The effect of treatment with flunixin meglumine at different times relative to hCG administration on ovulation failure and luteal function in mares

Armstrong, 1981, Prostaglandins and follicular functions, JReprod. Fertil., 62, 283, 10.1530/jrf.0.0620283 Chay, 1982, The pharmacology of nonsteroidal anti-inflammatory drugs in the horse: flunixin meglumine (Banamine), Equine Pract., 4, 16 Cuervo-Arango, 2011, Systemic treatment with high dose of flunixin-meglumine is able to block ovulation in mares by inducing hemorrhage and luteinization of follicles, Theriogenology, 75, 707, 10.1016/j.theriogenology.2010.10.011 Evans, 2006, Plasma LH concentrations after administration of human chorionic gonadotropin to estrous mares, Anim. Reprod. Sci., 94, 191, 10.1016/j.anireprosci.2006.03.029 Ginther, 1995 Ginther, 2005, Systemic concentrations of hormones during development of follicular waves in mares and women: a comparative study, Reproduction, 130, 379, 10.1530/rep.1.00757 Ginther, 2009, Treatment with human chorionic gonadotrophin (hCG) for ovulation induction is associated with an immediate 17β-estradiol decrease and a more rapid LH increase, Anim. Reprod. Sci., 114, 311, 10.1016/j.anireprosci.2008.08.026 Harrison, 1991, Comparison of hCG, Buserelin and Luprostiol for induction of ovulation in cycling mares, J. Equine Vet. Sci., 11, 163, 10.1016/S0737-0806(07)80039-6 Hedin, 1987, Prostaglandin endoperoxide synthase in rat ovarian follicles: content, cellular distribution, and evidence for hormonal induction preceding ovulation, Endocrinology, 121, 722, 10.1210/endo-121-2-722 Higgins, 1986, Flunixin meglumine: quantitative determination in and effects on composition of equine inflammatory exudate, Br. Vet. J., 142, 163, 10.1016/0007-1935(86)90093-X Killick, 1987, Pharmacologic production of luteinized unruptured follicles by prostaglandin synthetase inhibitors, Fertil. Steril., 47, 773, 10.1016/S0015-0282(16)59163-8 Murdoch, 1993, A review – role of eicosanoids in vertebrate ovulation, Prostaglandins, 46, 85, 10.1016/0090-6980(93)90037-8 Siddiqui, 2009, Effect of hCG in the presence of hCG antibodies on the follicle, hormone concentrations, and oocyte in mares, Reprod. Domest. Anim., 44, 474, 10.1111/j.1439-0531.2008.01133.x Sirois, 1997, The late induction of prostaglandin G/H synthase-2 in equine preovulatory follicles supports its role as a determinant of the ovulatory process, Endocrinology, 138, 4427, 10.1210/en.138.10.4427 Toutain, 1994, Plasma concentrations and therapeutic efficacy of phenylbutazone and flunixin meglumine in the horse: pharmacokinetic/pharmacodynamic modelling, J. Vet. Pharmacol. Ther., 17, 459, 10.1111/j.1365-2885.1994.tb00278.x Turner, 1979, Follicular and gonadotropic changes throughout the year in pony mares, Am. J. Vet. Res., 40, 1694 Van Niekerk, 1975, Relationship between the morphology of and progesterone production by the corpus luteum of the mare, J. Reprod. Fertil. Suppl., 23, 171 Watson, 1990, Secretion of prostaglandins and progesterone by cells from corpora lutea of mares, J. Reprod. Fertil., 88, 223, 10.1530/jrf.0.0880223