The emotional disorders associated with multiple sclerosis

Ahmed, 2013, Pseudobulbar affect: prevalence and management, Ther Clin Risk Manag, 9, 483 Alajbegovic, 2011, Depression in multiple sclerosis patients, Med Arh, 65, 115 Ameis, 2006, Treatment of neuropsychiatric conditions associated with multiple sclerosis, Expert Rev Neurother, 6, 1555, 10.1586/14737175.6.10.1555 American Psychiatric Association, 2013 American Psychiatric Association, 2019 Ang, 2017, Distinct subtypes of apathy revealed by the apathy motivation index, PLoS One, 12, 10.1371/journal.pone.0169938 Anhoque, 2011, Anxiety and depressive symptoms in clinically isolated syndrome and multiple sclerosis, Arq Neuropsiquiatr, 69, 882, 10.1590/S0004-282X2011000700006 Arnett, 2006, Longitudinal course of depression symptoms in multiple sclerosis, J Neurol Neurosurg Psychiatry, 77, 606, 10.1136/jnnp.2004.047712 Arnett, 1999, Depressed mood in multiple sclerosis: relationship to capacity-demanding memory and attentional functioning, Neuropsychology, 13, 434, 10.1037/0894-4105.13.3.434 Arnett, 1999, Depression in multiple sclerosis: relationship to working memory capacity, Neuropsychology, 13, 546, 10.1037/0894-4105.13.4.546 Arnett, 2002, Relationship between coping, depression, and cognitive dysfunction in multiple sclerosis, Clin Neuropsychol, 16, 341, 10.1076/clin.16.3.341.13852 Arnett, 2008, Depression in multiple sclerosis: review and theoretical proposal, J Int Neuropsychol Soc, 14, 691, 10.1017/S1355617708081174 Asghar-Ali, 2004, Pure neuropsychiatric presentation of multiple sclerosis, Am J Psychiatry, 161, 226, 10.1176/appi.ajp.161.2.226 Askari, 2014, Anxiety in patients with multiple sclerosis: association with disability, depression, disease type and sex, Acta Med Iran, 52, 889 Askey-Jones, 2013, Cognitive behaviour therapy for common mental disorders in people with multiple sclerosis: a bench marking study, Behav Res Ther, 51, 648, 10.1016/j.brat.2013.04.001 Ayache, 2016, Prefrontal tDCS decreases pain in patients with multiple sclerosis, Front Neurosci, 10, 147, 10.3389/fnins.2016.00147 Bandelow, 2015, Efficacy of treatments for anxiety disorders: a meta-analysis, Int Clin Psychopharmacol, 30, 183, 10.1097/YIC.0000000000000078 Baron, 2011, Impact of psychotherapy on insomnia symptoms in patients with depression and multiple sclerosis, J Behav Med, 34, 92, 10.1007/s10865-010-9288-2 Beck, 1961, An inventory for measuring depression, Arch Gen Psychiatry, 4, 561, 10.1001/archpsyc.1961.01710120031004 Beiske, 2008, Depression and anxiety amongst multiple sclerosis patients, Eur J Neurol, 15, 239, 10.1111/j.1468-1331.2007.02041.x Benedict, 2003, Validity of the beck depression inventory-fast screen in multiple sclerosis, Mult Scler, 9, 393, 10.1191/1352458503ms902oa Bishop, 2002, What do we really know about mindfulness-based stress reduction?, Psychosom Med, 64, 71, 10.1097/00006842-200201000-00010 Boeschoten, 2017, Prevalence of depression and anxiety in multiple sclerosis: a systematic review and meta-analysis, J Neurol Sci, 372, 331, 10.1016/j.jns.2016.11.067 Bolanos, 2004, Assessment of mood states in patients receiving long-term corticosteroid therapy and in controls with patient-rated and clinician-rated scales, Ann Allergy Asthma Immunol, 92, 500, 10.1016/S1081-1206(10)61756-5 Bonavita, 2013, Morphostructural MRI abnormalities related to neuropsychiatric disorders associated to multiple sclerosis, Mult Scler Int, 2013, 102454 Bonavita, 2017, Default mode network changes in multiple sclerosis: a link between depression and cognitive impairment?, Eur J Neurol, 24, 27, 10.1111/ene.13112 Bozikas, 2003, Familial bipolar disorder and multiple sclerosis: a three-generation HLA family study, Prog Neuro-Psychopharmacol Biol Psychiatry, 27, 835, 10.1016/S0278-5846(03)00116-7 Brajković, 2009, The connection between coping mechanisms, depression, anxiety and fatigue in multiple sclerosis, Coll Antropol, 33, 135 Braley, 2010, Fatigue in multiple sclerosis: mechanisms, evaluation, and treatment, Sleep, 33, 1061, 10.1093/sleep/33.8.1061 Brooks, 2013, PRISM: a novel research tool to assess the prevalence of pseudobulbar affect symptoms across neurological conditions, PLoS One, 8, 10.1371/journal.pone.0072232 Brown, 2009, Longitudinal assessment of anxiety, depression, and fatigue in people with multiple sclerosis, Psychol Psychother Theory Res Pract, 82, 41, 10.1348/147608308X345614 Bruce, 2010, Treatment adherence in multiple sclerosis: association with emotional status, personality, and cognition, J Behav Med, 33, 219, 10.1007/s10865-010-9247-y Burns, 2013, Prospective examination of anxiety and depression before and during confirmed and pseudoexacerbations in patients with multiple sclerosis, Psychosom Med, 75, 76, 10.1097/PSY.0b013e3182757b2b Butler, 2016, A systematic review of anxiety amongst people with multiple sclerosis, Mult Scler Relat Disord, 10, 145, 10.1016/j.msard.2016.10.003 Cairney, 2007, Evaluation of 2 measures of psychological distress as screeners for depression in the general population, Can J Psychiatr, 52, 111, 10.1177/070674370705200209 Calandri, 2017, Improving the quality of life and psychological well-being of recently diagnosed multiple sclerosis patients: preliminary evaluation of a group-based cognitive behavioral intervention, Disabil Rehabil, 39, 1474, 10.1080/09638288.2016.1198430 Cambron, 2019, Fluoxetine in progressive multiple sclerosis: the FLUOX-PMS trial, Mult Scler, 25, 1728, 10.1177/1352458519843051 Carta, 2014, The risk of bipolar disorders in multiple sclerosis, J Affect Disord, 155, 255, 10.1016/j.jad.2013.11.008 Cavalera, 2019, Online meditation training for people with multiple sclerosis: a randomized controlled trial, Mult Scler, 25, 610, 10.1177/1352458518761187 Chalah, 2017, Psychiatric event in multiple sclerosis: could it be the tip of the iceberg?, Braz J Psychiatry, 39, 365, 10.1590/1516-4446-2016-2105 Chalah, 2020, Bifrontal transcranial direct current stimulation modulates fatigue in multiple sclerosis: a randomized sham-controlled study, J Neural Transm, 127, 953, 10.1007/s00702-020-02166-2 Chalk, 2007, Mind over matter: cognitive behavioral determinants of emotional distress in multiple sclerosis patients, Psychol Health Med, 12, 556, 10.1080/13548500701244965 Chertcoff, 2020, Anxiety in Argentinian patients with multiple sclerosis: prevalence and associated factors, Mult Scler Relat Disord, 41, 102042, 10.1016/j.msard.2020.102042 Christodoulou, 2009, Negative affect predicts subsequent cognitive change in multiple sclerosis, J Int Neuropsychol Soc, 15, 53, 10.1017/S135561770809005X Chwastiak, 2007, Psychiatric issues in multiple sclerosis, Psychiatr Clin North Am, 30, 803, 10.1016/j.psc.2007.07.003 Chwastiak, 2002, Depressive symptoms and severity of illness in multiple sclerosis: epidemiologic study of a large community sample, Am J Psychiatry, 159, 1862, 10.1176/appi.ajp.159.11.1862 Colamonico, 2012, Pseudobulbar affect: burden of illness in the USA, Adv Ther, 29, 775, 10.1007/s12325-012-0043-7 Colasanti, 2016, Hippocampal neuroinflammation, functional connectivity, and depressive symptoms in multiple sclerosis, Biol Psychiatry, 80, 62, 10.1016/j.biopsych.2015.11.022 Coplan, 2015, Treating comorbid anxiety and depression: psychosocial and pharmacological approaches, World J Psychiatry, 5, 366, 10.5498/wjp.v5.i4.366 Cottrell, 1926, Original papers: the affective symptomatology of disseminated sclerosis: a study of 100 cases, J Neurol Psychopathol, 7, 1, 10.1136/jnnp.s1-7.25.1 Cuijpers, 2013, The efficacy of psychotherapy and pharmacotherapy in treating depressive and anxiety disorders: a meta-analysis of direct comparisons, World Psychiatry, 12, 137, 10.1002/wps.20038 Cuijpers, 2014, Psychological treatment of generalized anxiety disorder: a meta-analysis, Clin Psychol Rev, 34, 130, 10.1016/j.cpr.2014.01.002 Cummings, 2006, Defining and diagnosing involuntary emotional expression disorder, CNS Spectr, 11, 1, 10.1017/S1092852900026614 da Silva, 2011, Depression and anxiety in a Portuguese MS population: associations with physical disability and severity of disease, J Neurol Sci, 306, 66, 10.1016/j.jns.2011.03.042 Dahl, 2009, Anxiety and depression in multiple sclerosis. A comparative population-based study in Nord-Trøndelag County, Norway, Mult Scler, 15, 1495, 10.1177/1352458509351542 Damasio, 2000, Subcortical and cortical brain activity during the feeling of self-generated emotions, Nat Neurosci, 3, 1049, 10.1038/79871 Di Legge, 2003, Longitudinal evaluation of depression and anxiety in patients with clinically isolated syndrome at high risk of developing early multiple sclerosis, Mult Scler, 9, 302, 10.1191/1352458503ms921oa Diaz-Olavarrieta, 1999, Neuropsychiatric manifestations of multiple sclerosis, J Neuropsychiatr Clin Neurosci, 11, 51, 10.1176/jnp.11.1.51 Dowlati, 2010, A meta-analysis of cytokines in major depression, Biol Psychiatry, 67, 446, 10.1016/j.biopsych.2009.09.033 Dunlop, 2008, Combination treatment with benzodiazepines and SSRIs for comorbid anxiety and depression: a review, Prim Care Companion J Clin Psychiatry, 10, 222, 10.4088/PCC.v10n0307 Eaton, 2010, Autoimmune diseases, bipolar disorder, and non-affective psychosis, Bipolar Disord, 12, 638, 10.1111/j.1399-5618.2010.00853.x Edwards, 2004, A prospective study of conditions associated with multiple sclerosis in a cohort of 658 consecutive outpatients attending a multiple sclerosis clinic, Mult Scler, 10, 575, 10.1191/1352458504ms1087oa Ehde, 2008, Efficacy of paroxetine in treating major depressive disorder in persons with multiple sclerosis, Gen Hosp Psychiatry, 30, 40, 10.1016/j.genhosppsych.2007.08.002 Espinola-Nadurille, 2010, Mental disorders in Mexican patients with multiple sclerosis, J Neuropsychiatr Clin Neurosci, 22, 63, 10.1176/jnp.2010.22.1.63 Falk, 1979, Lithium prophylaxis of corticotropin-induced psychosis, JAMA, 241, 1011, 10.1001/jama.1979.03290360027021 Fassbender, 1998, Mood disorders and dysfunction of the hypothalamic-pituitary-adrenal axis in multiple sclerosis: association with cerebral inflammation, Arch Neurol, 55, 66, 10.1001/archneur.55.1.66 Feinstein, 2002, An examination of suicidal intent in patients with multiple sclerosis, Neurology, 59, 674, 10.1212/WNL.59.5.674 Feinstein, 2007, Neuropsychiatric syndromes associated with multiple sclerosis, J Neuro, 254, 1173, 10.1007/s00415-007-2017-2 Feinstein, 2010, Disorders of mood and affect in multiple sclerosis, 183 Feinstein, 1992, Clinically isolated lesions of the type seen in multiple sclerosis: a cognitive, psychiatric, and MRI follow up study, J Neurol Neurosurg Psychiatry, 55, 869, 10.1136/jnnp.55.10.869 Feinstein, 1997, Prevalence and neurobehavioral correlates of pathological laughing and crying in multiple sclerosis, Arch Neurol, 54, 1116, 10.1001/archneur.1997.00550210050012 Feinstein, 1999, Pathological laughing and crying in multiple sclerosis: a preliminary report suggesting a role for the prefrontal cortex, Mult Scler, 5, 69, 10.1177/135245859900500201 Feinstein, 2004, Structural brain abnormalities in multiple sclerosis patients with major depression, Neurology, 62, 586, 10.1212/01.WNL.0000110316.12086.0C Feinstein, 2010, Diffusion tensor imaging abnormalities in depressed multiple sclerosis patients, Mult Scler, 16, 189, 10.1177/1352458509355461 Fernie, 2015, Cognitive behavioural interventions for depression in chronic neurological conditions: a systematic review, J Psychosom Res, 78, 411, 10.1016/j.jpsychores.2015.02.012 Ferrando, 2007, Patient health Questionnaire-9 to screen for depression in outpatients with multiple sclerosis, Int J MS Care, 9, 99, 10.7224/1537-2073-9.3.99 Fiest, 2016, Systematic review and meta-analysis of interventions for depression and anxiety in persons with multiple sclerosis, Mult Scler Relat Disord, 5, 12, 10.1016/j.msard.2015.10.004 Figved, 2008, Relationship of cognitive impairment to psychiatric symptoms in multiple sclerosis, Mult Scler, 14, 1084, 10.1177/1352458508092262 Fischer, 2015, Diagnostic accuracy for major depression in multiple sclerosis using self-report questionnaires, Brain Behav, 5, 10.1002/brb3.365 Fishman, 2004, Construct validity and frequency of euphoria sclerotica in multiple sclerosis, J Neuropsychiatr Clin Neurosci, 16, 350, 10.1176/jnp.16.3.350 Fitzgerald, 2018, Pseudobulbar affect: prevalence and association with symptoms in multiple sclerosis, Neurol Clin Pract, 8, 472, 10.1212/CPJ.0000000000000523 Flachenecker, 2002, Fatigue in multiple sclerosis: a comparison of different rating scales and correlation to clinical parameters, Mult Scler, 8, 523, 10.1191/1352458502ms839oa Foley, 1987, Efficacy of stress-inoculation training in coping with multiple sclerosis, J Consult Clin Psychol, 55, 919, 10.1037/0022-006X.55.6.919 Foong, 2003, Neuropsychiatry: cognition and mood disorders, 115, 10.1016/S1877-3419(09)70037-6 Forman, 2010, Evaluation of an adjustment group for people with multiple sclerosis: a pilot randomized controlled trial, Clin Rehabil, 24, 211, 10.1177/0269215509343492 Fragoso, 2010, Severe depression, suicide attempts, and ideation during the use of interferon beta by patients with multiple sclerosis, Clin Neuropharmacol, 33, 312, 10.1097/WNF.0b013e3181f8d513 Galeazzi, 2005, Psychiatric disorders and depression in multiple sclerosis outpatients: impact of disability and interferon beta therapy, Neurol Sci, 26, 255, 10.1007/s10072-005-0468-8 Garfield, 2012, Factors affecting anxiety in multiple sclerosis, Disabil Rehabil, 34, 2047, 10.3109/09638288.2012.667503 Gascoyne, 2019, Modifiable factors associated with depression and anxiety in multiple sclerosis, Acta Neurol Scand, 140, 204, 10.1111/ane.13132 Gay, 2010, Predictors of depression in multiple sclerosis patients, Acta Neurol Scand, 121, 161, 10.1111/j.1600-0404.2009.01232.x Geest, 2019, Fronto-limbic disconnection in patients with multiple sclerosis and depression, Mult Scler, 25, 715, 10.1177/1352458518767051 Ghaffar, 2008, Neuroanatomy of pseudobulbar affect: a quantitative MRI study in multiple sclerosis, J Neurol, 255, 406, 10.1007/s00415-008-0685-1 Gill, 2019, Depressive symptoms are associated with more negative functional outcomes than anxiety symptoms in persons with multiple sclerosis, J Neuropsychiatr Clin Neurosci, 31, 37, 10.1176/appi.neuropsych.18010011 Giordano, 2011, Anxiety and depression in multiple sclerosis patients around diagnosis, J Neurol Sci, 307, 86, 10.1016/j.jns.2011.05.008 Gobbi, 2014, Influence of the topography of brain damage on depression and fatigue in patients with multiple sclerosis, Mult Scler, 20, 192, 10.1177/1352458513493684 Goeb, 2006, Psychiatric side effects of interferon-beta in multiple sclerosis, Eur Psychiatry, 21, 186, 10.1016/j.eurpsy.2005.09.013 Göksel Karatepe, 2011, Quality of life in patients with multiple sclerosis: the impact of depression, fatigue, and disability, Int J Rehabil Res, 34, 290, 10.1097/MRR.0b013e32834ad479 Gold, 2006, Depression and immunity: inflammation and depressive symptoms in multiple sclerosis, Neurol Clin, 24, 507, 10.1016/j.ncl.2006.03.007 Gold, 2009, Depression and immunity: inflammation and depressive symptoms in multiple sclerosis, Immunol Allergy Clin N Am, 29, 309, 10.1016/j.iac.2009.02.008 Gold, 2005, The role of stress-response systems for the pathogenesis and progression of MS, Trends Immunol, 26, 644, 10.1016/j.it.2005.09.010 Gold, 2014, Detection of altered hippocampal morphology in multiple sclerosis-associated depression using automated surface mesh modeling, Hum Brain Mapp, 35, 30, 10.1002/hbm.22154 Goldman Consensus Group, 2005, The Goldman consensus statement on depression in multiple sclerosis, Mult Scler, 11, 328, 10.1191/1352458505ms1162oa Goretti, 2009, Coping strategies, psychological variables and their relationship with quality of life in multiple sclerosis, Neurol Sci, 30, 15, 10.1007/s10072-008-0009-3 Goretti, 2010, Psychosocial issue in children and adolescents with multiple sclerosis, Neurol Sci, 31, 467, 10.1007/s10072-010-0281-x Goretti, 2014, Anxiety state affects information processing speed in patients with multiple sclerosis, Neurol Sci, 35, 559, 10.1007/s10072-013-1544-0 Graziano, 2014, The effects of a group-based cognitive behavioral therapy on people with multiple sclerosis: a randomized controlled trial, Clin Rehabil, 28, 264, 10.1177/0269215513501525 Grigsby, 1993, Prediction of deficits in behavioral self-regulation among persons with multiple sclerosis, Arch Phys Med Rehabil, 74, 1350, 10.1016/0003-9993(93)90091-N Gromisch, 2020, Cognitive behavioral therapy for the management of multiple sclerosis-related pain: a randomized clinical trial, Int J MS Care, 22, 8, 10.7224/1537-2073.2018-023 Grossman, 2010, MS quality of life, depression, and fatigue improve after mindfulness training: a randomized trial, Neurology, 75, 1141, 10.1212/WNL.0b013e3181f4d80d Hakim, 2000, The social impact of multiple sclerosis-a study of 305 patients and their relatives, Disabil Rehabil, 22, 288, 10.1080/096382800296755 Hamilton, 1960, Rating scale for depression, J Neurol Neurosurg Psychiatry, 23, 56, 10.1136/jnnp.23.1.56 Hanna, 2020, Anxiety and depression in multiple sclerosis (MS): antecedents, consequences, and differential impact on well-being and quality of life, Scler Relat Disord, 44, 102261, 10.1016/j.msard.2020.102261 Harding, 2012, Age at onset affects quality of life measures in multiple sclerosis, J Neurol, 1, S148 Harel, 2007, Dysregulation of affect in multiple sclerosis: new phenomenological approach, Psychiatry Clin Neurosci, 61, 94, 10.1111/j.1440-1819.2007.01616.x Heesen, 2012, Behavioral interventions in multiple sclerosis: a biopsychosocial perspective, Expert Rev Neurother, 12, 1089, 10.1586/ern.12.103 Heldner, 2017, Behavioral changes in patients with multiple sclerosis, Front Neurol, 8, 437, 10.3389/fneur.2017.00437 Henry, 2019, Anxiety and depression in patients with multiple sclerosis: the mediating effects of perceived social support, Mult Scler Relat Disord, 27, 46, 10.1016/j.msard.2018.09.039 Hirschfeld, 2000, Development and validation of a screening instrument for bipolar spectrum disorder: the mood disorder questionnaire, Am J Psychiatry, 157, 1873, 10.1176/appi.ajp.157.11.1873 Honarmand, 2009, Validation of the hospital anxiety and depression scale for use with multiple sclerosis patients, Mult Scler, 15, 1518, 10.1177/1352458509347150 Hunsley, 2014, The efficacy and effectiveness of psychological treatments for mood, anxiety, and related disorders, Can Psychol, 55, 161, 10.1037/a0036933 Hutchinson, 1993, Bipolar affective disorder prior to the onset of multiple sclerosis, Acta Neurol Scand, 88, 388, 10.1111/j.1600-0404.1993.tb05365.x Iacovides, 2011, Bipolar disorder and resembling special psychopathological manifestations in multiple sclerosis: a review, Curr Opin Psychiatry, 24, 336, 10.1097/YCO.0b013e328347341d Isaksson, 2006, From symptom to diagnosis: illness experiences of multiple sclerosis patients, J Neurosci Nurs, 38, 229, 10.1097/01376517-200608000-00005 Janssens, 2003, Impact of recently diagnosed multiple sclerosis on quality of life, anxiety, depression and distress of patients and partners, Acta Neurol Scand, 108, 389, 10.1034/j.1600-0404.2003.00166.x Jensen, 2014, Social support, depression, and physical disability: age and diagnostic group effects, Disabil Health J, 7, 164, 10.1016/j.dhjo.2013.11.001 Jiménez-Zambrano, 2020, Social anxiety disorder among patients with multiple sclerosis: a population-based case-control study in Ecuador, Rev Neurol, 70, 45 Joffe, 1987, Mood disorder and multiple sclerosis, Arch Neurol, 44, 376, 10.1001/archneur.1987.00520160018007 Johnson, 2012, Symptom profiles of individuals with multiple sclerosis grouped by levels of social support, Mult Scler, 1, 321 Jongen, 2006, Psychiatric onset of multiple sclerosis, J Neurol Sci, 245, 59, 10.1016/j.jns.2005.09.014 Julian, 2009, Relationships among anxiety, depression, and executive functioning in multiple sclerosis, Clin Neuropsychol, 23, 794, 10.1080/13854040802665808 Jun-O'Connell, 2017, The prevalence of bipolar disorders and association with quality of life in a cohort of patients with multiple sclerosis, J Neuropsychiatr Clin Neurosci, 29, 45, 10.1176/appi.neuropsych.15120403 Kabat-Zinn, 2013 Kallaur, 2016, Immune-inflammatory and oxidative and nitrosative stress biomarkers of depression symptoms in subjects with multiple sclerosis: increased peripheral inflammation but less acute neuroinflammation, Mol Neurobiol, 53, 5191, 10.1007/s12035-015-9443-4 Kehler, 2009, Is health anxiety a significant problem for individuals with multiple sclerosis?, J Behav Med, 32, 150, 10.1007/s10865-008-9186-z Kinsinger, 2010, Relationship between depression, fatigue, subjective cognitive impairment, and objective neuropsychological functioning in patients with multiple sclerosis, Neuropsychology, 24, 573, 10.1037/a0019222 Kiropoulos, 2016, A pilot randomized controlled trial of a tailored cognitive behavioural therapy based intervention for depressive symptoms in those newly diagnosed with multiple sclerosis, BMC Psychiatry, 16, 435, 10.1186/s12888-016-1152-7 Kirzinger, 2013, Relationship between disease-modifying therapy and depression in multiple sclerosis, Int J MS Care, 15, 107, 10.7224/1537-2073.2012-036 Koch, 2011, Pharmacologic treatment of depression in multiple sclerosis, Cochrane Database Syst Rev, 2 Kolanowski, 2005, Efficacy of theory based activities for behavioral symptoms of dementia, Nurs Res, 54, 219, 10.1097/00006199-200507000-00003 Konradi, 2012, Mitochondria, oligodendrocytes and inflammation in bipolar disorder: evidence from transcriptome studies points to intriguing parallels with multiple sclerosis, Neurobiol Dis, 45, 37, 10.1016/j.nbd.2011.01.025 Korostil, 2007, Anxiety disorders and their clinical correlates in multiple sclerosis patients, Mult Scler, 13, 67, 10.1177/1352458506071161 Kosmidis, 2012, Familial comorbidity of bipolar disorder and multiple sclerosis: genetic susceptibility, coexistence or causal relationship?, Behav Neurol, 25, 341, 10.1155/2012/894128 Kroencke, 2000, Fatigue in multiple sclerosis: relationship to depression, disability, and disease pattern, Mult Scler, 6, 131, 10.1177/135245850000600213 Kronfol, 2002, Immune dysregulation in major depression: a critical review of existing evidence, Int J Neuropsychopharmacol, 5, 333, 10.1017/S1461145702003024 Krupp, 1996, Mechanisms and management of fatigue in progressive neurological disorders, Curr Opin Neurol, 9, 456, 10.1097/00019052-199612000-00011 Krupp, 2002, Symptomatic therapy for underrecognized manifestations of multiple sclerosis, Neurology, 58, S32, 10.1212/WNL.58.8_suppl_4.S32 Langworthy, 1941, Disturbances of behavior in patients with disseminated sclerosis, Am J Psychiatry, 98, 243, 10.1176/ajp.98.2.243 Leonavičius, 2013, Anxiety and social activities in multiple sclerosis patients, Cent Eur J Med, 8, 56 Leone, 2013, Management of apathy in nursing homes using a teaching program for care staff: the STIM-EHPAD study, Int J Geriatr Psychiatry, 28, 383, 10.1002/gps.3836 Levy, 2006, Apathy and the functional anatomy of the prefrontal cortex–basal ganglia circuits, Cereb Cortex, 16, 916, 10.1093/cercor/bhj043 Lewis, 1983, Steroid-induced psychiatric syndromes. A report of 14 cases and a review of the literature, J Affect Disord, 5, 319, 10.1016/0165-0327(83)90022-8 Lima, 2007, Perceived behavioral changes in early multiple sclerosis, Behav Neurol, 18, 81, 10.1155/2007/674075 Lin, 2013, Regional gray matter atrophy and neuropsychologcal problems in relapsing-remitting multiple sclerosis, Neural Regen Res, 8, 1958 Lindsay, 2018, How mindfulness training promotes positive emotions: dismantling acceptance skills training in two randomized controlled trials, J Pers Soc Psychol, 115, 944, 10.1037/pspa0000134 Ling, 1981, Side effects of corticosteroid therapy. Psychiatric aspects, Arch Gen Psychiatry, 38, 471, 10.1001/archpsyc.1981.01780290105011 Litster, 2016, Screening tools for anxiety in people with multiple sclerosis: a systematic review, Int J MS Care, 18, 273, 10.7224/1537-2073.2016-004 Lopez, 2019, Factor analysis of the apathy scale in Parkinson's disease, Mov Disord Clin Pract, 6, 379, 10.1002/mdc3.12767 Lorefice, 2020, Bipolar disorders and deep grey matter in multiple sclerosis: a preliminary quantitative MRI study, Mult Scler Relat Disord, 46, 102564, 10.1016/j.msard.2020.102564 Löwe, 2004, Monitoring depression treatment outcomes with the patient health questionnaire-9, Med Care, 42, 1194, 10.1097/00005650-200412000-00006 Maguire, 1996, The effects of imagery on attitudes and moods in multiple sclerosis, Altern Ther Health Med, 2, 75 Manera, 2020, Recommendations for the nonpharmacological treatment of apathy in brain disorders, Am J Geriatr Psychiatry, 28, 410, 10.1016/j.jagp.2019.07.014 Marangoni, 2015, Bipolar disorder preceding the onset of multiple sclerosis, Neuroimmunol Neuroinflamm, 2, 195, 10.4103/2347-8659.167302 Marin, 1990, Differential diagnosis and classification of apathy, Am J Psychiatry, 147, 22, 10.1176/ajp.147.1.22 Marin, 1991, Reliability and validity of the apathy evaluation scale, Psychiatry Res, 38, 143, 10.1016/0165-1781(91)90040-V Marin, 1994, Group differences in the relationship between apathy and depression, J Nerv Ment Dis, 182, 235, 10.1097/00005053-199404000-00008 Marrie, 2013, Mental comorbidity and multiple sclerosis: validating administrative data to support population-based surveillance, BMC Neurol, 13, 16, 10.1186/1471-2377-13-16 Marrie, 2015, The incidence and prevalence of psychiatric disorders in multiple sclerosis: a systematic review, Mult Scler, 21, 305, 10.1177/1352458514564487 Marrie, 2015, Differences in the burden of psychiatric comorbidity in MS vs the general population, Neurology, 85, 1972, 10.1212/WNL.0000000000002174 Marrie, 2017, Estimating annual prevalence of depression and anxiety disorder in multiple sclerosis using administrative data, BMC Res Notes, 10, 619, 10.1186/s13104-017-2958-1 Marrie, 2018, Diagnoses of depression and anxiety versus current symptoms and quality of life in multiple sclerosis, Int J MS Care, 20, 76, 10.7224/1537-2073.2016-110 Matcham, 2015, Psychological correlates of fatigue in rheumatoid arthritis: a systematic review, Clin Psychol Rev, 39, 16, 10.1016/j.cpr.2015.03.004 Mattioli, 2011, Depression, disability and cognitive impairment in multiple sclerosis: a cross sectional Italian study, Neurol Sci, 32, 825, 10.1007/s10072-011-0624-2 Merikangas, 2007, Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replication, Arch Gen Psychiatry, 64, 543, 10.1001/archpsyc.64.5.543 Merlino, 2009, Prevalence of ‘poor sleep' among patients with multiple sclerosis: an independent predictor of mental and physical status, Sleep Med, 10, 26, 10.1016/j.sleep.2007.11.004 Middleton, 2006, The relationship between perceived and objective cognitive functioning in multiple sclerosis, Arch Clin Neuropsychol, 21, 487, 10.1016/j.acn.2006.06.008 Milanlioglu, 2014, Coping strategies and mood profiles in patients with multiple sclerosis, Arq Neuropsiquiatr, 72, 490, 10.1590/0004-282X20140089 Miller, 2009, Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression, Biol Psychiatry, 65, 732, 10.1016/j.biopsych.2008.11.029 Minden, 1996, Neuropsychiatric aspects of multiple sclerosis, Curr Opin Psychiatry, 9, 93, 10.1097/00001504-199601000-00019 Minden, 2000, Mood disorders in multiple sclerosis: diagnosis and treatment, J Neurovirol, 6, S160 Minden, 1990, Affective disorders in multiple sclerosis review and recommendations for clinical research, Arch Neurol, 47, 98, 10.1001/archneur.1990.00530010124031 Minden, 1988, Hypomanic reactions to ACTH and prednisone treatment for multiple sclerosis, Neurology, 38, 1631, 10.1212/WNL.38.10.1631 Minden, 2014, Evidence-based guideline: assessment and management of psychiatric disorders in individuals with MS: report of the guideline development Subcommittee of the American Academy of Neurology, Neurology, 82, 174, 10.1212/WNL.0000000000000013 Mohr, 1997, Treatment of depression improves adherence to interferon beta-1b therapy for multiple sclerosis, Arch Neurol, 54, 531, 10.1001/archneur.1997.00550170015009 Mohr, 2000, Telephone-administered cognitive behavioral therapy for the treatment of depressive symptoms in multiple sclerosis, J Consult Clin Psychol, 68, 356, 10.1037/0022-006X.68.2.356 Mohr, 2000, Psychological stress and the subsequent appearance of new brain MRI lesions in MS, Neurology, 55, 55, 10.1212/WNL.55.1.55 Mohr, 2001, Comparative outcomes for individual cognitive-behavior therapy, supportive-expressive group psychotherapy, and sertraline for the treatment of depression in multiple sclerosis, J Consult Clin Psychol, 69, 942, 10.1037/0022-006X.69.6.942 Mohr, 2004, Association between stressful life events and exacerbation in multiple sclerosis: a meta-analysis, BMJ, 328, 731, 10.1136/bmj.38041.724421.55 Mohr, 2005, Telephone-administered psychotherapy for depression, Arch Gen Psychiatry, 62, 1007, 10.1001/archpsyc.62.9.1007 Mohr, 2005, Self-injection anxiety training: a treatment for patients unable to self-inject injectable medications, Mult Scler, 11, 182, 10.1191/1352458505ms1146oa Mohr, 2007, Screening for depression among patients with multiple sclerosis: two questions may be enough, Mult Scler, 13, 215, 10.1177/1352458506070926 Montel, 2007, Coping and quality of life in one hundred and thirty five subjects with multiple sclerosis, Mult Scler, 13, 393, 10.1177/1352458506071170 Moore, 1997, A self report measure of affective lability, J Neurol Neurosurg Psychiatry, 63, 89, 10.1136/jnnp.63.1.89 Morrow, 2016, Anxiety and depressive symptoms are associated with worse performance on objective cognitive tests in MS, J Neuropsychiatr Clin Neurosci, 28, 118, 10.1176/appi.neuropsych.15070167 Moss-Morris, 2012, A pilot randomised controlled trial of an internet-based cognitive behavioural therapy self-management programme (MS Invigor8) for multiple sclerosis fatigue, Behav Res Ther, 50, 415, 10.1016/j.brat.2012.03.001 Mulin, 2011, Diagnostic criteria for apathy in clinical practice, Int J Geriatr Psychiatry, 26, 158, 10.1002/gps.2508 Nicholl, 2001, Assessment of emotional problems in people with multiple sclerosis, Clin Rehabil, 15, 657, 10.1191/0269215501cr427oa Nigro, 2015, Structural “connectomic” alterations in the limbic system of multiple sclerosis patients with major depression, Mult Scler, 21, 1003, 10.1177/1352458514558474 Niino, 2014, Apathy/depression, but not subjective fatigue, is related with cognitive dysfunction in patients with multiple sclerosis, BMC Neurol, 14, 3, 10.1186/1471-2377-14-3 Nocentini, 2012 Novo, 2016, Apathy in multiple sclerosis: gender matters, J Clin Neurosci, 33, 100, 10.1016/j.jocn.2016.02.038 Nygaard, 2015, Cortical thickness and surface area relate to specific symptoms in early relapsing-remitting multiple sclerosis, Mult Scler, 21, 402, 10.1177/1352458514543811 O'Connor, 2009, 250 μg or 500 μg interferon beta-1b vs 20 mg glatiramer acetate in relapsing-remitting multiple sclerosis: a prospective, randomised, multicentre study, Lancet Neurol, 8, 889, 10.1016/S1474-4422(09)70226-1 Pagonabarraga, 2015, Apathy in Parkinson's disease: clinical features, neural substrates, diagnosis, and treatment, Lancet Neurol, 14, 518, 10.1016/S1474-4422(15)00019-8 Pahlavanzadeh, 2017, The effect of group cognitive behavioral therapy on stress, anxiety, and depression of women with multiple sclerosis, Iran J Nurs Midwifery Res, 22, 271, 10.4103/1735-9066.212987 Pais-Ribeiro, 2018, The hospital anxiety and depression scale, in patients with multiple sclerosis, Neuropsychiatr Dis Treat, 14, 3193, 10.2147/NDT.S184260 Pandya, 2002, Depression in multiple sclerosis associated with interferon beta-1a (Rebif), Can J Psychiatr, 47, 686, 10.1177/070674370204700720 Panitch, 2006, Randomized, controlled trial of dextromethorphan/quinidine for pseudobulbar affect in multiple sclerosis, Ann Neurol, 59, 780, 10.1002/ana.20828 Paparrigopoulos, 2010, The neuropsychiatry of multiple sclerosis: focus on disorders of mood, affect and behaviour, Int Rev Psychiatry, 22, 14, 10.3109/09540261003589323 Paredes, 2012, Psychological symptoms in Spanish patients with multiple sclerosis: gender role and relationship with time since diagnosis, Rev Mex Psicol, 29, 147 Parvizi, 2009, Neuroanatomy of pathological laughing and crying: a report of the American Neuropsychiatric Association Committee on Research, J Neuropsychiatry Clin Neurosci, 21, 75, 10.1176/jnp.2009.21.1.75 Patrick, 2009, Longitudinal correlates of fatigue in multiple sclerosis, Mult Scler, 15, 258, 10.1177/1352458508097466 Patten, 2003, Depressive symptoms in a treated multiple sclerosis cohort, Mult Scler, 9, 616, 10.1191/1352458503ms960oa Pérez, 2015, Treatment of mood disorders in multiple sclerosis, Curr Treat Options Neurol, 17, 323, 10.1007/s11940-014-0323-4 Pham, 2018, The prevalence of anxiety and associated factors in persons with multiple sclerosis, Mult Scler Relat Disord, 19, 35, 10.1016/j.msard.2017.11.003 Phillips, 2013, Bipolar disorder diagnosis: challenges and future directions, Lancet, 381, 1663, 10.1016/S0140-6736(13)60989-7 Pilkonis, 2011, Item banks for measuring emotional distress from the patient-reported outcomes measurement information system (PROMIS®): depression, anxiety, and anger, Assessment, 18, 263, 10.1177/1073191111411667 Pilutti, 2014, Randomized controlled trial of a behavioral intervention targeting symptoms and physical activity in multiple sclerosis, Mult Scler, 20, 594, 10.1177/1352458513503391 Poder, 2009, Social anxiety in a multiple sclerosis clinic population, Mult Scler, 15, 393, 10.1177/1352458508099143 Poeck, 1969, Pathophysiology of emotional disorders associated with brain damage, 343 Potagas, 2008, Influence of anxiety and reported stressful life events on relapses in multiple sclerosis: a prospective study, Mult Scler, 14, 1262, 10.1177/1352458508095331 Pouyanfard, 2020, Effectiveness of mindfulness-integrated cognitive behavior therapy on anxiety, depression and hope in multiple sclerosis patients: a randomized clinical trial, Trends Psychiatry Psychother, 42, 55, 10.1590/2237-6089-2018-0105 Pravatà, 2017, Gray matter trophism, cognitive impairment, and depression in patients with multiple sclerosis, Mult Scler, 23, 1864, 10.1177/1352458517692886 Price, 2011, Antidepressants for the treatment of depression in neurological disorders: a systematic review and meta-analysis of randomised controlled trials, J Neurol Neurosurg Psychiatry, 82, 914, 10.1136/jnnp.2010.230862 PRISMS Study Group and the University of British Columbia MS/MRI Analysis Group, 2001, PRISMS-4: long-term efficacy of interferon-beta-1a in relapsing MS, Neurology, 56, 1628, 10.1212/WNL.56.12.1628 Pucak, 2007, Neuropsychiatric manifestations of depression in multiple sclerosis: neuroinflammatory, neuroendocrine, and neurotrophic mechanisms in the pathogenesis of immune-mediated depression, Dialogues Clin Neurosci, 9, 125, 10.31887/DCNS.2007.9.2/mpucak Quaranta, 2012, Different apathy profile in behavioral variant of frontotemporal dementia and Alzheimer's disease: a preliminary investigation, Curr Gerontol Geriatr Res, 2012, 719250, 10.1155/2012/719250 Rabinowitz, 2009, A longitudinal analysis of cognitive dysfunction, coping, and depression in multiple sclerosis, Neuropsychology, 23, 581, 10.1037/a0016064 Radakovic, 2014, Developing a new apathy measurement scale: dimensional apathy scale, Psychiatry Res, 219, 658, 10.1016/j.psychres.2014.06.010 Radloff, 1977, The CES-D scale: a self-report depression scale for research in the general population, Appl Psychol Meas, 1, 386, 10.1177/014662167700100306 Raimo, 2014, Apathy in multiple sclerosis: a validation study of the apathy evaluation scale, J Neurol Sci, 347, 295, 10.1016/j.jns.2014.10.027 Raimo, 2015, Psychometric properties of the Hamilton depression rating scale in multiple sclerosis, Qual Life Res, 24, 1973, 10.1007/s11136-015-0940-8 Raimo, 2016, The relationships between apathy and executive dysfunction in multiple sclerosis, Neuropsychology, 30, 767, 10.1037/neu0000279 Raimo, 2020, Assessing apathy in multiple sclerosis: validation of the dimensional apathy scale and comparison with apathy evaluation scale, Mult Scler Relat Disord, 38, 101870, 10.1016/j.msard.2019.101870 Raimo, 2020, Apathy as a herald of cognitive changes in multiple sclerosis: a 2-year follow-up study, Mult Scler, 26, 363, 10.1177/1352458519828296 Reischies, 1988, Cerebral magnetic resonance imaging findings in multiple sclerosis. Relation to disturbance of affect, drive, and cognition, Arch Neurol, 45, 1114, 10.1001/archneur.1988.00520340068014 Richards, 2014 Roberg, 2012, How patients with multiple sclerosis perceive cognitive slowing, Clin Neuropsychol, 26, 1278, 10.1080/13854046.2012.733413 Robert, 2018, Is it time to revise the diagnostic criteria for apathy in brain disorders? The 2018 international consensus group, Eur Psychiatry, 54, 71, 10.1016/j.eurpsy.2018.07.008 Robinson, 1993, Pathological laughing and crying following stroke: validation of a measurement scale and a double-blind treatment study, Am J Psychiatry, 150, 286, 10.1176/ajp.150.2.286 Rocca, 2015, Hippocampal-DMN disconnectivity in MS is related to WM lesions and depression, Hum Brain Mapp, 36, 5051, 10.1002/hbm.22992 Rossi, 2017, Neuroinflammation drives anxiety and depression in relapsing-remitting multiple sclerosis, Neurology, 89, 1338, 10.1212/WNL.0000000000004411 Rosti-Otajärvi, 2013, Behavioural symptoms and impairments in multiple sclerosis: a systematic review and meta-analysis, Mult Scler, 19, 31, 10.1177/1352458512439437 Roy-Bellina, 2009, Psychopathology in multiple sclerosis: coping strategies, representation of the disease, locus of control and social support, J Neurol, 256, S236 Roy-Bellina, 2010, Psychopathology of multiple sclerosis: influence of the perception of the disease on the disorders of mood and the emotions, J Neurol, 257, S189 Sacco, 2016, Psychometric properties and validity of beck depression inventory II in multiple sclerosis, Eur J Neurol, 23, 744, 10.1111/ene.12932 Saiote, 2014, Impact of transcranial direct current stimulation on fatigue in multiple sclerosis, Restor Neurol Neurosci, 32, 423 Santangelo, 2016, Anxiety in multiple sclerosis: psychometric properties of the state-trait anxiety inventory, Acta Neurol Scand, 134, 458, 10.1111/ane.12564 Schiffer, 1990, Antidepressant pharmacotherapy of depression associated with multiple sclerosis, Am J Psychiatry, 147, 1493, 10.1176/ajp.147.11.1493 Schiffer, 1988, Multiple sclerosis and affective disorder: family history, sex, and HLA-DR antigens, Arch Neurol, 45, 1345, 10.1001/archneur.1988.00520360063013 Schippling, 2016, Incidence and course of depression in multiple sclerosis in the multinational BEYOND trial, J Neurol, 263, 1418, 10.1007/s00415-016-8146-8 Scott, 2007, Depression-anxiety relationships with chronic physical conditions: results from the world mental health surveys, J Affect Disord, 103, 113, 10.1016/j.jad.2007.01.015 Sharma, 2015, Episodic mood changes preceding an exacerbation of multiple sclerosis, Prim Care Companion CNS Disord, 17 Shen, 2014, Depressive symptoms in multiple sclerosis from an in vivo study with TBSS, Biomed Res Int, 2014, 148465, 10.1155/2014/148465 Sidhom, 2014, Clinical features and disability progression in multiple sclerosis in Tunisia: do we really have a more aggressive disease course?, J Neurol Sci, 343, 110, 10.1016/j.jns.2014.05.049 Siegert, 2005, Depression in multiple sclerosis: a review, J Neurol Neurosurg Psychiatry, 76, 469, 10.1136/jnnp.2004.054635 Siepman, 2008, The role of disability and depression in cognitive functioning within 2 years after multiple sclerosis diagnosis, J Neurol, 255, 910, 10.1007/s00415-008-0814-x Silveira, 2019, Neuropsychiatric symptoms of multiple sclerosis: state of the art, Psychiatry Investig, 16, 877, 10.30773/pi.2019.0106 Simioni, 2007, Cognition, mood and fatigue in patients in the early stage of multiple sclerosis, Swiss Med Wkly, 137, 496 Simpson, 2019, Associations of demographic and clinical factors with depression over 2.5-years in an international prospective cohort of people living with MS, Mult Scler Relat Disord, 30, 165, 10.1016/j.msard.2019.02.014 Simpson, 2017, Mindfulness-based stress reduction for people with multiple sclerosis—a feasibility randomised controlled trial, BMC Neurol, 17, 94, 10.1186/s12883-017-0880-8 Smith, 2000, The role of affect on the perception of disability in multiple sclerosis, Clin Rehabil, 14, 50, 10.1191/026921500676724210 Smith, 2004, Validation of the CNS emotional lability scale for pseudobulbar affect (pathological laughing and crying) in multiple sclerosis patients, Mult Scler, 10, 679, 10.1191/1352458504ms1106oa Solari, 2010, Anxiety and depression symptoms in newly diagnosed multiple sclerosis patients, Mult Scler, 1, S21 Solaro, 2016, Depressive symptoms correlate with disability and disease course in multiple sclerosis patients: an Italian multi-center study using the beck depression inventory, PLoS One, 11, 10.1371/journal.pone.0160261 Spain, 2007, Illness perception and health-related quality of life in multiple sclerosis, Acta Neurol Scand, 116, 293, 10.1111/j.1600-0404.2007.00895.x Spencer, 2008 Spielberger, 1970 Staal, 2007, The effects of Snoezelen (multi-sensory behavior therapy) and psychiatric care on agitation, apathy, and activities of daily living in dementia patients on a short term geriatric psychiatric inpatient unit, Int J Psychiatry Med, 37, 357, 10.2190/PM.37.4.a Stanton, 2013, Behavioural and emotional symptoms of apathy are associated with distinct patterns of brain atrophy in neurodegenerative disorders, J Neurol, 260, 2481, 10.1007/s00415-013-6989-9 Stepleman, 2014, Depression screening in black Americans with multiple sclerosis, Psychol Health Med, 19, 33, 10.1080/13548506.2013.775466 Sugar, 1943, Mental symptoms in multiple sclerosis: a study of 28 cases with review of the literature, J Nerv Ment Dis, 98, 267, 10.1097/00005053-194309000-00004 Sullivan, 1995, Depression before and after diagnosis of multiple sclerosis, Mult Scler, 1, 104, 10.1177/135245859500100208 Sundgren, 2013, Cognitive impairment has a strong relation to nonsomatic symptoms of depression in relapsing-remitting multiple sclerosis, Arch Clin Neuropsychol, 28, 144, 10.1093/arclin/acs113 Surridge, 1969, An investigation into some psychiatric aspects of multiple sclerosis, Br J Psychiatry, 115, 749, 10.1192/bjp.115.524.749 Tan-Kristanto, 2015, Resilience, self-efficacy, coping styles and depressive and anxiety symptoms in those newly diagnosed with multiple sclerosis, Psychol Health Med, 20, 635, 10.1080/13548506.2014.999810 Tanriverdi, 2010, Quality of life in patients with multiple sclerosis in Turkey: relationship to depression and fatigue, J Neurosci Nurs, 42, 267, 10.1097/JNN.0b013e3181ecb019 Tauil, 2018, Suicidal ideation, anxiety, and depression in patients with multiple sclerosis, Arq Neuropsiquiatr, 76, 296, 10.1590/0004-282x20180036 Terrill, 2015, The 7-item generalized anxiety disorder scale as a tool for measuring generalized anxiety in multiple sclerosis, Int J MS Care, 17, 49, 10.7224/1537-2073.2014-008 Thant, 2018, Updating apathy: using research domain criteria to inform clinical assessment and diagnosis of disorders of motivation, J Nerv Ment Dis, 207, 707, 10.1097/NMD.0000000000000860 Théaudin, 2016, In multiple sclerosis anxiety, not depression, is related to gender, Mult Scler, 22, 239, 10.1177/1352458515588582 Theleritis, 2018, A systematic review of non-pharmacological treatments for apathy in dementia, Int J Geriatr Psychiatry, 33, e177, 10.1002/gps.4783 Trifilio, 2019, Changes in emotions and mood with aging, 127 Tsivgoulis, 2007, Associations of the expanded disability status scale with anxiety and depression in multiple sclerosis outpatients, Acta Neurol Scand, 115, 67, 10.1111/j.1600-0404.2006.00736.x Turner, 2020, Behavioral interventions in multiple sclerosis, Fed Pract, 37, S31 Vahter, 2007, One question as a screening instrument for depression in people with multiple sclerosis, Clin Rehabil, 21, 460, 10.1177/0269215507074056 van der Hiele, 2012, Daily hassles reported by Dutch multiple sclerosis patients, J Neurol Sci, 320, 85, 10.1016/j.jns.2012.06.023 Vargas, 2010, Positive everyday experiences interact with social support to predict depression in multiple sclerosis, J Int Neuropsychol Soc, 16, 1039, 10.1017/S1355617710000834 Vattakatuchery, 2011, Pathogenic mechanisms of depression in multiple sclerosis, J Neuropsychiatr Clin Neurosci, 23, 261, 10.1176/jnp.23.3.jnp261 Verdier-Taillefer, 2001, Psychometric properties of the center for epidemiologic Studies Depression scale in multiple sclerois, Neuroepidemiology, 20, 262, 10.1159/000054800 Vidović, 2015, Pseudobulbar affect in multiple sclerosis patients, Acta Clin Croat, 54, 159 Viner, 2014, Point prevalence and correlates of depression in a national community sample with multiple sclerosis, Gen Hosp Psychiatry, 36, 352, 10.1016/j.genhosppsych.2013.12.011 Vissicchio, 2019, Relationship between anxiety and cognition in multiple sclerosis: implications for treatment, Int J MS Care, 21, 151, 10.7224/1537-2073.2018-027 Wang, 2000, Major depression and quality of life in individuals with multiple sclerosis, Int J Psychiatry Med, 30, 309, 10.2190/PGWT-UXJ0-7UEH-LGRY Wang, 2020, Socioeconomic status and race are correlated with affective symptoms in multiple sclerosis, Mult Scler Relat Disord, 41, 102010, 10.1016/j.msard.2020.102010 Warrington, 2006, Psychiatric adverse effects of corticosteroids, Mayo Clin Proc, 81, 1361, 10.4065/81.10.1361 Watson, 2014, Validation of mood measures for people with multiple sclerosis, Int J MS Care, 16, 105, 10.7224/1537-2073.2013-013 Weisse, 1992, Depression and immunocompetence: a review of the literature, Psychol Bull, 111, 475, 10.1037/0033-2909.111.3.475 Whitlock, 1980, Depression as a major symptom of multiple sclerosis, J Neurol Neurosurg Psychiatry, 43, 861, 10.1136/jnnp.43.10.861 Whooley, 1997, Case-finding instruments for depression. Two questions are as good as many, J Gen Intern Med, 12, 439, 10.1046/j.1525-1497.1997.00076.x Wood, 2013, Prevalence and concurrence of anxiety, depression and fatigue over time in multiple sclerosis, Mult Scler, 19, 217, 10.1177/1352458512450351 Work, 2011, Pseudobulbar affect: an under-recognized and under-treated neurological disorder, Adv Ther, 28, 586, 10.1007/s12325-011-0031-3 Yamout, 2010, The effect of war stress on multiple sclerosis exacerbations and radiological disease activity, J Neurol Sci, 288, 42, 10.1016/j.jns.2009.10.012 Young, 2000, Young mania rating scale, 540 Zabad, 2005, The association of depression with disease course in multiple sclerosis, Neurology, 64, 359, 10.1212/01.WNL.0000149760.64921.AA Zigmond, 1983, The hospital anxiety and depression scale, Acta Psychiatr Scand, 67, 361, 10.1111/j.1600-0447.1983.tb09716.x Zorzon, 2001, Depression and anxiety in multiple sclerosis. A clinical and MRI study in 95 subjects, J Neurol, 248, 416, 10.1007/s004150170184