The effect of prednisone on serum thyrotropin, thyroxine and triiodothyronine concentrations in hypothyroid patients

Journal of Endocrinological Investigation - 2014
J. Jensen1, G. Nolan1, William Jubiz1
1Veterans Administration Hospital and Department of Medicine, University of Utah College of Medicine, Salt Lake City, USA

Tóm tắt

The effect of exogenous prednisone on serum thyrotropin (TSH), thyroxine (T4), and triiodothyronine (T3) concentrations was investigated in four patients with non-functioning thyroid glands receiving T4 replacement therapy. Orally administered prednisone, in a dose of 20 mg each day for nine days, resulted in a significant decrease in mean serum TSH levels (p < 0.01) without significant changes in levels of serum T4, T3, and thyroxine binding globulin (TBG). These findings suggest an inhibitory action of relatively low pharmacologic doses of prednisone on TSH release without changes in circulating thyroid hormone concentrations or inhibition of the peripheral conversion of T4 to T3.

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Tài liệu tham khảo

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Journal of Endocrinological Investigation

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