The embryonic development of mammalian neural tube defects

Adamson, 1979, The localization and synthesis of some collagen types in developing mouse embryos, Cell, 16, 953, 10.1016/0092-8674(79)90110-7 Alexandrov, 1971, Teratogenic effect of ethylurea and nitrite in rats, Experientia, 27, 538, 10.1007/BF02147586 Alles, 1990, Retinoic acid-induced spina bifida: evidence for a pathogenetic mechanism, Development, 108, 73, 10.1242/dev.108.1.73 Anderson, 1981, The mode of development of an inherited form of anencephaly in the house mouse, Neuropath. appl. Neurobiol., 7, 229, 10.1111/j.1365-2990.1981.tb00092.x Auerbach, 1954, Analysis of the developmental effects of a lethal mutation in the house mouse, J. exp. Zool., 127, 305, 10.1002/jez.1401270206 Austin, 1982, Differences in the toxicity and teratogenicity of cytochalasins D and E in various mouse strains, Teratology, 25, 11, 10.1002/tera.1420250103 Balkan, 1988, Somatomedin inhibitors from human serum produce abnormalities in mouse embryos in culture, Teratology, 38, 79, 10.1002/tera.1420380112 Bannigan, 1985, The effects of 5-bromodeoxyuridine on fusion of the cranial neural folds in the mouse embryo, Teratology, 32, 229, 10.1002/tera.1420320211 Bannigan, 1982, Ethanol teratogenicity in mice: a light microscopic study, Teratology, 26, 247, 10.1002/tera.1420260305 Beaudoin, 1974, Teratogenicity of sodium arsenate in rats, Teratology, 10, 153, 10.1002/tera.1420100211 Beck, 1967, Lysosomal enzyme inhibition by trypan blue: a theory of teratogenesis, Science, 157, 1180, 10.1126/science.157.3793.1180 Beck, 1987, Histochemical localization of IGF-I and -II mRNA in the developing rat embryo, Development, 101, 175, 10.1242/dev.101.1.175 Bensaude, 1983, Spontaneous high expression of heat-shock proteins in mouse embryonal carcinoma cells and ectoderm from day 8 mouse embryo, EMBO J., 2, 173, 10.1002/j.1460-2075.1983.tb01401.x Beyer, 1984, Incidence and potentiation of external and internal fetal anomalies resulting from chlordiazepoxide and amitriptyline alone and in combination, Teratology, 30, 39, 10.1002/tera.1420300106 Bower, 1989, Dietary folate as a risk factor for neural-tube defects: evidence from a case control study in Western Australia, Med. J. Aust., 150, 613, 10.5694/j.1326-5377.1989.tb136723.x Brock, 1972, Early prenatal diagnosis of anencephaly, Lancet, 2, 1252, 10.1016/S0140-6736(72)92306-9 Bruckner, 1983, Teratogenic effects of valproic acid and diphenylhydantoin on mouse embryos on culture, Teratology, 27, 29, 10.1002/tera.1420270106 Carter, 1974, Clues to the aetiology of neural tube malformations, Devl Med. Child Neurol., 16, 3 Chaineau, 1990, Embryotoxic effects of sodium arsenite and sodium arsenate on mouse embryos in culture, Teratology, 41, 105, 10.1002/tera.1420410111 Chernoff, 1988, Hyperthermiainduced exencephaly in mice: effect of multiple exposures, Teratology, 37, 37, 10.1002/tera.1420370107 Cockroft, 1988, Changes with gestational age in the nutritional requirements of postimplantation rat embryos in culture, Teratology, 38, 281, 10.1002/tera.1420380312 Cockroft, 1977, Teratogenic effects of excess glucose on headfold rat embryos in culture, Teratology, 16, 141, 10.1002/tera.1420160205 Cockroft, 1975, Effects of hyperthermia on rat embryos in culture, Nature, 258, 604, 10.1038/258604a0 Cohlan, 1953, Excessive intake of vitamin A as a cause of congenital anomalies in the rat, Science, 117, 535, 10.1126/science.117.3046.535 Cohn, 1976, Relationship of transformation, cell density, and growth control to the cellular distribution of newly synthesized glycosaminoglycan, J. Cell Biol., 71, 280, 10.1083/jcb.71.1.280 Cole, 1980, Gene-teratogen interaction in insulin-induced mouse exencephaly, Teratology, 22, 125, 10.1002/tera.1420220115 Copp, 1985, Relationship between timing of posterior neuropore closure and development of spinal neural tube defects in mutant (curly tail) and normal mouse embryos in culture, J. Embryol. exp. Morphol., 88, 39 Copp, 1988, Glycosaminoglycans vary in accumulation along the neuraxis during spinal neurulation in the mouse embryo, Devl Biol., 130, 573, 10.1016/0012-1606(88)90352-1 Copp, 1988, Accumulation of basement membrane-associated hyaluronate is reduced in the posterior neuropore region of mutant (curly tail) mouse embryos developing spinal neural tube defects, Devl Biol., 130, 583, 10.1016/0012-1606(88)90353-3 Copp, 1989, Does lumbosacral spina bifida arise by failure of neural folding or by defective canalisation?, J. Med. Genet., 26, 160, 10.1136/jmg.26.3.160 Copp, 1982, Neural tube development in mutant (curly tail) and normal mouse embryos: the timing of posterior neuropore closure in vivo and in vitro, J. Embryol. exp. Morphol., 69, 151 Copp, 1988, A cell-type-specific abnormality of cell proliferation in mutant (curly tail) mouse embryos developing spinal neural tube defects, Development, 104, 285, 10.1242/dev.104.2.285 Copp, 1988, Prevention of spinal neural tube defects in the mouse embryo by growth retardation during neurulation, Development, 104, 297, 10.1242/dev.104.2.297 Copp, 1981, Cranial glycosaminoglycans in early embryos of the Loop-tail (Lp) mutant mouse, J. Craniofac. genet. dev. Biol., 1, 253 Currie, 1970, Embryopathic effects of 7,12-dimethylbenz(a)anthracene and its hydroxymethyl derivatives in the Sprague-Dawley rat, Nature, 226, 911, 10.1038/226911a0 Daston, 1987, In vitro teratogenicity of ethylenethiourea in the rat, Teratology, 35, 239, 10.1002/tera.1420350210 Davidson, 1988, A gene with sequence similarity to Drosophila engrailed is expressed during the development of the neural tube and vertebrae in the mouse, Development, 104, 305, 10.1242/dev.104.2.305 Davis, 1988, Expression of the homeo box-containing gene En-2 delineates a specific region of the developing mouse brain, Genes Dev., 2, 361, 10.1101/gad.2.3.361 Davis, 1977, Fluorescence of trypan blue in frozen-dried embryos of the rat, Histochemistry, 54, 177, 10.1007/BF00492240 Dempsey, 1983, Early morphological abnormalities in splotch mouse embryos and predisposition to gene- and retinoic acid-induced neural tube defects, Teratology, 28, 461, 10.1002/tera.1420280318 Dencker, 1977, Trypan blue accumulation in the embryonic gut of rats and mice during the teratogenic phase, Teratology, 15, 179, 10.1002/tera.1420150208 De Sesso, 1979, Lectin teratogenesis: defects produced by concanavalin A in fetal rabbits, Teratology, 19, 15, 10.1002/tera.1420190104 Deuchar, 1971, The mechanism of axial rotation in the rat embryo: an experimental study in vitro, J. Embryol. exp. Morphol., 25, 189 Deuchar, 1975, Reconstitutive ability of axial tissue in early rat embryo after operations and culture in vitro, J. Embryol. exp. Morphol., 33, 217 Deutsch, 1988, Pax 1, a member of a paired box homologous murine gene family, is expressed in segmented structures during development, Cell, 53, 617, 10.1016/0092-8674(88)90577-6 Dickie, 1964, New splotch alleles in the mouse, J. Hered., 55, 97, 10.1093/oxfordjournals.jhered.a107317 Dolle, 1989, Differential expression of genes encoding alpha, beta and gamma retinoic acid receptors and CRABP in the developing limbs of the mouse, Nature, 342, 702, 10.1038/342702a0 Downs, 1989, Contrasting patterns of mye and N-myc expression during gastrulation of the mouse embryo, Genes Dev., 3, 860, 10.1101/gad.3.6.860 Dziadek, 1985, Expression of nidogen and laminin in basement membranes during mouse embryogenesis and in teratocarcinoma cells, Devl Biol., 111, 372, 10.1016/0012-1606(85)90491-9 Edwards, 1981, Clinical disorders of fetal brain development: defects due to hyperthermia, 335 Edwards, 1977, Extremes of temperature, Vol. 1, 421 Edwards, 1974, Mitotic cell death and delay of mitotic activity in guinea-pig embryos following brief maternal hyperthermia, J. Embryol. exp. Morphol., 32, 593 Elwood, 1980 Embury, 1979, Neural tube defects in curly-tail mice. I. Incidence and expression, 206, 85 Erickson, 1983, An SEM analysis of neural crest migration in the mouse, J. Embryol. exp. Morphol., 74, 97 Fantel, 1986, The toxicity of niridazole in rat embryos in vitro, Teratology, 33, 105, 10.1002/tera.1420330113 Fantel, 1989, Studies of embryotoxic mechanisms of niridazole: evidence that oxygen deletion plays a role in dysmorphogenicity, Teratology, 39, 243, 10.1002/tera.1420390306 Faustman-Watts, 1983, Teratogenicity in vitro of 2-acetoaminofluorene: role of biotransformation in the rat, Teratology, 27, 19, 10.1002/tera.1420270105 Faustman-Watts, 1985, Analysis of metabolites of 2-acetylaminofluorene generated in an embryo culture system, 34, 2953 Ferm, 1958, Teratogenic effects of trypan blue on hamster embryos, J. Embryol. exp. Morphol., 6, 284 Ferm, 1974, Toxicity of copper salts in hamster embryonic development, Biol. Reprod., 11, 97, 10.1095/biolreprod11.1.97 Ferm, 1977, Synergistic teratogenic effects of arsenic and hyperthermia in hamsters, Environ. Res., 14, 483, 10.1016/0013-9351(77)90055-X Finnell, 1986, Strain differences in heatinduced neural tube defects in mice, Teratology, 33, 247, 10.1002/tera.1420330213 Finnell, 1988, Common hierarchies of susceptibility to the induction of neural tube defects in mouse embryos by valproic acid and its 4-propyl-4-pentenoic acid metabolite, Teratology, 38, 313, 10.1002/tera.1420380403 Frakes, 1985, Developmental toxicity of the cyanogenic glycoside linamarin in the golden hamster, Teratology, 31, 241, 10.1002/tera.1420310209 Franke, 1982, Formation of cytoskeletal elements during mouse embryogenesis. III. Primary mesenchymal cells and the first appearance of vimentin filaments, Differentiation, 23, 43, 10.1111/j.1432-0436.1982.tb01266.x Freinkel, 1984, The honeybee syndrome—implications of the teratogenicity of mannose in rat-embryo culture, N. Engl. J. Med., 310, 223, 10.1056/NEJM198401263100404 Friedberg, 1987, Dose-incidence relationships for exencephalia, anophthalmia and pre-natal mortality in mouse embryos-irradiated with fission neutrons or 250 KV X-rays, Int. J. Radiat. Biol., 52, 223, 10.1080/09553008714551691 Geber, 1967, Congenital malformations induced by mescaline, lysergic acid diethylamide, and bromolysergic acid in the hamster, Science, 158, 265, 10.1126/science.158.3798.265 Geelen, 1979, Hypervitaminosis A induced teratogenesis, CRC Crit. Rev. Toxicol., 6, 351, 10.3109/10408447909043651 Geelen, 1977, Closure of the neural tube in the cephalic region of the mouse embryo, Anat. Rec., 189, 625, 10.1002/ar.1091890407 Geelen, 1979, Ultrastructural observations on closure of the neural tube in the mouse, Anat. Embryol., 156, 73, 10.1007/BF00315716 Geelen, 1980, The influence of excess vitamin A on neural tube closure in the mouse embryo, Anat. Embryol., 159, 223, 10.1007/BF00304980 Germain, 1985, Hyperthermia as a teratogen: parameters determining hyperthermia-induced head defects in the rat, Teratology, 31, 265, 10.1002/tera.1420310212 German, 1984, Embryonic stress hypothesis of teratogenesis, Am. J. Med., 76, 293, 10.1016/0002-9343(84)90788-5 Gillman, 1948, A preliminary report on hydrocephalus, spina bifida and other congenital anomalies in the rat produced by trypan blue, S. Afr. J. Med. Sci., 13, 47 Grabowski, 1977, Altered electrolyte and fluid balance, Vol. 2 Greenaway, 1983, Enhancement of rifampin teratogenicity in cultured rat embryos, Toxicol. appl. Pharmac., 69, 81, 10.1016/0041-008X(83)90122-9 Greenhouse, 1969, The effect of teratogenic doses of trypan blue on the yolk sac placenta of the mouse, 171, 343 Gruneberg, 1954, Genetical studies on the skeleton of the mouse. VIII. Curly tail, J. Genet., 52, 52, 10.1007/BF02981490 Gulamhusein, 1982, Trypan blue teratogenesis in the rat: further observations in vitro, Teratology, 26, 289, 10.1002/tera.1420260311 Hall, 1988, Clinical, genetic, and epidemiological factors in neural tube defects, Am. J. hum. Genet., 43, 827 Hamburg, 1954, The embryology of trypan blue induced abnormalities in mice, Anat. Rec., 119, 409, 10.1002/ar.1091190402 Hamburgh, 1975, Some additional observations relating to the mechanism of trypan blue induced teratogenesis, J. exp. Zool., 192, 1, 10.1002/jez.1401920102 Harris, 1988, Glutathione status and the incidence of neural tube defects elicited by direct acting teratogens in vitro, Teratology, 37, 577, 10.1002/tera.1420370607 Hartley, 1974, Brain cavitation and micrencephaly in lambs exposed to prenatal hyperthemia, Teratology, 9, 299, 10.1002/tera.1420090309 Hassell, 1986, Proteoglycan core protein families, A. Rev. Biochem., 55, 539, 10.1146/annurev.bi.55.070186.002543 Heine, 1987, Role of transforming growth factor-beta in the development of the mouse embryo, J. Cell Biol., 105, 2861, 10.1083/jcb.105.6.2861 Hendrickx, 1980, Craniofacial and CNS malformations induced by triamcinolone acetonide in nonhuman primates: I. General teratogenicity, Teratology, 22, 103, 10.1002/tera.1420220113 Hill, 1989, A new family of mouse homeo box-containing genes: molecular structure, chromosomal location, and developmental expression of Hox-7.1, Genes Dev., 3, 26, 10.1101/gad.3.1.26 Hoar, 1961, Time of teratogenic action of trypan blue in guinea pigs, Anat. Rec., 141, 173, 10.1002/ar.1091410302 Holland, 1988, Expression of homeo box genes during mouse development: a review, Genes Dev., 2, 773, 10.1101/gad.2.7.773 Holmes, 1976, Etiologic heterogeneity of neural-tube defects, N. Engl. J. Med., 294, 365, 10.1056/NEJM197602122940704 Hunter, 1987, d-(—)-Betahydroxybutyrate-induced effects on mouse embryos in vitro, Teratology, 36, 259, 10.1002/tera.1420360214 Jackson, 1981, Formation of cytoskeletal elements during mouse embryogenesis. II. Epithelial differentiation and intermediate-sized filaments in early postimplantation embryos, Differentiation, 20, 203, 10.1111/j.1432-0436.1981.tb01177.x Jacobson, 1976, Changes in the shape of the developing vertebrate nervous system analyzed experimentally, mathematically and by computer simulation, J. exp. Zool., 197, 191, 10.1002/jez.1401970205 Jacobson, 1982, Cephalic neurulation in the mouse embryo analyzed by SEM and morphometry, Anat. Rec., 203, 375, 10.1002/ar.1092030308 Jacobson, 1986, Neurulation and the cortical tractor model for epithelial folding, J. Embryol. exp. Morphol., 96, 19 Jelinek, 1966, Influence of mitotic activity on neurulation movements, Nature, 209, 822, 10.1038/209822a0 Johnson, 1967, Extra-toes: a new mutant gene causing multiple abnormalities in the mouse, J. Embryol. exp. Morphol., 17, 543 Johnson, 1970, Trypan blue and the extra-toes locus in the mouse, Teratology, 3, 105, 10.1002/tera.1420030202 Johnson, 1976, The interfrontal bone and mutant genes in the mouse, J. Anat., 121, 507 Jolly, 1936, Recherches sur l'oeuf du rat et de la souris, Archs Anat. Microsc., 32, 323 Jurand, 1974, Some aspects of the development of the motochord in mouse embryos, J. Embryol. exp. Morphol., 32, 1 Juriloff, 1989, Genetic analysis of the cause of exencephaly in the SELH/Bc mouse stock, Teratology, 40, 395, 10.1002/tera.1420400412 Kalter, 1981, Eye defects associated with a gene for exencephaly in mice, Teratology, 23, 44A Kalter, 1985, Experimental teratological studies with the mouse CNS mutations cranioschisis and delayed splotch, J. Craniofac. genet. dev. Biol., 1, 339 Kalter, 1988, Female preponderance for hereditary exencephaly in mice also exists in fetuses, Teratology, 37, 469 Kao, 1981, Teratogenicity of valproic acid: in vivo and in vitro investigations, Teratogenesis Carcinog. Mutagen., 1, 367, 10.1002/tcm.1770010405 Kapron-Bras, 1984, Geneteratogen interaction and its morphological basis in retinoic acid-induced mouse spina bifida, Teratology, 30, 143, 10.1002/tera.1420300118 Kapron-Bras, 1985, Reduction in the frequency of neural tube defects in splotch mice by retinoic acid, Teratology, 32, 87, 10.1002/tera.1420320112 Kapron-Bras, 1988, Histological comparison of the effects of the splotch gene and retinoic acid on the closure of the mouse neural tube, Teratology, 37, 389, 10.1002/tera.1420370412 Kapron-Bras, 1988, Interaction between the splotch mutation and retinoic acid in mouse neural tube defects in vitro, Teratology, 38, 165, 10.1002/tera.1420380209 Karfunkel, 1974, The mechanisms of neural tube formation, Int. Rev. Cytol., 38, 245, 10.1016/S0074-7696(08)60927-4 Karfunkel, 1978, Changes in cell adhesiveness in neurulation and optic cup formation, Zoon, 6, 23 Karnovsky, 1965, A formaldehyde-glutaraldehyde fixative of high osmolality for use in electron microscopy, J. Cell Biol., 27, 137A Kaufman, 1979, Cephalic neurulation and optic vesicle formation in the early mouse embryo, Am. J. Anat., 155, 425, 10.1002/aja.1001550403 Kay, 1988, Arachidonic acid reversal of phenytoin-induced neural tube and craniofacial defects in vitro in mice, J. Craniofac. genet. dev. Biol., 8, 179 Keeler, 1975, Teratogenic effects of cyclopamine and jervine in rats, mice and hamsters, 149, 302 Keeler, 1978, Congenital deformities produced in hamsters by potato sprouts, Teratology, 17, 327, 10.1002/tera.1420170311 Kernis, 1972, Cysteine interference with chlorambucil-induced teratogenesis in the rat, 139, 62 Khoury, 1982, Etiologic heterogeneity of neural tube defects: clues from epidemiology, Am. J. Epidemiol., 115, 538, 10.1093/oxfordjournals.aje.a113335 Kilham, 1976, Exencephaly in fetal hamsters following exposure to hyperthermia, Teratology, 14, 323, 10.1002/tera.1420140307 Knox, 1979, Cell adhesions and proteoglycans. I. The effects of exogenous proteoglycans on the attachment of chick embryo fibroblasts to tissue culture plastic and collagen, J. Cell Sci., 40, 77, 10.1242/jcs.40.1.77 Kothary, 1988, A transgene containing lacZ inserted into the dystonia locus is expressed in neural tube, Nature, 335, 435, 10.1038/335435a0 Koyama, 1970, Methylnitrosourea-induced malformations of brain in SD-JCL rat, Archs Neurol., 22, 342, 10.1001/archneur.1970.00480220056008 Kuchta, 1982, Experiments and ultrastructural investigations on the mouse embryo during early teratogensensitive stages, Acta Anat., 113, 218, 10.1159/000145558 Lammer, 1985, Retinoic acid embryopathy, N. Engl. J. Med., 313, 837, 10.1056/NEJM198510033131401 Lammer, 1987, Teratogen update: valproic acid, Teratology, 35, 465, 10.1002/tera.1420350319 Lary, 1982, Teratogenic effects on 27.12 radiofrequency radiation in rats, Teratology, 26, 299, 10.1002/tera.1420260312 Laurence, 1981, Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects, Br. med. J., 282, 1509, 10.1136/bmj.282.6275.1509 Layton, 1977, Craniomyeloschisis: a spontaneous mutation of the rat, Teratology, 15, 171, 10.1002/tera.1420150207 Leck, 1974, Causation of neural tube defects: clues from epidemiology, Br. Med. Bull., 30, 158, 10.1093/oxfordjournals.bmb.a071187 Leivo, 1980, Appearance and distribution of collagens and laminin in the early mouse embryo, Devl Biol., 76, 100, 10.1016/0012-1606(80)90365-6 Lemire, 1969, Variations in development of the caudal neural tube in human embryos (Horizons XIV-XXI), Teratology, 2, 361, 10.1002/tera.1420020410 Lemire, 1975 Lendon, 1975, The embryogenesis of trypan-blue induced spina bifida aperta and short tail in the rat, Devl Med. Child Neurol., 35, 3 Lorber, 1971, Results of treatment of myelomeningocele, 13, 279 MacDonald, 1989, Developmental study of neural tube closure in a mouse stock with a high incidence of exencephaly, Teratology, 39, 195, 10.1002/tera.1420390211 Manoury, 1988, Villin expression in the visceral endoderm and in the gut anlage during early mouse embryogenesis, EMBO J., 7, 3321, 10.1002/j.1460-2075.1988.tb03203.x Marin-Padilla, 1966, Mesodermal alterations induced by dimethyl sulphoxide, 122, 717 Marin-Padilla, 1966, Mesodermal alterations induced by hypervitaminosis A, J. Embryol. exp. Morphol., 15, 261 Marin-Padilla, 1979, Notochordal-basichondrocranium relationships: abnormalities in experimental axial skeletal (dysraphic) disorders, J. Embryol. exp. Morphol., 53, 15 Marin-Padilla, 1965, Somite necrosis and developmental malformations induced by vitamin A in the golden hamster, J. Embryol. exp. Morphol., 13, 1 Martins-Green, 1988, Origin of the dorsal surface of the neural tube by progressive delamination of epidermal ectoderm and neuroepithelium: implications for neurulation and neural tube defects, Development, 103, 687, 10.1242/dev.103.4.687 Martins-Green, 1986, Development of neural tube basal lamina during neurulation and neural crest cell emigration in the trunk of the mouse embryo, J. Embryol. exp. Morphol., 98, 219 Mason, 1982, Absence of covalently linked core protein from newly synthesised hyaluronate, Biochem. J., 207, 445, 10.1042/bj2070445 Matuoka, 1987, Hyaluronate synthetase inhibition by normal and transformed human fibroblasts during growth reduction, J. Cell Biol., 104, 1105, 10.1083/jcb.104.4.1105 Michejda, 1985, Induction of neural tube defects in non-human primates, Prog. clin. Biol. Res., 163B, 243 Miller, 1962, A strain difference in response to the teratogenic effect on maternal fasting in the house mouse, Can. J. Genet. Cytol., 4, 69, 10.1139/g62-010 Mills, 1989, The absence of a relation between the periconceptional use of vitamins and neural-tube defects, 321, 430 Milunsky, 1989, Multivitamin/folic acid supplementation in early pregnancy reduces the prevalence of neural tube defects, JAMA, 262, 2847, 10.1001/jama.262.20.2847 Mirkes, 1987, Hyperthermia-induced heat shock response and thermotolerance in postimplantation rat embryos, Devl Biol., 119, 115, 10.1016/0012-1606(87)90212-0 Moase, 1987, Retinoic acid-induced selective mortality of splotch-delayed mouse neural tube defect mutants, Teratology, 36, 335, 10.1002/tera.1420360310 Moase, 1988, The study of neural crest cells migrating from splotch and splotch-delayed neural tube explants, Teratology, 37, 477 Moase, 1989, Spinal ganglia reduction in the splotch-delayed mouse neural tube defect mutant, Teratology, 40, 67, 10.1002/tera.1420400109 Moore, 1982 Morgan, 1954, A new crooked-tail mutation involving distinct pleiotropism, J. Genet., 52, 354, 10.1007/BF02981530 Morris, 1983, Anomalies of neuroepithelial cell associations in the Splotch mutant embryo, Devl Brain Res., 9, 408, 10.1016/0165-3806(83)90041-X Morris-Wiman, 1990, Changes in mesenchymal cell and hyaluronate distribution correlate with in vivo elevation of the mouse mesencephalic neural folds, Anat. Rec., 226, 383, 10.1002/ar.1092260316 Morriss, 1972, Morphogenesis of the malformations induced in rat embryos by maternal hypervitaminosis A, J. Anat., 113, 241 Morriss, 1973, The ultrastructural effects of excess maternal vitamin A on the primitive streak stage rat embryo, J. Embryol. exp. Morphol., 30, 219 Morriss, 1979, Effect of oxygen concentration on morphogenesis of cranial neural folds and neural crest in cultured rat embryos, J. Embryol. exp. Morphol., 54, 17 Morriss, 1978, Regional differences in mesenchymal cell morphology and glycosaminoglycans in early neural-fold stage rat embryos, J. Embryol. exp. Morphol., 46, 37 Morriss, 1974, The effect of excess vitamin A on the development of rat embryos in culture, J. Embryol. exp. Morphol., 32, 505 Morriss, 1978, An approach to cranial neural crest cell migration and differentiation in mammalian embryos, Vol. 3, 363 Morriss-Kay, 1981, Growth and development of pattern in the cranial neural epithelium of rat embryos during neurulation, J. Embryol. exp. Morphol., 65, 225 Morriss-Kay, 1982, Culture of rat embryos with β-d-xyloside: evidence of a role for proteoglycans in neurulation, J. Anat., 134, 491 Morriss-Kay, 1986, Abnormal neural fold development in mouse trisomy 12 and trisomy 14. II. LM and TEM, Brain Res. Bull., 16, 825, 10.1016/0361-9230(86)90078-X Morriss-Kay, 1985, The role of microfilaments in cranial neurulation in rat embryos: effects of short-term exposure to cytochalasin D, J. Embryol. exp. Morphol., 88, 333 Morriss-Kay, 1989, Immunohistochemical localisation of chondroitin sulphate proteoglycans and the effects of chondroitinase ABC in 9- to 11-day rat embryos, Development, 106, 787, 10.1242/dev.106.4.787 Morriss-Kay, 1986, The effects of Streptomyces hyaluronidase on tissue organization and cell cycle time in rat embryos, J. Embryol. exp. Morphol., 98, 59 Morrissey, 1983, Arsenic-induced exencephaly in the mouse and associated lesions occurring during neurulation, Teratology, 28, 399, 10.1002/tera.1420280311 Mulinare, 1988, Periconceptional use of multivitamins and the occurrence of neural tube defects, JAMA, 260, 3141, 10.1001/jama.260.21.3141 Muller, 1987, The development of the human brain, the closure of the caudal neuropore, and the beginning of secondary neurulation at stage 12, Anat. Embryol., 176, 413, 10.1007/BF00310083 Nakashima, 1984, The effect of 5-bromodeoxyuridine on mouse embryos during neurulation in vitro, Experientia, 40, 924, 10.1007/BF01946441 Naruse, 1988, Strain differences in the teratogenicity induced by sodium valproate in cultured mouse embryos, Teratology, 38, 87, 10.1002/tera.1420380113 Nemirovsky, 1970, The induction of congenital abnormalities in mice by means of heterologous antimouse placenta serum, Experientia, 26, 1138, 10.1007/BF02112723 Office of Population Censuses and Surveys, 1985 O'Shea, 1982, Tunicamycin-induced defects in the mouse embryo: an in vitro study, 147 O'Shea, 1979, Influence of copper on the early post-implantation mouse embryo: an in vivo and vitro study, Roux's Arch. dev. Biol., 186, 297, 10.1007/BF00848455 O'Shea, 1980, Phospholipase C induced neural tube defects in the mouse embryo, Experientia, 36, 1217, 10.1007/BF01976138 O'Shea, 1980, Neural tube closure defects following in vitro exposure of mouse embryos to xylocaine, J. exp. Zool., 214, 235, 10.1002/jez.1402140217 O'Shea, 1981, Effect of acetaldehyde on the neuroepithelium of early mouse embryos, J. Anat., 132, 107 O'Shea, 1983, Chromosome translocation (T(2;4)1 Sn)-induced neural tube defects in the mouse embryo, J. Neurogenet., 1, 29, 10.3109/01677068309107070 O'Shea, 1987, Morphometric analysis of the forebrain anomalies in the delayed Splotch mutant embryo, J. Craniofac. genet. dev. Biol., 7, 357 Padmanabhan, 1984, Experimental induction of cranioschisis aperta and exencephaly after neural tube closure, 66, 235 Padmanabhan, 1988, Light microscopic studies on the pathogenesis of exencephaly and cranioschisis induced in the rat after neural tube closure, Teratology, 37, 29, 10.1002/tera.1420370106 Park, 1989, A mouse model for neural tube defects: the curtailed (Tc) mutation produces spina bifida occulta in Tc/+ animals and spina bifida with meningomyelocele in Tc/t, Teratology, 39, 303, 10.1002/tera.1420390312 Perez-Castro, 1989, Spatial and temporal pattern of expression of the cellular retinoic acid-binding protein and the cellular retinol-binding protein during mouse embryogenesis, 86, 8813 Perris, 1987, Amphibian neural crest cell migration on purified extracellular matrix components: a chondroitin sulphate proteoglycan inhibits locomotion on fibronectin substrates, J. Cell Biol., 105, 2511, 10.1083/jcb.105.6.2511 Persaud, 1968, Embryotoxic activity of hypoglycin-A in the rat, Naturwissenschaften, 55, 39, 10.1007/BF00593415 Peters, 1981, An experimental study on the morphogenesis of spina bifida, Acta morph. neerl.-scand., 19, 1 Poelmann, 1981, The head-process and the formation of the definitive endoderm in the mouse embryo, Anat. Embryol., 162, 41, 10.1007/BF00318093 Putz, 1981, Abnormal neural fold development in trisomy 12 and trisomy 14 mouse embryos. I. Scanning electron microscopy, J. Embryol. exp. Morphol., 66, 141 Robert, 1982, Maternal valproic acid and congenital NTD, Lancet, 2, 937, 10.1016/S0140-6736(82)90908-4 Rogers, 1986, Methacrylic acid as a teratogen in rat embryo culture, Teratology, 33, 113, 10.1002/tera.1420330114 Rogers, 1985, Studies on the mechanism of trypan blue teratogenicity in the rat developing in vitro and in vitro, Teratology, 31, 389, 10.1002/tera.1420310310 Ruberte, 1990, Specific spatial and temporal distribution of retinoic acid receptor gamma transcripts during mouse embryogenesis, Development, 108, 213, 10.1242/dev.108.2.213 Ruffolo, 1965, The embryocidal and teratogenic effects of 5-bromodeoxyuridine in the pregnant hamster, Lab. Invest., 14, 1547 Sadler, 1978, Distribution of surface coat material on fusing neural folds of mouse embryos during neurulation, Anat. Rec., 191, 345, 10.1002/ar.1091910307 Sadler, 1972, Ultrastructural alterations in neuroepithelial cells of mouse embryos exposed to cytotoxic doses of hydroxyurea, Anat. Rec., 188, 103, 10.1002/ar.1091880110 Sadler, 1982, Actin distribution patterns in the mouse neural tube during neurulation, Science, 215, 172, 10.1126/science.7031898 Sadler, 1986, A potential role for spectrin during neurulation, J. Embryol. exp. Morphol., 94, 73 Sakai, 1989, Neurulation in the mouse: manner and timing of neural tube closure, Anat. Rec., 223, 194, 10.1002/ar.1092230212 Schaart, 1989, Desmin and titin expression in early postimplantation mouse embryos, Development, 107, 585, 10.1242/dev.107.3.585 Schmid, 1985, Evidence for reopening of the cranial neural tube in mouse embryos treated with cadmium chloride, Experientia, 41, 271, 10.1007/BF02002632 Schmidt, 1979, Electron microscope observations of embryos from maternal rats treated with trypan blue, Teratology, 19, 285, 10.1002/tera.1420190304 Schoenwolf, 1984, Histological and ultrastructural studies of secondary neurulation of mouse embryos, Am. J. Anat., 169, 361, 10.1002/aja.1001690402 Schoenwolf, 1984, Histological and ultrastructural studies on the origin of caudal neural crest cells in mouse embryos, J. comp. Neurol., 222, 496, 10.1002/cne.902220404 Schoenwolf, 1988, A reexamination of the role of microfilaments in neurulation in the chick embryo, Anat. Rec., 220, 87, 10.1002/ar.1092200111 Scott, 1977, Cell death and reduced proliferative rate, Vol. 2, 81 Seller, 1987, Neural tube defects and sex ratios, Am. J. med. Genet., 26, 699, 10.1002/ajmg.1320260325 Seller, 1982, Prevention of neural tube defects in curly-tail mice by maternal administration of vitamin A, Prenatal Diag., 2, 297, 10.1002/pd.1970020409 Seller, 1983, Effect of hydroxyurea on neural tube defects in the curly-tail mouse, J. Craniofac. genet. dev. Biol., 3, 11 Seller, 1986, Effect of mitomycin C on the neural tube defects of the curly-tail mouse, Teratology, 33, 305, 10.1002/tera.1420330308 Seller, 1987, Hyperthermia and neural tube defects of the curly-tail mouse, J. Craniofac. genet. dev. Biol., 7, 321 Seller, 1987, Sex difference in mouse embryonic development at neurulation, J. Reprod. Fert., 79, 159, 10.1530/jrf.0.0790159 Seller, 1973, Early termination of anencephalic pregnancy after detection by raised alpha-fetoprotein levels, Lancet, 2, 73, 10.1016/S0140-6736(73)93264-9 Seller, 1979, Neural tube defects in curly-tail mice. II. Effect of maternal administration of vitamin A, 206, 95 Seller, 1983, Differential response of heterozygous curly-tail mouse embryos to vita in A teratogenesis depending on maternal genotype, Teratology, 28, 123, 10.1002/tera.1420280115 Shiota, 1988, Induction of neural tube defects and skeletal malformations in mice following brief hyperthermia in utero, Biol. Neonate, 53, 86, 10.1159/000242767 Shiota, 1982, Teratogenicity of di(2-ethylhexyl)phthalate (DEHP) and di-n-butyl phthalate (DBP) in mice, Envir. Health Perspect., 45, 65, 10.2307/3429385 Shiota, 1988, Teratogenic interaction of ethanol and hyperthermia in mice, 187, 142 Shum, 1988, Embryonic catch-up growth after exposure to the ketone body d,l-betahydroxybutyrate in vitro, Teratology, 38, 369, 10.1002/tera.1420380408 Singh, 1981, The teratogenic effects of dietary cassava on the pregnant albino rat: a preliminary report, Teratology, 24, 289, 10.1002/tera.1420240307 Skalko, 1971, The teratogenic response of mouse embryos to 5-bromodeoxyuridine, Teratology, 4, 87, 10.1002/tera.1420040112 Skreb, 1963, Developmental abnormalities in the rat induced by heat shock, J. Embryol. exp. Morphol., 11, 445 Smedley, 1984, Effect of the calmodulin inhibitor R24571 (calmidazolium) on rat embryos cultured in vitro, Experientia, 40, 992, 10.1007/BF01946475 Smedley, 1985, Calcium and neurulation in mammalian embryos, J. Embryol. exp. Morphol., 89, 1 Smedley, 1986, Calcium and neurulation in mammalian embryos, J. Embryol. exp. Morphol., 93, 167 Smith, 1987, Cell cycle and neuroepithelial cell shape during bending of the chick neural plate, Anat. Rec., 218, 196, 10.1002/ar.1092180215 Smith, 1962, Axial elongation in the mouse and its retardation in homozygous looptail mice, J. Embryol. exp. Morphol., 10, 73 Smithberg, 1963, Teratogenic effects of hypoglycaemic treatments in inbred strains in mice, Am. J. Anat., 113, 479, 10.1002/aja.1001130308 Smithells, 1976, Vitamin deficiencies and neural tube defects, Archs Dis. Childh., 51, 944, 10.1136/adc.51.12.944 Smithells, 1981, Apparent prevention of neural tube defects by periconceptional vitamin supplementation, Archs Dis. Childh., 56, 911, 10.1136/adc.56.12.911 Smits Van Prooue, 1986, The cell surface coat in neurulating mouse and rat embryos, studied with lectins, Anat. Embryol., 175, 111, 10.1007/BF00315461 Solursh, 1977, Glycosaminoglycan synthesis in rat embryos during the formation of the primary mesenchyme and neural folds, Devl Biol., 57, 75, 10.1016/0012-1606(77)90355-4 Stark, 1977 Stark, 1989, Microinjection of cultured rat embryos, 100, 411 Stark, 1989, Modulation of the embryotoxicity and cytoxicity elicited by 7-hydroxy-2-acetylaminofluorene and acetaminophen via deacetylation, Toxicol. appl. Pharmac., 97, 548, 10.1016/0041-008X(89)90260-3 Stein, 1953, Development of mice homozygous for the gene for loop-tail, J. Hered., 44, 59, 10.1093/oxfordjournals.jhered.a106356 Sternberg, 1986, Distribution of fibronectin, laminin and entactin in the environment of migrating neural crest cells in early mouse embryos, J. Embryol. exp. Morphol., 91, 267 Sternberg, 1986, The relationship between emerging neural crest cells and basement membranes in the trunk of the mouse embryo: a TEM and immunocytochemical study, J. Embryol. exp. Morphol., 98, 251 Takeichi, 1988, The cadherins: cell-cell adhesion molecules controlling animal morphogenesis, Development, 102, 639, 10.1242/dev.102.4.639 Takeuchi, 1978, The preventive influence of cysteamine on the teratogenic action of 5-azacytidine, Life Sci., 23, 897, 10.1016/0024-3205(78)90214-X Takeuchi, 1985, 5-Azacytidine-induced exencephaly in mice, J. Anat., 140, 403 Tam, 1986, A study on the pattern of prospective somites in the presomitic mesoderm of mouse embryos, J. Embryol. exp. Morphol., 92, 269 Taylor, 1978, Recombinant inbred strains: use in gene mapping, 423 Theiler, 1960, The development of rib fusions, a mutation in the house mouse, Am. J. Anat., 106, 171, 10.1002/aja.1001060208 Theodosis, 1978, Early changes in the mouse neuroepithelium preceding exencephaly induced by hypervitaminosis A, Teratology, 18, 219, 10.1002/tera.1420180207 Tibbles, 1988, A comparative study of the effects of retinoic acid given during the critical period for inducing spina bifida in mice and hamsters, Teratology, 37, 113, 10.1002/tera.1420370204 Toivonen, 1976, The transmission of morphogenetic signals from amphibian mesoderm to ectoderm in primary induction, Differentiation, 5, 49, 10.1111/j.1432-0436.1976.tb00891.x Tomida, 1975, Induction of hyaluronic acid synthetase activity in rat fibroblasts by medium change of confluent cultures, J. cell. Physiol., 86, 121, 10.1002/jcp.1040860114 Toriello, 1985, Possible causal heterogeneity in spina bifida cystics, Am. J. med. Genet., 21, 13, 10.1002/ajmg.1320210103 Trasler, 1988, Increased susceptibility to retinoic acid-induced exencephaly of heterozygote extra-toes mice, Teratology, 37, 498 Trotz, 1987, Valproic acid-induced neural tube defects: reduction by folinic acid in the mouse, Life Sci., 41, 103, 10.1016/0024-3205(87)90562-5 Tsunoda, 1985, Altered sex ratio of live young after transfer of fast- and slow-developing mouse embryos, Gamete Res., 12, 301, 10.1002/mrd.1120120308 Tuckett, 1986, The distribution of fibronectin, laminin and entactin in the neurulating rat embryo studied by indirect immunofluorescence, J. Embryol. exp. Morphol., 94, 95 Tuckett, 1989, Heparitinase treatment of rat embryos during cranial neurulation, Anat. Embryol., 180, 393, 10.1007/BF00311170 Turbow, 1966, Trypan blue induced teratogenesis of rat embryos cultivated in vitro, J. Embryol. exp. Morphol., 15, 387 Umpierre, 1977, Environmental heat stress effects in the hamster, Teratology, 16, 155, 10.1002/tera.1420160207 Waddington, 1953, A note on abnormalities induced in mouse embryos by trypan blue, J. Embryol. exp. Morphol., 1, 167 Wallace, 1978, Inheritance and morphology of exencephaly, a neonatal recessive with partial penetrance, in the house mouse, Genet. Res., 32, 135, 10.1017/S0016672300018632 Walsh, 1987, Heat shock and thermotolerance during early rat embryo development, Teratology, 36, 181, 10.1002/tera.1420360205 Walsh, 1989, Regulation of the inducible heat shock 71 genes in early neural development of cultured rat embryos, Teratology, 40, 321, 10.1002/tera.1420400404 Wartiovaara, 1979, Expression of the cell surface-associated glycoprotein, fibronectin, in the early mouse embryo, Devl Biol., 69, 247, 10.1016/0012-1606(79)90289-6 Waterman, 1976, Topographical changes along the neural fold associated with neurulation in the hamster and mouse, Am. J. Anat., 146, 151, 10.1002/aja.1001460204 Webster, 1980, Changes in the mouse neuroepithelium associated with cadmium-induced NTD, Teratology, 21, 79, 10.1002/tera.1420210110 Webster, 1984, Hyperthermia and the induction of neural tube defects in mice, Teratology, 29, 417, 10.1002/tera.1420290313 Webster, 1985, The induction of microphthalmia, encephalocele and other head defects following hyperthermia during the gastrulation process in the rat, Teratology, 31, 73, 10.1002/tera.1420310109 Wegner, 1986, Determination of folates in mouse plasma and embryo during organogenesis, Teratology, 33, 84C Weston, 1970, The migration and differentiation of neural crest cells, Adv. Morphog., 8, 41, 10.1016/B978-0-12-028608-9.50006-5 Wiley, 1980, The effects of cytochalasins on the ultrastructure of neurulating hamster embryos in vivo, Teratology, 22, 59, 10.1002/tera.1420220109 Wilkinson, 1989, Homeobox genes and development of the vertebrate CNS, Bioassays, 10, 82, 10.1002/bies.950100211 Wilkinson, 1987, Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo, Cell, 50, 79, 10.1016/0092-8674(87)90664-7 Wilkinson, 1988, Expression of the FGF-related protooncogene int-2 during gastrulation and neurulation in the mouse, EMBO J., 7, 691, 10.1002/j.1460-2075.1988.tb02864.x Wilkinson, 1989, Segment-specific expression of a zinc-finger gene in the developing nervous system of the mouse, Nature, 337, 461, 10.1038/337461a0 Wilkinson, 1989, Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain, Nature, 341, 405, 10.1038/341405a0 Willhite, 1981, Arsenic-induced axial skeletal (dysraphic) disorders, Expl Mol. Pathol., 34, 145, 10.1016/0014-4800(81)90071-X Willhite, 1982, Congenital malformations induced by laetrile, Science, 215, 1513, 10.1126/science.7063858 Willhite, 1981, Teratogenic effects of aliphatic nitriles, Teratology, 23, 317, 10.1002/tera.1420230306 Willhite, 1981, Morphogenesis of axial skeletal (dysraphic) disorders induced by aliphatic nitriles, Teratology, 23, 325, 10.1002/tera.1420230307 Williams, 1976, Inhibition of pinocytosis in rat yolk sac by trypan blue, Teratology, 14, 343, 10.1002/tera.1420140310 Wilson, 1974, Proliferation in the neural tube of the splotch (Sp) mutant mouse, J. comp. Neurol., 154, 249, 10.1002/cne.901540303 Wilson, 1978, The fine structure of ventricular cells in the brains of mouse embryos homozygous for the loop-tail gene, Teratology, 17, 115, 10.1002/tera.1420170204 Wilson, 1985, Ultrastructure of the neural basal lamina in loop-tail mice, Acta Anat., 123, 77, 10.1159/000146043 Wilson, 1985, Histochemical analysis of the neural basal lamina in the hindbrain region of exencephalic mutant mice, J. Craniofac. genet. dev. Biol., 5, 363 Wilson, 1974, Neural cell cycle in the Looptail mutant of the mouse (Lp), J. Embryol. exp. Morphol., 32, 697 Wilson, 1979, Gap junctional vesicles in the neural tube of the splotch (Sp) mutant mouse, Teratology, 19, 337, 10.1002/tera.1420190309 Wilson, 1980, Early development of the brain and spinal cord in dysraphic mice: a transmission electron microscopic study, J. comp. Neurol., 190, 363, 10.1002/cne.901900210 Wilson, 1975, Surface defects in ventricular cells of brains of mouse embryos homozygous for the loop-tail gene: scanning electron microscopic study, Teratology, 11, 87, 10.1002/tera.1420110111 Wilson, 1986, Pathogenesis of neural dysraphism in the mouse mutant vacuolated lens (vl), J. Neuropath. exp. Neurol., 45, 43, 10.1097/00005072-198601000-00004 Wilson, 1988, Closure of the posterior neuropore in the vl mutant mouse, Anat. Embryol., 178, 559, 10.1007/BF00305044 Wilson, 1988, Cytochemical analysis of neural dysraphism in the vl mutant mouse, J. Neuropath. exp. Neurol., 47, 609, 10.1097/00005072-198811000-00004 Wilson, 1963, Studies on the site of teratogenic action of C14-labelled trypan blue, Anat. Rec., 145, 300 Wood, 1984, Generation of anencephaly: 1. Aberrant neurulation and 2. Conversion of exencephaly to anencephaly, J. Neuropath. exp. Neurol., 43, 620, 10.1097/00005072-198411000-00006 Wu, 1983, Immunohistochemical localization of entactin and laminin in mouse embryos and fetuses, Devl Biol., 100, 496, 10.1016/0012-1606(83)90242-7 Yang, 1988, An ultrastructural study of spina bifida in the delayed splotch mutant mouse, Teratology, 37, 503 Yasuda, 1987, Developmental anomalies induced by all-trans-retinoic acid in fetal mice: II. Induction of abnormal neuroepithelium, Teratology, 35, 355, 10.1002/tera.1420350310