The effects of the painkiller diclofenac and hypoxia on gene transcription and antioxidant system in the gills of three-spined stickleback

Andreozzi, 2003, Pharmaceuticals in STP effluents and their photodegradation in aquatic environment, Chemosphere, 50, 1319, 10.1016/S0045-6535(02)00769-5 Bradford, 1976, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein–dye binding, Anal. Biochem., 7, 248, 10.1016/0003-2697(76)90527-3 Brown, 2007, Variations in bioconcentration of human pharmaceuticals from sewage effluents into fish blood plasma, Environ. Toxicol. Pharmacol., 24, 267, 10.1016/j.etap.2007.06.005 Brozinski, 2013, The anti-inflammatory drugs diclofenac, naproxen and ibuprofen are found in the bile of wild fish caught downstream of a wastewater treatment plant, Environ. Sci. Technol., 47, 342, 10.1021/es303013j Buser, 1998, Occurrence and fate of the pharmaceutical drug diclofenac in surface waters: rapid photodegradation in a lake, Environ. Sci. Technol., 32, 188, 10.1021/es9705811 Choe, 2006, COX2 in a euryhaline teleost, Fundulus heteroclitus: primary sequence, distribution, localization, and potential function in gills during salinity acclimation, J. Exp. Biol., 209, 1696, 10.1242/jeb.02198 Clerch, 1991, Perinatal rat lung catalase gene expression: influence of corticosteroid and hyperoxia, Am. J. Physiol., 260, 428 Crofford, 1997, COX-1 and COX-2 tissue expression: implications and predictions, J. Rheumatol. Suppl., 49, 15 Czyzyk-Krzeska, 1994, Hypoxia increases rate of transcription and stability of tyrosine hydroxylase mRNA in pheochromocytoma (PC12) cells, J. Biol. Chem., 269, 760, 10.1016/S0021-9258(17)42415-X Dalziel, 2012, Mechanisms underlying parallel reductions in aerobic capacity in non-migratory threespine stickleback (Gasterosteus aculeatus) populations, J. Exp. Biol., 215, 746, 10.1242/jeb.065425 Doherty, 2010, Circadian control of global gene expression patterns, Annu. Rev. Genet., 44, 419, 10.1146/annurev-genet-102209-163432 Edgar, 2012, Peroxiredoxins are conserved markers of circadian rhythms, Nature, 485, 459, 10.1038/nature11088 Egg, 2012, Linking oxygen to time: the bidirectional interaction between the hypoxic signaling pathway and the circadian clock, Chronobiol. Int., 30, 510, 10.3109/07420528.2012.754447 Evans, 1987, The fish gill: site of action and model for toxic effects of environmental pollutants, Environ. Health Perspect., 71, 47, 10.1289/ehp.877147 Fent, 2006, Ecotoxicology of human pharmaceuticals, Aquat. Toxicol., 76, 122, 10.1016/j.aquatox.2005.09.009 Firth, 1995, Hypoxic regulation of lactate dehydrogenase A. Interaction between hypoxia-inducible factor 1 and cAMP response elements, J. Biol. Chem., 270, 21021, 10.1074/jbc.270.36.21021 Gracey, 2001, Hypoxia-induced gene expression profiling in the euryoxic fish Gillichthys mirabilis, Proc. Natl. Acad. Sci. U. S. A., 98, 1993, 10.1073/pnas.98.4.1993 Hadfield, 2010, MCMC methods for multi-response generalized linear mixed models: the MCMCglmm R package, J. Stat. Softw., 33, 1, 10.18637/jss.v033.i02 Halliwell, 2006 Harper, 2008, Complexity of COX-2 gene regulation, Biochem. Soc. Trans., 36, 543, 10.1042/BST0360543 Heberer, 2004, Field studies on the fate and transport of pharmaceutical residues in bank filtration, Ground Water Monitoring and Remediation, 24, 70, 10.1111/j.1745-6592.2004.tb00714.x Hermes-Lima, 2004, Oxygen in biology and biochemistry: role of free radicals, 319 Hermes-Lima, 2002, Animal response to drastic changes in oxygen availability and physiological oxidative stress, Comp. Biochem. Physiol. C, 133, 537 Hoeger, 2005, Water-borne diclofenac affects kidney and gill integrity and selected immune parameters in brown trout (Salmo trutta f. fario), Aquat. Toxicol., 75, 53, 10.1016/j.aquatox.2005.07.006 Hong, 2007, Analysis of the effects diclofenac has on Japanese medaka (Oryzias latipes) using real-time PCR, Chemosphere, 67, 2115, 10.1016/j.chemosphere.2006.12.090 Ingermann, 2011, Vertebrate hemoglobins. Compr. Physiol., Supplement 30, 357 Islas-Flores, H., Gomez-Olivan, L. M., Galar-Martinez, M., Colin-Cruz, A., Neri-Cruz, N. und Garcia-Medina, S., 2013. Diclofenac-induced oxidative stress in brain, liver, gill and blood of common carp (Cyprinus carpio). Ecotoxicol. Environ. Saf. 92, 32–38. Jobling, 2002, Wild intersex roach (Rutilus rutilus) have reduced fertility, Biol. Reprod., 67, 515, 10.1095/biolreprod67.2.515 Jobling, 1998, Widespread sexual disruption in wild fish, Environ. Sci. Technol., 32, 2498, 10.1021/es9710870 Kaelin, 2008, Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway, Mol. Cell, 30, 393, 10.1016/j.molcel.2008.04.009 Kallio, 2010, Metabolites of the aquatic pollutant diclofenac in fish bile, Environ. Sci. Technol., 44, 7213, 10.1021/es903402c Kraemer, 2004, Prior PCB exposure suppresses hypoxia-induced up-regulation of glycolytic enzymes in Fundulus heteroclitus, Comp. Biochem. Physiol. C, 139, 23 Leveelahti, 2014, Revisiting redox-active antioxidant defenses in response to hypoxic challenge in both hypoxia-tolerant and hypoxia-sensitive fish species, Fish Physiol. Biochem., 40, 183, 10.1007/s10695-013-9835-1 Livak, 2001, Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method, Methods, 25, 402, 10.1006/meth.2001.1262 Lushchak, 2006, Effects of different environmental oxygen levels on free radical processes in fish, Comp. Biochem. Physiol. B, 144, 283, 10.1016/j.cbpb.2006.02.014 Matthiessen, 2003, Endocrine disruption in marine fish, Pure Appl. Chem., 75, 2249, 10.1351/pac200375112249 Mehinto, 2010, Uptake and biological effects of environmentally relevant concentrations of the nonsteroidal anti-inflammatory pharmaceutical diclofenac in rainbow trout (Oncorhynchus mykiss), Environ. Sci. Technol., 44, 2176, 10.1021/es903702m Memmert, 2013, Diclofenac: new data on chronic toxicity and bioconcentration in fish, Environ. Toxicol. Chem., 32, 442, 10.1002/etc.2085 Mitchell, 1999, Cyclo-oxygenase-2: pharmacology, physiology, biochemistry and relevance to NSAID therapy, Br. J. Pharmacol., 128, 1121, 10.1038/sj.bjp.0702897 Oaks, 2004, Diclofenac residues as the cause of vulture population decline in Pakistan, Nature, 427, 630, 10.1038/nature02317 Opazo, 2013, Whole-genome duplication and the functional diversification of teleost fish hemoglobins, Mol. Biol. Evol., 30, 140, 10.1093/molbev/mss212 Pärt, 1989, Bioavailability and uptake of xenobiotics in fish, 113 Peig, 2009, New perspectives for estimating body condition from mass/length data: the scaled mass index as an alternative method, Oikos, 118, 1883, 10.1111/j.1600-0706.2009.17643.x Prokkola, 2015, Hypoxia and the pharmaceutical diclofenac influence the circadian responses of three-spined stickleback, Aquat. Toxicol., 158, 116, 10.1016/j.aquatox.2014.11.006 R Core Team, 2014 Randall, 1990, Toxicant uptake across fish gills Ransberry, 2016, The oxidative stress response in freshwater-acclimated killifish (Fundulus heteroclitus) to acute copper and hypoxia exposure, Comp. Biochem. Physiol. C, 179, 11 Ribas, 2004, A differentially expressed enolase gene isolated from the gilthead sea bream (Sparus aurata) under high-density conditions is up-regulated in brain after in vivo lipopolysaccharide challenge, Aquaculture, 241, 195, 10.1016/j.aquaculture.2004.07.015 Richards, 2009, Metabolic and molecular responses of fish to hypoxia, Vol 27, 443 Riddle, 2000, Hypoxia induces hexokinase II gene expression in human lung cell line A549, Am. J. Physiol. Lung Cell. Mol. Physiol., 278, 407, 10.1152/ajplung.2000.278.2.L407 Roesner, 2006, Hypoxia induces a complex response of globin expression in zebrafish (Danio rerio), J. Exp. Biol., 209, 2129, 10.1242/jeb.02243 Ross, 1995, mRNA stability in mammalian cells, Microbiol. Rev., 59, 423, 10.1128/MMBR.59.3.423-450.1995 Salama, 1996, Diclofenac-induced immune haemolytic anemia: simultaneous occurrence of red blood cell autoantibodies and drug-depended antibodies, Br. J. Haematol., 95, 640, 10.1046/j.1365-2141.1996.d01-1947.x Sarasquete, 2000, Cytochrome P4501A (CYP1A) in teleostean fishes. A review of immunohistochemical studies, Sci. Total Environ., 247, 313, 10.1016/S0048-9697(99)00500-8 Saucedo-Vence, 2015, Short and long-term exposure to diclofenac alter oxidative stress status in common carp Cyprinus carpio, Ecotoxicology, 24, 527, 10.1007/s10646-014-1401-9 Schwaiger, 2004, Toxic effects of the non-steroidal anti-inflammatory drug diclofenac. Part I: histopathological alterations and bioaccumulation in rainbow trout, Aquat. Toxicol., 68, 141, 10.1016/j.aquatox.2004.03.014 Semenza, 1996, Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1, J. Biol. Chem., 271, 32529, 10.1074/jbc.271.51.32529 Shin, 2003, Identification of genes that are induced after cadmium exposure by suppression subtractive hybridization, Toxicology, 191, 121, 10.1016/S0300-483X(03)00210-5 Soitamo, 2001, Characterization of a hypoxia-inducible factor (HIF-1alpha) from rainbow trout. Accumulation of protein occurs at normal venous oxygen tension, J. Biol. Chem., 276, 19699, 10.1074/jbc.M009057200 Ternes, 1998, Occurrence of drugs in German sewage treatment plants and rivers, Water Res., 32, 3245, 10.1016/S0043-1354(98)00099-2 Ton, 2003, Gene expression profile of zebrafish exposed to hypoxia during development, Physiol. Genomics, 13, 97, 10.1152/physiolgenomics.00128.2002 Triebskorn, 2004, Toxic effects of the non-steroidal anti-inflammatory drug diclofenac. Part II: cytological effects in liver, kidney, gills and intestine of rainbow trout (Oncorhynchus mykiss), Aquat. Toxicol., 68, 151, 10.1016/j.aquatox.2004.03.015 Warner, 1999, Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis, Proc. Natl. Acad. Sci. U. S. A., 96, 7563, 10.1073/pnas.96.13.7563 Weber, 1988, Functional adaptations in hemoglobins from ectothermic vertebrates, Annu. Rev. Physiol., 50, 161, 10.1146/annurev.ph.50.030188.001113 WHO, 2011 Whyte, 2000, Ethoxyresorufin-O-deethylase (EROD) activity in fish as a biomarker of chemical exposure, Crit. Rev. Toxicol., 30, 347, 10.1080/10408440091159239 Wickham, 2009 Winston, 1991, Prooxidant and antioxidant mechanisms in aquatic organisms, Aquat. Toxicol., 19, 137, 10.1016/0166-445X(91)90033-6 Yan, 2000, Benzo[a]pyrene induces the transcription of cyclooxygenase-2 in vascular smooth muscle cells. Evidence for the involvement of extracellular signal-regulated kinase and NF-kappaB, J. Biol. Chem., 275, 4949, 10.1074/jbc.275.7.4949 Zhou, 2010, Molecular phylogenies and evolutionary behavior of AhR (aryl hydrocarbon receptor) pathway genes in aquatic animals: implications for the toxicology mechanism of some persistent organic pollutants (POPs), Chemosphere, 78, 193, 10.1016/j.chemosphere.2009.09.012