The future of renal denervation

Bhatt, 2014, A controlled trial of renal denervation for resistant hypertension, N. Engl. J. Med., 370, 1393, 10.1056/NEJMoa1402670

Booth, 2015, Reinnervation of renal afferent and efferent nerves at 5.5 and 11months after catheter-based radiofrequency renal denervation in sheep, Hypertension, 65, 393, 10.1161/HYPERTENSIONAHA.114.04176

Campese, 1995, Renal afferent denervation prevents hypertension in rats with chronic renal failure, Hypertension, 25, 878, 10.1161/01.HYP.25.4.878

Chandola, 2006, Chronic stress at work and the metabolic syndrome, Br. Med. J., 332, 521, 10.1136/bmj.38693.435301.80

Chinushi, 2013, Blood pressure and autonomic responses to electrical stimulation of the renal arterial nerves before and after ablation of the renal artery, Hypertension, 61, 450, 10.1161/HYPERTENSIONAHA.111.00095

Converse, 1992, Sympathetic overactivity in patients with chronic renal failure, N. Engl. J. Med., 327, 1912, 10.1056/NEJM199212313272704

DiBona, 1982, The functions of the renal nerves, Rev. Physiol. Biochem. Pharmacol., 94, 75, 10.1007/BFb0031333

DiBona, 2010, Translational medicine: the antihypertensive effect of renal denervation, Am. J. Physiol. Regul. Integr. Comp. Physiol., 298, R245, 10.1152/ajpregu.00647.2009

Esler, 2014, Illusions of truths in the Symplicity HTN-3 trial: generic design strengths but neuroscience failings, J. Am. Soc. Hypertens., 8, 593, 10.1016/j.jash.2014.06.001

Esler, 2014, The John shepherd lecture. Renal denervation for hypertension: observations and predictions of a founder, Eur. Heart J., 35, 1178, 10.1093/eurheartj/ehu091

Esler, 2014, The sympathetic nervous system in hypertension: back to the future?, Curr. Hypertens. Rep.

Esler, 2015, Renal denervation for treatment of drug-resistant hypertension, Trends Cardiovasc. Med., 25, 107, 10.1016/j.tcm.2014.09.014

Esler, 2015, Renal denervation: Not as easy as it looks, Sci. Transl. Med., 7, 10.1126/scitranslmed.aaa5457

Esler, 1984, Measurement of total and organ-specific norepinephrine kinetics in humans, Am. J. Phys., 247, E21

Esler, 1988, The assessment of human sympathetic nervous system activity from measurements of norepinephrine turnover, Hypertension, 11, 3, 10.1161/01.HYP.11.1.3

Esler, 1990, Overflow of catecholamine neurotransmitters to the circulation: source, fate and functions, Physiol. Rev., 70, 963, 10.1152/physrev.1990.70.4.963

Esler, 2004, Rilmenidine sympatholytic activity preserves mental stress, orthostatic sympathetic responses and adrenaline secretion, J. Hypertens., 22, 1529, 10.1097/01.hjh.0000125453.28861.b8

Ewen, 2015, Reduced effect of percutaneous renal denervation on blood pressure in patients with isolated systolic hypertension, Hypertension, 65, 193, 10.1161/HYPERTENSIONAHA.114.04336

Foss, 2015, A novel method of selective ablation of afferent renal nerves by periaxonal application of capsaicin, Am. J. Physiol. Reg. Integr. Comp. Physiol., 308, R112, 10.1152/ajpregu.00427.2014

Gal, 2015, Blood pressure response to renal nerve stimulation in patients undergoing renal denervatiom: a feasibility study, J. Hum. Hypertens., 29, 292, 10.1038/jhh.2014.91

Grassi, 2015, Compendium: Sympathetic nervous system alterations in human hypertension, Circ. Res., 10.1161/CIRCRESAHA.116.303604

Greenwood, 1999, Single-unit sympathetic discharge. Quantitative assessment in human hypertensive disease, Circulation, 100, 1305, 10.1161/01.CIR.100.12.1305

Henegar, 2014, Catheter-based radiofrequency renal denervation lowers blood pressure in obese hypertensive dogs, Am. J. Hypertens., 10.1093/ajh/hpu048

Henegar, 2015, Catheter-based radiofrequency renal denervation: location effects on renal norepinephrine, Am. J. Hypertens., 28, 909, 10.1093/ajh/hpu258

Hering, 2013, Substantial reduction in single sympathetic nerve firing after renal denervation inpatients with resistant hypertension, Hypertension, 61, 457, 10.1161/HYPERTENSIONAHA.111.00194

Hering, 2012, Renal denervation in moderate to severe CKD, J. Am. Soc. Nephrol., 23, 1250, 10.1681/ASN.2011111062

Kandzari, 2014, Predictors of blood pressure response in the SYMPLICITY HTN-3 trial, Eur. Heart J.

Kaye, 1993, Functional and neurochemical evidence for partial cardiac sympathetic reinnervation after cardiac transplantation in humans, Circulation, 88, 1101, 10.1161/01.CIR.88.3.1101

Kiuchi, 2016, Effects of renal sympathetic denervation in hypertensive patients with mild to moderate chronic kidney disease in the long term, Am. J. Hypertens., 18, 190

Krum, 2009, Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study, Lancet, 373, 1275, 10.1016/S0140-6736(09)60566-3

Lambert, 2007, Differing patterns of sympathoexcitation in normal weight and obesity-related hypertension, Hypertension, 50, 862, 10.1161/HYPERTENSIONAHA.107.094649

Lenski, 2013, Orthostatic function after renal sympathetic denervation in patients with resistant hypertension, Int. J. Cardiol., 169, 418, 10.1016/j.ijcard.2013.10.017

Lu, 2014, Effects of renal sympathetic denervation using saline-irrigated radiofrequency ablation catheter on the activity of the renin-angiotensin system and endothelin-I, J. Renin-Angiotensin-Aldosterone Syst., 10.1177/1470320313506480

Mahfoud, 2015, Renal denervation: Symply trapped by complexity, Eur. Heart J., 36, 199, 10.1093/eurheartj/ehu450

Mahfoud, 2011, Effect of renal sympathetic denervation on glucose metabolism in patients with resistant hypertension: a pilot study, Circulation, 123, 1940, 10.1161/CIRCULATIONAHA.110.991869

McGrath, 1978, Catecholamines in peripheral venous plasma in patients on chronic dialysis, Clin. Sci. Mol. Med., 55, 89

Meredith, 1991, Biochemical evidence of sympathetic denervation of the heart in pure autonomic failure, Clin. Auton. Res., 1, 187, 10.1007/BF01824986

Nathan, 2014, The future of renal denervation in resistant hypertension, Curr. Hypertens. Rep., 10.1007/s11906-014-0494-0

Oldham, 1950, Denervation of the kidney. Hunterian Lecture of the Royal College of Surgeons, England. 9th March, 1950, Ann. R. Coll. Surg. Engl., 7, 222

Pokushalov, 2012, A randomized comparison of pulmonary vein isolation with versus without concomitant renal artery denervation in patients with refractory symptomatic atrial fibrillation and resistant hypertension, J. Am. Coll. Cardiol., 60, 1163, 10.1016/j.jacc.2012.05.036

Poulter, 1990, The Kenyan Luo migration study: observations on the initiation of the rise in blood pressure, BMJ, 300, 967, 10.1136/bmj.300.6730.967

Rumantir, 1999, Neural mechanisms in human obesity-related hypertension, J. Hypertens., 17, 1125, 10.1097/00004872-199917080-00012

Sakakura, 2014, Anatomical distribution of human renal sympathetic nerves: pathological study, J. Am. Coll. Cardiol., 63

Schlaich, 2013, Feasibility of catheter-based renal nerve ablation and effects on sympathetic nerve activity and blood pressure in patients with end-stage renal disease, Int. J. Cardiol., 10.1016/j.ijcard.2013.01.218

Shun-Shun, 2014, Removing the hype from hypertension, BMJ, 348

Tzafriri, 2015, Arterial microanatomy induces variations in electric and thermal conductivity that dictate response to renal artery catheter energy denervation, Sci. Transl. Med., 7