyl-CoA carboxylase and NO synthase phosphorylation, Am J Physiol, 279, E1202 Christopherson, 1999, PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain, J Biol Chem, 274, 27467, 10.1074/jbc.274.39.27467 Decaval, 1990, GABA: a dominant neurotransmitter in the hypothalamus, J Comp Neurol, 302, 1019, 10.1002/cne.903020423 Deering, 2000, Paraventricular neurons elicit a volume expansion like change in sympathetic nerves to the heart and kidney in the rabbit, Exp Physiol, 85, 177, 10.1111/j.1469-445X.2000.01953.x Días, 2020, Neuroinflammation in heart failure: new insights for an old disease, J Physiol, 598, 33, 10.1113/JP278864 Elfering, 2002, Biochemistry of mitochondrial nitric oxide synthase, J Biol Chem, 277, 38079, 10.1074/jbc.M205256200 Francis, 2004, Acute myocardial infarction induces hypothalamic cytokine synthesis, Am J Physiol, 286, H2264 Francis, 2004, Neural regulation of the pro-inflammatory cytokine response to acute myocardial infarction, Am J Physiol, 287, H791 Garthwaite, 1989, NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slices, Eur J Pharmacol, 172, 413, 10.1016/0922-4106(89)90023-0 Gorlach, 2001, Thrombin activates the hypoxia inducible factor 1 signaling pathway in vascular smooth muscle cells; Role of the p22phox containing NADPH oxidase, Circ Res, 89, 47, 10.1161/hh1301.092678 Guggilam, 2007, TNF-α blockade decreases oxidative stress in the paraventricular nucleus and attenuates sympathoexcitation in heart failure rats, Am J Physiol, 293, H599 Guggilam, 2011, Central TNF inhibition results in attenuated neurohumoral excitation in heart failure: a role for superoxide and nitric oxide, Basic Res Cardiol, 106, 273, 10.1007/s00395-010-0146-8 Guix, 2005, The physiology and pathophysiology of nitric oxide in the brain, Prog Neurobiol, 76, 126, 10.1016/j.pneurobio.2005.06.001 Guyenet, 2006, The sympathetic control of blood pressure, Nat Neurosci, 7, 335, 10.1038/nrn1902 Haddad, 2001, A non hypoxic ROS-sensitive pathway mediates TNF-α dependent regulation of HIF-1α, FEBS Lett, 505, 269, 10.1016/S0014-5793(01)02833-2 Hainsworth, 1991, Reflexes from the heart, Physiol Rev, 71, 617, 10.1152/physrev.1991.71.3.617 Han, 2007, Reactive oxygen species in the paraventricular nucleus mediate the cardiac sympathetic afferent reflex in chronic heart failure rats, Eur J Heart Fail, 9, 967, 10.1016/j.ejheart.2007.07.004 Haselton, 1994, Parvocellular neurons of the paraventricular nucleus are involved in the reduction in renal nerve discharge during isotonic volume expansion, J Auton Nerv Syst, 50, 1, 10.1016/0165-1838(94)90117-1 Hayashi, 1999, Regulation of neuronal nitric oxide synthase by calmodulin kinases, J Biol Chem, 274, 20597, 10.1074/jbc.274.29.20597 Herman, 2000, Expression of ionotropic glutamate receptor subunit mRNAs in the hypothalamic paraventricular nucleus of the rat, J Comp Neurol, 422, 352, 10.1002/1096-9861(20000703)422:3<352::AID-CNE3>3.0.CO;2-F Hershko, 1998, The ubiquitin system, Annu Rev Biochem, 67, 425, 10.1146/annurev.biochem.67.1.425 Hirooka, 2003, Reduced nitric oxide synthase in the brainstem contributes to enhanced sympathetic drive in rats with heart failure, J Cardiovasc Pharmacol, 42, S111, 10.1097/00005344-200312001-00023 Hochstrasser, 1996, Ubiquitin dependent protein degradation, Annu Rev Genet, 30, 405, 10.1146/annurev.genet.30.1.405 Hosoya, 1980, The distribution of spinal projection neurons in the hypothalamus of the rat, studied with the HRP method, Exp Brain Res, 40, 79, 10.1007/BF00236665 Infanger, 2010, Silencing Nox4 in the paraventricular nucleus improves myocardial infarction-induced cardiac dysfunction by attenuating sympathoexcitation and periinfarct apoptosis, Circ Res, 16, 1763, 10.1161/CIRCRESAHA.109.213025 Jaffrey, 1996, PIN: an associated protein inhibitor of neuronal nitric oxide synthase, Science, 274, 774, 10.1126/science.274.5288.774 Jaffrey, 1998, CAPON: a protein associated with neuronal nitric acid synthase that regulates its interactions with PSD95, Neuron, 20, 115, 10.1016/S0896-6273(00)80439-0 Jaffrey, 2002, Neuronal nitric oxide synthase localisation mediated by a ternary complex with synapsin and CAPON, Proc Natl Acad Sci, 99, 3199, 10.1073/pnas.261705799 Kang, 2009, Brain tumour necrosis factor-α modulates neurotransmitters in hypothalamic paraventricular nucleus in heart failure, Cardiovasc Res, 83, 737, 10.1093/cvr/cvp160 Kappagoda, 1973, Effect of stimulating right atrial receptors on urine flow in the dog, J Physiol, 235, 493, 10.1113/jphysiol.1973.sp010399 Kennedy, 2000, Signal-processing machines at the postsynaptic density, Science, 290, 750, 10.1126/science.290.5492.750 Kleiber, 2010, Chronic AT1 receptor blockade normalises NMDA mediated changes in renal sympathetic nerve activity and NR1 expression within the PVN in rats with heart failure, Am J Physiol, 1152, 1546 Komeima, 2000, Inhibition of neuronal nitric oxide synthase by calcium/calmodulin-dependent protein kinase IIα through Ser847 phosphorylation in NG108-15 neuronal cells, J Biol Chem, 275, 28139, 10.1074/jbc.M003198200 Kone, 2000, Protein-protein interactions controlling nitric oxide synthase, Acta Physiol Scand, 168, 27, 10.1046/j.1365-201x.2000.00629.x Kornau, 1997, Interactions of ion channels and receptors with PDZ domain proteins, Curr Opin Neurobiol, 7, 368, 10.1016/S0959-4388(97)80064-5 Li, 2005, Angiotensin II attenuates synaptic GABA release and excites paraventricular-rostral ventrolateral medulla output, J Pharmacol Exp Ther, 313, 1035, 10.1124/jpet.104.082495 Li, 2006, Plasticity of GABAergic control of hypothalamic presympathetic neurons in hypertension, Am J Physiol, 290, H1110 Li, 2007, Role of GABAA and GABAB receptors in paraventricular nucleus maintain sympathetic vasomotor tone in hypertension, J Pharmacol Exp Ther, 320, 615, 10.1124/jpet.106.109538 Li, 2003, Paraventricular nucleus of the hypothalamus and elevated sympathetic activity in heart failure: altered inhibitory mechanisms, Acta Physiol Scand, 177, 17, 10.1046/j.1365-201X.2003.01043.x Li, 2003, Alterations in NMDA NR1 receptors within the paraventricular nucleus of hypothalamus in rats with heart failure, Circ Res, 93, 990, 10.1161/01.RES.0000102865.60437.55 Li, 2004, Signalling pathway of nitric oxide in synaptic GABA release in the rat paraventricular nucleus, J Physiol, 554, 100, 10.1113/jphysiol.2003.053371 Li, 2006, Interactions between glutamate and GABA systems in the integration of sympathetic outflow by the paraventricular nucleus of the hypothalamus, Am J Physiol, 291, H2847 Li, 2008, Pre- and postsynaptic plasticity underlying augmented glutamatergic inputs to hypothalamic presympathetic neurons in spontaneously hypertensive rats, J Physiol, 586, 1637, 10.1113/jphysiol.2007.149732 Li, 2008, Plasticity of pre- and postsynaptic GABAB receptor function in the paraventricular nucleus in in spontaneously hypertensive rats, Am J Physiol, 295, H807 Lovick, 1988, Effects of volume loading on paraventriculo-spinal neurons in the rat, J Auton Nerv Syst, 25, 135, 10.1016/0165-1838(88)90018-5 Lovick, 1993, Renal vasodilatation in response to acute volume load is attenuated following lesions of parvocellular neurons in the paraventricular nucleus in rats, J Auton Nerv Syst, 43, 247, 10.1016/0165-1838(93)90331-N Lucassen, 1997, Unchanged amounts of vasopressin mRNA in the supraoptic and paraventricular nucleus during aging and in Alzheimer's disease, J Neuroendocrinol, 9, 297, 10.1046/j.1365-2826.1997.t01-1-00583.x Martin, 1991, Cardiovascular response to bicuculline in the paraventricular nucleus of the rat, Hypertension, 18, 48, 10.1161/01.HYP.18.1.48 May, 2010, Specific control of sympathetic nerve activity to the heart and kidney, Exp Physiol, 95, 34, 10.1113/expphysiol.2008.046342 McKinley, 1994, Identification of neural pathways activated in dehydrated rats by mean of Fos-immunohistochemistry and neural tracing, Brain Res, 653, 305, 10.1016/0006-8993(94)90405-7 Nakane, 1991, Phosphorylation by calcium calmodulin dependent protein kinase II and protein kinase C modulates the activity of nitric oxide synthase, Biochem Biophys Res Commu, 180, 1396, 10.1016/S0006-291X(05)81351-8 Okada, 1998, Tetrahydrobiopterin dependent stabilization of neuronal nitric oxide synthase dimer reduces susceptibility to phosphorylation by protein kinase C in vitro, FEBS Lett, 434, 261, 10.1016/S0014-5793(98)00993-4 Patel, 1993, Alterations in brain hexokinase activity associated with heart failure in rats, Am J Physiol, 265, R923 Pyner, 1999, Identification of an efferent projecting from the paraventricular nucleus of the hypothalamus terminating close to spinally projecting rostral ventrolateral medullary neurons, Neuroscience, 88, 949, 10.1016/S0306-4522(98)00255-3 Pyner, 2000, Identification of branching paraventricular neurons of the hypothalamus that project to the rostroventrolateral medulla and spinal cord, Neuroscience, 100, 549, 10.1016/S0306-4522(00)00283-9 Pyner, 2002, Right atrial stretch induces renal nerve inhibition and c-fos expression in parvocellular neurons of the paraventricular nucleus in rats, Exp Physiol, 87, 25, 10.1113/eph8702279 Rameau, 2007, Biphasic coupling of neuronal nitric oxide synthase phosphorylation to the NMDA receptor regulates AMAP receptor trafficking and neuronal cell death, J Neurosci, 27, 3445, 10.1523/JNEUROSCI.4799-06.2007 Richard, 2000, Nonhypoxic pathway mediates the induction of hypoxia -inducible factor 1α in vascular smooth muscle cells, J Biol Chem, 275, 26765, 10.1016/S0021-9258(19)61441-9 Rinetti, 2010, Ubiquitination acutely regulates presynaptic neurotransmitter release in mammalian neurons, J Neurosci, 30, 3157, 10.1523/JNEUROSCI.3712-09.2010 Safran, 2003, HIF hydroxylation and the mammalian oxygen-sensing pathway, J Clin Invest, 111, 779, 10.1172/JCI200318181 Saper, 1976, Direct hypothalamic autonomic connections, Brain Res, 117, 305, 10.1016/0006-8993(76)90738-1 Shafton, 1998, Neurons in the hypothalamic paraventricular nucleus send collaterals to the spinal cord and to the rostral ventrolateral medulla in the rat, Brain Res, 801, 239, 10.1016/S0006-8993(98)00587-3 Shalizi, 2007, PIASx is a MEF2 SUMO E3 ligase that promotes postsynaptic dendritic morphogenesis, J Neurosci, 27, 10037, 10.1523/JNEUROSCI.0361-07.2007 Sharma, 2017, Posttranslational regulation of neuronal nitric oxide synthase: implications for sympatho-excitatory states, Expert Opin Ther Targets, 21, 11, 10.1080/14728222.2017.1265505 Sharma, 2011, Decreased nNOS in the PVN leads to increased sympathoexcitation in chronic heart failure: role for CAPON and Ang II, Cardiovasc Res, 92, 348, 10.1093/cvr/cvr217 Sharma, 2013, Angiotensin II-mediated posttranslational modification of nNOS in the PVN of rats with CHF: role for PIN, Am J Physiol, 305, H843 Sharma, 2016, HIF-1α mediates increased sympathoexcitation via glutamatergic NMDA receptors in the PVN of rats with chronic heart failure, Circ Heart Fail, 9, 1, 10.1161/CIRCHEARTFAILURE.116.003423 Sharma, 2020, Central angiotensin II-protein inhibitor of neuronal nitric oxide synthase (PIN) axis contribute to neurogenic hypertension, Nitric Oxide, 94, 54, 10.1016/j.niox.2019.10.007 Shenton, 2016, Vagal afferents, sympathetic efferents and the role of the PVN in heart failure, Auton Neurosci, 199, 38, 10.1016/j.autneu.2016.08.009 Shi, 2010, Brain microglial cytokines in neurogenic hypertension, Hypertension, 56, 297, 10.1161/HYPERTENSIONAHA.110.150409 Sriramula, 2015, Tumour necrosis factor-alpha is essential for angiotensin II-induced ventricular remodelling: role for oxidative stress, PLoS One, 10, 10.1371/journal.pone.0138372 Stern, 2004, Nitric oxide and homeostatic control: an intracellular signalling molecule contributing to autonomic and neuroendocrine integration?, Prog Biophys Mol Biol, 84, 197, 10.1016/j.pbiomolbio.2003.11.015 Stern, 2013, Bidirectional neuro-glial signalling modalities in the hypothalamus: role in neurohumoral regulation, Auton Neurosci, 175, 51, 10.1016/j.autneu.2012.12.009 Stiel, 2002, Normoxic induction of the hypoxia-inducible factor 1α by insulin and interleukin-1β involves the phosphatidylinositol 3-kinase pathway, FEBS Lett, 512, 157, 10.1016/S0014-5793(02)02247-0 Stocker, 2006, Water deprivation activates a glutamatergic projection from the hypothalamic paraventricular nucleus to the rostral ventrolateral medulla, J Comp Neurol, 494, 673, 10.1002/cne.20835 Swanson, 1983, Hypothalamic integration: organisation of the paraventricular and supraoptic nuclei, Annu Rev Neurosci, 6, 269, 10.1146/annurev.ne.06.030183.001413 Van Uden, 2008, Regulation of hypoxia inducible factor- 1α by NF-κB, Biochem J, 412, 477, 10.1042/BJ20080476 Voges, 1999, The 26S proteasome: a molecular machine designed for controlled proteolysis, Annu Rev Biochem, 68, 1015, 10.1146/annurev.biochem.68.1.1015 Wang, 2014, RNA silencing targeting PIN (protein inhibitor of neuronal nitric oxide synthase) attenuates the development of hypertension in young spontaneously hypertensive rats, J Am Soc Hypertens, 8, 5, 10.1016/j.jash.2013.07.010 Wang, 2014, Angiotensin II sympathetic nerve activity and chronic heart failure, Heart Fail Rev, 19, 187, 10.1007/s10741-012-9368-1 Watkins, 2009, An immunohistochemical investigation of the relationship between NOS, GABA and pre-sympathetic paraventricular neurons in the hypothalamus, Neuroscience, 159, 1079, 10.1016/j.neuroscience.2009.01.012 Wenger, 2000, Mammalian oxygen sensing, signalling and gene regulation, J Exp Biol, 203, 1253, 10.1242/jeb.203.8.1253 Wolf, 2004, Angiotensin II induces hypoxia-inducible factor-1α in PC 12 cells through a posttranscriptional mechanism: role of AT2 receptors, Am J Nephrol, 24, 415, 10.1159/000080086 Xu, 2015, Brain mechanisms of sympathetic activation in heart failure: roles of the renin-angiotensin system, nitric oxide and pro-inflammatory cytokines, Mol Med Rep, 12, 7823, 10.3892/mmr.2015.4434 Xu, 2012, Enhanced activation of RVLM-projecting PVN neurons in rats with chronic heart failure, Am J Physiol, 302, H1700 Yang, 2006, The role of the proteasome-ubiquitin pathway in regulation of the IFN-γ mediated anti-VSV response in neurons, J Neuroimmunol, 181, 34, 10.1016/j.jneuroim.2006.07.018 Zhang, 1997, Nitric oxide within the paraventricular nucleus mediates changes in renal sympathetic nerve activity, Am J Physiol, 276, H1608 Zhang, 2001, Blunted nitric oxide-mediated inhibition of renal nerve discharge within the PVN of rats with heart failure, Am J Physiol, 281, H995 Zheng, 2005, Exercise training improves endogenous nitric oxide mechanisms within the paraventricular nucleus in rats with heart failure, Am J Physiol, 288, H2332 Zheng, 2006, Blunted nitric oxide-mediated inhibition of sympathetic nerve activity within the paraventricular nucleus in diabetic rats, Am J Physiol, 290, R992 Zucker, 2001, The regulation of sympathetic outflow in heart failure. The roles of angiotensin II, nitric oxide and exercise training, Ann N Y Acad Sci, 940, 431, 10.1111/j.1749-6632.2001.tb03696.x Zucker, 2004, The origin of sympathetic outflow in heart failure: the roles of angiotensin II and nitric oxide, Prog Biophys Mol Biol, 84, 217, 10.1016/j.pbiomolbio.2003.11.010