The enhancement of bone regeneration by gene activated matrix encoding for platelet derived growth factor

Canalis, 1988, Growth factors and the regulation of bone remodeling, J Clin Invest, 81, 277, 10.1172/JCI113318 Lynch, 1989, Growth factors in wound healing. Single and synergistic effects on partial thickness porcine skin wounds, J Clin Invest, 84, 640, 10.1172/JCI114210 Elangovan, 2009, Novel regenerative strategies to enhance periodontal therapy outcome, Expert Opin Biol Ther, 9, 399, 10.1517/14712590902778423 Winn, 2000, Gene therapy approaches for modulating bone regeneration, Adv Drug Deliv Rev, 42, 121, 10.1016/S0169-409X(00)00057-0 Cotrim, 2008, Gene therapy: some history, applications, problems, and prospects, Toxicol Pathol, 36, 97, 10.1177/0192623307309925 Ramseier, 2006, Gene therapeutics for periodontal regenerative medicine, Dent Clin North Am, 50, 245, 10.1016/j.cden.2005.12.001 Lieberman, 1999, The effect of regional gene therapy with bone morphogenetic protein-2-producing bone-marrow cells on the repair of segmental femoral defects in rats, J Bone Jt Surg Am, 81, 905, 10.2106/00004623-199907000-00002 Fang, 1996, Stimulation of new bone formation by direct transfer of osteogenic plasmid genes, Proc Natl Acad Sci U S A, 93, 5753, 10.1073/pnas.93.12.5753 Bonadio, 1999, Localized, direct plasmid gene delivery in vivo: prolonged therapy results in reproducible tissue regeneration, Nat Med, 5, 753, 10.1038/10473 Goldstein, 1998, Potential role for direct gene transfer in the enhancement of fracture healing, Clin Orthop Relat Res, S154, 10.1097/00003086-199810001-00017 Patil, 2000, Interbody fusion augmentation using localized gene delivery, Trans Orthop Res Soc, 25, 360 Elangovan, 2010, Review paper: DNA delivery strategies to promote periodontal regeneration, J Biomater Appl, 25, 3, 10.1177/0885328210366490 Intra, 2008, Characterization of the transgene expression generated by branched and linear polyethylenimine-plasmid DNA nanoparticles in vitro and after intraperitoneal injection in vivo, J Control Release, 130, 129, 10.1016/j.jconrel.2008.04.014 Boussif, 1995, A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine, Proc Natl Acad Sci U S A, 92, 7297, 10.1073/pnas.92.16.7297 Dash, 1997, Synthetic polymers for vectorial delivery of DNA: characterisation of polymer-DNA complexes by photon correlation spectroscopy and stability to nuclease degradation and disruption by polyanions in vitro, J Control Release, 48, 269, 10.1016/S0168-3659(97)00043-6 Dunlap, 1997, Nanoscopic structure of DNA condensed for gene delivery, Nucleic Acids Res, 25, 3095, 10.1093/nar/25.15.3095 Godbey, 1999, Poly(ethylenimine) and its role in gene delivery, J Control Release, 60, 149, 10.1016/S0168-3659(99)00090-5 Abdallah, 1996, A powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: polyethylenimine, Hum Gene Ther, 7, 1947, 10.1089/hum.1996.7.16-1947 Godbey, 1999, Improved packing of poly(ethylenimine)/DNA complexes increases transfection efficiency, Gene Ther, 6, 1380, 10.1038/sj.gt.3300976 Godbey, 1999, Size matters: molecular weight affects the efficiency of poly(ethylenimine) as a gene delivery vehicle, J Biomed Mater Res, 45, 268, 10.1002/(SICI)1097-4636(19990605)45:3<268::AID-JBM15>3.0.CO;2-Q Papisov, 1989, 139 Hollinger, 2008, Recombinant human platelet-derived growth factor: biology and clinical applications, J Bone Jt Surg Am, 90, 48, 10.2106/JBJS.G.01231 Chang, 2009, PDGF-B gene therapy accelerates bone engineering and oral implant osseointegration, Gene Ther, 17, 95, 10.1038/gt.2009.117 Javed, 2011, Significance of the platelet-derived growth factor in periodontal tissue regeneration, Arch Oral Biol, 56, 1476, 10.1016/j.archoralbio.2011.06.020 Lee, 2000, The bone regenerative effect of platelet-derived growth factor-BB delivered with a chitosan/tricalcium phosphate sponge carrier, J Periodontol, 71, 418, 10.1902/jop.2000.71.3.418 Minagawa, 1991, Direct observation of the biphasic conformational change of DNA induced by cationic polymers, FEBS Lett, 295, 67, 10.1016/0014-5793(91)81386-M Conover, 1999 Evans, 2012, Gene delivery to bone, Adv Drug Deliv Rev, 64, 1331, 10.1016/j.addr.2012.03.013 Parker, 1995, Cancer gene therapy using plasmid DNA: safety evaluation in rodents and non-human primates, Hum Gene Ther, 6, 575, 10.1089/hum.1995.6.5-575 Huang, 2003, Fabrication and in vitro testing of polymeric delivery system for condensed DNA, J Biomed Mater Res A, 67, 1384, 10.1002/jbm.a.20036 Huang, 2005, Bone regeneration in a rat cranial defect with delivery of PEI-condensed plasmid DNA encoding for bone morphogenetic protein-4 (BMP-4), Gene Ther, 12, 418, 10.1038/sj.gt.3302439 Bettinger, 1999, Size reduction of galactosylated PEI/DNA complexes improves lectin-mediated gene transfer into hepatocytes, Bioconjug Chem, 10, 558, 10.1021/bc990006h Oku, 1986, The fusogenic effect of synthetic polycations on negatively charged lipid bilayers, J Biochem, 100, 935, 10.1093/oxfordjournals.jbchem.a121806 Wagner, 1991, Transferrin-polycation-DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells, Proc Natl Acad Sci U S A, 88, 4255, 10.1073/pnas.88.10.4255 Ferkol, 1995, Gene transfer into the airway epithelium of animals by targeting the polymeric immunoglobulin receptor, J Clin Invest, 95, 493, 10.1172/JCI117690 Plank, 1996, Activation of the complement system by synthetic DNA complexes: a potential barrier for intravenous gene delivery, Hum Gene Ther, 7, 1437, 10.1089/hum.1996.7.12-1437 Ferrari, 1997, ExGen 500 is an efficient vector for gene delivery to lung epithelial cells in vitro and in vivo, Gene Ther, 4, 1100, 10.1038/sj.gt.3300503 Hsu, 2008, Effects of size and topology of DNA molecules on intracellular delivery with non-viral gene carriers, BMC Biotechnol, 8, 23, 10.1186/1472-6750-8-23 Battegay, 1994, PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGF beta-receptors, J Cell Biol, 125, 917, 10.1083/jcb.125.4.917 Bolander, 1992, Regulation of fracture repair by growth factors, Proc Soc Exp Biol Med, 200, 165, 10.3181/00379727-200-43410A Banfi, 2012, Therapeutic angiogenesis due to balanced single-vector delivery of VEGF and PDGF-BB, FASEB J, 26, 2486, 10.1096/fj.11-197400 Putnam, 1996, Tissue engineering using synthetic extracellular matrices, Nat Med, 2, 824, 10.1038/nm0796-824 Chung, 2007, Surface engineered and drug releasing pre-fabricated scaffolds for tissue engineering, Adv Drug Deliv Rev, 59, 249, 10.1016/j.addr.2007.03.015 Pieper, 2002, Loading of collagen-heparan sulfate matrices with bFGF promotes angiogenesis and tissue generation in rats, J Biomed Mater Res, 62, 185, 10.1002/jbm.10267 Kim, 1998, Development of biocompatible synthetic extracellular matrices for tissue engineering, Trends Biotechnol, 16, 224, 10.1016/S0167-7799(98)01191-3 Marks, 1991, Effects of fibroblasts and basic fibroblast growth factor on facilitation of dermal wound healing by type I collagen matrices, J Biomed Mater Res, 25, 683, 10.1002/jbm.820250510 Helm, 1997, Utilization of type I collagen gel, demineralized bone matrix, and bone morphogenetic protein-2 to enhance autologous bone lumbar spinal fusion, J Neurosurg, 86, 93, 10.3171/jns.1997.86.1.0093 Sweeney, 1995, Repair of critical size rat calvarial defects using extracellular matrix protein gels, J Neurosurg, 83, 710, 10.3171/jns.1995.83.4.0710 Wake, 1994, Pore morphology effects on the fibrovascular tissue growth in porous polymer substrates, Cell Transplant, 3, 339, 10.1177/096368979400300411 Lynch, 1989, A combination of platelet-derived and insulin-like growth factors enhances periodontal regeneration, J Clin Periodontol, 16, 545, 10.1111/j.1600-051X.1989.tb02334.x Nevins, 2003, Periodontal regeneration in humans using recombinant human platelet-derived growth factor-BB (rhPDGF-BB) and allogenic bone, J Periodontol, 74, 1282, 10.1902/jop.2003.74.9.1282 Schneider, 1994, Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells, Science, 264, 1467, 10.1126/science.8197461 Cardoso, 1993, Reversal of terminal differentiation and control of DNA replication: cyclin A and cdk2 specifically localize at subnuclear sites of DNA replication, Cell, 74, 979, 10.1016/0092-8674(93)90721-2 Fathke, 2004, Contribution of bone marrow-derived cells to skin: collagen deposition and wound repair, Stem Cells, 22, 812, 10.1634/stemcells.22-5-812