The effect of topical phenytoin on healing in diabetic foot ulcers: a randomized controlled trial1

Diabetic Medicine - Tập 28 Số 10 - Trang 1154-1157 - 2011
Julia Shaw1, Ciara Hughes2, K.M. Lagan2, Mark Stevenson3, Chris R. Irwin4, P. M. Bell5
1Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast Health and Social Care Trust, Belfast, UK
2Health and Rehabilitation Sciences Institute, University of Ulster, Newtownabbey
3Department of Medical Statistics, Epidemiology and Public Health, Queen’s University
4School of Dentistry, Queen’s University, Belfast, UK
5Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast Health and Social Care Trust

Tóm tắt

Từ khóa


Tài liệu tham khảo

Mason, 1999, A systematic review of foot ulcer patients with Type 2 diabetes mellitus. 11: treatment, Diabet Med, 16, 889, 10.1046/j.1464-5491.1999.00137.x

Shaw, 2007, The use of topical phenytoin in wound healing: a systematic review, Br J Dermatol, 157, 997, 10.1111/j.1365-2133.2007.08160.x

Lipsky, 2004, Infectious diseases of America guidelines: diagnosis and treatment of diabetic foot infection, Clin Infect Dis, 39, 885, 10.1086/424846

Shaw, 2007, An evaluation of three wound measurement techniques in diabetic foot wounds, Diabetes Care, 30, 2641, 10.2337/dc07-0122

Carlson, 1983, Assessment of chronic pain. 1. Aspects of the reliability and validity of the Visual Analogue Scale, Pain, 16, 87, 10.1016/0304-3959(83)90088-X

Melzack, 1987, The Short Form McGill Pain Questionnaire, Pain, 30, 191, 10.1016/0304-3959(87)91074-8

Shaw, 2005, The research governance agenda: a new experience, Diabetic Foot, 8, 201

El, 1989, Preliminary experience with topical phenytoin in wound healing in a war zone, Mil Med, 154, 178, 10.1093/milmed/154.4.178

Yadav, 1993, Topical phenytoin in the treatment of split thickness skin autograft donor sites: a comparative study with polyurethane membrane drape and conventional dressing, Burns, 19, 306, 10.1016/0305-4179(93)90118-R

Carneiro, 2003, Topical phenytoin versus eusol in the treatment of non-malignant chronic leg ulcers, East Afr Med J, 80, 124

Pai, 2001, Topical phenytoin in diabetic ulcers: a double blind controlled trial, Indian J Med Sci, 55, 593

Bauer, 1980, Phenytoin therapy of recessive dystrophic epidermolysis bullosa. Clinical trial and proposed mechanism of action on collagenase, N Engl J Med, 303, 776, 10.1056/NEJM198010023031402

Masgrau-Peya, 1995, Topical phenytoin accelerates healing in epidermolysis bullosa simplex, Dermatology, 190, 254, 10.1159/000246708

Rhodes, 2001, Topical phenytoin treatment of stage ll decubitus ulcers in the elderly, Ann Pharmacother, 35, 675, 10.1345/aph.10267