The expression of CD86 in CD3+CD56+ NKT cells is associated with the occurrence and prognosis of sepsis-associated encephalopathy in sepsis patients: a prospective observational cohort study

Springer Science and Business Media LLC - Tập 71 - Trang 929-940 - 2023
Sheng-long Chen1,2,3,4, Xiao-yu Liu1, Jun-hong Huang1,5, Lu-hua Xian6, Xu-sheng Li1, Kang-rong Wang7, Jing Li1,4, Tian-cao Zhang1,2, Guo-ge Huang1,3, Xin-qiang Liu1, Hong-ke Zeng1, Mao-hua Zhou6, Wen-qiang Jiang1,2,3,4,5
1Department of Emergency&Department of Critical Care Medicine, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
2Medical College, Shantou University, Shantou, China
3Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
4The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China
5School of Medicine, South China University of Technology, Guangzhou, China
6Laboratory Medicine, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
7Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China

Tóm tắt

The role of CD3+CD56+ natural killer T (NKT) cells and its co-signaling molecules in patients with sepsis-associated encephalopathy (SAE) is unknown. In this prospective observational cohort study, we initially recruited 260 septic patients and eventually analyzed 90 patients, of whom 57 were in the SAE group and 37 were in the non-SAE group. Compared to the non-SAE group, 28-day mortality was significantly increased in the SAE group (33.3% vs. 12.1%, p = 0.026), while the mean fluorescence intensity (MFI) of CD86 in CD3+CD56+ NKT cells was significantly lower (2065.8 (1625.5 ~ 3198.8) vs. 3117.8 (2278.1 ~ 5349), p = 0.007). Multivariate analysis showed that MFI of CD86 in NKT cells, APACHE II score, and serum albumin were independent risk factors for SAE. Furthermore, the Kaplan–Meier survival analysis indicated that the mortality rate was significantly higher in the high-risk group than in the low-risk group (χ2 = 14.779, p < 0.001). This study showed that the decreased expression of CD86 in CD3+CD56+ NKT cells is an independent risk factor of SAE; thus, a prediction model including MFI of CD86 in NKT cells, APACHE II score, and serum albumin can be constructed for diagnosing SAE and predicting prognosis.

Tài liệu tham khảo

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