The glucocorticoid receptor: Pivot of depression and of antidepressant treatment?

Adzic, 2009, Acute or chronic stress induce cell compartment-specific phosphorylation of glucocorticoid receptor and alter its transcriptional activity in Wistar rat brain, J. Endocrinol., 202, 87, 10.1677/JOE-08-0509 Alt, 2009, Differential expression of glucocorticoid receptor transcripts in major depressive disorder is not epigenetically programmed, Psychoneuroendocrinology Antoni, 1993, Vasopressinergic control of pituitary adrenocorticotropin secretion comes of age, Front. Neuroendocrinol., 14, 76, 10.1006/frne.1993.1004 Ardayfio, 2006, Anxiogenic-like effect of chronic corticosterone in the light-dark emergence task in mice, Behav. Neurosci., 120, 249, 10.1037/0735-7044.120.2.249 Augustyn, 2005, Effects of some new antidepressant drugs on the glucocorticoid receptor-mediated gene transcription in fibroblast cells, Pharmacol. Rep., 57, 766 Bamberger, 1995, Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans, J. Clin. Invest., 95, 2435, 10.1172/JCI117943 Beger, 2003, Expression and structural analysis of glucocorticoid receptor isoform gamma in human leukaemia cells using an isoform-specific real-time polymerase chain reaction approach, Br. J. Haematol., 122, 245, 10.1046/j.1365-2141.2003.04426.x Blazer, 2000, Controversies in community-based psychiatric epidemiology: let the data speak for themselves, Arch. Gen. Psychiatry, 57, 227, 10.1001/archpsyc.57.3.227 Bledsoe, 2002, Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition, Cell, 110, 93, 10.1016/S0092-8674(02)00817-6 Blind, 2008, Differential recruitment of glucocorticoid receptor phospho-isoforms to glucocorticoid-induced genes, J. Steroid Biochem. Mol. Biol., 109, 150, 10.1016/j.jsbmb.2008.01.002 Boldrini, 2009, Antidepressants increase neural progenitor cells in the human hippocampus, Neuropsychopharmacology, 34, 2376, 10.1038/npp.2009.75 Bouwer, 2000, Prednisone augmentation in treatment-resistant depression with fatigue and hypocortisolaemia: a case series, Depress. Anxiety, 12, 44, 10.1002/1520-6394(2000)12:1<44::AID-DA6>3.0.CO;2-C Boyle, 2004, Genetic dissection of stress response pathways in vivo, Endocr. Res., 30, 859, 10.1081/ERC-200044120 Boyle, 2005, Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behavior, Proc. Natl. Acad. Sci. U.S.A., 102, 473, 10.1073/pnas.0406458102 Budziszewska, 2000, Antidepressant drugs inhibit glucocorticoid receptor-mediated gene transcription—a possible mechanism, Br. J. Pharmacol., 130, 1385, 10.1038/sj.bjp.0703445 Carvalho, 2008, In vitro modulation of the glucocorticoid receptor by antidepressants, Stress, 11, 411, 10.1080/10253890701850759 Carvalho, 2008, Clomipramine in vitro reduces glucocorticoid receptor function in healthy subjects but not in patients with major depression, Neuropsychopharmacology, 33, 3182, 10.1038/npp.2008.44 Chen, 2000, Enhancement of hippocampal neurogenesis by lithium, J. Neurochem., 75, 1729, 10.1046/j.1471-4159.2000.0751729.x Chen, 2001, Expression of the cAMP response element binding protein (CREB) in hippocampus produces an antidepressant effect, Biol. Psychiatry, 49, 753, 10.1016/S0006-3223(00)01114-8 Chen, 2008, Glucocorticoid receptor phosphorylation differentially affects target gene expression, Mol. Endocrinol., 22, 1754, 10.1210/me.2007-0219 Colla, 2007, Hippocampal volume reduction and HPA-system activity in major depression, J. Psychiatr. Res., 41, 553, 10.1016/j.jpsychires.2006.06.011 David, 2009, Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression, Neuron, 62, 479, 10.1016/j.neuron.2009.04.017 Davies, 2008, Cross talk of signaling pathways in the regulation of the glucocorticoid receptor function, Mol. Endocrinol., 22, 1331, 10.1210/me.2007-0360 De Bosscher, 2009, Minireview: latest perspectives on antiinflammatory actions of glucocorticoids, Mol. Endocrinol., 23, 281, 10.1210/me.2008-0283 De Kloet, 1998, Brain corticosteroid receptor balance in health and disease, Endocr. Rev., 19, 269, 10.1210/er.19.3.269 de Kloet, 2007, Therapy Insight: is there an imbalanced response of mineralocorticoid and glucocorticoid receptors in depression?, Nat. Clin. Pract. Endocrinol. Metab., 3, 168, 10.1038/ncpendmet0403 DeBattista, 2000, Acute antidepressant effects of intravenous hydrocortisone and CRH in depressed patients: a double-blind, placebo-controlled study, Am. J. Psychiatry, 157, 1334, 10.1176/appi.ajp.157.8.1334 DeBattista, 2006, Mifepristone versus placebo in the treatment of psychosis in patients with psychotic major depression, Biol. Psychiatry, 60, 1343, 10.1016/j.biopsych.2006.05.034 Dinan, 1997, Dexamethasone augmentation in treatment-resistant depression, Acta Psychiatr. Scand., 95, 58, 10.1111/j.1600-0447.1997.tb00374.x Duma, 2006, Multiple glucocorticoid receptor isoforms and mechanisms of post-translational modification, J. Steroid Biochem. Mol. Biol., 102, 11, 10.1016/j.jsbmb.2006.09.009 Duman, 2002, Structural alterations in depression: cellular mechanisms underlying pathology and treatment of mood disorders, CNS Spectr., 7, 10.1017/S1092852900017454 Duman, 2004, Role of neurotrophic factors in the etiology and treatment of mood disorders, Neuromol. Med., 5, 11, 10.1385/NMM:5:1:011 Eickelberg, 1999, Ligand-independent activation of the glucocorticoid receptor by beta2-adrenergic receptor agonists in primary human lung fibroblasts and vascular smooth muscle cells, J. Biol. Chem., 274, 1005, 10.1074/jbc.274.2.1005 Flores, 2006, Clinical and biological effects of mifepristone treatment for psychotic depression, Neuropsychopharmacology, 31, 628, 10.1038/sj.npp.1300884 Focking, 2003, Chronic glucocorticoid receptor activation impairs CREB transcriptional activity in clonal neurons, Biochem. Biophys. Res. Commun., 304, 720, 10.1016/S0006-291X(03)00665-X Fruchter, 2005, The human glucocorticoid receptor (GR) isoform {beta} differentially suppresses GR{alpha}-induced transactivation stimulated by synthetic glucocorticoids, J. Clin. Endocrinol. Metab., 90, 3505, 10.1210/jc.2004-1646 Funato, 2006, Differential effects of antidepressants on dexamethasone-induced nuclear translocation and expression of glucocorticoid receptor, Brain Res., 1117, 125, 10.1016/j.brainres.2006.08.029 Funder, 1992, Glucocorticoid receptors, J. Steroid Biochem. Mol. Biol., 43, 389, 10.1016/0960-0760(92)90074-S Geuze, 2005, MR-based in vivo hippocampal volumetrics. 2. Findings in neuropsychiatric disorders, Mol. Psychiatry, 10, 160, 10.1038/sj.mp.4001579 Glass, 2000, The coregulator exchange in transcriptional functions of nuclear receptors, Genes Dev., 14, 121 Gould, 1992, Adrenal hormones suppress cell division in the adult rat dentate gyrus, J. Neurosci., 12, 3642, 10.1523/JNEUROSCI.12-09-03642.1992 Haynes, 2004, Chronic antidepressant medication attenuates dexamethasone-induced neuronal death and sublethal neuronal damage in the hippocampus and striatum, Brain Res., 1026, 157, 10.1016/j.brainres.2004.05.117 Heiske, 2003, Differential effects of antidepressants on glucocorticoid receptors in human primary blood cells and human monocytic U-937 cells, Neuropsychopharmacology, 28, 807, 10.1038/sj.npp.1300056 Herr, 2003, Antidepressants differentially influence the transcriptional activity of the glucocorticoid receptor in vitro, Neuroendocrinology, 78, 12, 10.1159/000071701 Hery, 2000, The effects of serotonin on glucocorticoid receptor binding in rat raphe nuclei and hippocampal cells in culture, J. Neurochem., 74, 406, 10.1046/j.1471-4159.2000.0740406.x Holsboer, 2000, The corticosteroid receptor hypothesis of depression, Neuropsychopharmacology, 23, 477, 10.1016/S0893-133X(00)00159-7 Holsboer, 1987, Stimulation response to corticotropin-releasing hormone (CRH) in patients with depression, alcoholism and panic disorder, Horm. Metab. Res. Suppl., 16, 80 Huang, 2006, Stimulation of neurogenesis in the hippocampus of the adult rat by fluoxetine requires rhythmic change in corticosterone, Biol. Psychiatry, 59, 619, 10.1016/j.biopsych.2005.09.016 Ismaili, 2004, Modulation of glucocorticoid receptor function via phosphorylation, Ann. N. Y. Acad. Sci., 1024, 86, 10.1196/annals.1321.007 Jonat, 1990, Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone, Cell, 62, 1189, 10.1016/0092-8674(90)90395-U Juruena, 2006, Different responses to dexamethasone and prednisolone in the same depressed patients, Psychopharmacology (Berl.), 189, 225, 10.1007/s00213-006-0555-4 Kalman, 2002, Rapid corticosteroid-dependent regulation of mineralocorticoid receptor protein expression in rat brain, Endocrinology, 143, 4184, 10.1210/en.2002-220375 Karssen, 2001, Multidrug resistance P-glycoprotein hampers the access of cortisol but not of corticosterone to mouse and human brain, Endocrinology, 142, 2686, 10.1210/en.142.6.2686 Karssen, 2004, Localization of mRNA expression of P-glycoprotein at the blood–brain barrier and in the hippocampus, Ann. N. Y. Acad. Sci., 1032, 308, 10.1196/annals.1314.048 Kim, 2004, Dexamethasone inhibits proliferation of adult hippocampal neurogenesis in vivo and in vitro, Brain Res., 1027, 1, 10.1016/j.brainres.2004.07.093 Krett, 1995, A variant glucocorticoid receptor messenger RNA is expressed in multiple myeloma patients, Cancer Res., 55, 2727 Kronenberg, 2009, Reduced hippocampal neurogenesis in the GR(+/-) genetic mouse model of depression, Eur. Arch. Psychiatry Clin. Neurosci., 10.1007/s00406-009-0036-y Krstic, 1997, Mitogen-activated and cyclin-dependent protein kinases selectively and differentially modulate transcriptional enhancement by the glucocorticoid receptor, Mol. Cell Biol., 17, 3947, 10.1128/MCB.17.7.3947 Lai, 2003, Differential regulation of corticosteroid receptors by monoamine neurotransmitters and antidepressant drugs in primary hippocampal culture, Neuroscience, 118, 975, 10.1016/S0306-4522(03)00038-1 Lin, 2006, ABC transporters, neural stem cells and neurogenesis—a different perspective, Cell Res., 16, 857, 10.1038/sj.cr.7310107 Lowy, 1984, Glucocorticoid resistance in depression: the dexamethasone suppression test and lymphocyte sensitivity to dexamethasone, Am. J. Psychiatry, 141, 1365, 10.1176/ajp.141.11.1365 Malberg, 2000, Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus, J. Neurosci., 20, 9104, 10.1523/JNEUROSCI.20-24-09104.2000 Mason, 2008, A revised role for P-glycoprotein in the brain distribution of dexamethasone, cortisol, and corticosterone in wild-type and ABCB1A/B-deficient mice, Endocrinology, 149, 5244, 10.1210/en.2008-0041 Matsubara, 2006, Reduced Glucocorticoid Receptor alpha Expression in Mood Disorder Patients and First-Degree Relatives, Biol. Psychiatry, 59, 689, 10.1016/j.biopsych.2005.09.026 Mayer, 2006, Brief treatment with the glucocorticoid receptor antagonist mifepristone normalises the corticosterone-induced reduction of adult hippocampal neurogenesis, J. Neuroendocrinol., 18, 629, 10.1111/j.1365-2826.2006.01455.x McEwen, 1999, Protective and damaging effects of mediators of stress. Elaborating and testing the concepts of allostasis and allostatic load, Ann. N. Y. Acad. Sci., 896, 30, 10.1111/j.1749-6632.1999.tb08103.x McGowan, 2009, Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse, Nat. Neurosci., 12, 342, 10.1038/nn.2270 McKay, 1998, Cross-talk between nuclear factor-kappa B and the steroid hormone receptors: mechanisms of mutual antagonism, Mol. Endocrinol., 12, 45, 10.1210/me.12.1.45 Miller, 2002, The phosphodiesterase type 4 inhibitor, rolipram, enhances glucocorticoid receptor function, Neuropsychopharmacology, 27, 939, 10.1016/S0893-133X(02)00381-0 Moalli, 1993, Alternatively spliced glucocorticoid receptor messenger RNAs in glucocorticoid-resistant human multiple myeloma cells, Cancer Res., 53, 3877 Murray, 2008, Chronic low dose corticosterone exposure decreased hippocampal cell proliferation, volume and induced anxiety and depression like behaviours in mice, Eur. J. Pharmacol., 583, 115, 10.1016/j.ejphar.2008.01.014 Nalepa, 1991, Involvement of protein kinase C in the mechanism of in vitro effects of imipramine on generation of second messengers by noradrenaline in cerebral cortical slices of the rat, Neuroscience, 44, 585, 10.1016/0306-4522(91)90079-4 Nemeroff, 1992, Adrenal gland enlargement in major depression. A computed tomographic study, Arch. Gen. Psychiatry, 49, 384, 10.1001/archpsyc.1992.01820050048008 Nestler, 2002, Neurobiology of depression, Neuron, 34, 13, 10.1016/S0896-6273(02)00653-0 Oakley, 1996, The human glucocorticoid receptor beta isoform. Expression, biochemical properties, and putative function, J. Biol. Chem., 271, 9550, 10.1074/jbc.271.16.9550 Odermatt, 2008, mineralocorticoid action: why should we consider influences by environmental chemicals?, Biochem. Pharmacol., 76, 1184, 10.1016/j.bcp.2008.07.019 Okugawa, 1999, Long-term treatment with antidepressants increases glucocorticoid receptor binding and gene expression in cultured rat hippocampal neurones, J. Neuroendocrinol., 11, 887, 10.1046/j.1365-2826.1999.00405.x Oomen, 2007, Brief treatment with the glucocorticoid receptor antagonist mifepristone normalizes the reduction in neurogenesis after chronic stress, Eur. J. Neurosci., 26, 3395, 10.1111/j.1460-9568.2007.05972.x Papolos, 1993, Effects of the antiglucocorticoid RU 38486 on the induction of learned helpless behavior in Sprague-Dawley rats, Brain Res., 615, 304, 10.1016/0006-8993(93)90042-L Pariante, 2003, Depression, stress and the adrenal axis, J. Neuroendocrinol., 15, 811, 10.1046/j.1365-2826.2003.01058.x Pariante, 2009, Risk factors for development of depression and psychosis, Ann. N. Y. Acad. Sci., 1179, 144, 10.1111/j.1749-6632.2009.04978.x Pariante, 2008, The HPA axis in major depression: classical theories and new developments, Trends Neurosci., 31, 464, 10.1016/j.tins.2008.06.006 Pariante, 2001, Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment, Biol. Psychiatry, 49, 391, 10.1016/S0006-3223(00)01088-X Pariante, 1997, Steroid-independent translocation of the glucocorticoid receptor by the antidepressant desipramine, Mol. Pharmacol., 52, 571, 10.1124/mol.52.4.571 Pariante, 2003, The antidepressant clomipramine regulates cortisol intracellular concentrations and glucocorticoid receptor expression in fibroblasts and rat primary neurones, Neuropsychopharmacology, 28, 1553, 10.1038/sj.npp.1300195 Pariante, 2003, Antidepressant fluoxetine enhances glucocorticoid receptor function in vitro by modulating membrane steroid transporters, Br. J. Pharmacol., 139, 1111, 10.1038/sj.bjp.0705357 Peiffer, 1991, Antidepressant and other centrally acting drugs regulate glucocorticoid receptor messenger RNA levels in rat brain, Psychoneuroendocrinology, 16, 505, 10.1016/0306-4530(91)90034-Q Pepin, 1989, Antidepressants regulate glucocorticoid receptor messenger RNA concentrations in primary neuronal cultures, Brain Res. Mol. Brain Res., 6, 77, 10.1016/0169-328X(89)90031-4 Pepin, 1992, Increased glucocorticoid receptor gene promoter activity after antidepressant treatment, Mol. Pharmacol., 41, 1016 Pratt, 1997, Steroid receptor interactions with heat shock protein and immunophilin chaperones, Endocr. Rev., 18, 306, 10.1210/er.18.3.306 Rangarajan, 1992, Modulation of glucocorticoid receptor function by protein kinase A, Mol. Endocrinol., 6, 1451, 10.1210/me.6.9.1451 Rasenick, 1996, G protein-mediated signal transduction as a target of antidepressant and antibipolar drug action: evidence from model systems, J. Clin. Psychiatry, 57, 49 Reif, 2006, Neural stem cell proliferation is decreased in schizophrenia, but not in depression, Mol. Psychiatry, 11, 514, 10.1038/sj.mp.4001791 Roberts, 1994, Sensitivity of the circadian rhythm of kainic acid-induced convulsion susceptibility to manipulations of corticosterone levels and mineralocorticoid receptor binding, Neuropharmacology, 33, 1087, 10.1016/0028-3908(94)90147-3 Rogatsky, 1998, Phosphorylation and inhibition of rat glucocorticoid receptor transcriptional activation by glycogen synthase kinase-3 (GSK-3). Species-specific differences between human and rat glucocorticoid receptor signaling as revealed through GSK-3 phosphorylation, J. Biol. Chem., 273, 14315, 10.1074/jbc.273.23.14315 Sahay, 2007, Dentate gyrus neurogenesis and depression, Prog. Brain Res., 163, 697, 10.1016/S0079-6123(07)63038-6 Sanchez, 1990, Hormone-free mouse glucocorticoid receptors overexpressed in Chinese hamster ovary cells are localized to the nucleus and are associated with both hsp70 and hsp90, J. Biol. Chem., 265, 20123, 10.1016/S0021-9258(17)30478-7 Sapolsky, 1985, Glucocorticoid toxicity in the hippocampus: temporal aspects of neuronal vulnerability, Brain Res., 359, 300, 10.1016/0006-8993(85)91440-4 Sapolsky, 2000, The possibility of neurotoxicity in the hippocampus in major depression: a primer on neuron death, Biol. Psychiatry, 48, 755, 10.1016/S0006-3223(00)00971-9 Sapolsky, 2001, Depression, antidepressants, and the shrinking hippocampus, Proc. Natl. Acad. Sci. U.S.A., 98, 12320, 10.1073/pnas.231475998 Sapolsky, 2002, Chickens eggs and hippocampal atrophy, Nat. Neurosci., 5, 1111, 10.1038/nn1102-1111 Savory, 1999, Discrimination between NL1- and NL2-mediated nuclear localization of the glucocorticoid receptor, Mol. Cell. Biol., 19, 1025, 10.1128/MCB.19.2.1025 Schmidt, 2007, The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior, Behav. Pharmacol., 18, 391, 10.1097/FBP.0b013e3282ee2aa8 Schmidt, 2009, Postnatal glucocorticoid excess due to pituitary glucocorticoid receptor deficiency: differential short- and long-term consequences, Endocrinology, 150, 2709, 10.1210/en.2008-1211 Sen, 2008, Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications, Biol. Psychiatry, 64, 527, 10.1016/j.biopsych.2008.05.005 Sheline, 1996, Hippocampal atrophy in recurrent major depression, Proc. Natl. Acad. Sci. U.S.A., 93, 3908, 10.1073/pnas.93.9.3908 Shirayama, 2002, Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression, J. Neurosci., 22, 3251, 10.1523/JNEUROSCI.22-08-03251.2002 Silver, 1986, Antidepressants and protein kinases: inhibition of Ca2+-regulated myosin phosphorylation by fluoxetine and iprindole, Eur. J. Pharmacol., 121, 65, 10.1016/0014-2999(86)90393-6 Sousa, 2008, Corticosteroid receptors and neuroplasticity, Brain Res. Rev., 57, 561, 10.1016/j.brainresrev.2007.06.007 Tanapat, 1998, Stress inhibits the proliferation of granule cell precursors in the developing dentate gyrus, Int. J. Dev. Neurosci., 16, 235, 10.1016/S0736-5748(98)00029-X Uchida, 2008, Characterization of the vulnerability to repeated stress in Fischer 344 rats: possible involvement of microRNA-mediated down-regulation of the glucocorticoid receptor, Eur. J. Neurosci., 27, 2250, 10.1111/j.1460-9568.2008.06218.x Vedder, 1999, Regulation of glucocorticoid receptor-mRNA in human blood cells by amitriptyline and dexamethasone, J. Psychiatr. Res., 33, 303, 10.1016/S0022-3956(99)00006-0 Videbech, 2004, Hippocampal volume and depression: a meta-analysis of MRI studies, Am. J. Psychiatry, 161, 1957, 10.1176/appi.ajp.161.11.1957 Vreugdenhil, 2009, MicroRNA 18 and 124a down-regulate the glucocorticoid receptor: implications for glucocorticoid responsiveness in the brain, Endocrinology, 150, 2220, 10.1210/en.2008-1335 Weaver, 2004, Epigenetic programming by maternal behavior, Nat. Neurosci., 7, 847, 10.1038/nn1276 Wodarz, 1991, Normal lymphocyte responsiveness to lectins but impaired sensitivity to in vitro glucocorticoids in major depression, J. Affect Disord., 22, 241, 10.1016/0165-0327(91)90070-9 Yau, 2007, The antidepressant desipramine requires the ABCB1 (Mdr1)-type p-glycoprotein to upregulate the glucocorticoid receptor in mice, Neuropsychopharmacology, 32, 2520, 10.1038/sj.npp.1301389 Young, 1991, Loss of glucocorticoid fast feedback in depression, Arch. Gen. Psychiatry, 48, 693, 10.1001/archpsyc.1991.01810320017003 Young, 2004, Improvements in neurocognitive function and mood following adjunctive treatment with mifepristone (RU-486) in bipolar disorder, Neuropsychopharmacology, 29, 1538, 10.1038/sj.npp.1300471 Zhou, 2005, The human glucocorticoid receptor: one gene, multiple proteins and diverse responses, Steroids, 70, 407, 10.1016/j.steroids.2005.02.006 Zhou, 2009, Evidence for selective microRNAs and their effectors as common long-term targets for the actions of mood stabilizers, Neuropsychopharmacology, 34, 1395, 10.1038/npp.2008.131