The functional mechanism of simvastatin in experimental osteoporosis

Springer Science and Business Media LLC - Tập 34 Số 1 - Trang 23-32 - 2016
Lifen Dai1,2, Ming Xu2, Haiying Wu3, Lanjie Xue4, Dekai Yuan2, Yuan Wang2, Shen Zhi-qiang5, Hongbin Zhao3, Min Hu1,2
1Department of Endocrinology, Second Affiliated Hospital of Kunming Medical University, Kunming, People’s Republic of China
2Kunming Research Center for Molecular Medicine, Kunming University, Kunming, People’s Republic of China
3Department of Emergency Medicine and Intensive Care Unit, First Affiliated Hospital of Kunming Medical University, Kunming, People’s Republic of China
4Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, People’s Republic of China
5School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, People’s Republic of China

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Tài liệu tham khảo

Du Z, Chen J, Yan F, Xiao Y (2009) Effects of simvastatin on bone healing around titanium implants in osteoporotic rats. Clin Oral Implants Res 20:145–150

Lasota A, Danowska-Klonowska D (2004) Experimental osteoporosis–different methods of ovariectomy in female white rats. Rocz Akad Med Bialymst 49(Suppl 1):129–131

Reginster JY, Burlet N (2006) Osteoporosis: a still increasing prevalence. Bone 38:S4–S9

Shirke SS, Jadhav SR, Jagtap AG (2008) Methanolic extract of Cuminum cyminum inhibits ovariectomy-induced bone loss in rats. Exp Biol Med (Maywood) 233:1403–1410

Canalis E, Giustina A, Bilezikian JP (2007) Mechanisms of anabolic therapies for osteoporosis. N Engl J Med 357:905–916

Grey A, Reid IR (2005) Emerging and potential therapies for osteoporosis. Expert Opin Investig Drugs 14:265–278

Lane NE, Kelman A (2003) A review of anabolic therapies for osteoporosis. Arthritis Res Ther 5:214–222

Dominguez LJ, Scalisi R, Barbagallo M (2010) Therapeutic options in osteoporosis. Acta Biomed 81(Suppl 1):55–65

Lacey JV Jr, Mink PJ, Lubin JH, Sherman ME, Troisi R et al (2002) Menopausal hormone replacement therapy and risk of ovarian cancer. JAMA 288:334–341

Reginster JY, Sarlet N (2006) The treatment of severe postmenopausal osteoporosis: a review of current and emerging therapeutic options. Treat Endocrinol 5:15–23

Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C et al (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomized controlled trial. JAMA 288:321–333

Salari Sharif P, Abdollahi M, Larijani B (2011) Current, new and future treatments of osteoporosis. Rheumatol Int 31:289–300

Meier CR, Schlienger RG, Kraenzlin ME, Schlegel B, Jick H (2000) HMG-CoA reductase inhibitors and the risk of fractures. JAMA 283:3205–3210

Wang PS, Solomon DH, Mogun H, Avorn J (2000) HMG-CoA reductase inhibitors and the risk of hip fractures in elderly patients. JAMA 283:3211–3216

Mundy G, Garrett R, Harris S, Chan J, Chen D et al (1999) Stimulation of bone formation in vitro and in rodents by statins. Science 286:1946–1949

Emmanuele L, Ortmann J, Doerflinger T, Traupe T, Barton M (2003) Lovastatin stimulates human vascular smooth muscle cell expression of bone morphogenetic protein-2, a potent inhibitor of low-density lipoprotein-stimulated cell growth. Biochem Biophys Res Commun 302:67–72

Hatano H, Maruo A, Bolander ME, Sarkar G (2003) Statin stimulates bone morphogenetic protein-2, aggrecan, and type 2 collagen gene expression and proteoglycan synthesis in rat chondrocytes. J Orthop Sci 8:842–848

Song C, Guo Z, Ma Q, Chen Z, Liu Z et al (2003) Simvastatin induces osteoblastic differentiation and inhibits adipocytic differentiation in mouse bone marrow stromal cells. Biochem Biophys Res Commun 308:458–462

Sugiyama M, Kodama T, Konishi K, Abe K, Asami S et al (2000) Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells. Biochem Biophys Res Commun 271:688–692

Izumo N, Fujita T, Nakamuta H, Koida M (2001) Lipophilic statins can be osteogenic by promoting osteoblastic calcification in a Cbfa1- and BMP-2-independent manner. Methods Find Exp Clin Pharmacol 23:389–394

Li X, Cui Q, Kao C, Wang GJ, Balian G (2003) Lovastatin inhibits adipogenic and stimulates osteogenic differentiation by suppressing PPARgamma2 and increasing Cbfa1/Runx2 expression in bone marrow mesenchymal cell cultures. Bone 33:652–659

Wong RW, Rabie AB (2005) Early healing pattern of statin-induced osteogenesis. Br J Oral Maxillofac Surg 43:46–50

Alam S, Ueki K, Nakagawa K, Marukawa K, Hashiba Y et al (2009) Statin-induced bone morphogenetic protein (BMP) 2 expression during bone regeneration: an immunohistochemical study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107:22–29

Rizzo M, Rini GB (2006) Statins, fracture risk, and bone remodeling: what is true? Am J Med Sci 332:55–60

Castaneda S, Largo R, Calvo E, Rodriguez-Salvanes F, Marcos ME et al (2006) Bone mineral measurements of subchondral and trabecular bone in healthy and osteoporotic rabbits. Skelet Radiol 35:34–41

Li GW, Tang GY, Liu Y, Tang RB, Peng YF et al (2012) MR spectroscopy and micro-CT in evaluation of osteoporosis model in rabbits: comparison with histopathology. Eur Radiol 22:923–929

Arens AM, Barr B, Puchalski SM, Poppenga R, Kulin RM et al (2011) Osteoporosis associated with pulmonary silicosis in an equine bone fragility syndrome. Vet Pathol 48:593–615

Zhang Y, Yu L, Ao M, Jin W (2006) Effect of ethanol extract of Lepidium meyenii Walp. on osteoporosis in ovariectomized rat. J Ethnopharmacol 105:274–279

Scholz-Ahrens KE, Delling G, Stampa B, Helfenstein A, Hahne HJ et al (2007) Glucocorticosteroid-induced osteoporosis in adult primiparous Gottingen miniature pigs: effects on bone mineral and mineral metabolism. Am J Physiol Endocrinol Metab 293:E385–E395

Liu X, Lei W, Wu Z, Cui Y, Han B et al (2012) Effects of glucocorticoid on BMD, micro-architecture and biomechanics of cancellous and cortical bone mass in OVX rabbits. Med Eng Phys 34:2–8

Baofeng L, Zhi Y, Bei C, Guolin M, Qingshui Y et al (2010) Characterization of a rabbit osteoporosis model induced by ovariectomy and glucocorticoid. Acta Orthop 81:396–401

Schorlemmer S, Ignatius A, Claes L, Augat P (2005) Inhibition of cortical and cancellous bone formation in glucocorticoid-treated OVX sheep. Bone 37:491–496

Akhter MP, Cullen DM, Gong G, Recker RR (2001) Bone biomechanical properties in prostaglandin EP1 and EP2 knockout mice. Bone 29:121–125

Chen H, Wu M, Kubo KY (2012) Combined treatment with a traditional Chinese medicine, Hachimi-jio-gan (Ba-Wei-Di-Huang-Wan) and alendronate improves bone microstructure in ovariectomized rats. J Ethnopharmacol 142:80–85

Hordon LD, Itoda M, Shore PA, Shore RC, Heald M et al (2006) Preservation of thoracic spine microarchitecture by alendronate: comparison of histology and microCT. Bone 38:444–449

Zhao FD, Pollintine P, Hole BD, Adams MA, Dolan P (2009) Vertebral fractures usually affect the cranial endplate because it is thinner and supported by less-dense trabecular bone. Bone 44:372–379

Li L, Zeng Z, Cai G (2011) Comparison of neoeriocitrin and naringin on proliferation and osteogenic differentiation in MC3T3-E1. Phytomedicine 18:985–989

Chen PY, Sun JS, Tsuang YH, Chen MH, Weng PW et al (2010) Simvastatin promotes osteoblast viability and differentiation via Ras/Smad/Erk/BMP-2 signaling pathway. Nutr Res 30:191–199

Ho ML, Chen YH, Liao HJ, Chen CH, Hung SH et al (2009) Simvastatin increases osteoblasts and osteogenic proteins in ovariectomized rats. Eur J Clin Invest 39:296–303

Oxlund H, Andreassen TT (2004) Simvastatin treatment partially prevents ovariectomy-induced bone loss while increasing cortical bone formation. Bone 34:609–618

Yin H, Shi ZG, Yu YS, Hu J, Wang R et al (2012) Protection against osteoporosis by statins is linked to a reduction of oxidative stress and restoration of nitricoxide formation in aged and ovariectomized rats. Eur J Pharmacol 674:200–206

Baek KH, Lee WY, Oh KW, Tae HJ, Lee JM et al (2005) The effect of simvastatin on the proliferation and differentiation of human bone marrow stromal cells. J Korean Med Sci 20:438–444

Hwang R, Lee EJ, Kim MH, Li SZ, Jin YJ et al (2004) Calcyclin, a Ca2+ ion-binding protein, contributes to the anabolic effects of simvastatinon bone. J Biol Chem 279:21239–21247

Maeda T, Matsunuma A, Kawane T, Horiuchi N (2001) Simvastatin promotes osteoblast differentiation and mineralization in MC3T3-E1cells. Biochem Biophys Res Commun 280:874–877

von Stechow D, Fish S, Yahalom D, Bab I, Chorev M et al (2003) Does simvastatin stimulate bone formation in vivo? BMC Musculoskelet Disord 4:8

Yazawa H, Zimmermann B, Asami Y, Bernimoulin JP (2005) Simvastatin promotes cell metabolism, proliferation, and osteoblastic differentiation in human periodontal ligament cells. J Periodontol 76:295–302

Chuang SC, Liao HJ, Li CJ, Wang GJ, Chang JK et al (2013) Simvastatin enhances human osteoblast proliferation involved in mitochondrial energy generation. Eur J Pharmacol 714:74–82

Phimphilai M, Zhao Z, Boules H, Roca H, Franceschi RT (2006) BMP signaling is required for RUNX2-dependent induction of the osteoblast phenotype. J Bone Miner Res 21:637–646

Lee MH, Kim YJ, Kim HJ, Park HD, Kang AR et al (2003) BMP-2-induced Runx2 expression is mediated by Dlx5, and TGF-beta 1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expression. J Biol Chem 278:34387–34394

Kim T, Ha H, Shim KS, Cho WK, Ma JY (2013) The anti-osteoporotic effect of Yijung-tang in an ovariectomized rat model mediated by inhibition of osteoclast differentiation. J Ethnopharmacol 146:83–89

Maeda T, Matsunuma A, Kurahashi I, Yanagawa T, Yoshida H et al (2004) Induction of osteoblast differentiation indices by statins in MC3T3-E1 cells. J Cell Biochem 92:458–471

Liu XY, Zhang SS, Lu XM, Zheng SN, Li FM et al (2012) Metabonomic study on the anti-osteoporosis effect of Rhizoma Drynariae and its action mechanism using ultra-performance liquid chromatography-tandem mass spectrometry. J Ethnopharmacol 139:311–317