The efficacy of Polyporus Umbellatus polysaccharide in treating hepatitis B in China

Zhihua Guo1,2, Yunjin Zang3, Lijuan Zhang1
1Systems Biology and Medicine Center for Complex Diseases, Affiliated Hospital of Qingdao University, Qingdao, China
2School of Medicine and Pharmacy, Ocean University of China, Qingdao, China
3Department of Liver Transplantation, Affiliated Hospital of Qingdao University, Qingdao, China

Tài liệu tham khảo

Zhao, 2013, Traditional uses, phytochemistry, pharmacology, pharmacokinetics and quality control of Polyporus umbellatus (Pers.) fries: a review, J Ethnopharmacol, 149, 35, 10.1016/j.jep.2013.06.031 Zong, 2012, Anticancer polysaccharides from natural resources: a review of recent research, Carbohydr Polym, 90, 1395, 10.1016/j.carbpol.2012.07.026 Xu, 2003, Advances in the study of polyporus in China, J Fungal Res, 01, 58 Chen, 2001, Short-term curative observation of polyporus polysaccharide capsules in the treatment of 28 cases with chronic hepatitis B, Clin Focus, 07, 313 Liu, 1993, Clinical observation of polyporus polysaccharide injection in the treatment for 156 cases with hepatitis B, Shandong Med J, 06, 27 Zhang, 1994, Clinical observation of polyporus polysaccharide in the treatment for 36 cases with chronic hepatitis B, Acta Acad Med Xuzhou, 03, 240 Tao, 2013, Applied research of polyporus polysaccharide in the hemodialysis patients of hepatitis B vaccination, Guid China Med, 22, 7 Zhao, 2012, Polyporus polysaccharide combined with hepatitis B vaccine in the treatment of 60 cases with chronic active hepatitis B, Shaanxi J Tradit Chin Med, 09, 1117 Liu, 2009, Polyporus polysaccharide combined with hepatitis B vaccine in treatment of128 cases with chronic hepatitis B, Clin Med, 06, 15 Ma, 2005, Efficacy of polyporus polysaccharide combined with hepatitis B vaccine in the treatment of chronic hepatitis B, Occup Health, 02, 300 Zeng, 2004, Clinical observation of polyporus polysaccharide combined with hepatitis B vaccine in the treatment of chronic hepatitis B, Occup Health, 05, 117 Ren, 2004, Integrative medicine in the treatment of 21 cases with hepatitis B, Shaanxi J Tradit Chin Med, 09, 832 Feng, 2002, Polyporus polysaccharide combined with hepatitis B vaccine in treatment of chronic hepatitis B, Henan Med Inf, 23, 39 Dong, 2000, Efficacy analysis of polyporus polysaccharide combined with hepatitis B vaccine in the treatment of chronic hepatitis B, J Pract Med Tech, 10, 781 Shi, 1999, Clinical observation of polyporus polysaccharide combined hepatitis B vaccine in the treatment of acute and chronic hepatitis B, J Norman Bethune Univ Med Sci, 02, 174 Wang, 1999, Efficacy of different course on hepatitis B vaccine combined polyporus polysaccharide in the treatment of chronic hepatitis B, J Prev Med Inf, 02, 62 Cui, 1999, Polyporus polysaccharide combined with hepatitis B vaccine in treatment of 78 cases with chronic hepatitis B, Chin J Integr Tradit West Med Liver Dis, S1, 50 Zhang, 1998, Polyporus polysaccharide combined with hepatitis B vaccine in closure joint treatment of 31 cases with chronic hepatitis B, Chin J Integr Tradit West Med Liver Dis, S1, 329 He, 1997, Compare clinical observation of anti-hepatitis B-specific placental transfer factor in the treatment of phase II chronic hepatitis B, Chongqing Med, 02, 69 Ding, 1997, Polyporus polysaccharide combined with hepatitis B vaccine in treatment of 86 cases with chronic hepatitis B, J Bengbu Med Coll, 02, 62 He, 1997, Polyporus polysaccharide combined with hepatitis B vaccine in treatment of 48 cases with chronic hepatitis B, J Jining Med Coll, 04, 70 Si, 1997, Efficacy of three treatments for chronic hepatitis B, Chin J Intern Med, 10, 14 Wu, 1996, Efficacy analysis of polyporus polysaccharide injection combined with hepatitis B vaccine for chronic hepatitis B, New Med, 02, 63 Du, 1996, Efficacy of polyporus polysaccharide combined with hepatitis B vaccine in the treatment of 60 cases with chronic hepatitis B, Clin Focus, 16, 757 Wu, 1996, Clinical analysis of polyporus polysaccharide combined with hepatitis B vaccine in the treatment of chronic hepatitis B, Med J Commun, 01, 83 He, 1996, Efficacy of polyporus polysaccharide injection combined with hepatitis B vaccine in the treatment of chronic hepatitis B, J Pharm Pract, 03, 142 Shu, 1996, Clinical observation of polyporus polysaccharide combined large doses of hepatitis B vaccine in the treatment of 64 cases with chronic hepatitis B, Med J Natl Defending Forces Southwest China, 04, 211 Miu, 1996, Clinical analysis of polyporus polysaccharide combined with hepatitis B vaccine in the treatment of chronic hepatitis B, China Pract J Med, 02, 2 Yang, 1996, Comparative observation of polyporus polysaccharide combined with hepatitis B vaccine and polyinosinic in the treatment of chronic hepatitis B, Chin Med Fact Mine, 05, 336 Xia, 1995, Efficacy of polyporus polysaccharide injection combined with hepatitis B vaccine for chronic hepatitis B, Chin J Pract Intern Med, 03, 172 He, 1995, Efficacy of polyporus polysaccharide injection combined with hepatitis B vaccine for chronic hepatitis B, Chin J Integr Tradit West Med, 07, 429 Yang, 1995, Polyporus polysaccharide combined with hepatitis B vaccine in the treatment of chronic hepatitis B, Chin J Dig, 04, 238 Lou, 1994, Experiences of polyporus polysaccharide injection combined with moderate doses of hepatitis B vaccine in the treatment of chronic hepatitis B, Heilongjiang Med J, 04, 23 Ren, 1994, Polyporus polysaccharide combined with hepatitis B vaccine in treatment of 32 cases with chronic hepatitis B, Chin J Integr Tradit West Med Liver Dis, 03, 37 Zheng, 1994, Efficacy of polyporus polysaccharide combined with hepatitis B vaccine in the treatment of 23 cases with chronic hepatitis B, Henan J Prev Med, 02, 94 Zhang, 1994, Efficacy analysis polyporus polysaccharide combined with RNA and hepatitis B vaccine in the treatment of 78 cases with chronic hepatitis B, Med J Commun, 01, 42 Zhu, 1994, Preliminary observation of polyporus polysaccharide combined with hepatitis B vaccine efficacy against hepatitis B virus, Anhui Med J, 05, 33 Zheng, 1994, Impact for serum HBV markers of polyporus polysaccharide combined with hepatitis B vaccine in the treatment of chronic hepatitis B, Chin J Dig, 01, 8 Yang, 1994, Polyporus polysaccharide combined with hepatitis B vaccine in treatment of 58 cases with chronic hepatitis B, Chin J Integr Tradit West Med Liver Dis, 01, 42 Wang, 1994, Polyporus polysaccharide combined with hepatitis B vaccine in treatment of 120 cases with chronic hepatitis B, Chin J Integr Tradit West Med Liver Dis, 04, 30 Liu, 1994, Controlled study of polyporus polysaccharide combined with hepatitis B vaccine in the treatment of chronic hepatitis B, J Qiannan Med Coll Natl, Z2, 10 Xu, 1993, Efficacy of polyporus polysaccharide injection combined with hepatitis B vaccine in the treatment of chronic hepatitis B, Jilin Med J, 05, 276 Mao, 1993, Polyporus polysaccharide combined with hepatitis B vaccine in the treatment of hepatitis B, Chin J Hosp Pharm, 11, 22 Wang, 1992, Anti-hepatitis B new drug-polyporus polysaccharide injection, Chin J Hosp Pharm, 10, 47 Yang, 1990, Clinical research of hepatitis B vaccine combined polyporus polysaccharide in the treatment of chronic viral hepatitis B, People's Mil Surg, 05, 25 Wang, 2001, The treatment of polyporus polysaccharide combined lamivudine and hepatitis B vaccine for chronic hepatitis B, Mod Med Health, 04, 252 Sun, 2000, 47 cases of phyllanthus liver slices combined polyporus polysaccharide and hepatitis B vaccine in the treatment of chronic hepatitis B, Chin J Integr Tradit West Med Liver Dis, 06, 41 Zhang, 1999, Polyporus polysaccharide combined with hepatitis B vaccine and traditional Chinese medicines in the treatment of 44 cases with chronic hepatitis B, Chin J Integr Tradit West Med Liver Dis, 04, 42 Tan, 1997, Clinical observation of polyporus polysaccharide injection combined hepatitis B vaccine and interleukin-II in the treatment of chronic hepatitis B, J Youjiang Med Coll Natl, S1, 58 Bai, 1999, Efficacy of thymic peptide combined polyporus polysaccharide and hepatitis B vaccine in the treatment of chronic hepatitis B, Hebei Med, 03, 23 Yang, 2000, Comparison of effects of four antiviral therapy for the treatment of chronic hepatitis B, J Clin Hepatol, 03, 167 Wang, 1995, Efficacy of ganyanling combined with polyporus polysaccharide in the treatment of chronic hepatitis B, J Integr Tradit Chin West Med Chin Spleen Stomach, 03, 141 Lin, 1994, Clinical observation of acyclovir combined polyporus polysaccharide in 67 cases with chronic hepatitis B, Chin J Hepatol, 03, 185 Lvhong, 2005, Efficacy of interferon, polyporus polysaccharide combined hepatitis B vaccine in the treatment of chronic hepatitis B, Mod Prev Med, 05, 537 Yuan, 2002, Observation of α-2b interferon combined polyporus polysaccharide injection in the treatment of chronic hepatitis B, Tianjin Pharm, 03, 50 Wang, 2001, Polyporus polysaccharide combined interferon and hepatitis B vaccine in the treatment of chronic hepatitis B, Chin J Integr Tradit West Med, 15, 1488 Zhang, 2000, Comparison of effects on the treatment of three groups of drugs in chronic hepatitis B, J Clin Hepatol, 01, 32 Gan, 1999, Efficacy Of interferon combined acyclovir in the treatment of chronic hepatitis B, Chin J Gastroenterol Hepatol, 03, 218 Shen, 1999, Clinical observation of interferon and polyporus polysaccharide, hepatitis B vaccine combination therapy for chronic hepatitis B, Chin J Gastroenterol Hepatol, S1, 65 Pang, 1998, Observation of polyporus polysaccharide combined interferon in the treatment of 40 cases with chronic hepatitis B, Acta Med Sin, 05, 54 Lv, 1998, Comparison of effects on the treatment of three kinds of pathogens in chronic hepatitis B, Acta Acad Med Xuzhou, 03, 48 Yuan, 1998, Interferon combined polyporus polysaccharide in the treatment of 30 cases with chronic hepatitis B, Chin J Integr Tradit West Med Liver Dis, S1, 61 Lv, 1997, Polyporus polysaccharide combined interferon in the treatment of 60 cases with chronic hepatitis B, J Pract Med, 12, 823 Gao, 1997, Efficacy of polyporus polysaccharide combined interferon in the treatment of 28 cases with chronic hepatitis B, Med J Chin People's Armed Police Forces, 02, 25 He, 1997, Efficacy Of interferon combined polyporus polysaccharide in the treatment of chronic hepatitis B, Acad Med Jiangxi, 02, 50 Liang, 1996, 32 cases of polyporus polysaccharide combined interferon in the treatment of chronic hepatitis B, Guangdong Med J, 08, 547 Xu, 1996, Short-term curative observation of interferon, polyporus polysaccharide and immune RNA in the treatment of 116 cases with chronic hepatitis B, Inner Mong Med J, 02, 81 Xie, 1995, Short-term efficacy of polyporus polysaccharide combined with small dose interferon in the treatment of chronic hepatitis B, Chin J Biol, 04, 181 Ju, 1995, Short-term curative observation of interferon, polyporus polysaccharide and anti-hepatitis B immune RNA in the treatment of chronic hepatitis B, J Zhenjiang Med Coll, 03, 222 Liao, 1994, Short-term curative observation of interferon, polyporus polysaccharide and thymic factor in the treatment of chronic hepatitis B, J Clin Hepatol, 01, 49 Jin, 1994, Efficacy of genetic engineering-interferon combined acyclovir in the treatment of chronic hepatitis B, J Zhenjiang Med Coll, 04, 58 Chen, 2010, Clinical treatment discussion for 89 cases of chronic hepatitis B, Chin J Mod Drug Appl, 01, 82 Dang, 2005, Clinical research on comprehensive immunotherapy treatment of chronic hepatitis B, Chin Arch Tradit Chin Med, 02, 373 Ma, 2004, Lamivudine and polyporus polysaccharide in the treatment of chronic hepatitis B, J Med Forum, 15, 48 Sun, 2003, Clinical efficacy of shendan yiganqing in the treatment of chronic hepatitis B degrading enzyme, Pract Clin J Integr Tradit Chin West Med, 01, 8 Jing, 2000, Observation of compound muji powder in the treatment of chronic hepatitis B, J Pract Tradit Chin Med, 03, 37 Ma, 2000, Clinical efficacy of integrated traditional and western treatment for chronic hepatitis B, Chin J Inf Tradit Chin Med, 08, 66 Ma, 1999, Cinobufotalin combined with polyporus polysaccharide in the treatment of 60 cases with chronic hepatitis B, Shanxi J Tradit Chin Med, 01, 11 Xie, 1998, Ganyanling, polyporus polysaccharide and astragalus injection combined with hepatitis B vaccine in the treatment of 67 cases of chronic asymptomatic HBV carriers, Chin J Integr Tradit West Med, 04, 250 Zhou, 1998, Clinical observation of polyporus polysaccharide acupoint injection in the treatment of chronic hepatitis B, J Changchun Univ Tradit Chin Med, 04, 13 Gao, 1998, 72 cases of polyporus polysaccharide in the treatment of hepatitis B, Henan Med Inf, 04, 49 Hu, 1998, Observation of mongolian and western medicine combination in the treatment of 32 cases with chronic hepatitis B, J Med Pharm Chin Minor, 04, 26 Fan, 1995, Efficacy of Chinese drugs combined polyporus polysaccharide injection in the treatment of chronic hepatitis B, Chin Community Doct, 12, 26 Gao, 1995, Polyporus polysaccharide combined with chaoyang pill for 56 cases of hepatitis B, Shaanxi J Tradit Chin Med, 07, 292 Xiong, 1993, Efficacy of danshen combined with polyporus polysaccharide in the treatment of chronic hepatitis B, Chin J Integr Tradit West Med, 09, 533 Sun, 1998, Clinical observation of Chinese drugs combined umbilical dressing in the treatment for 81 cases with chronic hepatitis B, J New Chin Med, 12, 37 Tan, 1998, Clinical observation of acyclovir and polyporus polysaccharide combined therapy against chronic hepatitis B virus infection, Chin J Exp Clin Virol, 01, 17 Shi, 1998, Efficacy of acyclovir + polyporus polysaccharide in the treatment of 377 cases with chronic hepatitis B, Suzhou Univ J Med Sci, 05, 514 Diao, 1996, Efficacy of acyclovir combined with polyporus polysaccharide in the treatment of hepatitis B, J Clin Hepatol, 01, 49 Li, 1995, Efficacy of acyclovir combined with polyporus polysaccharide in the treatment of chronic hepatitis B (40 cases), J Heilongjiang Med, 04, 3 Han, 1995, Efficacy of acyclovir combined with polyporus polysaccharide in the treatment of chronic hepatitis B, J Zhenjiang Med Coll, 02, 119 Li, 1997, Efficacy of polyporus polysaccharide combined anti-HBV RNA in the treatment of Hepatitis B, J Heze Med Coll, 03, 66 Liu, 1998, The treatment of anti-hepatitis B immune RNA combined polyporus polysaccharide for chronic hepatitis B, Clin Focus, 12, 550 Lian, 1997, Short-term curative observation of combination therapy for 120 cases of chronic hepatitis B, J Hubei Med Staff Coll, 03, 9 Wang, 1996, Compare the efficacy of polyporus polysaccharide combined with anti-hepatitis B immune RNA and interferon in the treatment of chronic hepatitis B, Chin J Hepatol, 01, 39 Cheng, 2005, Efficacy of polyporus polysaccharide combined hepatitis B vaccine and lamivudine in the treatment of chronic hepatitis B, Guangdong Med J, 06, 843 Li, 2005, Efficacy of chronic hepatitis B with oral polyporus polysaccharide combined or sequential lamivudine, Guangdong Med J, 09, 1278 Du, 2002, Efficacy of polyporus polysaccharide combined lamivudine in the treatment of chronic hepatitis B, J Huaihai Med, 06, 456 Yao, 2000, Efficacy of thymic peptide combined polyporus polysaccharide in the treatment of chronic hepatitis B, Chin Med Fact Mine, 06, 34 Yao, 2000, Efficacy of thymic peptide combined polyporus polysaccharide in the treatment of chronic hepatitis B, Railw Med, 02, 95 Yu, 1997, Clinical analysis of polyporus polysaccharide combined interleukin-2 in the treatment for 60 cases with chronic hepatitis B, Jiangxi Med, 03, 33 Qin, 2010, 40 cases of chronic hepatitis B with adefovir dipivoxil and polyporus polysaccharide combined therapy, Herald Med, 04, 494 Fu, 2008, 60 cases of chronic hepatitis B with oral polyporus polysaccharide and entecavir combined therapy, Chin J Integr Tradit West Med Liver Dis, 01, 51 Long, 1998, Compare the efficacy of the treatment of polyporus polysaccharide alone or in combination with hepatitis B immune globulin for hepatitis B virus infection, J Guangdong Med Coll, 03, 22 Liu, 1995, The observation of polyporus polysaccharide comprehensive treatment in advanced hepatic carcinomaanalysis of 120 cases, Strait Pharm J, 01, 27 Bian, 1997, Short-term curative observation of polyporus polysaccharide with COEP combined treatment in 50 cases of small cell lung cancer, Chin J Cancer Biother, 03, 233 Gu, 1984, The efficacy of polyporus polysaccharide and its extract (757) in the treatment of lung cancer, J Norman Bethune Univ Med Sci, 01, 43 Gu, 1981, Application of polyporus polysaccharide in the treatment of lung cancer, J Norman Bethune Univ Med Sci, 04, 51 Wan, 1999, One case report of limb joint sting caused by polyporus polysaccharide, Qinghai Med J, 06, 50 Zheng, 1998, One case of transient migratory joint pain caused by intramuscular injection of polyporus polysaccharide, Henan J Prev Med, 06, 364 Gao, 1998, One case report of allergic purpura caused by polyporus polysaccharide, J Fact Med Health, 14, 64 Dong, 1998, One case of systemic lupus erythematosus caused by polyporus polysaccharide, Northwest Pharm J, 13 Jiao, 1997, One case of allergies concurrent transient tinnitus caused by polyporus polysaccharide, Chin J Nurs, 32 Fan, 1996, One case of severe joint pain caused by polyporus polysaccharide, Appl Mod Med, 02, 63 Li, 1996, Three cases of allergic reactions caused by polyporus polysaccharide, Chin J Hosp Pharm, 02, 93 Zhang, 1995, One case of vaginal bleeding caused by polyporus polysaccharide intramuscular injection, Chin J New Drugs Clin Remedies, 03, 183 Jiang, 1995, One case of gastrointestinal reactions caused by polyporus polysaccharide injection, Herald Med, 04, 183 Yi, 1995, One case of dermatitis caused by polyporus polysaccharide, Chin J Pharmacoepidemiol, 3 Yang, 1994, One case of skin allergies caused by polyporus polysaccharide injection, Chin J Nurs, 02, 125 Zhao, 1994, One case of anaphylactic shock caused by polyporus polysaccharide, Chin J Pract Intern Med, 9 Zhou, 1994, One case of acute arthritis caused by polyporus polysaccharide, Mod Pract Med, 6, 3 Zhou, 1994, One case of angioneurotic edema caused by polyporus polysaccharide, Chin J Pharmacoepidemiol, 01, 35 Zhang, 1990, Two cases of drug-induced dermatitis caused by polyporus polysaccharide, Chin J New Drugs Clin Remedies, 3, 14 Zhu, 1994, Two case reports of fever and severe joint pain caused by polyporus polysaccharide injection, Chin J Hepatol, 02, 234 Zeng, 2004, Retrospective analysis of 25 cases of adverse reactions of polyporus polysaccharide injection, Eval Anal Drug-Use Hosp China, 06, 364