The effects of vibration on the neuronal activity of lateral vestibular nuclei in unilaterally labyrinthectomized rats
Tóm tắt
Unilateral labyrinthectomy causes distinct oculomotor and postural disorder syndromes that gradually deteriorate. Simultaneously, compensatory mechanisms for the suppression of pathological disorders were activated. The current study aimed to investigate the characteristics of impulse activity in the ipsilateral and contralateral neurons of the lateral vestibular nucleus of unilaterally labyrinthectomized rats during various periods of vibration exposure. A program analysis of the background impulse activity of the neurons in the right- and left-lateral vestibular nuclei of rats under normal condition and after right-sided labyrinthectomy was performed. The animals were subjected to different periods of vibration exposure 2 days after surgery (5-, 10-, and 15-day periods). A comparison of the characteristics of the background impulse activity of neurons in both nuclei of intact rats revealed an initial asymmetry in the values of the mean impulse frequency and coefficient of variation of interimpulse intervals. After 5 days of vibration exposure, the values of the mean impulse frequency of neurons in both Deiters’ nuclei were almost equal in labyrinthectomized rats. The mean impulse frequency of neurons on the uninjured side was higher than that on the injured side on the days following vibration exposure. The characteristics and functional significance of the findings are discussed.
Tài liệu tham khảo
Abad-Alegria F (1971) Esterotaxistroncoencefalica. Trab Inst Cajalinvest Biol 63(1):193–224
Beraneck M, Hachemaoui M, Idoux E, Ris L et al (2003) Long-term plasticity of ipsilesional medial vestibular nucleus neurons after unilateral labyrinthectomy. J Neurophysiol 84(4):515–526
Besnard S, Machado ML, Vignaux G, Boulouard M, Coquerel A, Bouet V, Freret T, Denise P, Lelong-Boulouard V (2012) Influence of vestibular input on spatial and nonspatial memory and on hippocampal NMDA receptors. Hippocampus 22(4):814–826
Cameron SA, Dutia MB (1997) Cellular basis of vestibular compensation: changes in intrinsic excitability of MVN neurones. NeuroReport 8(11):2595–2599
Cass SP, Kartush JM, Graham MD (1992) Patterns of vestibular function following vestibular nerve section. Laryngoscope 102(4):388–394
Cullen KE, Minor LB, Beraneck M, Sadeghi SG (2009) Neural substrates underlying vestibular compensation: contribution of peripheral versus central processing. J Vestib Res 19(5–6):171–182
Curthoys IS, Halmagyi GM (1995) Vestibular compensation: a review of the oculomotor, neural, and clinical consequences of unilateral vestibular loss. J Vestib Res 5(2):67–107
Curthoys IS, Halmagyi GM (1998) Vestibular compensation: a review of the oculomotor neural and clinical consequences of unilateral vestibular loss. J. Vestibul. Res. 5:67–107
Darlington CL, Smith PF (1996) The recovery of static vestibular function following peripheral vestibular lesions in mammals: the intrinsic mechanism hypothesis. J Vestib Res 6(3):185–201
Dieringer N, Precht W (1979) Mechanisms of compensation for vestibular deficits in the frog. I Modification of the excitatory commissural system. Exp Brain Res 36(2):311–328
Galiana HL, Flohr H, Jones GH (1984) A revalution of intervestibular nuclear copling: its role in vestibular compensation. J Neurophysiol 51:242–259
Hamann KF, Lannou J (1987) Dynamic characteristics of vestibular nuclear neurons responses to vestibular and optokinetic stimulation during vestibular compensation in the rat. Acta Otolaryngol Suppl 445:1–19
Jenkins H, Cohen H, Kimball K (2000) Long-term vestibulo-ocullar reflex changes in patients with vestibular ablation. Actaoto-Laryngologica. 120(2):187–191
Jones SM, Jones TA, Mills KN, Gaines GC (2009) Anatomical and physiological considerations in vestibular dysfunction and compensation. Semin Hear 30(4):231–241
Maioli C, Precht W, Ried S (1983) Short- and long-term modifications of vestibulo-ocular response dynamics following unilateral vestibular nerve lesions in the cat. Exp Brain Res 50(2–3):259–274
Ris L, de Waele C, Serafin M, Vidal P, Godaux E (1995) Neuronal activity in the ipsilateral vestibular nucleus following unilateral labyrinthectomy in the alert guinea pig. J. Neurophysiology. 74:2087–2099
Sadeghi SG, Minor LB, Cullen KE (2007) Response of vestibular-nerve afferents to active and passive rotations under normal conditions and after unilateral labyrinthectomy. J Neurophysiol 97(2):1503–1514
Sarkisian VH (2000) Input-output relations of Deiter’s lateral vestibulospinal neurons with different structures of the brain. Arch Italiennes De Biologie. 138:295–353
Sarkisyan SH, Chavushyan VA, Kamenecki VS et al (2015) The effects of the stimulation of hypothalamic nuclei on the inferior vestibular nucleus after long-term vibration action and administration of proline rich peptide-1. Russ J Physiol 101(5):538–549
Shaabani M, Lotfi Y, Karimian SM, Rahgozar M, Hooshmandi M (2016) Short-term galvanic vestibular stimulation promotes functional recovery and neurogenesis in unilaterally labyrinthectomized rats. Brain Res 1648(Pt A):152–162
Smith PF, Curthoys JS (1988) Neuronal activity in the ipsilateral medial vestibular nucleus of the guinea pig following unilateral labyrinthectomy. Brain Res 444:308–319
Vibert N et al (1999) Plastic changes underlying vestibular compensation in the Guinea-pig persist in isolated, in vitro whole brain preparations. Neuroscience 93(2):413–432
Vidal PP et al (2005) Recovery after vestibular lesions: from animal models to patients. Neuroembryology and Aging 3(4):194–206
Yamanaka T et al (2000) Rapid compensatory changes in GABA receptor efficacy in rat vestibular neurones after unilateral labyrinthectomy. J Physiol 523(2):413–424