The efficacy and safety of perioperative administration of dexamethasone: a systematic review and meta-analysis

Ain-Shams Journal of Anesthesiology - Tập 15 - Trang 1-12 - 2023
Mohammad Javad Najafzadeh1, Mohadeseh Shafiei1, Meraj Sharifi1, Parvaneh Nazari2, Naser Nasiri3, Morteza Hashemian4
1Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
2Clinical Research Development Unit, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran
3HIV/STI Surveillance Research Center and WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran
4Department of Anesthesiology and Pain Medicine, Kerman University of Medical Sciences, Kerman, Iran

Tóm tắt

Perioperative prophylactic dexamethasone is commonly administered to reduce postoperative nausea and vomiting (PONV) and pain after surgery. In this study, we aimed to systematically review the efficacy and adverse effects of perioperative dexamethasone administration. We conducted a systematic search until January 2023 in scientific databases, including PubMed, Scopus, Embase, Web of Science, and Google Scholar. After assessing the methodological quality of relevant studies, we synthesized those focusing on PONV, oral food intake tolerance, impaired wound healing, major postoperative complications, and postoperative infections following the perioperative administration of dexamethasone. A total of 27 studies were included in this systematic review and meta-analysis. The dexamethasone group showed decreased PONV (OR = 0.19; 95% CI 0.06–0.55), increased oral food intake tolerance (OR = 7.38; 95% CI 1.07–51.11), increased risk of impaired wound healing (OR = .48; 95% CI 0.52–4.21), decreased probability of postoperative infection (OR = 0.61; 95% CI 0.51–0.72), and increased risk of major postoperative complications (OR = 1.27; 95% CI 0.68–2.39) compared to the controls. The results of our pooled data analysis showed that dexamethasone was superior to the control in terms of PONV, oral food intake tolerance, and postoperative infections.

Tài liệu tham khảo

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