The effects of the noncompetitive NMDA receptor antagonist MK 801 on DRL performance in rats
Tóm tắt
When rats were under a DRL 10-sec schedule and had to rely on internai cues for obtaining food, the noncompetitive NMDA receptor antagonist MK 801 (0.20 and 0.25 mg/kg) increased response rate (number of leverpresses/session) and decreased the efficiency in obtaining reward in a dose-dependent fashion. MK 801 shifted the median of the interresponse time interval (IRT) distribution to the left (shorter intervais) and increased the number of short IRT intervais (0–2 sec) generated. When the end of the 10-sec interval in a DRL 10-sec schedule was signaled by an S+ (light), saline-injected, as well as MK 801-injected, animais improved their performance. Further-more, the effect of MK 801 on response rate was less pronounced, and no shift in the median of the IRT distribution could be seen. A high dose of MK 801 (0.30 mg/kg) dramatically decreased response rate and efficiency independent of the presence of the S+.
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