The fortification method relying on assumed human milk composition overestimates the actual energy and macronutrient intakes in very preterm infants

Eidelman AI. The aap's 2012 Breastfeeding policy statement: is there anything new? Breastfeed Med. 2012;7:203–4. https://doi.org/10.1089/bfm.2012.9989 .

Agostoni C, Buonocore G, Carnielli VP, De Curtis M, Darmaun D, Decsi T, Domellof M, Embleton ND, Fusch C, Genzel-Boroviczeny O, et al. Enteral nutrient supply for preterm infants: commentary from the european society of paediatric gastroenterology, hepatology and nutrition committee on nutrition. J Pediatr Gastroenterol Nutr. 2010;50:85–91. https://doi.org/10.1097/MPG.0b013e3181adaee0 .

Ziegler EE. Meeting the nutritional needs of the low-birth-weight infant. Ann Nutr Metab. 2011;58(Suppl 1):8–18. https://doi.org/10.1159/000323381 .

Nutritional composition of breast milk produced by mothers of preterm infants. Nutr Rev. 1980;38:312–3.

Corvaglia L, Aceti A, Paoletti V, Mariani E, Patrono D, Ancora G, Capretti MG, Faldella G. Standard fortification of preterm human milk fails to meet recommended protein intake: bedside evaluation by near-infrared-reflectance-analysis. Early Hum Dev. 2010;86:237–40. https://doi.org/10.1016/j.earlhumdev.2010.04.001 .

Macedo I, Pereira-da-Silva L, Cardoso M. Associations of measured protein and energy intakes with growth and adiposity in human milk-fed preterm infants at term postmenstrual age: a cohort study. Am J Perinatol. 2018;35:882–91. https://doi.org/10.1055/s-0038-1626717 .

Polberger S. III. Individualized fortification of human milk: Targeted fortification. J Pediatr Gastroenterol Nutr. 2015;61(Suppl 1):S3–4. https://doi.org/10.1097/01.mpg.0000471451.55494.e4 .

McLeod G, Sherriff J, Hartmann PE, Nathan E, Geddes D, Simmer K. Comparing different methods of human breast milk fortification using measured v. Assumed macronutrient composition to target reference growth: a randomised controlled trial. Br J Nutr. 2016;115:431–9. https://doi.org/10.1017/S0007114515004614 .

Rochow N, Fusch G, Zapanta B, Ali A, Barui S, Fusch C. Target fortification of breast milk: how often should milk analysis be done? Nutrients. 2015;7:2297–310. https://doi.org/10.3390/nu7042297 .

Kemp JE, Wenhold FA. Human milk fortification strategies for improved in-hospital growth of preterm infants. S Afr J Clin Nutr. 2016;29:8. https://doi.org/10.1080/16070658.2016.1217646 .

Rochow N, Fusch G, Choi A, Chessell L, Elliott L, McDonald K, Kuiper E, Purcha M, Turner S, Chan E, et al. Target fortification of breast milk with fat, protein, and carbohydrates for preterm infants. J Pediatr. 2013;163:1001–7. https://doi.org/10.1016/j.jpeds.2013.04.052 .

Cooper AR, Barnett D, Gentles E, Cairns L, Simpson JH. Macronutrient content of donor human breast milk. Arch Dis Child Fetal Neonatal Ed. 2013;98:F539–41. https://doi.org/10.1136/archdischild-2013-304422 .

de Halleux V, Rigo J. Variability in human milk composition: benefit of individualized fortification in very-low-birth-weight infants. Am J Clin Nutr. 2013;98:529S–35S. https://doi.org/10.3945/ajcn.112.042689 .

Morlacchi L, Mallardi D, Gianni ML, Roggero P, Amato O, Piemontese P, Consonni D, Mosca F. Is targeted fortification of human breast milk an optimal nutrition strategy for preterm infants? An interventional study. J Transl Med. 2016;14:195. https://doi.org/10.1186/s12967-016-0957-y .

Mimouni FB, Lubetzky R, Yochpaz S, Mandel D. Preterm human milk macronutrient and energy composition: a systematic review and meta-analysis. Clin Perinatol. 2017;44:165–72. https://doi.org/10.1016/j.clp.2016.11.010 .

Drummond M, A.G., Arkley C, Gillen D. Donor milk banks: Service operation, clinical guidelines. In NICE clinical guidelines, NICE: London, 2010; p 35.

Peila C, Moro GE, Bertino E, Cavallarin L, Giribaldi M, Giuliani F, Cresi F, Coscia A. The effect of holder pasteurization on nutrients and biologically-active components in donor human milk: a review. Nutrients. 2016;8 https://doi.org/10.3390/nu8080477 .

Polberger S, Raiha NC, Juvonen P, Moro GE, Minoli I, Warm A. Individualized protein fortification of human milk for preterm infants: comparison of ultrafiltrated human milk protein and a bovine whey fortifier. J Pediatr Gastroenterol Nutr. 1999;29:332–8.

Nutrition Committee, C.P.S. Nutrient needs and feeding of premature infants. CMAJ. 1995;152:1765–85.

Kreissl A, Zwiauer V, Repa A, Binder C, Haninger N, Jilma B, Berger A, Haiden N. Effect of fortifiers and additional protein on the osmolarity of human milk: is it still safe for the premature infant? J Pediatr Gastroenterol Nutr. 2013;57:432–7. https://doi.org/10.1097/MPG.0b013e3182a208c7 .

Roggero P, Gianni ML, Amato O, Orsi A, Piemontese P, Morlacchi L, Mosca F. Is term newborn body composition being achieved postnatally in preterm infants? Early Hum Dev. 2009;85:349–52. https://doi.org/10.1016/j.earlhumdev.2008.12.011 .

Cormack BE, Bloomfield FH. Increased protein intake decreases postnatal growth faltering in elbw babies. Arch Dis Child Fetal Neonatal Ed. 2013;98:F399–404. https://doi.org/10.1136/archdischild-2012-302868 .

Valla FV, Gaillard-Le Roux B, Ford-Chessel C, De Monte M, Tume L, Letois F, Mura T, Choueiry E, Rooze S, Moullet C, et al. A nursing survey on nutritional care practices in french-speaking pediatric intensive care units: Nutrirea-ped 2014. J Pediatr Gastroenterol Nutr. 2016;62:174–9. https://doi.org/10.1097/MPG.0000000000000930 .

Vieira AA, Soares FV, Pimenta HP, Abranches AD, Moreira ME. Analysis of the influence of pasteurization, freezing/thawing, and offer processes on human milk's macronutrient concentrations. Early Hum Dev. 2011;87:577–80. https://doi.org/10.1016/j.earlhumdev.2011.04.016 .