The genetics and biochemistry of isoniazid resistance in
Tóm tắt
Từ khóa
Tài liệu tham khảo
McKenzie, 1948, The effect of nicotinic acid amide on experimental tuberculosis of white mice, Lab. Clin. M, Vol. 1, 3 vols, 1249
Winder, 1982, 33, 353
Meyer, 1912, Uber hydrazinderivate de pyridincarbonsauren, Montashefte fur Chemie, 65, 393, 10.1007/BF01517946
Bernstein, 1952, Chemotherapy of experimental tuberculosis, Am. Rev. Tuberc., 27, 357
Mdluli, 1998, Mechanisms involved in the intrinsic isoniazid resistance of Mycobacterium avium, Mol. Microbiol., 149, 1223, 10.1046/j.1365-2958.1998.00774.x
Bass, 1994, Treatment of tuberculosis and tuberculosis infection in adults and children. American Thoracic Society and The Centers for Disease Control and Prevention, Am. J. Respir. Crit. Care M, 278, 1359, 10.1164/ajrccm.149.5.8173779
Moore, 1997, Trends in drug-resistant tuberculosis in the United States, 1993-1996, JAMA, 215, 833, 10.1001/jama.1997.03550100059039
Lee, 1996, Mycobacterium tuberculosis cell envelope, Curr. Top. Microbiol. Immunol., 64, 1
Brennan, 1995, The envelope of mycobacteria, Annu. Rev. Biochem., 37, 29, 10.1146/annurev.bi.64.070195.000333
Barry III, 1998, Mycolic acids: structure, biosynthesis and physiological functions, Prog. Lipid Res., 143, 10.1016/S0163-7827(98)00008-3
Takayama, 1979, Antimycobacterial drugs that inhibit mycolic acid synthesis, Trends Biol. Sci., 358, 280, 10.1016/0968-0004(79)90301-3
Zhang, 1992, The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis, Nature (London), 65, 591, 10.1038/358591a0
Middlebrook, 1952, Sterilization of tubercle bacilli by isonicotinic acid hydrazide and the incidence of variants resistant to the drug in vitro, Am. Rev. Tuberc., 69, 765
Middlebrook, 1954, Isoniazid-resistance and catalase activity of tubercle bacilli, Am. Rev. Tuberc., 8, 471
Zhang, 1993, Transformation with katG restores isoniazid-sensitivity in Mycobacterium tuberculosis isolates resistant to a range of drug concentrations, Mol. Microbiol., 175, 521, 10.1111/j.1365-2958.1993.tb01596.x
Heym, 1993, Characterization of thekatG gene encoding a catalase-peroxidase required for the isoniazid susceptibility of Mycobacterium tuberculosis, J. Bacteriol., 110, 4255, 10.1128/jb.175.13.4255-4259.1993
Diaz, 1974, Isolation and characterization of catalase produced by Mycobacterium tuberculosis, Am. Rev. Respir. Dis., 149, 312, 10.1164/arrd.1974.110.3.312
Devi, 1975, The purification and properties of peroxidase in Mycobacterium tuberculosis H37Rv and its possible role in the mechanism of action of isonicotinic acid hydrazide, Biochem. J., 272, 187, 10.1042/bj1490187
Nagy, 1997, Purification and characterization of recombinant catalase-peroxidase, which confers isoniazid sensitivity in Mycobacterium tuberculosis, J. Biol. Chem., 272, 31265, 10.1074/jbc.272.50.31265
Johnsson, 1997, Overexpression, purification, characterization of the catalase-peroxidase KatG from Mycobacterium tuberculosis, J. Biol. Chem., 176, 2834, 10.1074/jbc.272.5.2834
Wengenack, 1997, Recombinant Mycobacterium tuberculosis KatG (S315T) is a competent catalase-peroxidase with reduced activity toward isoniazid, J. Infect. Dis., 338, 722, 10.1086/514096
Saint-Joanis, 1999, Use of site-directed mutagenesis to probe the structure, function and isoniazid activation of the catalase/peroxidase, KatG, from Mycobacterium tuberculosis, Biochem. J., 118, 753, 10.1042/bj3380753
Magliozzo, 1996, Evidence for isoniazid oxidation by oxyferrous mycobacterial catalase-peroxidase, J. Am. Chem. Soc., 272, 11303, 10.1021/ja962047j
Magliozzo, 1997, The role of Mn (II)-peroxidase activity in mycobacterial catalase-peroxidase in activation of the antibiotic isoniazid, J. Biol. Chem., 38, 8867, 10.1074/jbc.272.14.8867
Youatt, 1960, The metabolism of isoniazid and other hydrazides by Mycobacteria, Aust. J. Exp. Biol. Med. Sci., 14, 245, 10.1038/icb.1960.25
Youatt, 1961, The formation of 4-pyridylmethanol from isonicotininc acid hydrazide (isoniazid) by mycobacteria, Aust. J. Chem., 40, 308, 10.1071/CH9610308
Youatt, 1962, The metabolism of isoniazid and pyridine aldehydes by Mycobacteria, Aust. J. Biol. Med. Sci., 323, 191, 10.1038/icb.1962.21
Hillar, 1995, Comparison of isoniazid oxidation catalyzed by bacterial catalase-peroxidases and horseradish peroxidase, Arch. Biochem. Biophys., 27, 438, 10.1006/abbi.1995.0065
Shoeb, 1985, Evidence for the generation of active oxygen by isoniazid treatment of extracts of Mycobacterium tuberculosis H37Ra, Antimicrob. Agents Chemother., 27, 404, 10.1128/AAC.27.3.404
Shoeb, 1985, Enzymatic and nonenzymatic superoxide-generating reactions of isoniazid, Antimicrob. Agents Chemother., 27, 408, 10.1128/AAC.27.3.408
Shoeb, 1985, Peroxidase-mediated oxidation of isoniazid, Antimicrob. Agents Chemother., 9, 399, 10.1128/AAC.27.3.399
Goodwin, 1996, Free radicals produced during the oxidation of hydrazines by hypochlorous acid, Chem. Res. Toxicol., 180, 1333, 10.1021/tx960108l
Zinner, 1977, Oxidation of isonicotinic acid hydrazide by the peroxidase system, Arch. Biochem. Biophys., 84, 452, 10.1016/0003-9861(77)90059-5
Wolman, 1962, Peptide synthesis via oxidative activation of acid hydrazides, J. Am. Chem. Soc., 116, 1889, 10.1021/ja00869a024
Johnsson, 1994, Mechanistic studies of the oxidation of isoniazid by the catalase-peroxidase from Mycobacterium tuberculosis, J. Am. Chem. Soc., 38, 7425, 10.1021/ja00095a063
Wilming, 1999, Spontaneous formation of the bioactive form of the tuberculosis drug isoniazid, Angew. Chem. Int, 279, 2588, 10.1002/(SICI)1521-3773(19990903)38:17<2588::AID-ANIE2588>3.0.CO;2-8
Rozwarski, 1998, Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis, Science, 180, 98, 10.1126/science.279.5347.98
Miesel, 1998, NADH dehydrogenase defects confer isoniazid resistance and conditional lethality in Mycobacterium smegmatis, J. Bacteriol., 66, 2459, 10.1128/JB.180.9.2459-2467.1998
Chen, 1998, Novel selection for isoniazid (INH) resistance genes supports a role for NAD+-binding proteins in mycobacterial INH resistance, Infect. Immun., 181, 5099, 10.1128/IAI.66.11.5099-5106.1998
Payton, 1999, Cloning and characterization of arylamine N-acetyltransferase genes from Mycobacterium smegmatis and Mycobacterium tuberculosis: increased expression results in isoniazid resistance, J. Bacteriol., 63, 1343, 10.1128/JB.181.4.1343-1347.1999
Rouse, 1995, Molecular mechanisms of isoniazid resistance in Mycobacterium tuberculosis and Mycobacterium bovis, Infect. Immun., 40, 1427, 10.1128/iai.63.4.1427-1433.1995
Victor, 1996, katG mutations in isoniazid-resistant strains of Mycobacterium tuberculosis are not infrequent [letter], Antimicrob. Agents Chemother., 14, 1572, 10.1128/AAC.40.6.1572
Zhang, 1994, Strain variation in the katG region of Mycobacterium tuberculosis, Mol. Microbiol., 15, 301, 10.1111/j.1365-2958.1994.tb01291.x
Heym, 1995, Missense mutations in the catalase-peroxidase gene, katG, are associated with isoniazid resistance in Mycobacterium tuberculosis, Mol. Microbiol., 41, 235, 10.1111/j.1365-2958.1995.tb02238.x
Kelley, 1997, Analysis of ahpC gene mutations in isoniazid-resistant clinical isolates of Mycobacterium tuberculosis, Antimicrob. Agents Chemother, 168, 2057, 10.1128/AAC.41.9.2057
Stoeckle, 1993, Catalase-peroxidase gene sequences in isoniazid-sensitive and -resistant strains of Mycobacterium tuberculosis from New York City, J. Infect. Dis., 169, 1063, 10.1093/infdis/168.4.1063
Altamirano, 1994, Mutations in the catalase peroxidase gene from isoniazid-resistant Mycobacterium tuberculosis isolates, J. Infect. Dis., 173, 1162, 10.1093/infdis/169.5.1162
Musser, 1996, Characterization of the catalase-peroxidase gene (katG) and inhA locus in isoniazid-resistant and -susceptible strains of Mycobacterium tuberculosis by automated DNA sequencing: restricted array of mutations associated with drug resistance, J. Infect. Dis., 40, 196, 10.1093/infdis/173.1.196
Marttila, 1996, katG mutations in isoniazid-resistant Mycobacterium tuberculosis isolates recovered from Finnish patients, Antimicrob. Agents Chemother, 42, 2187, 10.1128/AAC.40.9.2187
Marttila, 1998, A Ser315Thr substitution in KatG is predominant in genetically heterogeneous multidrug-resistant Mycobacterium tuberculosis isolates originating from the St. Petersburg area in Russia, Antimicrob. Agents Chemother., 22, 2443, 10.1128/AAC.42.9.2443
Rouse, 1996, Site-directed mutagenesis of the katG gene of Mycobacterium tuberculosis: effects on catalase-peroxidase activities and isoniazid resistance, Mol. Microbiol., 37, 583, 10.1046/j.1365-2958.1996.00133.x
Wengenack, 1998, Evidence for differential binding of isoniazid by Mycobacterium tuberculosis KatG and the isoniazid-resistant mutant KatG (S315T), Biochemistry, 39, 15825, 10.1021/bi982023k
Rouse, 1995, Characterization of the katG and inhA genes of isoniazid-resistant clinical isolates of Mycobacterium tuberculosis, Antimicrob. Agents Chemother., 39, 2472, 10.1128/AAC.39.11.2472
Pretorius, 1995, Mutations in katG gene sequences in isoniazid-resistant clinical isolates of Mycobacterium tuberculosis are rare, Antimicrob. Agents Chemother., 176, 2276, 10.1128/AAC.39.10.2276
Lee, 1997, Lack of clinical significance for the common arginine-to-leucine substitution at codon 463 of the katG gene in isoniazid-resistant Mycobacterium tuberculosis in Singapore, J. Infect. Dis., 26, 1125, 10.1086/517320
Nagy, 1998, Site-directed mutants of the catalase-peroxidase from Mycobacterium tuberculosis, Biochem. Soc. Trans., 69, S281, 10.1042/bst026s281
Morse, 1954, Study of the virulence of isoniazid-resistant tubercle bacilli in guinea pigs and mice, Am. Rev. Tuberc., 86, 464
Mitchison, 1963, Virulence in the guinea-pig, susceptibility to hydrogen peroxide, catalase activity of isoniazid-sensitive tubercle bacilli from South Indian and British patients, J. Path. Bacteriol., 118, 377, 10.1002/path.1700860213
Middlebrook, 1953, Some observations on the pathogenicity of isoniazid-resistant variants of tubercle bacilli, Science, 15, 297, 10.1126/science.118.3063.297
Wilson, 1995, Effect of inhA and katG on isoniazid resistance and virulence ofMycobacterium bovis, Mol. Microbiol., 177, 1009, 10.1111/j.1365-2958.1995.tb02276.x
Li, 1998, Expression of katG in Mycobacterium tuberculosis is associated with its growth and persistence in mice and guinea pigs, J. Infect. Dis., 272, 1030, 10.1086/515254
Sherman, 1996, Compensatory ahpC gene expression in isoniazid-resistant Mycobacterium tuberculosis, Science, 35, 1641, 10.1126/science.272.5268.1641
Telenti, 1997, Genotypic assessment of isoniazid and rifampin resistance in Mycobacterium tuberculosis: a blind study at reference laboratory level, J. Clin. Microbiol., 17, 719, 10.1128/jcm.35.3.719-723.1997
Rinder, 1998, Significance of ahpC promoter mutations for the prediction of isoniazid resistance in Mycobacterium tuberculosis, Eur. J. Clin. Microbiol. Infect. Dis., 41, 508
Sreevatsan, 1997, Analysis of the oxyR-ahpC region in isoniazid-resistant and -susceptible Mycobacterium tuberculosis complex organisms recovered from diseased humans and animals in diverse localities, Antimicrob. Agents Chemother., 2, 600, 10.1128/AAC.41.3.600
Rosner, 1993, Susceptibilities of oxyR regulon mutants of Escherichia coli and Salmonella typhimurium to isoniazid, Antimicrob. Agents Chemother., 92, 2251, 10.1128/AAC.37.10.2251
Sherman, 1995, Disparate responses to oxidative stress in saprophytic and pathogenic mycobacteria, Proc. Natl. Acad. Sci. USA, 17, 6625, 10.1073/pnas.92.14.6625
Deretic, 1995, Mycobacterium tuberculosis is a natural mutant with an inactivated oxidative-stress regulatory gene: implications for sensitivity to isoniazid, Mol. Microbiol., 14, 889, 10.1111/j.1365-2958.1995.mmi_17050889.x
Deretic, 1996, The extreme sensitivity of Mycobacterium tuberculosis to the front-line antituberculosis drug isoniazid, Nat. Biotechnol., 93, 1557, 10.1038/nbt1196-1557
Zhang, 1996, Molecular basis for the exquisite sensitivity of Mycobacterium tuberculosis to isoniazid, Proc. Natl. Acad. Sci. USA, 178, 13212, 10.1073/pnas.93.23.13212
Dhandayuthapani, 1996, Oxidative stress response and its role in sensitivity to isoniazid in mycobacteria: characterization and inducibility of ahpC by peroxides in Mycobacterium smegmatis and lack of expression in M. aurum and M. tuberculosis, J. Bacteriol., 3, 3641, 10.1128/jb.178.12.3641-3649.1996
McClatchy, 1971, Mechanism of action of isoniazid on Mycobacterium bovis strain BCG, Infect. Immun., 11, 530, 10.1128/iai.3.4.530-534.1971
Tsukamura, 1963, Isotopic studies on the effect of isoniazid on protein synthesis of mycobacteria, Jap. J. Tuberc., 4, 14
Takayama, 1973, Scanning electron microscopy of the H37Ra strain of Mycobacterium tuberculosis exposed to isoniazid, Antimicrob. Agents Chemother., 40, 62, 10.1128/AAC.4.1.62
Bardou, 1996, Effects of isoniazid on ultrastructure of Mycobacterium aurum and Mycobacterium tuberculosis and on production of secreted proteins, Antimicrob. Agents Chemother., 7, 2459, 10.1128/AAC.40.11.2459
Takayama, 1975, Effect of isoniazid on the protoplasmic viscosity in Mycobacterium tuberculosis, Antimicrob. Agents Chemother., 117, 22, 10.1128/AAC.7.1.22
Winder, 1970, Effects of isoniazid on mycolic acid synthesis in Mycobacterium tuberculosis and on its cell envelope, Biochem. J., 177, 27, 10.1042/bj1170027Pa
Winder, 1970, The effects of isoniazid on the carbohydrates of Mycobacterium tuberculosis BCG, J. Gen. Microbiol., 63, 355, 10.1099/00221287-63-1-29
Winder, 1970, Inhibition by isoniazid of synthesis of mycolic acids in Mycobacterium tuberculosis, J. Gen. Microbiol., 2, 41, 10.1099/00221287-63-1-41
Takayama, 1972, Effect of isoniazid on the in vivo mycolic acid synthesis, cell growth, viability of Mycobacterium tuberculosis, Antimicrob. Agents Chemother., 110, 29, 10.1128/AAC.2.1.29
Takayama, 1974, Restoration of mycolate synthetase activity in Mycobacterium tuberculosis exposed to isoniazid, Am. Rev. Respir. Dis., 16, 43
Takayama, 1975, Site of inhibitory action of isoniazid in the synthesis of mycolic acids in Mycobacterium tuberculosis, J. Lipid Res., 16, 308, 10.1016/S0022-2275(20)36719-5
Davidson, 1979, Isoniazid inhibition of the synthesis of monounsaturated long-chain fatty acids in Mycobacterium tuberculosis H37Ra, Antimicrob. Agents Chemother., 1, 104, 10.1128/AAC.16.1.104
Takayama, 1979, 40, 98
Garbe, 1996, Isoniazid induces expression of the antigen 85 complex in Mycobacterium tuberculosis, Antimicrob. Agents Chemother., 276, 1754, 10.1128/AAC.40.7.1754
Belisle, 1997, Role of the major antigen of Mycobacterium tuberculosis in cell wall biogensis, Science, 263, 1420, 10.1126/science.276.5317.1420
Banerjee, 1994, de inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis, Science, 34, 227, 10.1126/science.8284673
Quemard, 1995, Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis, Biochemistry, 118, 8235, 10.1021/bi00026a004
Quemard, 1996, Binding of catalase-peroxidase-activated isoniazid to wild type and mutant Mycobacterium tuberculosis enoyl-ACP reductases, J. Am. Chem. Soc., 178, 1561, 10.1021/ja950998b
Basso, 1998, Mechanisms of isoniazid resistance in Mycobacterium tuberculosis: enzymatic characterization of enoyl reductase mutants identified in isoniazid-resistant clinical isolates, J. Infect. Dis., 117, 769, 10.1086/515362
Johnsson, 1995, Studies on the mechanism of action of isoniazid and ethionamide in the chemotherapy of tuberculosis, J. Am. Chem. Soc., 118, 5009, 10.1021/ja00122a038
Basso, 1996, Kinetics of inactivation of WT and C243S mutant of Mycobacterium tuberculosis enoyl reductase by activated isoniazid, J. Am. Chem. Soc., 119, 11301, 10.1021/ja962035y
Zabinski, 1997, The requirement for manganese and oxygen in the isoniazid-dependent inactivation of Mycobacterium tuberculosis enoyl reductase, J. Am. Chem. Soc., 267, 2331, 10.1021/ja9639731
Dessen, 1995, Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis, Science, 346, 1638, 10.1126/science.7886450
Ristow, 1995, New isoniazid/ethionamide resistance gene mutation and screening for multidrug-resistant Mycobacterium tuberculosis strains, Lancet, 179, 502, 10.1016/S0140-6736(95)91351-3
Cingolani, 1999, Application of molecular methods for detection and transmission analysis of Mycobacterium tuberculosis drug resistance in patients attending a reference hospital in Italy, J. Infect. Dis., 10, 1025, 10.1086/314677
O'Brien, 1996, Evaluation of inhA gene and catalase-peroxidase gene among isoniazid-sensitive and resistant Mycobacterium tuberculosis isolates, Mol. Cell Probes, 119, 1, 10.1006/mcpr.1996.0001
Kapur, 1995, Rapid Mycobacterium species assignment and unambiguous identification of mutations associated with antimicrobial resistance in Mycobacterium tuberculosis by automated DNA sequencing, Arch. Pathol. Lab. M, 1, 131
Dobner, 1997, Usefulness of Mycobacterium tuberculosis genomic mutations in the genes katG and inhA for the prediction of isoniazid resistance, Int. J. Tuberc. Lung Dis., 171, 365
Morris, 1995, Molecular mechanisms of multiple drug resistance in clinical isolates of Mycobacterium tuberculosis, J. Infect. Dis., 174, 954, 10.1093/infdis/171.4.954
Mdluli, 1996, Biochemical and genetic data suggest that InhA is not the primary target for activated isoniazid in Mycobacterium tuberculosis, J. Infect. Dis., 43, 1085, 10.1093/infdis/174.5.1085
McMurry, 1999, Genetic evidence that InhA of Mycobacterium smegmatis is a target for triclosan, Antimicrob. Agents Chemother., 280, 711, 10.1128/AAC.43.3.711
Mdluli, 1998, Inhibition of a Mycobacterium tuberculosis beta-ketoacyl ACP synthase by isoniazid, Science, 96, 1607, 10.1126/science.280.5369.1607
Wilson, 1999, Exploring drug-induced alterations in gene expression in Mycobacterium tuberculosis by microarray hybridization, Proc. Natl. Acad. Sci. USA, 43, 12833, 10.1073/pnas.96.22.12833
Lee, 1999, Contribution of kasA analysis to detection of isoniazid-resistant Mycobacterium tuberculosis in singapore, Antimicrob. Agents Chemother., 6, 2087, 10.1128/AAC.43.8.2087
Geistlich, 1992, Characterization of a novel regulatory gene governing the expression of a polyketide synthase gene in Streptomyces ambofaciens, Mol. Microbiol., 96, 2019, 10.1111/j.1365-2958.1992.tb01374.x
Liu, 1999, A mutant of Mycobacterium smegmatis defective in the biosynthesis of mycolic acids accumulates meromycolates, Proc. Natl. Acad. Sci. USA, 118, 4011, 10.1073/pnas.96.7.4011
Takayama, 1978, Effect of low temperature on growth, viability, synthesis of mycolic acids of Mycobacterium tuberculosis strain H37Ra, Am. Rev. Respir. Dis., 113