The extracellular proteins of Lactobacillus acidophilus DSM 20079T display anti-inflammatory effect in both in piglets, healthy human donors and Crohn’s Disease patients

Barratt-Stopper, 2016, P-159 Crohn’s disease and ulcerative colitis show unique cytokine profiles, Inflammatory Bowel Diseases, 10.1097/01.MIB.0000480254.25267.ff Bernardo, 2012, Microbiota/host crosstalk biomarkers: Regulatory response of human intestinal dendritic cells exposed to Lactobacillus extracellular encrypted peptide, PLoS ONE, 7, 1, 10.1371/journal.pone.0036262 Call, 2015, Sortase-deficient lactobacilli: Effect on immunomodulation and gut retention, Microbiology (United Kingdom), 161, 311 Chaparro, 2019, EpidemIBD: Rationale and design of a large-scale epidemiological study of inflammatory bowel disease in Spain, Therapeutic Advances in Gastroenterology, 10.1177/1756284819847034 Dai, 2017, Decreased CD8+CD28+/CD8+CD28- T cell ratio can sensitively predict poor outcome for patients with complicated Crohn disease, Medicine, 96, e7247, 10.1097/MD.0000000000007247 Dai, 2017, CD8 + CD28 + /CD8 + CD28 − T cell equilibrium can predict the active stage for patients with inflammatory bowel disease, Clinics and Research in Hepatology and Gastroenterology, 41, 693, 10.1016/j.clinre.2017.03.009 de la Rosa, 2004, Interleukin-2 is essential for CD4+CD25+ regulatory T cell function, European Journal of Immunology, 34, 2480, 10.1002/eji.200425274 Fantini, 2007, In vitro generation of CD4+CD25+ regulatory cells from murine naive T cells, Nature Protocols, 2, 1789, 10.1038/nprot.2007.258 Goh, 2010, Functional roles of aggregation-promoting-like factor in stress tolerance and adherence of lactobacillus acidophilus NCFM, Applied and Environmental Microbiology, 76, 5005, 10.1128/AEM.00030-10 Hidalgo-Cantabrana, 2017, In silico screening of the human gut metaproteome identifies Th17-promoting peptides encrypted in proteins of commensal bacteria, Frontiers in Microbiology, 8 Johnson, 2016, Conserved S-layer-associated proteins revealed by exoproteomic survey of S-layer-forming lactobacilli, Applied and Environmental Microbiology, 82, 134, 10.1128/AEM.01968-15 Konstantinov, 2008, S layer protein A of Lactobacillus acidophilus NCFM regulates immature dendritic cell and T cell functions, Proceedings of the National Academy of Sciences, 105, 19474, 10.1073/pnas.0810305105 Laemmli, 1970, Cleavage of structural proteins during the assembly of the head of bacteriophage T4, Nature, 227, 680, 10.1038/227680a0 Lebeer, 2010, Host interactions of probiotic bacterial surface molecules: Comparison with commensals and pathogens, Nature Reviews Microbiology, 8, 171, 10.1038/nrmicro2297 Lightfoot, 2015, SIGNR 3 -dependent immune regulation by Lactobacillus acidophilus surface layer protein A in colitis, Embo Journal, 34, 1 López, 2012, Treg-inducing membrane vesicles from Bifidobacterium bifidum LMG13195 as potential adjuvants in immunotherapy, Vaccine, 30, 825, 10.1016/j.vaccine.2011.11.115 Maslowski, 2009, Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43, Nature, 461, 1282, 10.1038/nature08530 Mohamadzadeh, 2011, Regulation of induced colonic inflammation by Lactobacillus acidophilus deficient in lipoteichoic acid, Proceedings of the National Academy of Sciences, 108, 4623, 10.1073/pnas.1005066107 O’Flaherty, 2010, Functional and phenotypic characterization of a protein from Lactobacillus acidophilus involved in cell morphology, stress tolerance and adherence to intestinal cells, Microbiology, 156, 3360, 10.1099/mic.0.043158-0 Romero, 2007, Four functionally distinct populations of human effector-memory CD8 + T lymphocytes, The Journal of Immunology, 10.4049/jimmunol.178.7.4112 Ryan, P. D., Hammer, Ø., & Harper, D. A. (2001). Past: Paleontological statistics software package for education and data analysis. Palaeontologia Electronica 178kb. T. Harper. Geological Museum. Doi: 10.1016/j.bcp.2008.05.025. Sánchez, 2009, A method for the identification of proteins secreted by lactic acid bacteria grown in complex media, FEMS Microbiology Letters, 295, 226, 10.1111/j.1574-6968.2009.01599.x Sánchez, 2011, Human cecum content modulates production of extracellular proteins by food and probiotic bacteria, FEMS Microbiology Letters, 324, 189, 10.1111/j.1574-6968.2011.02408.x Sanders, 2001, Invited review: The scientific basis of Lactobacillus acidophilus NCFM functionality as a probiotic, Journal of Dairy Science, 84, 319, 10.3168/jds.S0022-0302(01)74481-5 Walter, 2011, The human gut microbiome: Ecology and recent evolutionary changes, Annual Review of Microbiology, 65, 411, 10.1146/annurev-micro-090110-102830 Willing, 2009, Twin studies reveal specific imbalances in the mucosa-associated microbiota of patients with ileal Crohn’s disease, Inflammatory Bowel Diseases, 15, 653, 10.1002/ibd.20783 Yokoyama, 2011, The CD4+CD28null and the regulatory CD4+CD25High T-cell phenotypes in patients with ulcerative colitis during active and quiescent disease, and following colectomy, Cytokine, 56, 466, 10.1016/j.cyto.2011.06.021