The endocrine disrupting effects of sodium arsenite in the rat testis is not mediated through macrophage activation

WHO, 2010, 5 Flora, 2017 Dangleben, 2013, Arsenic immunotoxicity: a review, Environ. Heal. A Glob. Access Sci. Source, 12, 1 Minatel, 2018, Environmental arsenic exposure: from genetic susceptibility to pathogenesis, Environ. Int., 112, 183, 10.1016/j.envint.2017.12.017 WHO, 2010, 1 IARC, 2004, 84 Bourguignon, 2017, Evaluation of sodium arsenite exposure on reproductive competence in pregnant and postlactational dams and their offspring, Reprod. Toxicol., 69, 1, 10.1016/j.reprotox.2017.01.002 Chowdhury, 2017, The role of arsenic on skin diseases, hair fall and inflammation: an immunological review and case studies, J. Clin. Exp. Dermatol. Res., 08, 10.4172/2155-9554.1000384 Iavicoli, 2009, The effects of metals as endocrine disruptors, J. Toxicol. Environ. Health - Part B Crit. Rev., 12, 206, 10.1080/10937400902902062 James, 2015, Association between lifetime exposure to inorganic arsenic in drinking water and coronary heart disease in Colorado residents, Environ. Health Perspect., 123, 128, 10.1289/ehp.1307839 Sun, 2016, Mechanisms of arsenic disruption on gonadal, adrenal and thyroid endocrine systems in humans: a review, Environ. Int., 95, 61, 10.1016/j.envint.2016.07.020 Jana, 2006, Effects of chronic exposure to sodium arsenite on hypothalamo-pituitary-testicular activities in adult rats: possible an estrogenic mode of action, Reprod. Biol. Endocrinol., 4, 1, 10.1186/1477-7827-4-9 Rosenblatt, 2009, Inhibition of androgen receptor transcriptional activity as a novel mechanism of action of arsenic, Mol. Endocrinol., 23, 412, 10.1210/me.2008-0235 Chiou, 2008, Arsenic trioxide impairs spermatogenesis via reducing gene expression levels in testosterone synthesis pathway, Chem. Res. Toxicol., 21, 1562, 10.1021/tx700366x Darbre, 2006, Metalloestrogens: an emerging class of inorganic xenoestrogens with potential to add to the oestrogenic burden of the human breast, J. Appl. Toxicol., 26, 191, 10.1002/jat.1135 Sarkar, 2008, Arsenic induced toxicity on testicular tissue of mice, Indian J. Physiol. Pharmacol., 52, 84 de Araújo Ramos, 2017, Morphological and morphometrical changes on adult Wistar rat testis caused by chronic sodium arsenite exposure, Environ. Sci. Pollut. Res., 24, 10.1007/s11356-017-0200-2 Shapouri-Moghaddam, 2018 Hutson, 2006, Physiologic interactions between macrophages and Leydig cells, Exp. Biol. Med., 231, 1, 10.1177/153537020623100101 Bhushan, 2017, The macrophages in testis function, J. Reprod. Immunol., 119, 107, 10.1016/j.jri.2016.06.008 Hales, 2002, Testicular macrophage modulation of Leydig cell steroidogenesis, J. Reprod. Immunol., 57, 3, 10.1016/S0165-0378(02)00020-7 Telles, 2017, Effects of binge-like ethanol exposure during adolescence on the febrile response in rats, Alcohol. Clin. Exp. Res., 41, 507, 10.1111/acer.13333 Winnall, 2011, Rat resident testicular macrophages have an alternatively activated phenotype and constitutively produce interleukin-10 in vitro, J. Leukoc. Biol., 90, 133, 10.1189/jlb.1010557 Rebourcet, 2010, The effects of an in utero exposure to 2,3,7,8-tetrachloro-dibenzo-p-dioxin on male reproductive function: identification of Ccl5 as a potential marker, Int. J. Androl., 33, 413, 10.1111/j.1365-2605.2009.01020.x Curi, 2019, In utero and lactational exposure to diisopentyl phthalate induces fetal toxicity and antiandrogenic effects in rats, Toxicol. Sci., 171, 347, 10.1093/toxsci/kfz159 Chomczynski, 2006, The single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction: twenty-something years on, Nat. Protoc., 1, 581, 10.1038/nprot.2006.83 Livak, 2001, Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method, Methods, 25, 402, 10.1006/meth.2001.1262 Seed, 1996, Methods for assessing sperm motility, morphology, and counts in the rat, rabbit, and dog: a consensus report, Reprod. Toxicol., 10, 237, 10.1016/0890-6238(96)00028-7 De Souza Predes, 2010, Testis response to low doses of cadmium in Wistar rats, Int. J. Exp. Pathol., 91, 125, 10.1111/j.1365-2613.2009.00692.x De Souza Predes, 2011, Testicular histomorphometry and ultrastructure of rats treated with cadmium and Ginkgo biloba, Biol. Trace Elem. Res., 140, 330, 10.1007/s12011-010-8702-5 Prabu, 2012, Silibinin ameliorates arsenic induced nephrotoxicity by abrogation of oxidative stress, inflammation and apoptosis in rats, Mol. Biol. Rep., 39, 11201, 10.1007/s11033-012-2029-6 O’Bryan, 2000, Bacterial lipopolysaccharide-induced inflammation compromises testicular function at multiple levels in vivo, Endocrinology, 141, 238, 10.1210/endo.141.1.7240 de C. Borges, 2015, Protein tyrosine phosphatase-1b contributes to Lps-induced Leptin resistance in male rats, Am. J. Physiol. - Endocrinol. Metab., 308, E40, 10.1152/ajpendo.00094.2014 Renu, 2018, Review on molecular and biochemical insights of arsenic-mediated male reproductive toxicity, Life Sci., 212, 37, 10.1016/j.lfs.2018.09.045 Mitchell, 2010, Xenografting of human fetal testis tissue: a new approach to study fetal testis development and germ cell differentiation, Hum. Reprod., 25, 2405, 10.1093/humrep/deq183 Chapin, 2012, Assessment of circulating hormones in regulatory toxicity studies II. Male reproductive hormones, Toxicol. Pathol., 40, 1063, 10.1177/0192623312443321 Chen, 2016, Testicular immunoregulation and spermatogenesis, Semin. Cell Dev. Biol., 59, 157, 10.1016/j.semcdb.2016.01.019 Bhushan, 2015, Differential activation of inflammatory pathways in testicular macrophages provides a rationale for their subdued inflammatory capacity, J. Immunol., 194, 5455, 10.4049/jimmunol.1401132 Xu, 2014, Arsenic-induced cancer cell phenotype in human breast epithelia is estrogen receptor-independent but involves aromatase activation, Arch. Toxicol., 88, 263, 10.1007/s00204-013-1131-4 Khan, 2013, Arsenic-induced oxidative stress, apoptosis and alterations in testicular steroidogenesis and spermatogenesis in wistar rats: ameliorative effect of curcumin, Wudpecker J. Pharm. Pharmacol., 2, 33 Chang, 2007, Arsenic-induced toxicity and the protective role of ascorbic acid in mouse testis, Toxicol. Appl. Pharmacol., 218, 196, 10.1016/j.taap.2006.11.009 Kajihara, 2006, LPS-induced transient testicular dysfunction accompanied by apoptosis of testicular germ cells in mice, Med. Mol. Morphol., 39, 203, 10.1007/s00795-006-0334-7 Reddy, 2006, Bacterial lipopolysaccharide-induced oxidative stress in the impairment of steroidogenesis and spermatogenesis in rats, Reprod. Toxicol., 22, 493, 10.1016/j.reprotox.2006.03.003 Sharma, 2012, Antioxidant and modulatory role of Chlorophytum borivilianum against arsenic induced testicular impairment, J. Environ. Sci. (China), 24, 2159, 10.1016/S1001-0742(11)61019-X Ramos-Treviño, 2017, In vitro evaluation of damage by heavy metals in tight and gap junctions of sertoli cells, DNA Cell Biol., 36, 829, 10.1089/dna.2017.3839 Cheng, 2012, The blood-testis barrier and its implications for male contraception, Pharmacol. Rev., 64, 16, 10.1124/pr.110.002790 Mruk, 2015, The mammalian blood-testis barrier: its biology and regulation, Endocr. Rev., 36, 564, 10.1210/er.2014-1101 Pant, 2001, Male reproductive effect of arsenic in mice, BioMetals, 14, 113, 10.1023/A:1016686113763 Zubair, 2016, Toxic effects of arsenic on semen and hormonal profile and their amelioration with vitamin E in Teddy goat bucks, Andrologia, 48, 1220, 10.1111/and.12564 Souza, 2016, Effects of sodium arsenate and arsenite on male reproductive functions in Wistar rats, J. Toxicol. Environ. Health - Part A Curr. Issues, 79, 274, 10.1080/15287394.2016.1150926