The effect of supplementation with milk fat globule membranes on psychological health: A randomized clinical trial in healthy adults with moderate stress

Argentiero, V., & Tavolato, B. (1980). Dopamine (DA) and serotonin metabolic levels in the cerebrospinal fluid (CSF) in Alzheimer's presenile dementia under basic conditions and after stimulation with cerebral cortex phospholipids (BC-PL). Journal of Neurology, 224(0340-5354 (Print)), 53-58. Baliyan, 2023, Milk fat globule membrane concentrate as a nutritional supplement prevents age-related cognitive decline in old rats: A lipidomic study of synaptosomes, Food Research International (Ottawa, Ont.), 10.1016/j.foodres.2022.112163 Bech, 2004, Measuring the dimensions of psychological general well-being by the WHO-5, QoL Newsletter, 32, 15 Benton, 2001, The influence of phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor, Nutritional Neuroscience, 4, 169, 10.1080/1028415X.2001.11747360 Bhattarai, 2018, Compliance with saliva collection protocol in healthy volunteers: strategies for managing risk and errors, International Journal of Medical Sciences, 15, 823, 10.7150/ijms.25146 Billeaud, 2014, Safety and tolerance evaluation of milk fat globule membrane-enriched infant formulas: A randomized controlled multicenter non-inferiority trial in healthy term infants, Clinical Medicine Insights: Pediatrics, 8, 51 Boyle, 2019, Effects of milk-based phospholipids on cognitive performance and subjective responses to psychosocial stress: A randomized, double-blind, placebo-controlled trial in high-perfectionist men, Nutrition, 57, 183, 10.1016/j.nut.2018.05.002 Brink, 2019, Effects of milk fat globule membrane and its various components on neurologic development in a postnatal growth restriction rat model, The Journal of Nutritional Biochemistry, 69, 163, 10.1016/j.jnutbio.2019.03.013 Brink, 2020, Milk fat globule membrane: The role of its various components in infant health and development, The Journal of Nutritional Biochemistry, 85, 10.1016/j.jnutbio.2020.108465 Buysse, 1988, The Pittsburgh sleep quality index: A new instrument for psychiatric research and practice, Psychiatry Research, 28, 193, 10.1016/0165-1781(89)90047-4 Capodivento, 2017, Sphingomyelin as a myelin biomarker in CSF of acquired demyelinating neuropathies, Scientific Reports, 7, 7831, 10.1038/s41598-017-08314-1 Castilho, 2004, Phosphatidylserine: An antidepressive or a cognitive enhancer?, Progress in Neuro-Psychopharmacology & Biological Psychiatry, 10.1016/j.pnpbp.2004.05.013 Cohen, 1983, A Global Measure of Perceived Stress, Journal of Health and Social Behaviour, 24, 385, 10.2307/2136404 Crespo, 2018, Modulation of miRNA expression in aged rat hippocampus by buttermilk and krill oil, Scientific Reports, 8, 3993, 10.1038/s41598-018-22148-5 Dinan, T.G., Stanton, C., & Cryan, J.F. (2013). Psychobiotics: a novel class of psychotropic. (1873-2402 (Electronic)). Faria, 2014, Alterations in phospholipidomic profile in the brain of mouse model of depression induced by chronic unpredictable stress, Neuroscience, 273, 1, 10.1016/j.neuroscience.2014.04.042 Foster, J.A., Rinaman, L., & Cryan, J.F. (2017). Stress & the gut-brain axis: Regulation by the microbiome. (2352-2895 (Print)). Fraser, 2022, Impacts of formula supplemented with milk fat globule membrane on the neurolipidome of brain regions of piglets, Metabolites, 12, 10.3390/metabo12080689 Gallier, S., MacGibbon, A. K. H., & McJarrow, P. (2018). Milk fat globule membrane (MFGM) supplementation and cognition. Agro FOOD Industry Hi Tech, 29. García-Serrano, 2020, Concentrates of buttermilk and krill oil improve cognition in aged rats Gázquez, 2023, Milk fat globule membrane plus milk fat increase docosahexaenoic acid availability in infant formulas, European Journal of Nutrition Golden, S. H., Sánchez Bn Fau - Wu, M., Wu M Fau - Champaneri, S., Champaneri S Fau - Diez Roux, A. V., Diez Roux Av Fau - Seeman, T., Seeman T Fau - Wand, G. S., & Wand, G. S. (2013). Relationship between the cortisol awakening response and other features of the diurnal cortisol rhythm: the Multi-Ethnic Study of Atherosclerosis. Psychoneuroendocrinology, 38(11), 2720-2728. Guan, 2015, Long-term supplementation with beta serum concentrate (BSC), a complex of milk lipids, during post-natal brain development improves memory in rats, Nutrients, 7, 4526, 10.3390/nu7064526 Hammen, C. (2005). Stress and depression. Annual Review of Clinical Psychology(2005), 1(1), 293-319. Hari, S., Ochiai R Fau - Shioya, Y., Shioya Y Fau - Katsuragi, Y., & Katsuragi, Y. (2015). Safety evaluation of the consumption of high dose milk fat globule membrane in healthy adults: a double-blind, randomized controlled trial with parallel group design. Biosci Biotechnol Biochem, 79(7), 1172-1177. Hellhammer, 2004, Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress, Stress, 7, 119, 10.1080/10253890410001728379 Hellhammer, 2010, Effects of milk phospholipid on memory and psychological stress response, British Food Journal, 10.1108/00070701011080258 Hernell, 2016, Clinical benefits of milk fat globule membranes for infants and children, The Journal of Pediatrics, 173, S60, 10.1016/j.jpeds.2016.02.077 Hung, 2001, Learning behaviour and cerebral protein kinase C, antioxidant status, lipid composition in senescence-accelerated mouse: Influence of a phosphatidylcholine–vitamin B12 diet, British Journal of Nutrition, 86, 163, 10.1079/BJN2001391 Krishnan, 2008, The molecular neurobiology of depression, Nature, 455, 894, 10.1038/nature07455 Küllenberg, 2012, Health effects of dietary phospholipids, Lipids in health and disease, 11, 1, 10.1186/1476-511X-11-3 Ladd, S. L., Sommer, S. A., LaBerge, S., & Toscano, W. (1993). Effect of phosphatidylcholine on explicit memory. Clinical neuropharmacology, 16, 540-540. Li, 2019, Improved neurodevelopmental outcomes associated with bovine milk fat globule membrane and lactoferrin in infant formula: A randomized, controlled trial, The Journal of Pediatrics, 215, e28 Lovibond, 1998, Long-Term Stability of Depression, Anxiety, and Stress Syndromes, Journal of Abnormal Psychology, 107, 520, 10.1037/0021-843X.107.3.520 Mather, 2011, Milk Lipids | Milk Fat Globule Membrane, 680 McKinlay, 2017, Effect of collection methods on salivary cortisol, Journal of Diagnostic Techniques and Biomedical Analysis, 06, 10.4172/2469-5653.1000121 Mika, 2018, Feeding the developing brain: Juvenile rats fed diet rich in prebiotics and bioactive milk fractions exhibit reduced anxiety-related behavior and modified gene expression in emotion circuits, Neuroscience Letters, 677, 103, 10.1016/j.neulet.2018.01.052 Oliveira, 2016, The impact of chronic stress on the rat brain lipidome, Molecular Psychiatry, 21, 80, 10.1038/mp.2015.14 Ortega-Anaya, 2019, Symposium review: The relevance of bovine milk phospholipids in human nutrition—Evidence of the effect on infant gut and brain development, Journal of Dairy Science, 102, 2738, 10.3168/jds.2018-15342 Schneider, 2017, Lipids in psychiatric disorders and preventive medicine, Neuroscience & Biobehavioral Reviews, 76, 336, 10.1016/j.neubiorev.2016.06.002 Scholey, A. B., Camfield, D. A., Hughes, M. E., Woods, W., K Stough, C. K., White, D. J., Gondalia, S. V., & Frederiksen, P. D. (2013). A randomized controlled trial investigating the neurocognitive effects of Lacprodan® PL-20, a phospholipid-rich milk protein concentrate, in elderly participants with age-associated memory impairment: the Phospholipid Intervention for Cognitive Ageing Reversal (PLICAR): study protocol for a randomized controlled trial. Trials, 14(1), 404. 10.1186/1745-6215-14-404. Schubert, 2011, Milk-based phospholipids increase morning cortisol availability and improve memory in chronically stressed men, Nutrition Research, 31, 413, 10.1016/j.nutres.2011.05.012 Schverer, 2022, Dietary Milk Phospholipids Attenuate Chronic Stress-Induced Changes in Behavior and Endocrine Responses across the Lifespan, Molecular Nutrition & Food Research, 66, 2100665, 10.1002/mnfr.202100665 Strain, 2018, The psychobiology of stress, depression, adjustment disorders and resilience, The World Journal of Biological Psychiatry, 19, S14, 10.1080/15622975.2018.1459049 Tanaka, 2013, The pilot study: Sphingomyelin-fortified milk has a positive association with the neurobehavioural development of very low birth weight infants during infancy, randomized control trial, Brain Dev, 35, 45, 10.1016/j.braindev.2012.03.004 Timby, 2014, Neurodevelopment, nutrition, and growth until 12 mo of age in infants fed a low-energy, low-protein formula supplemented with bovine milk fat globule membranes: A randomized controlled trial, The American Journal of Clinical Nutrition, 99, 860, 10.3945/ajcn.113.064295 Tomé-Carneiro, 2018, Buttermilk and Krill Oil Phospholipids Improve Hippocampal Insulin Resistance and Synaptic Signaling in Aged Rats, Molecular Neurobiology, 55, 7285, 10.1007/s12035-018-0934-y Topp, 2015, The WHO-5 Well-Being Index: A systematic review of the literature, Psychotherapy and Psychosomatics, 84, 167, 10.1159/000376585 Venkat, 2022, Milk polar lipids composition and functionality: A systematic review, Critical Reviews in Food Science and Nutrition, 1, 10.1080/10408398.2022.2104211