The first deltex null mutant indicates tissue-specific deltex-dependent Notch signaling in Drosophila

Springer Science and Business Media LLC - Tập 275 Số 3 - Trang 251-263 - 2006
Takashi J. Fuwa1, Kazuya Hori1, Takeshi Sasamura1, Jenny Higgs2, Martín Baron2, Kenji Matsuno3
1Department of Biological Science and Technology, Tokyo University of Science, 2641 Yamazaki, 278-8510, Noda, Chiba, Japan
2Faculty of Life Sciences Michael Smith Building, University of Manchester, Stopford Road, M13 9PT, Manchester, United Kingdom
3PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho Kawaguchi, Saitama, Japan

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Amin A (2004) Genetic cross-talk during head development in Drosophila. J Biomed Biotechnol 2004:16–23

Artavanis-Tsakonas S, Rand MD, Lake RJ (1999) Notch signaling: cell fate control and signal integration in development. Science 284:770–776

Bailey AM, Posakony JW (1995) Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity. Genes Dev 9:2609–2622

Barolo S, Stone T, Bang AG, Posakony JW (2002) Default repression and notch signaling: hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to suppressor of hairless. Genes Dev 16:1964–1976

Bishop SA, Klein T, Arias AM, Couso JP (1999) Composite signalling from serrate and delta establishes leg segments in Drosophila through Notch. Development 126:2993–3003

Brennan K, Tateson R, Lewis K, Arias AM (1997) A functional analysis of Notch mutations in Drosophila. Genetics 147:177–188

Busseau I, Diederich RJ, Xu T, Artavanis-Tsakonas S (1994) A member of the Notch group of interacting loci, deltex encodes a cytoplasmic basic protein. Genetics 136:585–596

Certel K, Hudson A, Carroll SB, Johnson WA (2000) Restricted patterning of vestigial expression in Drosophila wing imaginal discs requires synergistic activation by both Mad and the drifter POU domain transcription factor. Development 127:3173–3183

Couso JP, Knust E, Martinez Arias A (1995) Serrate and wingless cooperate to induce vestigial gene expression and wing formation in Drosophila. Curr Biol 5:1437–1448

Dan L Lindsley GGZ (1992) The genome of Drosophila melanogaster. Academic, San Diego

de Celis JF, Garcia-Bellido A, Bray SJ (1996) Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc. Development 122:359–369

De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R (1999) A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature 398:518–522

Diederich RJ, Matsuno K, Hing H, Artavanis-Tsakonas S (1994) Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway. Development 120:473–481

Doherty D, Feger G, Younger-Shepherd S, Jan LY, Jan YN (1996) Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation. Genes Dev 10:421–434

Endo Y, Osumi N, Wakamatsu Y (2003) Deltex/Dtx mediates NOTCH signaling in regulation of Bmp4 expression in cranial neural crest formation during avian development. Dev Growth Differ 45:241–248

Fanto M, Mlodzik M (1999) Asymmetric Notch activation specifies photoreceptors R3 and R4 and planar polarity in the Drosophila eye. Nature 397:523–526

Fehon RG, Johansen K, Rebay I, Artavanis-Tsakonas S (1991) Complex cellular and subcellular regulation of notch expression during embryonic and imaginal development of Drosophila: implications for notch function. J Cell Biol 113:657–669

Fehon RG, Kooh PJ, Rebay I, Regan CL, Xu T, Muskavitch MA, Artavanis-Tsakonas S (1990) Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila. Cell 61:523–534

Fleming RJ, Gu Y, Hukriede NA (1997) Serrate-mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginal disc. Development 124:2973–2981

Fortini ME, Artavanis-Tsakonas S (1994) The suppressor of hairless protein participates in notch receptor signaling. Cell 79:273–282

Furriols M, Bray S (2000) Dissecting the mechanisms of suppressor of hairless function. Dev Biol 227:520–532

Gorman MJ, Girton JR (1992) A genetic analysis of deltex and its interaction with the Notch locus in Drosophila melanogaster. Genetics 131:99–112

Grimwade BG, Muskavitch MA, Welshons WJ, Yedvobnick B, Artavanis-Tsakonas S (1985) The molecular genetics of the Notch locus in Drosophila melanogaster. Dev Biol 107:503–519

Gubb D (1993) Genes controlling cellular polarity in Drosophila. Development Suppl:269–277

Hansson EM, Lendahl U, Chapman G (2004) Notch signaling in development and disease. Semin Cancer Biol 14:320–328

Heitzler P, Simpson P (1991) The choice of cell fate in the epidermis of Drosophila. Cell 64:1083–1092

Heitzler P, Simpson P (1993) Altered epidermal growth factor-like sequences provide evidence for a role of Notch as a receptor in cell fate decisions. Development 117:1113–1123

Hori K, Fostier M, Ito M, Fuwa TJ, Go MJ, Okano H, Baron M, Matsuno K (2004) Drosophila deltex mediates suppressor of Hairless-independent and late-endosomal activation of Notch signaling. Development 131:5527–5537

Horowitz H, Berg CA (1995) Aberrant splicing and transcription termination caused by P element insertion into the intron of a Drosophila gene. Genetics 139:327–335

Hu QD, Ang BT, Karsak M, Hu WP, Cui XY, Duka T, Takeda Y, Chia W, Sankar N, Ng YK, Ling EA, Maciag T, Small D, Trifonova R, Kopan R, Okano H, Nakafuku M, Chiba S, Hirai H, Aster JC, Schachner M, Pallen CJ, Watanabe K, Xiao ZC (2003) F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation. Cell 115:163–175

Jacobsen TL, Brennan K, Arias AM, Muskavitch MA (1998) Cis-interactions between Delta and Notch modulate neurogenic signalling in Drosophila. Development 125:4531–4540

Joazeiro CA, Weissman AM (2000) RING finger proteins: mediators of ubiquitin ligase activity. Cell 102:549–552

Johnson RL, Grenier JK, Scott MP (1995) Patched overexpression alters wing disc size and pattern: transcriptional and post-transcriptional effects on hedgehog targets. Development 121:4161–4170

Kao HY, Ordentlich P, Koyano-Nakagawa N, Tang Z, Downes M, Kintner CR, Evans RM, Kadesch T (1998) A histone deacetylase corepressor complex regulates the Notch signal transduction pathway. Genes Dev 12:2269–2277

Kidd S, Lockett TJ, Young MW (1983) The Notch locus of Drosophila melanogaster. Cell 34:421–433

Kim J, Sebring A, Esch JJ, Kraus ME, Vorwerk K, Magee J, Carroll SB (1996) Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene. Nature 382:133–138

Kishi N, Tang Z, Maeda Y, Hirai A, Mo R, Ito M, Suzuki S, Nakao K, Kinoshita T, Kadesch T, Hui C, Artavanis-Tsakonas S, Okano H, Matsuno K (2001) Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis. Int J Dev Neurosci 19:21–35

Kitagawa M, Oyama T, Kawashima T, Yedvobnick B, Kumar A, Matsuno K, Harigaya K (2001) A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promoters. Mol Cell Biol 21:4337–4346

Klein T, Arias AM (1998) Different spatial and temporal interactions between Notch, wingless, and vestigial specify proximal and distal pattern elements of the wing in Drosophila. Dev Biol 194:196–212

Lai EC (2004) Notch signaling: control of cell communication and cell fate. Development 131:965–973

Le Borgne R, Bardin A, Schweisguth F (2005) The roles of receptor and ligand endocytosis in regulating Notch signaling. Development 132:1751–1762

Lecourtois M, Schweisguth F (1995) The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling. Genes Dev 9:2598–2608

Lieber T, Kidd S, Young MW (2002) kuzbanian-mediated cleavage of Drosophila Notch. Genes Dev 16:209–221

Ligoxygakis P, Yu SY, Delidakis C, Baker NE (1998) A subset of notch functions during Drosophila eye development require Su(H) and the E(spl) gene complex. Development 125:2893–2900

Liu WH, Lai MZ (2005) Deltex regulates T-cell activation by targeted degradation of active MEKK1. Mol Cell Biol 25:1367–1378

Llimargas M (1999) The Notch pathway helps to pattern the tips of the Drosophila tracheal branches by selecting cell fates. Development 126:2355–2364

Matsuno K, Diederich RJ, Go MJ, Blaumueller CM, Artavanis-Tsakonas S (1995) Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats. Development 121:2633–2644

Matsuno K, Eastman D, Mitsiades T, Quinn AM, Carcanciu ML, Ordentlich P, Kadesch T, Artavanis-Tsakonas S (1998) Human deltex is a conserved regulator of Notch signalling. Nat Genet 19:74–78

Matsuno K, Ito M, Hori K, Miyashita F, Suzuki S, Kishi N, Artavanis-Tsakonas S, Okano H (2002) Involvement of a proline-rich motif and RING-H2 finger of Deltex in the regulation of Notch signaling. Development 129:1049–1059

Micchelli CA, Blair SS (1999) Dorsoventral lineage restriction in wing imaginal discs requires Notch. Nature 401:473–476

Morel V, Schweisguth F (2000) Repression by suppressor of hairless and activation by Notch are required to define a single row of single-minded expressing cells in the Drosophila embryo. Genes Dev 14:377–388

Mullis KB, Faloona FA (1987) Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. Methods Enzymol 155:335–350

Mumm JS, Kopan R (2000) Notch signaling: from the outside in. Dev Biol 228:151–165

Neumann CJ, Cohen SM (1996) A hierarchy of cross-regulation involving Notch, wingless, vestigial and cut organizes the dorsal/ventral axis of the Drosophila wing. Development 122:3477–3485

Ordentlich P, Lin A, Shen CP, Blaumueller C, Matsuno K, Artavanis-Tsakonas S, Kadesch T (1998) Notch inhibition of E47 supports the existence of a novel signaling pathway. Mol Cell Biol 18:2230–2239

Pampeno CL, Meruelo D (1996) A novel cDNA transcript expressed in fractionated X-irradiation-induced murine thymomas. Cell Growth Differ 7:1113–1123

Pan D, Rubin GM (1997) Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis. Cell 90:271–280

Panin VM, Papayannopoulos V, Wilson R, Irvine KD (1997) Fringe modulates Notch-ligand interactions. Nature 387:908–912

Parks AL, Muskavitch MA (1993) Delta function is required for bristle organ determination and morphogenesis in Drosophila. Dev Biol 157:484–496

Qiu L, Joazeiro C, Fang N, Wang HY, Elly C, Altman Y, Fang D, Hunter T, Liu YC (2000) Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase. J Biol Chem 275:35734–35737

Ramain P, Khechumian K, Seugnet L, Arbogast N, Ackermann C, Heitzler P (2001) Novel Notch alleles reveal a Deltex-dependent pathway repressing neural fate. Curr Biol 11:1729–1738

Rebay I, Fleming RJ, Fehon RG, Cherbas L, Cherbas P, Artavanis-Tsakonas S (1991) Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor. Cell 67:687–699

Robertson HM, Preston CR, Phillis RW, Johnson-Schlitz DM, Benz WK, Engels WR (1988) A stable genomic source of P element transposase in Drosophila melanogaster. Genetics 118:461–470

Rooke J, Pan D, Xu T, Rubin GM (1996) KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis. Science 273:1227–1231

Rorth P (1996) A modular misexpression screen in Drosophila detecting tissue-specific phenotypes. Proc Natl Acad Sci USA 93:12418–12422

Sakata T, Sakaguchi H, Tsuda L, Higashitani A, Aigaki T, Matsuno K, Hayashi S (2004) Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation. Curr Biol 14:2228–2236

Sestan N, Artavanis-Tsakonas S, Rakic P (1999) Contact-dependent inhibition of cortical neurite growth mediated by notch signaling. Science 286:741–746

Shellenbarger DL, Mohler JD (1975) Temperature-sensitive mutations of the notch locus in Drosophila melanogaster. Genetics 81:143–162

Shepard SB, Broverman SA, Muskavitch MA (1989) A tripartite interaction among alleles of Notch, Delta, and Enhancer of split during imaginal development of Drosophila melanogaster. Genetics 122:429–438

Speicher SA, Thomas U, Hinz U, Knust E (1994) The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginal discs: control of cell proliferation. Development 120:535–544

Struhl G, Greenwald I (1999) Presenilin is required for activity and nuclear access of Notch in Drosophila. Nature 398:522–525

Struhl G, Greenwald I (2001) Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila. Proc Natl Acad Sci USA 98:229–234

Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA (2003) The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. J Biol Chem 278:21930–21937

Theisen H, Purcell J, Bennett M, Kansagara D, Syed A, Marsh JL (1994) dishevelled is required during wingless signaling to establish both cell polarity and cell identity. Development 120:347–360

Tramboo NA, Iqbal K, Dar MA, Malik RA, Naikoo BA, Andrabi MA (2002) Unusual dysmorphic features in five patients with Noonan’s syndrome: a brief review. J Paediatr Child Health 38:521–525

van den Heuvel M, Nusse R, Johnston P, Lawrence PA (1989) Distribution of the wingless gene product in Drosophila embryos: a protein involved in cell-cell communication. Cell 59:739–749

Wharton KA, Johansen KM, Xu T, Artavanis-Tsakonas S (1985) Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats. Cell 43:567–581

Wilkin MB, Carbery AM, Fostier M, Aslam H, Mazaleyrat SL, Higgs J, Myat A, Evans DA, Cornell M, Baron M (2004) Regulation of notch endosomal sorting and signaling by Drosophila Nedd4 family proteins. Curr Biol 14:2237–2244

Wu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, Griffin JD (2000) MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. Nat Genet 26:484–489

Xu T, Artavanis-Tsakonas S (1990a) Deltex, a locus interacting with the neurogenic genes, Notch, Delta and mastermind in Drosophila melanogaster. Genetics 126:665–677

Xu T, Rebay I, Fleming RJ, Scottgale TN, Artavanis-Tsakonas S (1990b) The Notch locus and the genetic circuitry involved in early Drosophila neurogenesis. Genes Dev 4:464–475

Xu T, Rubin GM (1993) Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117:1223–1237

Zecchini V, Brennan K, Martinez-Arias A (1999) An activity of Notch regulates JNK signalling and affects dorsal closure in Drosophila. Curr Biol 9:460–469

Zeng C, Younger-Shepherd S, Jan LY, Jan YN (1998) Delta and Serrate are redundant Notch ligands required for asymmetric cell divisions within the Drosophila sensory organ lineage. Genes Dev 12:1086–1091

Zhang YQ, Matthies HJ, Mancuso J, Andrews HK, Woodruff E, 3rd, Friedman D, Broadie K (2004) The Drosophila fragile X-related gene regulates axoneme differentiation during spermatogenesis. Dev Biol 270:290–307

Zheng L, Zhang J, Carthew RW (1995) frizzled regulates mirror-symmetric pattern formation in the Drosophila eye. Development 121:3045–3055