The fission yeast FLCN/FNIP complex augments TORC1 repression or activation in response to amino acid (AA) availability

iScience - Tập 24 - Trang 103338 - 2021
Isabel A. Calvo1, Shalini Sharma1, Joao A. Paulo2, Alexander O.D. Gulka1, Andras Boeszoermenyi3,4, Jingyu Zhang1, Jose M. Lombana1, Christina M. Palmieri1, Laura A. Laviolette1, Haribabu Arthanari3,4, Othon Iliopoulos1,5, Steven P. Gygi6, Mo Motamedi1
1Massachusetts General Hospital Center for Cancer Research and Department of Medicine Harvard Medical School, Charlestown, MA 02129, USA
2Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
3Department of Biochemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
4Dana-Farber Cancer Institute, Boston, MA 02215, USA
5Division of Hematology-Oncology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
6Department of Cell Biology, Harvard Medical School, Boston, MA 02115 USA

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