The ends in sight: Mre11-Rad50-Nbs1 complex structures come into focus

Molecular Cell - Tập 83 - Trang 160-162 - 2023
Jessica L. Wojtaszek1, R. Scott Williams1
1Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Department of Health and Human Services, Durham, Research Triangle Park, NC 27709, USA

Tài liệu tham khảo

Rotheneder, 2022, Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions, Mol. Cell, 83, 167, 10.1016/j.molcel.2022.12.003 Gut, 2022, Structural mechanism of endonucleolytic processing of blocked DNA ends and hairpins by Mre11-Rad50, Mol. Cell, 82, 3513, 10.1016/j.molcel.2022.07.019 Stracker, 2011, The MRE11 complex: starting from the ends, Mol. Cell Biol., 12, 90 Williams, 2007, Mre11–Rad50–Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template, Biochem. Cell. Biol., 85, 509, 10.1139/O07-069 Kashammer, 2019, Mechanism of DNA End Sensing and Processing by the Mre11-Rad50 Complex, Mol. Cell, 76, 382, 10.1016/j.molcel.2019.07.035 Cejka, 2021, DNA End Resection: Mechanism and Control, Annu. Rev. Genet., 55, 285, 10.1146/annurev-genet-071719-020312 Lim, 2011, Crystal structure of the Mre11–Rad50–ATPγS complex: understanding the interplay between Mre11 and Rad50, Genes Dev., 25, 1091, 10.1101/gad.2037811 Williams, 2008, Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair, Cell, 135, 97, 10.1016/j.cell.2008.08.017 Seifert, 2016, Structural mechanism of ATP-dependent DNA binding and DNA end bridging by eukaryotic Rad50, EMBO J., 35, 759, 10.15252/embj.201592934 Andres, 2017, CtIP/Ctp1/Sae2, molecular form fit for function, DNA Repair, 56, 109, 10.1016/j.dnarep.2017.06.013